Carsten Saft

Summary

Country: Germany

Publications

  1. doi request reprint Post pump chorea in a 77-year-old male
    Carsten Saft
    Department of Neurology, St Josef Hospital Bochum, Ruhr University, Bochum, Germany
    Neurol Sci 32:699-701. 2011
  2. pmc Supracubital perineurioma misdiagnosed as carpal tunnel syndrome: case report
    Carsten Saft
    Department of Neurology, St, Josef Hospital, Ruhr University Bochum, Germany
    BMC Neurol 4:19. 2004
  3. pmc Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series
    Carsten Saft
    Department of Neurology, Huntington Center NRW, St, Josef Hospital, Bochum, Germany
    BMC Neurol 6:11. 2006
  4. ncbi request reprint Hepatic mitochondrial dysfunction in manifest and premanifest Huntington disease
    Sven H Stüwe
    Department of Neurology, Huntington Centre NRW, Ruhr University Bochum, Bochum, Germany
    Neurology 80:743-6. 2013
  5. ncbi request reprint NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Hum Genet 122:175-82. 2007
  6. doi request reprint Mentalizing in preclinical Huntington's disease: an fMRI study using cartoon picture stories
    Carsten Saft
    Department of Neurology, Huntington Centre NRW, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791 Bochum, Germany
    Brain Imaging Behav 7:154-62. 2013
  7. doi request reprint ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    J Mol Med (Berl) 86:485-90. 2008
  8. doi request reprint Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1
    Elahe Taherzadeh-Fard
    Department of Human Genetics, Ruhr University Bochum, 44780, Bochum, Germany
    Neurogenetics 11:435-9. 2010
  9. doi request reprint Response inhibition subprocesses and dopaminergic pathways: basal ganglia disease effects
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University of Bochum, Bochum, Germany
    Neuropsychologia 48:366-73. 2010
  10. doi request reprint Huntington's disease as caused by 34 CAG repeats
    Jürgen Andrich
    Department of Neurology, St Josef Hospital Bochum, Ruhr University Bochum, Gudrunstr 56, Bochum, Germany
    Mov Disord 23:879-81. 2008

Collaborators

Detail Information

Publications51

  1. doi request reprint Post pump chorea in a 77-year-old male
    Carsten Saft
    Department of Neurology, St Josef Hospital Bochum, Ruhr University, Bochum, Germany
    Neurol Sci 32:699-701. 2011
    ..We discuss a long aortic clamp, resp. pump time presumably as a risk factor in this case. The symptoms improved after treatment with tetrabenazine...
  2. pmc Supracubital perineurioma misdiagnosed as carpal tunnel syndrome: case report
    Carsten Saft
    Department of Neurology, St, Josef Hospital, Ruhr University Bochum, Germany
    BMC Neurol 4:19. 2004
    ..Perineuriomas have been defined as tumorous lesions of the peripheral nerves which derive from perineurial cell proliferation and may be associated with abnormalities on chromosome 22...
  3. pmc Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series
    Carsten Saft
    Department of Neurology, Huntington Center NRW, St, Josef Hospital, Bochum, Germany
    BMC Neurol 6:11. 2006
    ..In earlier studies valproic acid showed no beneficial effect on involuntary choreatic movements. Myoclonus is rare in HD and is often overseen or misdiagnosed as chorea...
  4. ncbi request reprint Hepatic mitochondrial dysfunction in manifest and premanifest Huntington disease
    Sven H Stüwe
    Department of Neurology, Huntington Centre NRW, Ruhr University Bochum, Bochum, Germany
    Neurology 80:743-6. 2013
    ..In this cross-sectional study, we investigated whether there is evidence for hepatic mitochondrial dysfunction in manifest and/or premanifest Huntington disease (HD) by using the ¹³C-methionine breath test...
  5. ncbi request reprint NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Hum Genet 122:175-82. 2007
    ..We speculate that altered hormone levels herald protective effects of this genotype. Together, GRIN2A and GRIN2B genotype variations explain 7.2% additional variance in AO for HD...
  6. doi request reprint Mentalizing in preclinical Huntington's disease: an fMRI study using cartoon picture stories
    Carsten Saft
    Department of Neurology, Huntington Centre NRW, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791 Bochum, Germany
    Brain Imaging Behav 7:154-62. 2013
    ..This suggests that impaired mentalizing emerges with the clinical manifestation of the disease, but is not necessarily part of the pre-manifest stage...
  7. doi request reprint ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    J Mol Med (Berl) 86:485-90. 2008
    ....
  8. doi request reprint Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1
    Elahe Taherzadeh-Fard
    Department of Human Genetics, Ruhr University Bochum, 44780, Bochum, Germany
    Neurogenetics 11:435-9. 2010
    ..Additionally, we identified new associations in the same gene, thus further supporting the potential contribution of ADORA2A to the pathogenesis of HD...
  9. doi request reprint Response inhibition subprocesses and dopaminergic pathways: basal ganglia disease effects
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University of Bochum, Bochum, Germany
    Neuropsychologia 48:366-73. 2010
    ..In contrast, inhibition monitoring is most likely modulated by the mesocortico-limbic dopamine system. These processes are equally affected in healthy aging and both basal ganglia diseases (i.e. PD, HD)...
  10. doi request reprint Huntington's disease as caused by 34 CAG repeats
    Jürgen Andrich
    Department of Neurology, St Josef Hospital Bochum, Ruhr University Bochum, Gudrunstr 56, Bochum, Germany
    Mov Disord 23:879-81. 2008
    ..There is an intermediate range of rare alleles between 27 and 35 CAG repeats with a higher risk for further expansion in subsequent generations. Here, we report a 75-year-old male with clinical features of HD and 34 CAG repeat units...
  11. ncbi request reprint Progressive hepatic mitochondrial dysfunction in premanifest Huntington's disease
    Rainer Hoffmann
    Department of Neurology, Huntington Center NRW, Ruhr University Bochum, St Josef Hospital, Bochum, Germany
    Mov Disord 29:831-4. 2014
    ..In this longitudinal pilot study, we investigated whether there is evidence for progressive hepatic mitochondrial dysfunction in premanifest HD...
  12. doi request reprint Mechanisms mediating parallel action monitoring in fronto-striatal circuits
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Neuroimage 62:137-46. 2012
    ....
  13. pmc Failure to confirm influence of methyltetrahydrofolate reductase (MTHFR) polymorphisms on age at onset of Huntington disease
    Wiebke Hansen
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    J Negat Results Biomed 4:12. 2005
    ....
  14. doi request reprint Mitochondrial haplogroup H correlates with ATP levels and age at onset in Huntington disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780, Bochum, Germany
    J Mol Med (Berl) 88:431-6. 2010
    ..Our data suggest that an evolutionarily advantageous mitochondrial haplogroup is associated with functional mitochondrial alterations and may modify disease phenotype in the context of neurodegenerative conditions such as HD...
  15. pmc No association between polymorphisms in the BDNF gene and age at onset in Huntington disease
    Maren Mai
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    BMC Med Genet 7:79. 2006
    ..In particular, the functional Val66Met polymorphism appeared to exert a significant effect. Here we evaluate BDNF variability with respect to AO of HD using markers that represent the entire locus...
  16. pmc A novel cognitive-neurophysiological state biomarker in premanifest Huntington's disease validated on longitudinal data
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Sci Rep 3:1797. 2013
    ..The study provides a biomarker, which could change practice of progression diagnostics in a major basal ganglia disease and which may help to evaluate potential neuroprotective treatments in future clinical trials...
  17. ncbi request reprint Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease
    Carsten Saft
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Mov Disord 20:674-9. 2005
    ..Our findings suggest that mitochondrial dysfunction is an early and persistent component of the pathophysiology of HD...
  18. doi request reprint On the role of fronto-striatal neural synchronization processes for response inhibition--evidence from ERP phase-synchronization analyses in pre-manifest Huntington's disease gene mutation carriers
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr University Bochum, Bochum, Germany
    Neuropsychologia 49:3484-93. 2011
    ..This suggests that phase-locking parameters may prove useful in future studies evaluating a possible function as a biomarker in Huntington's disease...
  19. doi request reprint Response inhibition in Huntington's disease-a study using ERPs and sLORETA
    Christian Beste
    Department of Neurology, Huntington Centre NRW, St Josef Hospital, Ruhr University Bochum, Germany
    Neuropsychologia 46:1290-7. 2008
    ..The differentially affected Nogo-components suggest that they rely on different neuronal circuits, even within the ACC. For HD this suggests that this structure is not entirely dysfunctional...
  20. pmc Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD)
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    BMC Med Genet 6:35. 2005
    ..A single nucleotide polymorphism (SNP) resulting in the R72P exchange in TP53 protein might modulate the variation in AO. In addition, also the R196K replacement in human caspase activated DNase (hCAD) may theoretically affect the AO...
  21. ncbi request reprint NR2A and NR2B receptor gene variations modify age at onset in Huntington disease
    Larissa Arning
    Department of Human Genetics, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Neurogenetics 6:25-8. 2005
    ..Neuroprotective strategies for HD patients and persons at risk should be reconsidered in the light of these findings...
  22. doi request reprint CNR1 variation is associated with the age at onset in Huntington disease
    Eugen Kloster
    Department of Human Genetics, Ruhr University Bochum, Germany
    Eur J Med Genet 56:416-9. 2013
    ..These findings support the idea that CNR1 variation may have modifying effects on the AO in HD...
  23. ncbi request reprint Assessment of simple movements reflects impairment in Huntington's disease
    Carsten Saft
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Mov Disord 21:1208-12. 2006
    ..Results of our applied instrumental tool measure impaired movement performance, which is not specific for HD, but reflects the various methods assessed and the slowly evolving symptoms of the degenerative process in HD...
  24. pmc Time processing in Huntington's disease: a group-control study
    Christian Beste
    Department of Neurology, Huntington Centre NRW, St Josef Hospital, Ruhr University, Bochum, Germany
    PLoS ONE 2:e1263. 2007
    ..It may be hypothesized that timing functions may be deteriorated to a different extent in motor and non-motor timing, because in motor timing the underlying brain structures may be more demanding than in non-motor timing...
  25. ncbi request reprint Functional compensation or pathology in cortico-subcortical interactions in preclinical Huntington's disease?
    Christian Beste
    Department of Neurology, Huntington Centre NRW, St Josef Hospital, Ruhr University Bochum, Germany
    Neuropsychologia 45:2922-30. 2007
    ..It is proposed that compensation is a transient effect of the whole pathogenetic dynamics of HD, with these two processes not foreclosing each other...
  26. ncbi request reprint Complex movement behaviour and progression of Huntington's disease
    Jürgen Andrich
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Neurosci Lett 416:272-4. 2007
    ..We conclude, that instrumental assessment of complex movement sequences is an additional simple method to follow impairment in HD patients in addition to clinical rating...
  27. doi request reprint Altered ventral striatal activation during reward and punishment processing in premanifest Huntington's disease: a functional magnetic resonance study
    Björn Enzi
    Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital Bochum, Ruhr University Bochum, Bochum, Germany
    Exp Neurol 235:256-64. 2012
    ..Altered reward and punishment processing could therefore reflect a motivational deficit that may contribute to the pathogenesis of Huntington's disease...
  28. pmc PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease
    Elahe Taherzadeh-Fard
    Department of Human Genetics, Ruhr University Bochum, Germany
    Mol Neurodegener 6:32. 2011
    ..abstract:..
  29. ncbi request reprint Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD
    Jürgen Andrich
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Mov Disord 19:226-8. 2004
    ..Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD...
  30. pmc Assessment of simple movements and progression of Huntington's disease
    Jürgen Andrich
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    J Neurol Neurosurg Psychiatry 78:405-7. 2007
    ..Instrumental test results significantly correlated with both UHDRS scores at each assessment. Assessment of simple movement sequences is an additional simple method to follow impairment in patients with HD in addition to clinical rating...
  31. doi request reprint fMRI reveals altered auditory processing in manifest and premanifest Huntington's disease
    Carsten Saft
    Department of Neurology, Huntington Center NRW, St Josef Hospital, Ruhr University Bochum, Germany
    Neuropsychologia 46:1279-89. 2008
    ..They also stress the involvement of the basal ganglia-thalamic circuits in the processing of sensory auditory stimuli...
  32. pmc The role of the immune system in Huntington's disease
    Gisa Ellrichmann
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany
    Clin Dev Immunol 2013:541259. 2013
    ..Further understanding the influence of inflammation in HD using mouse models may open various avenues for promising therapeutic approaches aiming at slowing disease progression or forestalling onset of disease. ..
  33. ncbi request reprint Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation
    Christiane Reick
    Department of Neurology St Josef Hospital, Ruhr University Bochum, Germany International Graduate School of Neuroscience, Ruhr University Bochum, Germany
    Exp Neurol 257:50-6. 2014
    ..Based on the modes of action of interferon-beta (IFN-β) and dimethyl fumarate (DMF), we hypothesized that anti-inflammatory and neuroprotective effects may synergize in experimental autoimmune encephalomyelitis (EAE)...
  34. doi request reprint Upper gastrointestinal findings in Huntington's disease: patients suffer but do not complain
    Jürgen E Andrich
    Department of Neurology, Huntington Center NRW, St Josef Hospital, Gudrunstrasse 56, 44791 Bochum, Germany
    J Neural Transm 116:1607-11. 2009
    ..There was no correlation with motor disturbances but with the duration and severity of HD. Influences from the disease itself as well as secondary mechanisms like malnutrition, medication and general disability may contribute...
  35. pmc Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    BMC Med Genet 5:7. 2004
    ..Recently an association of Glutathione S-Transferase Omega 1 (GSTO1) and possibly of GSTO2 with AO was demonstrated for, both, Alzheimer's (AD) and Parkinson's disease (PD)...
  36. pmc Hepatic mitochondrial dysfunction in Friedreich ataxia
    Sven H Stüwe
    Department of Neurology, Ruhr University, St Josef Hospital, Bochum, Germany
    BMC Neurol 11:145. 2011
    ..Mitochondrial dysfunction due to respiratory chain impairment is a key feature in pathogenesis of Friedreich ataxia. Friedreich ataxia affects the nervous system, heart and pancreas...
  37. pmc PGC-1alpha as modifier of onset age in Huntington disease
    Elahe Taherzadeh-Fard
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Mol Neurodegener 4:10. 2009
    ..Our data suggest that PGC-1alpha has modifying effects on the pathogenic process in HD...
  38. pmc Music perception and movement deterioration in Huntington's disease
    Christian Beste
    Institute for Cognitive Neuroscience, Ruhr University, Bochum, Germany Department of Clinical Radiology, University of Munster, Germany and Department of Neurology, Ruhr University, St Josef Hospital, Bochum, Germany
    PLoS Curr 3:RRN1252. 2011
    ..Generally, no relations were found in pHDs.Conclusion: The results suggest modulation of auditory music processing in a movement disorder, which seems to relate to severity of movement deterioration...
  39. pmc Depression in patients with Huntington disease correlates with alterations of the brain stem raphe depicted by transcranial sonography
    Christos Krogias
    Department of Neurology, St Josef Hospital, Ruhr University, Bochum, Germany
    J Psychiatry Neurosci 36:187-94. 2011
    ..Studies of TCS report alterations of the mesencephalic raphe in patients with depression. The aim of this study was to evaluate TCS findings in patients with Huntington disease in correlation with their neurologic and psychiatric status...
  40. pmc Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease
    Gisa Ellrichmann
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 6:e16172. 2011
    ..In conclusion, DMF may exert beneficial effects in mouse models of HD. Given its excellent side effect profile, further studies with DMF as new therapeutic approach in HD and other neurodegenerative diseases are warranted...
  41. doi request reprint "Theory of mind" is impaired in Huntington's disease
    Martin Brune
    Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Bochum, Germany
    Mov Disord 26:671-8. 2011
    ..Schizophrenia patients are frequently impaired in "theory of mind" (ToM), that is, the ability to reflect on the mental states of self and others, with mixed evidence for a ToM deficit in HD...
  42. ncbi request reprint Diadochokinetic movements differ between patients with Huntington's disease and controls
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    NeuroRehabilitation 33:649-55. 2013
    ..Assessment of impaired motor behaviour serves as tool for diagnosis and for evaluation of progression of chronic neurodegeneration...
  43. ncbi request reprint Assessment of complex movements reflects dysfunction in Huntington's disease
    Carsten Saft
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    J Neurol 250:1469-74. 2003
    ..Therefore peg insertion particularly reflects executive dysfunction in early HD and additionally motor impairment in advanced HD...
  44. pmc No evidence of impaired gastric emptying in early Huntington's Disease
    Carsten Saft
    Department of Neurology, Huntington Center NRW, Ruhr University, St Josef Hospital, Bochum, Germany Department of Medicine 1, St Josef Hospital, University of Bochum, Germany Department of Neurology, Huntington Center NRW, Ruhr University, St Josef Hospital, Bochum, Germany Department of Neurology, Huntington Center NRW, Ruhr University, St Joseph Hospital, Bochum, Germany and Division of Gastroenterology and Hepatology University Hospital Zurich Zurich, Switzerland
    PLoS Curr 3:RRN1284. 2011
    ..Conclusion: According to our data, there is no evidence of impaired gastric emptying in early HD. We can not exclude that gastric emptying contributes to weight loss at more advanced stages of the disease...
  45. doi request reprint Impaired motor speech performance in Huntington's disease
    Sabine Skodda
    Department of Neurology, Knappschaftskrankenhaus, Ruhr University of Bochum, In der Schornau 23 25, 44892, Bochum, Germany
    J Neural Transm 121:399-407. 2014
    ....
  46. ncbi request reprint Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation
    Ferdinando Squitieri
    Neurogenetics Unit, IRCCS Neuromed, Pozzilli, IS, Italy
    Mech Ageing Dev 127:217-20. 2006
    ..We argue that early mitochondrial impairment at basal level may affect the severity of HD progression in patients...
  47. ncbi request reprint Is the retina affected in Huntington disease?
    Elisabeth Petrasch-Parwez
    Acta Neuropathol 110:523-5. 2005
  48. ncbi request reprint Levels of error processing in Huntington's disease: a combined study using event-related potentials and voxel-based morphometry
    Christian Beste
    Leibniz Research Centre for Working Environment and Human Factors, WHO Collaborating Centre for Occupational Health and Human Factors, Dortmund, Germany
    Hum Brain Mapp 29:121-30. 2008
    ..In conclusion a deterioration in error processing in HD compared to pHD is mainly reflected by the Ne. The deterioration might rely on two factors: a neurofunctional and a neuroanatomical...
  49. ncbi request reprint [Amisulpride in Huntington's disease]
    Carsten Saft
    Neurologische Klinik der Ruhr Universität Bochum, St Josef Hospital, Huntington Zentrum NRW, Bochum
    Psychiatr Prax 32:363-6. 2005
    ..Amisulpride is a substituted benzamide derivative with atypical antipsychotic properties and low side effects...
  50. doi request reprint Stimulus-response compatibility in Huntington's disease: a cognitive-neurophysiological analysis
    Christian Beste
    Leibniz Research Centre for Working Environment and Human Factors, WHO Collaborating Centre for Occupational Health and Human Factors, Ardeystrasse 67, Dortmund, Germany
    J Neurophysiol 99:1213-23. 2008
    ..Overall, the results suggest alterations in attentional control, conflict processing, and controlled response selection in HD but not in automatic response selection...