Jörg Spiegel

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. pmc Diagnostic and Pathophysiological Impact of Myocardial MIBG Scintigraphy in Parkinson's Disease
    Jörg Spiegel
    Department of Neurology, Saarland University, Kirrberger Strase, 66421 Homburg Saar, Germany
    Parkinsons Dis 2010:295346. 2010
  2. doi request reprint [Perioperative management of patients with Parkinson's disease]
    J Spiegel
    Neurologische Klinik, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg Saar, Deutschland
    Orthopade 38:843-5. 2009
  3. ncbi request reprint Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease
    Jörg Spiegel
    Department of Neurology, Saarland University, D 66421 Homburg Saar, Germany
    Mov Disord 22:1004-8. 2007
  4. ncbi request reprint Orthostatic tremor during modification of standing
    Jörg Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany
    Mov Disord 21:173-8. 2006
  5. ncbi request reprint Quantification of temporal and spatial accuracy of alternating arm movements in multiple sclerosis patients treated with deep brain stimulation of the thalamic ventralis intermedius nucleus (VIM)
    J Spiegel
    Department of Neurology, Saarland University, Homburg, Saar, Germany
    Zentralbl Neurochir 68:67-72. 2007
  6. ncbi request reprint FP-CIT and MIBG scintigraphy in early Parkinson's disease
    Jörg Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany
    Mov Disord 20:552-61. 2005
  7. ncbi request reprint Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's disease
    Jörg Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany e mail
    Brain 129:1188-93. 2006
  8. ncbi request reprint Echogenic substantia nigra in patients with orthostatic tremor
    J Spiegel
    Department of Neurology, University of the Saarland, Homburg, Saar, Germany
    J Neural Transm 112:915-20. 2005
  9. ncbi request reprint Progressive dementia caused by Hashimoto's encephalopathy -- report of two cases
    J Spiegel
    Department of Neurology, University of the Saarland, Homburg Saar, Germany
    Eur J Neurol 11:711-3. 2004
  10. ncbi request reprint [Bilateral spontaneous carotid artery dissection in osteogenesis imperfecta (type I)]
    C Becker
    Neurologische Klinik, Universitatsklinikum des Saarlandes, Homburg Saar
    Nervenarzt 80:1222-5. 2009

Collaborators

Detail Information

Publications28

  1. pmc Diagnostic and Pathophysiological Impact of Myocardial MIBG Scintigraphy in Parkinson's Disease
    Jörg Spiegel
    Department of Neurology, Saarland University, Kirrberger Strase, 66421 Homburg Saar, Germany
    Parkinsons Dis 2010:295346. 2010
    ..In combination with cerebral dopamine transporter imaging, MIBG scintigraphy allows to correlate cerebral and extracranial Lewy body type-degeneration in PD...
  2. doi request reprint [Perioperative management of patients with Parkinson's disease]
    J Spiegel
    Neurologische Klinik, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg Saar, Deutschland
    Orthopade 38:843-5. 2009
    ..The elevated perioperative risk in PD can be reduced by appropriate perioperative management and no longer represents a contraindication to surgery in PD patients...
  3. ncbi request reprint Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease
    Jörg Spiegel
    Department of Neurology, Saarland University, D 66421 Homburg Saar, Germany
    Mov Disord 22:1004-8. 2007
    ..No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor...
  4. ncbi request reprint Orthostatic tremor during modification of standing
    Jörg Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany
    Mov Disord 21:173-8. 2006
    ..The fact that tilting modifies OT, whereas relief does not, suggests an important role of postural set in OT generation. Afferent input and muscle forcing seem to play less important role...
  5. ncbi request reprint Quantification of temporal and spatial accuracy of alternating arm movements in multiple sclerosis patients treated with deep brain stimulation of the thalamic ventralis intermedius nucleus (VIM)
    J Spiegel
    Department of Neurology, Saarland University, Homburg, Saar, Germany
    Zentralbl Neurochir 68:67-72. 2007
    ..We studied whether stimulation of the thalamic ventralis intermedius nucleus (VIM) improves the performance of alternating forearm movements in MS patients...
  6. ncbi request reprint FP-CIT and MIBG scintigraphy in early Parkinson's disease
    Jörg Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany
    Mov Disord 20:552-61. 2005
    ..In addition, the functional loss of nigrostriatal and cardiac sympathetic neurons seems to be coupled closely...
  7. ncbi request reprint Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's disease
    Jörg Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany e mail
    Brain 129:1188-93. 2006
    ..Obviously SN hyperechogenicity and degeneration of presynaptic dopaminergic nerve terminals exist independently from each other and may be based on different pathomechanisms...
  8. ncbi request reprint Echogenic substantia nigra in patients with orthostatic tremor
    J Spiegel
    Department of Neurology, University of the Saarland, Homburg, Saar, Germany
    J Neural Transm 112:915-20. 2005
    ..Previous studies suggest that the nigrostriatal dopaminergic transmission is impaired in patients with primary orthostatic tremor...
  9. ncbi request reprint Progressive dementia caused by Hashimoto's encephalopathy -- report of two cases
    J Spiegel
    Department of Neurology, University of the Saarland, Homburg Saar, Germany
    Eur J Neurol 11:711-3. 2004
    ..The symptoms receded completely during a high-dose glucocorticoid therapy. In patients with rapidly progressive dementia or with dementia of unknown origin, HE should be considered...
  10. ncbi request reprint [Bilateral spontaneous carotid artery dissection in osteogenesis imperfecta (type I)]
    C Becker
    Neurologische Klinik, Universitatsklinikum des Saarlandes, Homburg Saar
    Nervenarzt 80:1222-5. 2009
    ..The identification of an - initially unknown - hereditary connective tissue disorder may con-tribute to primary and secondary prophylaxis of cerebral ischemia...
  11. ncbi request reprint Impact of different stimulation types on orthostatic tremor
    J Spiegel
    Department of Neurology, University of the Saarland, Homburg Saar, D 66421 Germany
    Clin Neurophysiol 115:569-75. 2004
    ..Primary orthostatic tremor (OT) is thought to be generated by a unique supraspinal tremor generator. Here we studied the effect of ipsi- and contralateral stimulation of the central and peripheral nervous system on OT...
  12. ncbi request reprint Early diagnosis of Parkinson's disease
    Jörg Spiegel
    Dept of Neurology, Saarland University, Kirrberger Strasse, 66421, Homburg Saar, Germany
    J Neurol 253:IV2-7. 2006
    ..All these methods and primarily their combination allow the detection of PD in early and--probably--preclinical stages. This requires sufficient therapeutic strategies to prevent and treat preclinical and early PD...
  13. ncbi request reprint Influence of proprioceptive input on parkinsonian tremor
    Jörg Spiegel
    Department of Neurology, University of the Saarland, D 66421 Homburg Saar, Germany
    J Clin Neurophysiol 19:84-9. 2002
    ..85 +/- 0.57 Hz versus 5.05 +/- 0.65 Hz, P < 0.05). Contralateral median nerve stimulation had no significant effect. These results suggest a close interaction between proprioceptive input and PT generation...
  14. ncbi request reprint Evaluation of transcranial sonographic findings and MIBG cardiac scintigraphy in the diagnosis of idiopathic Parkinson's disease
    Stefanie Behnke
    Department of Neurology, Saarland University, Kirrberger Strasse, 66421 Homburg Saar, Germany
    Parkinsonism Relat Disord 19:995-9. 2013
    ..The combination of both measurements reached a sensitivity of 95%. TCS and MIBG scintigraphy may disclose complementary aspects of IPD. The combined use of both neuroimaging methods might improve the diagnostic sensitivity regarding IPD...
  15. doi request reprint Myocardial MIBG scintigraphy may predict the course of motor symptoms in Parkinson's disease
    Julia Dorschner
    Department of Neurology, Saarland University, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Parkinsonism Relat Disord 17:372-5. 2011
    ..In this study we examined the predictive value of the MIBG scintigraphy concerning the severity and progression of the parkinsonian motor symptoms...
  16. pmc Cerebral and Extracranial Neurodegeneration are Strongly Coupled in Parkinson's Disease
    Jörg Spiegel
    Department of Neurology Saarland University, D 66421 Homburg Saar, Germany
    Open Neurol J 1:1-4. 2007
    ..Obviously cerebral and extracranial changes are driven by at least similar pathomechanisms. Our findings in controls contradict a physiological correlation between nigrostriatal dopaminergic and myocardial sympathetic function...
  17. ncbi request reprint Improvement of upper limb ataxia and intention tremor allowing cessation of thalamic electrostimulation after four years
    Jean Richard Moringlane
    Department of Neurosurgery, Saarland University Hospital, 66421 Homburg Saar, Germany
    Mult Scler 10:708-10. 2004
    ..However, scientific proof has yet to be found. This exceptional observation emphasizes the need for longterm studies...
  18. ncbi request reprint Transient dystonia following magnetic resonance imaging in a patient with deep brain stimulation electrodes for the treatment of Parkinson disease. Case report
    Jörg Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany
    J Neurosurg 99:772-4. 2003
    ..In the following months, this focal movement disorder resolved completely. This case demonstrates the possible risks of MR imaging in patients with deep brain stimulators...
  19. doi request reprint Is reduced myocardial sympathetic innervation associated with clinical symptoms of autonomic impairment in idiopathic Parkinson's disease?
    Daniel Guidez
    Department of Neurology, Saarland University, Kirrberger Strasse, 66421, Homburg Saar, Germany
    J Neurol 261:45-51. 2014
    ..This association is more pronounced in male than in female patients. The cause for this gender-specific phenomenon is unclear...
  20. doi request reprint Long-term course of substantia nigra hyperechogenicity in Parkinson's disease
    Stefanie Behnke
    Department of Neurology, Saarland University, Homburg Saar, Germany
    Mov Disord 28:455-9. 2013
    ..SN+ represents a largely stable biomarker in iPD and does not reflect disease progression. The size of SN+ does not predict the further course of the disease...
  21. doi request reprint Performance of repetitive alternating elbow movements in Parkinson's disease
    Jörg Spiegel
    Department of Neuroradiology, Saarland University, Homburg Saar, Germany
    Eur Neurol 71:84-8. 2014
    ..Bradydiadochokinesia is one main clinical symptom in idiopathic Parkinson's disease (IPD). The pathogenesis of bradydiadochokinesia is not completely clear...
  22. ncbi request reprint Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease
    Alexander Storch
    Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Arch Neurol 64:938-44. 2007
    ..Coenzyme Q(10) (CoQ(10)) is an electron acceptor bridging mitochondrial complexes I and II/III and a potent antioxidant that consistently partially recovers the function of dopaminergic neurons...
  23. ncbi request reprint Improvement of apraxia of lid opening by STN-stimulation in a 70-year-old patient with Parkinson's disease. A case report
    G Fuss
    Department of Neurology, Saarland University, Homburg Saar, Germany
    Minim Invasive Neurosurg 47:58-60. 2004
    ..We suggest that these differences may be due to the region of the nucleus subthalamicus that is influenced by the stimulation...
  24. doi request reprint Principal Component Analysis of gait in Parkinson's disease: relevance of gait velocity
    Ulrich Dillmann
    Department of Neurology, Saarland University Hospital, D 66421 Homburg, Saar, Germany Electronic address
    Gait Posture 39:882-7. 2014
    ..The changes of the PC's with higher gait velocities in healthy subjects are suggestive of an increase of intersegmental coordination. This is impaired even in less severely affected Parkinsonian patients. ..
  25. doi request reprint Response of Toll-like receptors in experimental Guillain-Barré syndrome: a kinetic analysis
    Manuela Gries
    Department of Neurology, Saarland University, 66421 Homburg Saar, Germany
    Neurosci Lett 518:154-60. 2012
    ..This first systematic analysis of TLR expression pattern may contribute to elucidating the role of TLRs in GBS pathophysiology...
  26. ncbi request reprint Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease
    J Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany
    J Neural Transm 114:331-5. 2007
    ..05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor...
  27. doi request reprint Doxepin concentrations in plasma and cerebrospinal fluid
    Robert Schomburg
    Department of Neurology, University of the Saarland, Kirrberger Strase, 66421, Homburg Saar, Germany
    J Neural Transm 118:641-5. 2011
    ..001; Pearson's correlation) and nordoxepin (r = +0.74; p < 0.001). These highly significant correlations between the plasma and CSF concentrations indicate a constant CSF permeability of doxepin and its active metabolite nordoxepin...
  28. ncbi request reprint [The 10-minute office visit. Differential diagnosis of tremor. The hands shake -- Parkinson?]
    U Dillmann
    Neurologische Klinik, Universitatsklinikum des Saarlandes, Homburg, Saar
    MMW Fortschr Med 147:59-60. 2005