Oliver Wirths

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease
    Oliver Wirths
    Department of Psychiatry, University of the Saarland, 66421 Homburg Saar, Germany
    Exp Gerontol 41:220-4. 2006
  2. ncbi request reprint A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade
    Oliver Wirths
    Saarland University, Department of Psychiatry, Division of Neurobiology, 66421 Homburg Saar, Germany
    J Neurochem 91:513-20. 2004
  3. doi request reprint Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice
    Ditte Zerlang Christensen
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Acta Neuropathol 116:647-55. 2008
  4. doi request reprint Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease
    Oliver Wirths
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Neurobiol Aging 31:747-57. 2010
  5. doi request reprint APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy
    Henning Breyhan
    Division of Molecular Psychiatry, Department of Psychiatry, Alzheimer Ph D Graduate School, University of Goettingen, Goettingen, Germany
    Acta Neuropathol 117:677-85. 2009
  6. doi request reprint Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease
    Andrea Marcello
    University Medicine of Goettingen, Department of Psychiatry, Goettingen, Germany
    Neurobiol Aging 32:1379-87. 2011
  7. doi request reprint Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease
    Ditte Z Christensen
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Neurobiol Aging 31:1153-63. 2010
  8. doi request reprint Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease
    Anika Saul
    Division of Molecular Psychiatry, Department of Psychiatry, University Medicine Goettingen, Goettingen, Germany
    Neurobiol Aging 34:2564-73. 2013
  9. doi request reprint Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice
    Marie Caroline Cotel
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Gottingen, Germany
    Neurobiol Aging 33:96-107. 2012
  10. doi request reprint No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease
    Antje Hillmann
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University Medicine Goettingen, Goettingen, Germany
    Neurobiol Aging 33:833.e39-50. 2012

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease
    Oliver Wirths
    Department of Psychiatry, University of the Saarland, 66421 Homburg Saar, Germany
    Exp Gerontol 41:220-4. 2006
    ..Furthermore, statistical analysis revealed a significant negative correlation between plasma cholesterol and brain Abeta42 levels during aging in the mice expressing both APP and PS1...
  2. ncbi request reprint A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade
    Oliver Wirths
    Saarland University, Department of Psychiatry, Division of Neurobiology, 66421 Homburg Saar, Germany
    J Neurochem 91:513-20. 2004
    ..Based on these results, a modified A beta hypothesis is formulated, that integrates biochemical, neuropathological and genetic observations with AD-typical neuron loss and plaque formation...
  3. doi request reprint Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice
    Ditte Zerlang Christensen
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Acta Neuropathol 116:647-55. 2008
    ..This study suggests that plaques have no effect on neuron death whereas accumulation of intraneuronal A beta may be an early transient pathological event leading to neuron loss in AD...
  4. doi request reprint Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease
    Oliver Wirths
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Neurobiol Aging 31:747-57. 2010
    ..These data add further evidence to the assumption that inflammatory processes are tightly associated with axonal degeneration and neuron loss, as is evident in the APP/PS1KI mouse model...
  5. doi request reprint APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy
    Henning Breyhan
    Division of Molecular Psychiatry, Department of Psychiatry, Alzheimer Ph D Graduate School, University of Goettingen, Goettingen, Germany
    Acta Neuropathol 117:677-85. 2009
    ..Overall, these data provide the basis for the observed robust working memory deficits in this mouse model for AD at 6 months of age...
  6. doi request reprint Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease
    Andrea Marcello
    University Medicine of Goettingen, Department of Psychiatry, Goettingen, Germany
    Neurobiol Aging 32:1379-87. 2011
    ..58, d.f. = 13, p = 0.022). These observations indicate that the level of IgM autoantibodies against pGluAβ is a promising plasma biomarker for AD and correlates with the cognitive status of individuals at risk to develop AD...
  7. doi request reprint Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease
    Ditte Z Christensen
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Neurobiol Aging 31:1153-63. 2010
    ..This study supports the hypothesis of intracellular Abeta accumulation as an early pathological alteration contributing to cell death in AD...
  8. doi request reprint Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease
    Anika Saul
    Division of Molecular Psychiatry, Department of Psychiatry, University Medicine Goettingen, Goettingen, Germany
    Neurobiol Aging 34:2564-73. 2013
    ..These data support the assumption of tau pathology being downstream of amyloid pathology, suggesting that both pathologies together trigger the severe neuron loss in the hippocampus in the 5XFAD/PS19 mouse model. ..
  9. doi request reprint Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice
    Marie Caroline Cotel
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Gottingen, Germany
    Neurobiol Aging 33:96-107. 2012
    ..Therefore our data might suggest that physical activity and enriched environment might be more beneficial in patients with mild cognitive impairment than in patients with incipient AD...
  10. doi request reprint No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease
    Antje Hillmann
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University Medicine Goettingen, Goettingen, Germany
    Neurobiol Aging 33:833.e39-50. 2012
    ....
  11. doi request reprint Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Abeta peptides in mouse models of Alzheimer's disease
    Ditte Z Christensen
    Department of Psychiatry, University of Goettingen, Germany
    Brain Res 1301:116-25. 2009
    ..It was found that FA is essential for the staining of highly aggregated intraneuronal Abeta peptides in AD transgenic mouse tissue...
  12. pmc Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases
    Oliver Wirths
    Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Gottingen, Germany
    J Neural Transm 117:85-96. 2010
    ....
  13. ncbi request reprint Age-dependent axonal degeneration in an Alzheimer mouse model
    Oliver Wirths
    Department of Psychiatry, Division of Neurobiology, Saarland University, Building 90, D 66421 Homburg Saar, Germany
    Neurobiol Aging 28:1689-99. 2007
    ..We conclude that the intraneuronal accumulation of Abeta-amyloid peptides is followed by axonal degeneration, and thus might be a causative factor for the axonal changes seen in AD...
  14. pmc Accumulation of intraneuronal Abeta correlates with ApoE4 genotype
    Ditte Z Christensen
    Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Acta Neuropathol 119:555-66. 2010
    ....
  15. pmc Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
    Oliver Wirths
    Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Von Siebold Strasse 5, Goettingen, Germany
    Acta Neuropathol 118:487-96. 2009
    ..Although the TBA2 model lacks important AD-typical neuropathological features like tangles and hippocampal degeneration, it clearly demonstrates that intraneuronal Abeta(3(pE)-42) is neurotoxic in vivo...
  16. doi request reprint Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice
    Marie Caroline Cotel
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Strasse 5, Goettingen, Germany
    Brain Res 1222:207-13. 2008
    ..Stereological analysis revealed a strongly significant decrease of GCLs in aged APP/PS1KI mice, compared to age-matched PS1KI control animals (-44%), however, the volume of the GCL was not different...
  17. doi request reprint Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease
    Sadim Jawhar
    Division of Molecular Psychiatry, Alzheimer Ph D, Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Neurobiol Aging 33:196.e29-40. 2012
    ..In addition, comparable to the APP/PS1KI mouse model, 5XFAD mice develop an age-dependent axonopathy likely contributing to the behavioral deficits...
  18. doi request reprint Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model
    Thomas A Bayer
    Department of Psychiatry, Division of Molecular Psychiatry, University of Goettingen, Goettingen, Germany
    Neurodegener Dis 5:140-2. 2008
    ..These observations support a pivotal role of intraneuronal Abeta accumulation as a principal pathological trigger in AD...
  19. ncbi request reprint Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease
    Oliver Wirths
    Department of Psychiatry, Division of Neurobiology, Saarland University, Building 90, 66421, Homburg, Saar, Germany
    Acta Neuropathol 111:312-9. 2006
    ..This strengthens the prevailing amyloid hypothesis as a primary trigger of AD-typical pathological alterations...
  20. ncbi request reprint Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice
    Oliver Wirths
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Brain Pathol 12:275-86. 2002
    ..This is most likely due to an APP/A beta transport problem and may be a model region to study APP/A beta trafficking as an early pathological event...
  21. ncbi request reprint Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease
    Oliver Wirths
    Department of Psychiatry, University of Goettingen, Von Siebold Str 5, D 37075 Goettingen, Germany
    Neurobiol Aging 29:891-901. 2008
    ....
  22. pmc Circulating immune complexes of Abeta and IgM in plasma of patients with Alzheimer's disease
    Andrea Marcello
    Department of Psychiatry, University Medicine Goettingen, Gottingen 37075, Germany
    J Neural Transm 116:913-20. 2009
    ..Using an ELISA assay detecting Abeta-IgM complexes, we observed that high levels of Abeta-IgMs were detectable in HC and MCI patients; however, there was no significant difference to the AD group...
  23. ncbi request reprint Altered cholesterol metabolism in APP695-transfected neuroblastoma cells
    Oliver Wirths
    Department of Psychiatry, Section Neurobiology, University of Goettingen, Von Siebold Str 5, D 37075 Goettingen, Germany
    Brain Res 1152:209-14. 2007
    ....
  24. ncbi request reprint Alpha-synuclein, Abeta and Alzheimer's disease
    Oliver Wirths
    Department of Psychiatry, Section Neurobiology and European Graduate School of Neuroscience EURON, University of Saarland Medical Center, Building 90, D 66421 Homburg Saar, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 27:103-8. 2003
    ..In this review, we report on recent findings on the physiological and pathological role of alpha-synuclein and try to elucidate its possible contribution to AD pathology...
  25. ncbi request reprint Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models
    Jochim Reinert
    Division of Molecular Psychiatry, Department of Psychiatry, University Medicine Goettingen, Goettingen, Germany
    J Alzheimers Dis 39:871-81. 2014
    ..Furthermore we demonstrate that Aβ38 deposits in the form of extracellular plaques are common in several AD transgenic mouse models carrying either only AβPP, or combinations of AβPP, PSEN1, and tau transgenes. ..
  26. doi request reprint Amyloid precursor protein is a biomarker for transformed human pluripotent stem cells
    Vivek Venkataramani
    Division of Molecular Psychiatry, Department of Psychiatry, University Medicine Goettingen, Goettingen, Germany
    Am J Pathol 180:1636-52. 2012
    ..These observations suggest that APP represents a novel and specific biomarker in human transformed pluripotent stem cells that can be selectively modulated by HDAC inhibitors...
  27. doi request reprint Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 11:243-50. 2010
    ..However, our study sample was small and results of this exploratory study should be verified in a larger sample...
  28. pmc Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease
    Thomas A Bayer
    Division of Molecular Psychiatry and Alzheimer Ph D Graduate School, Department of Psychiatry, University of Göttingen Göttingen, Germany
    Front Aging Neurosci 2:8. 2010
    ..The present review discusses the impact of intraneuronal Abeta accumulation on synaptic impairment and neuron loss and provides an overview of currently available AD mouse models showing these pathological alterations...
  29. ncbi request reprint Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice
    Veronique Blanchard
    Neurodegenerative Disease Group, Centre de Recherche de Paris, Aventis Pharma 94403, Vitry sur Seine Cedex, France
    Exp Neurol 184:247-63. 2003
    ..The present study demonstrates that oxidative and mitochondrial stress factors are present at several phases of Abeta pathology progression, confirming the neuronal dysfunction in APP transgenic mice...
  30. ncbi request reprint No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 12:110-20. 2003
    ..These data implicate that expression of beta-CTF per se is not neurotoxic, and that other mechanisms are responsible for the neurotoxic events in Alzheimer's disease brain...
  31. pmc Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
    Caty Casas
    Department of Central Nervous System Alzheimer Disease, Aventis Pharma Paris Research Center, Vitry sur Seine, France
    Am J Pathol 165:1289-300. 2004
    ..Thus, APP(SL)PS1KI mice further confirm the critical role of intraneuronal Abeta(42) in neuronal loss and provide an excellent tool to investigate therapeutic strategies designed to prevent AD neurodegeneration...
  32. pmc Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
    Christoph Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Am J Pathol 164:1495-502. 2004
    ..These findings point to the potential involvement of more than one mechanism in hippocampal neuron loss in this APP/PS-1 double-transgenic mouse model of Alzheimer's disease...