Sascha Tierling

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. pmc A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation
    Sascha Tierling
    Universitat des Saarlandes, FR, 8, 3 Biowissenschaften, Genetik Epigenetik, 66041 Saarbrucken, Germany
    Epigenetics Chromatin 3:12. 2010
  2. doi request reprint A fast, cost-efficient and sensitive approach for KRAS mutation detection using multiplexed primer extension with IP/RP-HPLC separation
    Sascha Tierling
    Saarland University, FR 8 3 Life Sciences, Genetics Epigenetics, 66041 Saarbrucken, Germany
    Int J Cancer 130:567-74. 2012
  3. doi request reprint DNA methylation studies on imprinted loci in a male monozygotic twin pair discordant for Beckwith-Wiedemann syndrome
    S Tierling
    Universitat des Saarlandes, FR8 3 Biowissenschaften, Genetik Epigenetik, Saarbrucken, Germany
    Clin Genet 79:546-53. 2011
  4. ncbi request reprint Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in human
    Sascha Tierling
    Universitat des Saarlandes, FR 8 3 Biowissenschaften, Genetik Epigenetik, Postfach 151150, D 66041 Saarbrucken, Germany
    J Med Genet 47:371-6. 2010
  5. pmc Bi-PROF: bisulfite profiling of target regions using 454 GS FLX Titanium technology
    Jasmin Gries
    Department of Genetics Epigenetics, FR8 3 Life Sciences, Saarland University, Saarbrucken, Germany
    Epigenetics 8:765-71. 2013
  6. pmc CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Genet 2:e26. 2006
  7. ncbi request reprint High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12
    Sascha Tierling
    Genetik Epigenetik, FR 8 3 Biowissenschaften, Universitat des Saarlandes, Postfach 151150, D 66041 Saarbrucken, Germany
    Genomics 87:225-35. 2006
  8. doi request reprint Inflammation-induced up-regulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island
    Britta Diesel
    Department of Pharmaceutical Biology, Saarland University, Saarbrucken, Germany
    Innate Immun 18:112-23. 2012
  9. doi request reprint The Begain gene marks the centromeric boundary of the imprinted region on mouse chromosome 12
    Sascha Tierling
    FR 8 3 Biowissenschaften, Genetik Epigenetik, Universitat des Saarlandes, Postfach 151150, Saarbrücken 66041, Germany
    Mamm Genome 20:699-710. 2009
  10. pmc Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype
    Elisabeth Tybl
    Saarland University, Department of Pharmacy, Pharmaceutical Biology, Saarbrucken, Germany
    J Hepatol 54:994-1001. 2011

Collaborators

Detail Information

Publications11

  1. pmc A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation
    Sascha Tierling
    Universitat des Saarlandes, FR, 8, 3 Biowissenschaften, Genetik Epigenetik, 66041 Saarbrucken, Germany
    Epigenetics Chromatin 3:12. 2010
    ....
  2. doi request reprint A fast, cost-efficient and sensitive approach for KRAS mutation detection using multiplexed primer extension with IP/RP-HPLC separation
    Sascha Tierling
    Saarland University, FR 8 3 Life Sciences, Genetics Epigenetics, 66041 Saarbrucken, Germany
    Int J Cancer 130:567-74. 2012
    ..The highly sensitive assay gives easily interpretable and reproducible results at affordable costs. We describe the method and an application example for diagnosis in early colorectal cancer screening...
  3. doi request reprint DNA methylation studies on imprinted loci in a male monozygotic twin pair discordant for Beckwith-Wiedemann syndrome
    S Tierling
    Universitat des Saarlandes, FR8 3 Biowissenschaften, Genetik Epigenetik, Saarbrucken, Germany
    Clin Genet 79:546-53. 2011
    ....
  4. ncbi request reprint Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in human
    Sascha Tierling
    Universitat des Saarlandes, FR 8 3 Biowissenschaften, Genetik Epigenetik, Postfach 151150, D 66041 Saarbrucken, Germany
    J Med Genet 47:371-6. 2010
    ..CONCLUSION This study supports the notion that children conceived by ART do not show a higher degree of imprint variability and hence do not have an a priori higher risk for imprinting disorders...
  5. pmc Bi-PROF: bisulfite profiling of target regions using 454 GS FLX Titanium technology
    Jasmin Gries
    Department of Genetics Epigenetics, FR8 3 Life Sciences, Saarland University, Saarbrucken, Germany
    Epigenetics 8:765-71. 2013
    ....
  6. pmc CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure
    Christoph Bock
    Max Planck Institut für Informatik, Saarbrucken, Germany
    PLoS Genet 2:e26. 2006
    ..This finding may have a strong impact on our understanding of changes in CpG island methylation in development and disease...
  7. ncbi request reprint High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12
    Sascha Tierling
    Genetik Epigenetik, FR 8 3 Biowissenschaften, Universitat des Saarlandes, Postfach 151150, D 66041 Saarbrucken, Germany
    Genomics 87:225-35. 2006
    ..Hence, tissue-specific coregulation of maternally expressed genes might be an important feature of this domain...
  8. doi request reprint Inflammation-induced up-regulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island
    Britta Diesel
    Department of Pharmaceutical Biology, Saarland University, Saarbrucken, Germany
    Innate Immun 18:112-23. 2012
    ..Taken together, employing different methodological approaches, our data show no implication of methylation pattern changes in inflammatory induction of TLR2 expression in human endothelial cells...
  9. doi request reprint The Begain gene marks the centromeric boundary of the imprinted region on mouse chromosome 12
    Sascha Tierling
    FR 8 3 Biowissenschaften, Genetik Epigenetik, Universitat des Saarlandes, Postfach 151150, Saarbrücken 66041, Germany
    Mamm Genome 20:699-710. 2009
    ..Nevertheless, imprinting effects do not spread further centromeric to the Wdr25 gene, which is biallelically expressed as the previously studied neighbouring Wars and Yy1 genes...
  10. pmc Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype
    Elisabeth Tybl
    Saarland University, Department of Pharmacy, Pharmaceutical Biology, Saarbrucken, Germany
    J Hepatol 54:994-1001. 2011
    ..Still, its potential role in liver disease is largely unknown. In this study, we investigated pathophysiological implications of p62 overexpression in mice...
  11. pmc Evolution of the Beckwith-Wiedemann syndrome region in vertebrates
    Martina Paulsen
    Universitat des Saarlandes, FR 8 3 Biowissenschaften, Genetik Epigenetik, Postfach 151150, D 66041 Saarbrucken, Germany
    Genome Res 15:146-53. 2005
    ..In line with that, imprinting centers in mammals apparently exhibit a high degree of structural and sequence variation despite conserved epigenetic marking...