- A case of nasal leiomyosarcoma: the first comparative genomic hybridization analysis
Department of Otolaryngology, Head and Neck Surgery, University Hospital Homburg, Saar, Germany
Kulak Burun Bogaz Ihtis Derg 11:113-6. 2003
..1. With augmented experience, the transnasal approach may be appropriate to resect circumscribed malignant tumors located in the nasal cavity...
- The role of endonasal surgery in the management of frontoethmoidal osteomas
Department of Ear, Nose and Throat Diseases, Head, Neck and Facial Plastic Surgery, Communication Disorders, Klinikum Fulda, Germany
Rhinology 39:66-70. 2001
..We favour the osteoplastic frontal sinus approach with coronal incision if an external approach is required to achieve tumour resection with the best aesthetic results...
- First evidence of genetic imbalances in angiofibromas
Department of Otolaryngology Head and Neck Surgery, University Homburg Saar, Homburg, Germany
Laryngoscope 112:397-401. 2002
..However, their etiology and genetic causes remain unknown. The present study addresses genetic imbalances in angiofibromas...
- Comprehensive genomic analysis identifies MDM2 and AURKA as novel amplified genes in juvenile angiofibromas
Department of Otolaryngology, Head and Neck Surgery, University of Erlangen Nuremberg, Waldstrasse 1, D 91054 Erlangen, Germany
Head Neck 29:479-87. 2007
..Frequent beta-catenin mutations have been detected in juvenile angiofibromas, but the tumor pathogenesis remains unknown...
- Laminin expression in juvenile angiofibroma indicates vessel's early developmental stage
Department of Otolaryngology, Head and Neck Surgery, University Erlangen Nuremberg, Erlangen, Germany
Acta Otolaryngol 127:1310-5. 2007
- Mast cells and T-lymphocytes in juvenile angiofibromas
Department of Otolaryngology, Head and Neck Surgery, Friedrich Alexander University Erlangen Nuremberg, 91054, Erlangen, Germany
Eur Arch Otorhinolaryngol 264:769-75. 2007
..Regarding these observations JAs are certainly not only built up by vascular cells and fibrous stroma cells. High rates of inflammatory cells like mast cells and T-lymphocytes have to be considered in this tumour...
- Genetic heterogeneity of the MYC oncogene in advanced juvenile angiofibromas
Department of Otolaryngology, University Erlangen Nurnberg, Germany
Cancer Genet Cytogenet 164:25-31. 2006
..The finding of genetic MYC heterogeneity associated with C-MYC overexpression on the mRNA and protein level in advanced juvenile angiofibromas indicates involvement of the MYC oncogene in aggressive growth behavior...
- p53 and Her-2/neu in juvenile angiofibromas
Department of Otolaryngology, University Erlangen Nurnberg, Waldstrasse 1, D 91054 Erlangen, Germany
Oncol Rep 13:453-7. 2005
..However, comparison of p53 and Her-2/neu mRNA levels in laser microdissected endothelial and stromal cells were not conclusive to answer the question of the tumour cell of origin in JA...
- New aspects of pathogenesis of juvenile angiofibroma
Department of Otolaryngology, Friedrich Alexander Universitat Erlangen Nurnberg, D 91054, Erlangen, Germany
Hosp Med 65:269-73. 2004
..Interesting new findings, reviewed here, are beginning to elucidate the aetiology of this fascinating tumour...
- Numerical sex chromosome aberrations in juvenile angiofibromas: genetic evidence for an androgen-dependent tumor?
Department of Otolaryngology, Saarland University, D 66421 Homburg Saar, Germany
Oncol Rep 10:1251-5. 2003
..A gain of chromosome X leads to AR gene gain indicating that JAs are androgen-dependent tumors. This is supported by the finding that beta-catenin known to be overexpressed in JAs acts as a co-activator of the AR...
- Metalloproteinases in juvenile angiofibroma--a collagen rich tumor
Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
Hum Pathol 39:259-68. 2008
..These MMPs are assumed to be involved in tumor pathology with an influence on tumor growth and angiogenesis...