Jan Christian Reil

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. doi request reprint Heart rate and heart failure: the role of ivabradine therapy
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Curr Opin Cardiol 28:326-31. 2013
  2. doi request reprint Is heart rate a treatment target in heart failure?
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, Homburg Saar, Germany
    Curr Cardiol Rep 14:308-13. 2012
  3. ncbi request reprint Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH
    Michael Bohm
    Klinik für Innere Medizin III Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Homburg Saar, Germany
    J Hypertens 26:18-25. 2008
  4. doi request reprint Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, 66424, Homburg Saar, Germany
    Clin Res Cardiol 102:11-22. 2013
  5. doi request reprint Aldosterone promotes atrial fibrillation
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, D 66421 Homburg Saar, Germany
    Eur Heart J 33:2098-108. 2012
  6. doi request reprint Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    J Am Coll Cardiol 62:1977-85. 2013
  7. doi request reprint BEAUTIFUL results--the slower, the better?
    Jan Christian Reil
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, 66421 Homburg Saar, Germany
    Lancet 372:779-80. 2008
  8. doi request reprint Impact of left bundle branch block on heart rate and its relationship to treatment with ivabradine in chronic heart failure
    Jan Christian Reil
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Kardiologie, Angiologie und Internistische Intensivmedizin, Homburg Saar, Germany
    Eur J Heart Fail 15:1044-52. 2013
  9. doi request reprint Procollagen propeptides: serum markers for atrial fibrosis?
    Hans Ruprecht Neuberger
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:655-61. 2012
  10. doi request reprint Heart rate reduction by I(f)-channel inhibition and its potential role in heart failure with reduced and preserved ejection fraction
    Jan Christian Reil
    Klinik fur Innere Medizin III, University of the Saarland, Homburg Saar, Germany
    Trends Cardiovasc Med 19:152-7. 2009

Detail Information

Publications20

  1. doi request reprint Heart rate and heart failure: the role of ivabradine therapy
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Curr Opin Cardiol 28:326-31. 2013
    ..The clinical data about the impact of heart rate reduction in heart failure therapy will be reviewed...
  2. doi request reprint Is heart rate a treatment target in heart failure?
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, Homburg Saar, Germany
    Curr Cardiol Rep 14:308-13. 2012
    ..Since heart rate can be easily determined during physical examination, decrease in heart rate of patients allows a simple hint on prognosis and efficiency of heart failure therapy...
  3. ncbi request reprint Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH
    Michael Bohm
    Klinik für Innere Medizin III Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Homburg Saar, Germany
    J Hypertens 26:18-25. 2008
    ..In patients in sinus rhythm (n = 18 900) the relationship between increased heart rate and the prevalence of MAU was analysed...
  4. doi request reprint Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, 66424, Homburg Saar, Germany
    Clin Res Cardiol 102:11-22. 2013
    ..A cut-off value of ≥75 bpm was chosen by the EMEA for approval for the use of ivabradine in chronic heart failure...
  5. doi request reprint Aldosterone promotes atrial fibrillation
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, D 66421 Homburg Saar, Germany
    Eur Heart J 33:2098-108. 2012
    ..However, it is unclear whether this is the consequence of altered haemodynamics or a direct aldosterone effect. It was the aim of the study to demonstrate load-independent effects of aldosterone on atrial structure and electrophysiology...
  6. doi request reprint Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    J Am Coll Cardiol 62:1977-85. 2013
    ..The study aimed to determine whether isolated heart rate (HR) reduction with ivabradine reduces afterload of patients with systolic heart failure...
  7. doi request reprint BEAUTIFUL results--the slower, the better?
    Jan Christian Reil
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, 66421 Homburg Saar, Germany
    Lancet 372:779-80. 2008
  8. doi request reprint Impact of left bundle branch block on heart rate and its relationship to treatment with ivabradine in chronic heart failure
    Jan Christian Reil
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Kardiologie, Angiologie und Internistische Intensivmedizin, Homburg Saar, Germany
    Eur J Heart Fail 15:1044-52. 2013
    ..Therefore, we aimed to analyse the impact of LBBB on outcomes in patients with systolic HF as a function of heart rate, and the relationship between LBBB and the effect of treatment with ivabradine...
  9. doi request reprint Procollagen propeptides: serum markers for atrial fibrosis?
    Hans Ruprecht Neuberger
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:655-61. 2012
    ..During collagen synthesis and degradation, collagen propeptides and telopeptides are released into the blood. This study tested the hypothesis that serum markers of collagen turnover correlate with atrial fibrosis...
  10. doi request reprint Heart rate reduction by I(f)-channel inhibition and its potential role in heart failure with reduced and preserved ejection fraction
    Jan Christian Reil
    Klinik fur Innere Medizin III, University of the Saarland, Homburg Saar, Germany
    Trends Cardiovasc Med 19:152-7. 2009
    ....
  11. doi request reprint Heart rate reduction in cardiovascular disease and therapy
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg Saar, Germany
    Clin Res Cardiol 100:11-9. 2011
    ..Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy...
  12. pmc Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Straße D 66421, Homburg Saar, Germany
    Eur Heart J 34:2839-49. 2013
    ..The aim of this study was to characterize myocardial function and ventricular-arterial coupling in a mouse model of diabetes and to analyse the effect of selective heart rate (HR) reduction by If-inhibition in this HFPEF-model...
  13. doi request reprint Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Homburg Saar D 66421, Germany
    Cardiovasc Res 87:485-93. 2010
    ..The small GTPase Rac1 seems to play a role in the pathogenesis of atrial fibrillation (AF). The aim of the present study was to characterize the effects of Rac1 overexpression on atrial electrophysiology...
  14. ncbi request reprint Perspectives of I(f) inhibition by ivabradine in cardiology
    Michael Bohm
    Klinik für Innere Medizin III Kardiologie Angiologie Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Drugs 67:43-9. 2007
    ..Further clinical and mechanistic studies to clarify the pathophysiological background are needed to fully define the role of heart rate reduction in the broad spectrum of cardiovascular interventions...
  15. doi request reprint Heart rate: a global target for cardiovascular disease and therapy along the cardiovascular disease continuum
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany Electronic address
    J Cardiol 62:183-7. 2013
    ..Future interventional studies will further clarify the significance of heart rate and targeted heart rate reduction for primary and secondary prevention in cardiovascular and cerebrovascular events. ..
  16. pmc HDAC4 controls histone methylation in response to elevated cardiac load
    Mathias Hohl
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    J Clin Invest 123:1359-70. 2013
    ....
  17. pmc Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar 66421, Germany
    J Transl Med 10:187. 2012
    ..The additive effects of obesity and metabolic syndrome on left ventricular (LV) maladaptive remodeling and function in hypertension are not characterized...
  18. ncbi request reprint Atrial fibrillation in heart failure: current treatment of patients with remodeled atria
    Hans Ruprecht Neuberger
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421, Homburg Saar, Germany
    Curr Heart Fail Rep 5:219-25. 2008
    ..Thus, prevention of AF entirely is an important goal. This review summarizes recent data concerning prognostic relevance, treatment, and means of primary and secondary prevention of AF in patients with CHF...
  19. doi request reprint Heart failure with normal left ventricular ejection fraction: what is the evidence?
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Trends Cardiovasc Med 18:280-92. 2008
    ..In contrast to heart failure with reduced ejection fraction, large-scale randomized controlled drug trials for HFNEF are scarce and could not demonstrate mortality reduction so far...
  20. doi request reprint Atrial fibrillation and heart rate independently correlate to microalbuminuria in hypertensive patients
    Michael Bohm
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitat des Saarlandes, Kirrberger Strasse, 66424 Homburg Saar, Germany
    Eur Heart J 30:1364-71. 2009
    ..To investigate the relationship between microalbuminuria (MAU) and atrial fibrillation (AF) and to further evaluate whether the heart rate dependency of MAU in patients without AF is maintained in patients with a history of AF...