B Saile

Summary

Country: Germany

Publications

  1. ncbi request reprint The bcl, NFkappaB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-beta or TNF-alpha on activated hepatic stellate cells
    B Saile
    , Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Germany
    Eur J Cell Biol 80:554-61. 2001
  2. pmc Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes
    Katrin Neubauer
    University of Gottingen, Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Gottingen, Germany
    BMC Physiol 8:9. 2008
  3. ncbi request reprint Inflammation, damage repair and liver fibrosis--role of cytokines and different cell types
    B Saile
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, University of Gottingen, Gottingen, Germany
    Z Gastroenterol 45:77-86. 2007
  4. ncbi request reprint Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat
    T Knittel
    Department of Internal Medicine, University of Gottingen, Germany
    Histochem Cell Biol 113:443-53. 2000
  5. ncbi request reprint Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair
    T Knittel
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Histochem Cell Biol 112:387-401. 1999
  6. pmc Role of the Ets-1 transcription factor during activation of rat hepatic stellate cells in culture
    T Knittel
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, University of Gottingen, Gottingen, Germany
    Am J Pathol 155:1841-8. 1999
  7. pmc Irradiation leads to apoptosis of Kupffer cells by a Hsp27-dependant pathway followed by release of TNF-alpha
    K Tello
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg August University Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Radiat Environ Biophys 47:389-97. 2008
  8. ncbi request reprint The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium
    J Dudas
    Department of Gastroenterology and Endocrinology, Georg August University Gottingen, Robert Koch Strasse 40, Gottingen, Germany
    Anat Embryol (Berl) 208:359-66. 2004
  9. ncbi request reprint Mesenchymal cells in the liver--one cell type or two?
    G Ramadori
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg August University Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Liver 22:283-94. 2002
  10. ncbi request reprint Inflammation, damage repair, immune cells, and liver fibrosis: specific or nonspecific, this is the question
    G Ramadori
    Gastroenterology 127:997-1000. 2004

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The bcl, NFkappaB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-beta or TNF-alpha on activated hepatic stellate cells
    B Saile
    , Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Germany
    Eur J Cell Biol 80:554-61. 2001
    ..The interaction with these factors may lead to the generation of new antifibrotic drugs...
  2. pmc Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes
    Katrin Neubauer
    University of Gottingen, Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Gottingen, Germany
    BMC Physiol 8:9. 2008
    ..This study aims to identify in vitro conditions (cytokine treatment) which may allow a better understanding of the changes in PECAM (platelet endothelial cell adhesion molecule)-1-gene-expression observed in vivo...
  3. ncbi request reprint Inflammation, damage repair and liver fibrosis--role of cytokines and different cell types
    B Saile
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, University of Gottingen, Gottingen, Germany
    Z Gastroenterol 45:77-86. 2007
    ....
  4. ncbi request reprint Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat
    T Knittel
    Department of Internal Medicine, University of Gottingen, Germany
    Histochem Cell Biol 113:443-53. 2000
    ....
  5. ncbi request reprint Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair
    T Knittel
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Histochem Cell Biol 112:387-401. 1999
    ..Acute liver injury is followed by an almost exclusive increase in the number of HSC, while in chronically injured livers not only HSC but also rMF are involved in scar formation...
  6. pmc Role of the Ets-1 transcription factor during activation of rat hepatic stellate cells in culture
    T Knittel
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, University of Gottingen, Gottingen, Germany
    Am J Pathol 155:1841-8. 1999
    ....
  7. pmc Irradiation leads to apoptosis of Kupffer cells by a Hsp27-dependant pathway followed by release of TNF-alpha
    K Tello
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg August University Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Radiat Environ Biophys 47:389-97. 2008
    ..Furthermore, we suggest that apoptosis of Kupffer cells leads to an increase of TNF-alpha concentration in the culture medium which may be due to cell death rather than active release or synthesis...
  8. ncbi request reprint The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium
    J Dudas
    Department of Gastroenterology and Endocrinology, Georg August University Gottingen, Robert Koch Strasse 40, Gottingen, Germany
    Anat Embryol (Berl) 208:359-66. 2004
    ..Its absence from bile duct epithelial cells suggests a function for the specification of hepatoblasts into hepatocytes. The genes controlled by Prox1 need to be studied in the future...
  9. ncbi request reprint Mesenchymal cells in the liver--one cell type or two?
    G Ramadori
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg August University Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Liver 22:283-94. 2002
    ..On the contrary an increasing amount of data support the conviction that HSC and MF represent two similar but not identical cell populations the latter being comparable to those of other organs...
  10. ncbi request reprint Inflammation, damage repair, immune cells, and liver fibrosis: specific or nonspecific, this is the question
    G Ramadori
    Gastroenterology 127:997-1000. 2004
  11. ncbi request reprint Liver fibrosis and altered matrix synthesis
    K Neubauer
    , , Germany
    Can J Gastroenterol 15:187-93. 2001
    ..However, until now, the elimination of the hepatotoxins has been the sole therapeutic concept available for the treatment of liver fibrogenesis in humans...