Takeshi Sakaba

Summary

Country: Germany

Publications

  1. ncbi request reprint The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release
    Kristian Wadel
    Research Group Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, Gottingen, 37077, Germany
    Neuron 53:563-75. 2007
  2. ncbi request reprint Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage
    Takeshi Sakaba
    Department of Neurobiology and Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen 37077, Germany
    Science 309:491-4. 2005
  3. ncbi request reprint Estimation of quantal parameters at the calyx of Held synapse
    Takeshi Sakaba
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, D37077 Gottingen, Germany
    Neurosci Res 44:343-56. 2002
  4. doi request reprint Two Ca(2+)-dependent steps controlling synaptic vesicle fusion and replenishment at the cerebellar basket cell terminal
    Takeshi Sakaba
    Max Planck Institute for Biophysical Chemistry, 37077, Gottingen, Germany
    Neuron 57:406-19. 2008
  5. ncbi request reprint Roles of the fast-releasing and the slowly releasing vesicles in synaptic transmission at the calyx of held
    Takeshi Sakaba
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 26:5863-71. 2006
  6. ncbi request reprint Quantitative analysis of calcium-dependent vesicle recruitment and its functional role at the calyx of Held synapse
    Nobutake Hosoi
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    J Neurosci 27:14286-98. 2007
  7. doi request reprint Calcium dependence of exo- and endocytotic coupling at a glutamatergic synapse
    Nobutake Hosoi
    Independent Junior Research Group of Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 63:216-29. 2009
  8. doi request reprint Target-dependent feedforward inhibition mediated by short-term synaptic plasticity in the cerebellum
    Jin Bao
    Independent Junior Research Group Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 30:8171-9. 2010
  9. doi request reprint Multivesicular release differentiates the reliability of synaptic transmission between the visual cortex and the somatosensory cortex
    Chao hua Huang
    Independent Junior Research Group Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany
    J Neurosci 30:11994-2004. 2010
  10. doi request reprint cAMP modulates intracellular Ca2+ sensitivity of fast-releasing synaptic vesicles at the calyx of Held synapse
    Lijun Yao
    Independent Junior Research Group of Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
    J Neurophysiol 104:3250-60. 2010

Collaborators

Detail Information

Publications16

  1. ncbi request reprint The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release
    Kristian Wadel
    Research Group Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, Gottingen, 37077, Germany
    Neuron 53:563-75. 2007
    ..We conclude that recruitment of synaptic vesicles to sites where Ca2+ channels cluster, rather than fusion competence, is a limiting step for rapid neurotransmitter release in response to presynaptic action potentials...
  2. ncbi request reprint Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage
    Takeshi Sakaba
    Department of Neurobiology and Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen 37077, Germany
    Science 309:491-4. 2005
    ..When stimulating release by calcium influx through channels, a difference between BoNT/C1 and TeNT emerged, which suggests that cleavage of synaptobrevin modifies the coupling between channels and release-competent vesicles...
  3. ncbi request reprint Estimation of quantal parameters at the calyx of Held synapse
    Takeshi Sakaba
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, D37077 Gottingen, Germany
    Neurosci Res 44:343-56. 2002
    ..These factors should always be taken into account for fully understanding the mechanisms of synaptic transmission and plasticity...
  4. doi request reprint Two Ca(2+)-dependent steps controlling synaptic vesicle fusion and replenishment at the cerebellar basket cell terminal
    Takeshi Sakaba
    Max Planck Institute for Biophysical Chemistry, 37077, Gottingen, Germany
    Neuron 57:406-19. 2008
    ....
  5. ncbi request reprint Roles of the fast-releasing and the slowly releasing vesicles in synaptic transmission at the calyx of held
    Takeshi Sakaba
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 26:5863-71. 2006
    ..The latter is less subject to depression presumably because of a rapid vesicular recruitment process, which is a characteristic of this component...
  6. ncbi request reprint Quantitative analysis of calcium-dependent vesicle recruitment and its functional role at the calyx of Held synapse
    Nobutake Hosoi
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    J Neurosci 27:14286-98. 2007
    ..We could also demonstrate an approximate sixfold increase in release probability (facilitation) during the initial 5-15 AP-like stimuli of such trains in our experimental condition, regardless of EPSC depression...
  7. doi request reprint Calcium dependence of exo- and endocytotic coupling at a glutamatergic synapse
    Nobutake Hosoi
    Independent Junior Research Group of Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 63:216-29. 2009
    ..Rather, we postulate that perturbation of a step linking exocytosis and endocytosis temporarily prevents new vesicles from docking at specialized sites for exocytosis...
  8. doi request reprint Target-dependent feedforward inhibition mediated by short-term synaptic plasticity in the cerebellum
    Jin Bao
    Independent Junior Research Group Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 30:8171-9. 2010
    ....
  9. doi request reprint Multivesicular release differentiates the reliability of synaptic transmission between the visual cortex and the somatosensory cortex
    Chao hua Huang
    Independent Junior Research Group Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany
    J Neurosci 30:11994-2004. 2010
    ..In addition, the slower decay of synaptic current and the intrinsic membrane properties of the postsynaptic neuron also contribute to the reliable transmission between S1 neurons...
  10. doi request reprint cAMP modulates intracellular Ca2+ sensitivity of fast-releasing synaptic vesicles at the calyx of Held synapse
    Lijun Yao
    Independent Junior Research Group of Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
    J Neurophysiol 104:3250-60. 2010
    ..We suggest that synaptic vesicles have to be positionally primed to the release sites close to the Ca(2+) channel cluster for cAMP to modulate intracellular Ca(2+) sensitivity of transmitter release...
  11. doi request reprint Multiple roles of calcium ions in the regulation of neurotransmitter release
    Erwin Neher
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 59:861-72. 2008
    ..Such coupling is essential for rendering vesicles sensitive to short [Ca(2+)] transients, generated during action potentials...
  12. ncbi request reprint Vesicle pools and short-term synaptic depression: lessons from a large synapse
    Ralf Schneggenburger
    Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Am Fassberg, D 37077 Gottingen, Germany
    Trends Neurosci 25:206-12. 2002
    ..By influencing the synaptic output during repetitive activity, vesicle pool dynamics are expected to modulate information processing in neuronal networks of the CNS...
  13. ncbi request reprint Direct modulation of synaptic vesicle priming by GABA(B) receptor activation at a glutamatergic synapse
    Takeshi Sakaba
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen 37077, Germany
    Nature 424:775-8. 2003
    ....
  14. pmc Activity-dependent modulation of endocytosis by calmodulin at a large central synapse
    Lijun Yao
    Independent Junior Research Group of Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 109:291-6. 2012
    ....
  15. ncbi request reprint Combining deconvolution and fluctuation analysis to determine quantal parameters and release rates
    Erwin Neher
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    J Neurosci Methods 130:143-57. 2003
    ..Several ways to handle non-stationarities are described. Examples are provided for the Calyx of Held, a glutamatergic synapse, in which both the pre- and the postsynaptic compartments can be voltage-clamped...
  16. ncbi request reprint Involvement of actin polymerization in vesicle recruitment at the calyx of Held synapse
    Takeshi Sakaba
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Gottingen, D 37077, Germany
    J Neurosci 23:837-46. 2003
    ..The results suggest that intact actin polymerization is involved in vesicle recruitment...