Jörg Reichrath

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint The challenge resulting from positive and negative effects of sunlight: how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer?
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Prog Biophys Mol Biol 92:9-16. 2006
  2. doi request reprint Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?
    J Reichrath
    Klinik fur Dermatologie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Br J Dermatol 161:54-60. 2009
  3. ncbi request reprint Vitamin D and the skin: an ancient friend, revisited
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Exp Dermatol 16:618-25. 2007
  4. ncbi request reprint Sunlight, skin cancer and vitamin D: What are the conclusions of recent findings that protection against solar ultraviolet (UV) radiation causes 25-hydroxyvitamin D deficiency in solid organ-transplant recipients, xeroderma pigmentosum, and other risk gro
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 103:664-7. 2007
  5. doi request reprint Dermatologic management, sun avoidance and vitamin D status in organ transplant recipients (OTR)
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Photochem Photobiol B 101:150-9. 2010
  6. ncbi request reprint Vitamin D analogs in cancer prevention and therapy
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Anticancer Res 26:2511-4. 2006
  7. ncbi request reprint Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients
    Jörg Reichrath
    Dermatology Clinic, The Saarland University Hospital, Homburg Saar, Germany
    J Am Acad Dermatol 53:273-83. 2005
  8. ncbi request reprint No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM)
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Kirrberger Str, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 89:163-6. 2004
  9. ncbi request reprint Analysis of the vitamin D system in cutaneous squamous cell carcinomas
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    J Cutan Pathol 31:224-31. 2004
  10. doi request reprint Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs)
    Jörg Reichrath
    Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, 66421 Homburg Saar, Germany
    Adv Exp Med Biol 624:203-14. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint The challenge resulting from positive and negative effects of sunlight: how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer?
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Prog Biophys Mol Biol 92:9-16. 2006
    ....
  2. doi request reprint Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?
    J Reichrath
    Klinik fur Dermatologie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Br J Dermatol 161:54-60. 2009
    ..These recommendations will hopefully protect us against vitamin D-deficiency without increasing the risk to develop UV-induced skin cancer...
  3. ncbi request reprint Vitamin D and the skin: an ancient friend, revisited
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Exp Dermatol 16:618-25. 2007
    ..Additionally, it can be assumed that dermatological recommendations on sun protection and health campaigns for skin cancer prevention will have to be re-evaluated to guarantee a sufficient vitamin D status...
  4. ncbi request reprint Sunlight, skin cancer and vitamin D: What are the conclusions of recent findings that protection against solar ultraviolet (UV) radiation causes 25-hydroxyvitamin D deficiency in solid organ-transplant recipients, xeroderma pigmentosum, and other risk gro
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 103:664-7. 2007
    ..Our finding that protection against solar UV radiation causes vitamin D deficiency underlines the need for re-defining dermatological recommendations for solar UV protection in skin cancer prevention programs...
  5. doi request reprint Dermatologic management, sun avoidance and vitamin D status in organ transplant recipients (OTR)
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Photochem Photobiol B 101:150-9. 2010
    ..This review discusses guidelines for the optimal management of these patients, that require communication between the transplant teams, the treating dermatologist and other clinicians...
  6. ncbi request reprint Vitamin D analogs in cancer prevention and therapy
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Anticancer Res 26:2511-4. 2006
    ..However, the era of vitamin D analogs in cancer therapy has just begun and efforts to perform well-designed clinical studies and to develop new analogs with fewer systemic side-effects have to continue...
  7. ncbi request reprint Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients
    Jörg Reichrath
    Dermatology Clinic, The Saarland University Hospital, Homburg Saar, Germany
    J Am Acad Dermatol 53:273-83. 2005
    ....
  8. ncbi request reprint No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM)
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Kirrberger Str, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 89:163-6. 2004
    ..Our results do not support the hypothesis that amplification of 1alpha-OHase or 24-OHase genes may be of importance for pathogenesis or progression of MM...
  9. ncbi request reprint Analysis of the vitamin D system in cutaneous squamous cell carcinomas
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    J Cutan Pathol 31:224-31. 2004
    ....
  10. doi request reprint Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs)
    Jörg Reichrath
    Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, 66421 Homburg Saar, Germany
    Adv Exp Med Biol 624:203-14. 2008
    ..In the future, dermatology clinics that are integrated into transplant centers may make it easier to manage and to treat OTRs, may make an interdisciplinary approach more effective and may thereby improve the clinical outcome in OTRs...
  11. ncbi request reprint Treatment of genito-anal lesions in inflammatory skin diseases with PUVA cream photochemotherapy: an open pilot study in 12 patients
    Jörg Reichrath
    Department of Dermatology, Saarland University Hospital, Homburg Saar, Germany
    Dermatology 205:245-8. 2002
    ..Another form of topical PUVA therapy, 8-methoxypsoralen-containing cream or gel preparations, has been proven to be as effective as PUVA bath therapy for palmoplantar dermatoses...
  12. ncbi request reprint Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin
    Jörg Reichrath
    Department of Dermatology, University of Saarland, Homburg, Germany
    J Pathol 199:509-16. 2003
    ....
  13. ncbi request reprint Analysis of the vitamin D system in cutaneous malignancies
    Jorn Kamradt
    Department of Dermatology, University of Saarland, Kirrberger Str, 66421 Homburg Saar, Germany
    Recent Results Cancer Res 164:259-69. 2003
    ....
  14. doi request reprint Characterization of the vitamin D endocrine system in human sebocytes in vitro
    Christina Krämer
    Department of Dermatology, The Saarland University Hospital, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 113:9-16. 2009
    ..We conclude that sebaceous glands represent potential targets for therapy with vitamin D analogues or for pharmacological modulation of 1,25(OH)(2)D(3) synthesis/metabolism...
  15. ncbi request reprint In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg Germany
    Cancer Biol Ther 6:48-55. 2007
    ....
  16. ncbi request reprint Vitamin D receptor (VDR) expression is not a prognostic factor in cervical cancer
    Michael Friedrich
    Department of Gynecology, University Hospital of Saarland, Homburg Saar, Germany
    Anticancer Res 22:299-304. 2002
    ..The aim of this study was to analyze whether VDR status is a prognostic factor that may be of importance for the assessment of recurrence in cervical cancer...
  17. ncbi request reprint Association of genetic variants of the vitamin D receptor (VDR) with cutaneous squamous cell carcinomas (SCC) and basal cell carcinomas (BCC): a pilot study in a German population
    Kim Köstner
    Department of Dermatology, The Saarland University Hospital, 66421 Homburg Saar, Germany
    Anticancer Res 32:327-33. 2012
    ..Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies...
  18. doi request reprint Peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) signaling pathways in melanoma cells: promising new therapeutic targets?
    Pit Sertznig
    Department of Dermatology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    J Steroid Biochem Mol Biol 121:383-6. 2010
    ..This review summarizes the currently available data on the roles of the PPARs and the VDR in pathogenesis and progression of melanoma as well as their role as promising future therapeutic targets...
  19. doi request reprint 1,25-dihydroxyvitamin D3 modulates effects of ionizing radiation (IR) on human keratinocytes: in vitro analysis of cell viability/proliferation, DNA-damage and -repair
    Lea Tremezaygues
    Department of Dermatology, The Saarland University Hospital, Kirrberger Str, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 121:324-7. 2010
    ..To put it in a nutshell, our data support the hypothesis that 1,25(OH)2D3 modulates the effects of low-dose IR (1-5 Gy) on cultured human keratinocytes...
  20. doi request reprint Hope and challenge: the importance of ultraviolet (UV) radiation for cutaneous vitamin D synthesis and skin cancer
    Jörg Reichrath
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Scand J Clin Lab Invest Suppl 243:112-9. 2012
    ..In this review, we analyze the present literature to help developing well-balanced guidelines on UV-protection that ensure an adequate vitamin D-status without increasing the risk to develop UV-induced skin cancer...
  21. ncbi request reprint Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells
    Pit Sertznig
    Department of Dermatology, The Saarland University Hospital, Homburg Saar, Germany
    Anticancer Res 29:3647-58. 2009
    ....
  22. doi request reprint Molecular genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variations
    Annika Schäfer
    Department of Dermatology, Venerology and Allergology, University Medical Center Gottingen, Gottingen, Germany
    Exp Dermatol 22:24-9. 2013
    ..This mutation results in a classical XP phenotype, a non-functional XPC protein, but elevated XPC mRNA expression. Our study indicates that extrinsic factors may contribute to XP-C symptom severity due to nonsense-mediated message decay...
  23. ncbi request reprint Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines
    Salma Essa
    Department of Dermatology, The Saarland University Hospital, Kirrbergerstr, 66421 Homburg, Germany
    Anticancer Res 32:383-9. 2012
    ..This study aimed at gaining further insights into the molecular mechanisms that underlie the epigenetic modulation of 1,25(OH)(2)D(3)-sensitivity in melanoma cells...
  24. ncbi request reprint Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro
    Markus Seifert
    Universitäts Hautklinik, Universitatsklinikum des Saarlandes, Homburg, Germany
    Anticancer Res 29:3659-67. 2009
    ..Further study of the impact of CYP27B1 splice variants on the vitamin D pathway in keratinocytes and other cell types is warranted...
  25. doi request reprint Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines
    Sandra Reichrath
    Department of Internal Medicine I, The Saarland University Hospital, Homburg Saar, Germany
    J Steroid Biochem Mol Biol 121:420-4. 2010
    ..Our findings do not support the hypothesis that modulation of Notch-signaling pathways by 1,25(OH)2D3 may regulate growth of GBM cell lines...
  26. ncbi request reprint The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells
    Markus Seifert
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    J Invest Dermatol 128:203-13. 2008
    ..In conclusion, we demonstrate that MSH2 modulates in human melanocytes both UV-B-induced cell cycle regulation and apoptosis, most likely via independent, uncoupled mechanisms...
  27. ncbi request reprint Immunohistochemical analysis of 1,25-dihydroxyvitamin-D3-receptors, estrogen and progesterone receptors and Ki-67 in ovarian carcinoma
    Carlos Villena-Heinsen
    Department of Gynecology, University of Saarland, Homburg, Germany
    Anticancer Res 22:2261-7. 2002
    ..The aim of this study was to analyze immunohistochemically the expression of VDR in normal and carcinomatous ovarian tissue to evaluate whether ovarian tissue may be a new potential target for biologically active vitamin D analogues...
  28. doi request reprint UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer
    Knuth Rass
    Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, 66421 Homburg Saar, Germany
    Adv Exp Med Biol 624:162-78. 2008
    ....
  29. pmc High-throughput miRNA profiling of human melanoma blood samples
    Petra Leidinger
    Institute of Human Genetics, Medical School, Saarland University, Building 60, 66421 Homburg Saar, Germany
    BMC Cancer 10:262. 2010
    ..MicroRNA (miRNA) signatures are not only found in cancer tissue but also in blood of cancer patients. Specifically, miRNA detection in blood offers the prospect of a non-invasive analysis tool...
  30. pmc No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study
    Annika Schäfer
    Department of Dermatology, Venereology, and Allergology, Georg August University Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Arch Dermatol Res 304:353-61. 2012
    ..We, however, found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in our study population...
  31. doi request reprint Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
    ..These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland...
  32. pmc Transcriptional profiling of human endogenous retrovirus group HERV-K(HML-2) loci in melanoma
    Katja Schmitt
    Institute of Human Genetics, Medical Faculty, University of Saarland, Homburg Saar, Germany
    Genome Biol Evol 5:307-28. 2013
    ..Transcription of HERVs appears as a complex mechanism requiring specific studies to elucidate which HERV loci are transcribed and how transcribed HERVs may be involved in disease...
  33. ncbi request reprint Pyoderma gangrenosum: clinical presentation and outcome in 18 cases and review of the literature
    Dirk O Hasselmann
    Clinic of Dermatology, Venereology and Allergology, The Saarland University Hospital, Homburg Saar, Germany
    J Dtsch Dermatol Ges 5:560-4. 2007
    ..Because its incidence is low, no prospective randomized controlled trials and only a few large case studies on PG have been reported...
  34. ncbi request reprint Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases
    Pit Sertznig
    Department of Dermatology, The Saarland University Hospital, Homburg Saar, Germany
    Am J Clin Dermatol 9:15-31. 2008
    ....
  35. ncbi request reprint Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain
    Markus Seifert
    Department of Human Genetics, Saarland University Hospital, Homburg, Saar, Germany
    Oncol Rep 17:1207-11. 2007
    ..These results indicate that ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function...
  36. ncbi request reprint The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature
    Kim Köstner
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Anticancer Res 29:3511-36. 2009
    ..We have now performed a systematic review of the literature to analyse the relevance of VDR polymorphisms for individual malignancies, including cancer of the skin, prostate, breast, colon, ovary, kidney and bladder...
  37. ncbi request reprint Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in cervical tissue
    Michael Friedrich
    Department of Gynecology and Obstetrics, University of Saarland, Homburg Saar, Germany
    Anticancer Res 22:183-6. 2002
    ....
  38. ncbi request reprint Verrucae vulgares in children: successful simulated X-ray treatment (a suggestion-based therapy)
    Viktor Meineke
    Department of Dermatology, University of the Saarland, Homburg Saar, Germany
    Dermatology 204:287-9. 2002
    ..Treatment of verrucae vulgares is sometimes difficult. Invasive methods should not be used for young children...
  39. ncbi request reprint The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer
    Markus Seifert
    Department of Dermatology, The Saarland University Hospital, Building 18, Kirrberger Strasse, 66421 Homburg, Germany
    J Mol Histol 37:301-7. 2006
    ..This review summarizes our present understanding of the function of MSH2 for DNA repair, cell cycle control, and apoptosis and discusses its importance for pathogenesis, progression and therapy of cancer...
  40. doi request reprint Notch-signaling and nonmelanoma skin cancer: an ancient friend, revisited
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Adv Exp Med Biol 727:265-71. 2012
    ..It can be speculated that pharmacologic modulation of Notch signaling may be an interesting target for the prevention and therapy of skin cancer...
  41. pmc From the bench to emerging new clinical concepts: Our present understanding of the importance of the vitamin D endocrine system (VDES) for skin cancer
    Lea Tremezaygues
    Klinik fur Dermatologie, Venerologie und Allergologie Universitätsklinikum des Saarlandes, Homburg Saar, Germany
    Dermatoendocrinol 3:11-7. 2011
    ..It is the aim of this review to summarize our present understanding of the cutaneous vitamin D endocrine system (VDES) and its importance for the prevention of skin cancerogenesis...