Research Topics
Genomes and GenesSpecies | Jörg ReichrathSummaryAffiliation: Saarland University Country: Germany Publications
| Collaborators
|
Detail Information
Publications
The challenge resulting from positive and negative effects of sunlight: how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer?Jörg Reichrath
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
Prog Biophys Mol Biol 92:9-16. 2006....
Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?J Reichrath
Klinik fur Dermatologie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
Br J Dermatol 161:54-60. 2009..These recommendations will hopefully protect us against vitamin D-deficiency without increasing the risk to develop UV-induced skin cancer...- Vitamin D and the skin: an ancient friend, revisitedJörg Reichrath
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
Exp Dermatol 16:618-25. 2007..Additionally, it can be assumed that dermatological recommendations on sun protection and health campaigns for skin cancer prevention will have to be re-evaluated to guarantee a sufficient vitamin D status... - Sunlight, skin cancer and vitamin D: What are the conclusions of recent findings that protection against solar ultraviolet (UV) radiation causes 25-hydroxyvitamin D deficiency in solid organ-transplant recipients, xeroderma pigmentosum, and other risk groJörg Reichrath
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
J Steroid Biochem Mol Biol 103:664-7. 2007..Our finding that protection against solar UV radiation causes vitamin D deficiency underlines the need for re-defining dermatological recommendations for solar UV protection in skin cancer prevention programs... - Vitamin D analogs in cancer prevention and therapyJörg Reichrath
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
Anticancer Res 26:2511-4. 2006..However, the era of vitamin D analogs in cancer therapy has just begun and efforts to perform well-designed clinical studies and to develop new analogs with fewer systemic side-effects have to continue... - Dermatologic management, sun avoidance and vitamin D status in organ transplant recipients (OTR)Jörg Reichrath
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
J Photochem Photobiol B 101:150-9. 2010..This review discusses guidelines for the optimal management of these patients, that require communication between the transplant teams, the treating dermatologist and other clinicians... - Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patientsJörg Reichrath
Dermatology Clinic, The Saarland University Hospital, Homburg Saar, Germany
J Am Acad Dermatol 53:273-83. 2005.... - No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM)Jörg Reichrath
Department of Dermatology, The Saarland University Hospital, Kirrberger Str, 66421 Homburg Saar, Germany
J Steroid Biochem Mol Biol 89:163-6. 2004..Our results do not support the hypothesis that amplification of 1alpha-OHase or 24-OHase genes may be of importance for pathogenesis or progression of MM... - Analysis of the vitamin D system in cutaneous squamous cell carcinomasJörg Reichrath
Department of Dermatology, The Saarland University Hospital, Homburg, Germany
J Cutan Pathol 31:224-31. 2004.... - Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs)Jörg Reichrath
Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, 66421 Homburg Saar, Germany
Adv Exp Med Biol 624:203-14. 2008..In the future, dermatology clinics that are integrated into transplant centers may make it easier to manage and to treat OTRs, may make an interdisciplinary approach more effective and may thereby improve the clinical outcome in OTRs... - Treatment of genito-anal lesions in inflammatory skin diseases with PUVA cream photochemotherapy: an open pilot study in 12 patientsJörg Reichrath
Department of Dermatology, Saarland University Hospital, Homburg Saar, Germany
Dermatology 205:245-8. 2002..Another form of topical PUVA therapy, 8-methoxypsoralen-containing cream or gel preparations, has been proven to be as effective as PUVA bath therapy for palmoplantar dermatoses... - Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skinJörg Reichrath
Department of Dermatology, University of Saarland, Homburg, Germany
J Pathol 199:509-16. 2003.... - Analysis of the vitamin D system in cutaneous malignanciesJorn Kamradt
Department of Dermatology, University of Saarland, Kirrberger Str, 66421 Homburg Saar, Germany
Recent Results Cancer Res 164:259-69. 2003.... - Characterization of the vitamin D endocrine system in human sebocytes in vitroChristina Krämer
Department of Dermatology, The Saarland University Hospital, 66421 Homburg Saar, Germany
J Steroid Biochem Mol Biol 113:9-16. 2009..We conclude that sebaceous glands represent potential targets for therapy with vitamin D analogues or for pharmacological modulation of 1,25(OH)(2)D(3) synthesis/metabolism... - In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cellsJörg Reichrath
Department of Dermatology, The Saarland University Hospital, Homburg Germany
Cancer Biol Ther 6:48-55. 2007.... - Vitamin D receptor (VDR) expression is not a prognostic factor in cervical cancerMichael Friedrich
Department of Gynecology, University Hospital of Saarland, Homburg Saar, Germany
Anticancer Res 22:299-304. 2002..The aim of this study was to analyze whether VDR status is a prognostic factor that may be of importance for the assessment of recurrence in cervical cancer... - Association of genetic variants of the vitamin D receptor (VDR) with cutaneous squamous cell carcinomas (SCC) and basal cell carcinomas (BCC): a pilot study in a German populationKim Köstner
Department of Dermatology, The Saarland University Hospital, 66421 Homburg Saar, Germany
Anticancer Res 32:327-33. 2012..Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies... - Peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) signaling pathways in melanoma cells: promising new therapeutic targets?Pit Sertznig
Department of Dermatology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
J Steroid Biochem Mol Biol 121:383-6. 2010..This review summarizes the currently available data on the roles of the PPARs and the VDR in pathogenesis and progression of melanoma as well as their role as promising future therapeutic targets... - 1,25-dihydroxyvitamin D3 modulates effects of ionizing radiation (IR) on human keratinocytes: in vitro analysis of cell viability/proliferation, DNA-damage and -repairLea Tremezaygues
Department of Dermatology, The Saarland University Hospital, Kirrberger Str, 66421 Homburg Saar, Germany
J Steroid Biochem Mol Biol 121:324-7. 2010..To put it in a nutshell, our data support the hypothesis that 1,25(OH)2D3 modulates the effects of low-dose IR (1-5 Gy) on cultured human keratinocytes... - Hope and challenge: the importance of ultraviolet (UV) radiation for cutaneous vitamin D synthesis and skin cancerJörg Reichrath
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
Scand J Clin Lab Invest Suppl 243:112-9. 2012..In this review, we analyze the present literature to help developing well-balanced guidelines on UV-protection that ensure an adequate vitamin D-status without increasing the risk to develop UV-induced skin cancer... - Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cellsPit Sertznig
Department of Dermatology, The Saarland University Hospital, Homburg Saar, Germany
Anticancer Res 29:3647-58. 2009.... - Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell linesSalma Essa
Department of Dermatology, The Saarland University Hospital, Kirrbergerstr, 66421 Homburg, Germany
Anticancer Res 32:383-9. 2012..This study aimed at gaining further insights into the molecular mechanisms that underlie the epigenetic modulation of 1,25(OH)(2)D(3)-sensitivity in melanoma cells... - Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitroMarkus Seifert
Universitäts Hautklinik, Universitatsklinikum des Saarlandes, Homburg, Germany
Anticancer Res 29:3659-67. 2009..Further study of the impact of CYP27B1 splice variants on the vitamin D pathway in keratinocytes and other cell types is warranted... - Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell linesSandra Reichrath
Department of Internal Medicine I, The Saarland University Hospital, Homburg Saar, Germany
J Steroid Biochem Mol Biol 121:420-4. 2010..Our findings do not support the hypothesis that modulation of Notch-signaling pathways by 1,25(OH)2D3 may regulate growth of GBM cell lines... - The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cellsMarkus Seifert
Department of Dermatology, The Saarland University Hospital, Homburg, Germany
J Invest Dermatol 128:203-13. 2008..In conclusion, we demonstrate that MSH2 modulates in human melanocytes both UV-B-induced cell cycle regulation and apoptosis, most likely via independent, uncoupled mechanisms... - UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancerKnuth Rass
Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, 66421 Homburg Saar, Germany
Adv Exp Med Biol 624:162-78. 2008.... - Immunohistochemical analysis of 1,25-dihydroxyvitamin-D3-receptors, estrogen and progesterone receptors and Ki-67 in ovarian carcinomaCarlos Villena-Heinsen
Department of Gynecology, University of Saarland, Homburg, Germany
Anticancer Res 22:2261-7. 2002..The aim of this study was to analyze immunohistochemically the expression of VDR in normal and carcinomatous ovarian tissue to evaluate whether ovarian tissue may be a new potential target for biologically active vitamin D analogues... 
High-throughput miRNA profiling of human melanoma blood samplesPetra Leidinger
Institute of Human Genetics, Medical School, Saarland University, Building 60, 66421 Homburg Saar, Germany
BMC Cancer 10:262. 2010..MicroRNA (miRNA) signatures are not only found in cancer tissue but also in blood of cancer patients. Specifically, miRNA detection in blood offers the prospect of a non-invasive analysis tool...- No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control studyAnnika Schäfer
Department of Dermatology, Venereology, and Allergology, Georg August University Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
Arch Dermatol Res 304:353-61. 2012..We, however, found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in our study population... - Frontiers in sebaceous gland biology and pathologyChristos C Zouboulis
Department of Dermatology, Dessau Medical Center, Dessau, Germany
Exp Dermatol 17:542-51. 2008..These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland... - Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brainMarkus Seifert
Department of Human Genetics, Saarland University Hospital, Homburg, Saar, Germany
Oncol Rep 17:1207-11. 2007..These results indicate that ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function... - Pyoderma gangrenosum: clinical presentation and outcome in 18 cases and review of the literatureDirk O Hasselmann
Clinic of Dermatology, Venereology and Allergology, The Saarland University Hospital, Homburg Saar, Germany
J Dtsch Dermatol Ges 5:560-4. 2007..Because its incidence is low, no prospective randomized controlled trials and only a few large case studies on PG have been reported... - Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseasesPit Sertznig
Department of Dermatology, The Saarland University Hospital, Homburg Saar, Germany
Am J Clin Dermatol 9:15-31. 2008.... - The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literatureKim Köstner
Department of Dermatology, The Saarland University Hospital, Homburg, Germany
Anticancer Res 29:3511-36. 2009..We have now performed a systematic review of the literature to analyse the relevance of VDR polymorphisms for individual malignancies, including cancer of the skin, prostate, breast, colon, ovary, kidney and bladder... - Molecular genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variationsAnnika Schäfer
Department of Dermatology, Venerology and Allergology, University Medical Center Gottingen, Gottingen, Germany
Exp Dermatol 22:24-9. 2013..This mutation results in a classical XP phenotype, a non-functional XPC protein, but elevated XPC mRNA expression. Our study indicates that extrinsic factors may contribute to XP-C symptom severity due to nonsense-mediated message decay... - Verrucae vulgares in children: successful simulated X-ray treatment (a suggestion-based therapy)Viktor Meineke
Department of Dermatology, University of the Saarland, Homburg Saar, Germany
Dermatology 204:287-9. 2002..Treatment of verrucae vulgares is sometimes difficult. Invasive methods should not be used for young children... - Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in cervical tissueMichael Friedrich
Department of Gynecology and Obstetrics, University of Saarland, Homburg Saar, Germany
Anticancer Res 22:183-6. 2002.... - The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancerMarkus Seifert
Department of Dermatology, The Saarland University Hospital, Building 18, Kirrberger Strasse, 66421 Homburg, Germany
J Mol Histol 37:301-7. 2006..This review summarizes our present understanding of the function of MSH2 for DNA repair, cell cycle control, and apoptosis and discusses its importance for pathogenesis, progression and therapy of cancer... - Notch-signaling and nonmelanoma skin cancer: an ancient friend, revisitedJörg Reichrath
Department of Dermatology, The Saarland University Hospital, Homburg, Germany
Adv Exp Med Biol 727:265-71. 2012..It can be speculated that pharmacologic modulation of Notch signaling may be an interesting target for the prevention and therapy of skin cancer... - Transcriptional profiling of human endogenous retrovirus group HERV-K(HML-2) loci in melanomaKatja Schmitt
Institute of Human Genetics, Medical Faculty, University of Saarland, Homburg Saar, Germany
Genome Biol Evol 5:307-28. 2013..Transcription of HERVs appears as a complex mechanism requiring specific studies to elucidate which HERV loci are transcribed and how transcribed HERVs may be involved in disease... - From the bench to emerging new clinical concepts: Our present understanding of the importance of the vitamin D endocrine system (VDES) for skin cancerLea Tremezaygues
Klinik fur Dermatologie, Venerologie und Allergologie Universitätsklinikum des Saarlandes, Homburg Saar, Germany
Dermatoendocrinol 3:11-7. 2011..It is the aim of this review to summarize our present understanding of the cutaneous vitamin D endocrine system (VDES) and its importance for the prevention of skin cancerogenesis...