Guido Plotz

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi Analysis of the human MutLalpha.MutSalpha complex
    Guido Plotz
    University of the Saarland, Klinik fur Innere Medizin II, Homburg Saar, Germany
    Biochem Biophys Res Commun 340:852-9. 2006
  2. ncbi DNA mismatch repair and Lynch syndrome
    Guido Plotz
    Klinik fur Innere Medizin II, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 41, D 66421 Homburg, Germany
    J Mol Histol 37:271-83. 2006
  3. ncbi N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha
    Guido Plotz
    2nd Department of Medicine, University of the Saarland, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Nucleic Acids Res 31:3217-26. 2003
  4. ncbi BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors
    Nikolaus Lubomierski
    2nd Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
    Cancer 104:952-61. 2005
  5. ncbi Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair
    Guido Plotz
    Klinik fur Innere Medizin II, Gebäude 41 Kirrberger Strasse, Universitat des Saarlandes, D 66421 Homburg Saar, Germany
    Nucleic Acids Res 34:6574-86. 2006
  6. ncbi Hypothesis: Possible role of retinoic acid therapy in patients with biallelic mismatch repair gene defects
    Sven Gottschling
    Department of Pediatric Hematology and Oncology Saarland University, University Children s Hospital, Homburg, Germany
    Eur J Pediatr 167:225-9. 2008
  7. ncbi Adenoma development in a patient with MUTYH-associated polyposis (MAP): new insights into the natural course of polyp development
    Markus Casper
    Department of Internal Medicine II, Saarland University Hospital, Kirrberger Strasse, Homburg Saar, Germany
    Dig Dis Sci 55:1711-5. 2010
  8. ncbi hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA
    Guido Plotz
    Second Department of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Nucleic Acids Res 30:711-8. 2002
  9. ncbi Thymosin beta 4 expression and nuclear transport are regulated by hMLH1
    Angela Brieger
    Department of Internal Medicine I, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt a M, Germany
    Biochem Biophys Res Commun 364:731-6. 2007
  10. ncbi The PMS2 subunit of human MutLalpha contains a metal ion binding domain of the iron-dependent repressor protein family
    Jan Kosinski
    Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, Trojdena 4, 02 109 Warsaw, Poland
    J Mol Biol 382:610-27. 2008

Detail Information

Publications12

  1. ncbi Analysis of the human MutLalpha.MutSalpha complex
    Guido Plotz
    University of the Saarland, Klinik fur Innere Medizin II, Homburg Saar, Germany
    Biochem Biophys Res Commun 340:852-9. 2006
    ..The described conditions likely capture an intermediate of the repair reaction which has bound ATP and ADP in the two nucleotide-binding sites of MutSalpha...
  2. ncbi DNA mismatch repair and Lynch syndrome
    Guido Plotz
    Klinik fur Innere Medizin II, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 41, D 66421 Homburg, Germany
    J Mol Histol 37:271-83. 2006
    ..We review the biochemistry of mismatch repair and also introduce the clinical, diagnostic and genetic aspects of Lynch syndrome...
  3. ncbi N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha
    Guido Plotz
    2nd Department of Medicine, University of the Saarland, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Nucleic Acids Res 31:3217-26. 2003
    ..We also examined another human homologue of bacterial MutL, hMutLbeta (hMLH1-hPMS1). We show that hMutLbeta interacts as efficiently with hMutSalpha as hMutLalpha, and that it predominantly binds to hMutSalpha via hMLH1 as well...
  4. ncbi BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors
    Nikolaus Lubomierski
    2nd Department of Internal Medicine, Saarland University Hospital, Homburg Saar, Germany
    Cancer 104:952-61. 2005
    ..These alterations were attributed to defective DNA mismatch repair, which underlies MSI. It was the objective of this study to clarify the role of BRAF in colorectal carcinoma with MSI...
  5. ncbi Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair
    Guido Plotz
    Klinik fur Innere Medizin II, Gebäude 41 Kirrberger Strasse, Universitat des Saarlandes, D 66421 Homburg Saar, Germany
    Nucleic Acids Res 34:6574-86. 2006
    ....
  6. ncbi Hypothesis: Possible role of retinoic acid therapy in patients with biallelic mismatch repair gene defects
    Sven Gottschling
    Department of Pediatric Hematology and Oncology Saarland University, University Children s Hospital, Homburg, Germany
    Eur J Pediatr 167:225-9. 2008
    ..We propose to take a retinoic acid chemoprevention into account in children with proven biallelic PMS2 mismatch repair mutations being at highest risk concerning the development of a malignancy...
  7. ncbi Adenoma development in a patient with MUTYH-associated polyposis (MAP): new insights into the natural course of polyp development
    Markus Casper
    Department of Internal Medicine II, Saarland University Hospital, Kirrberger Strasse, Homburg Saar, Germany
    Dig Dis Sci 55:1711-5. 2010
    ..Affected patients present with a wide range of clinical phenotypes at the time of diagnosis, but there is little precise information about the natural course of this disease...
  8. ncbi hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA
    Guido Plotz
    Second Department of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Nucleic Acids Res 30:711-8. 2002
    ..Purified hMutLalpha showed an intrinsic affinity for DNA, with a preference for single-stranded over double-stranded DNA...
  9. ncbi Thymosin beta 4 expression and nuclear transport are regulated by hMLH1
    Angela Brieger
    Department of Internal Medicine I, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt a M, Germany
    Biochem Biophys Res Commun 364:731-6. 2007
    ..Moreover, loss of hMLH1 causes Tbeta4 deprivation and results in reduced migratory activity in vitro. These data give insight into novel functions of hMLH1 and probably disease related dysregulated mechanisms...
  10. ncbi The PMS2 subunit of human MutLalpha contains a metal ion binding domain of the iron-dependent repressor protein family
    Jan Kosinski
    Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, Trojdena 4, 02 109 Warsaw, Poland
    J Mol Biol 382:610-27. 2008
    ..Finally, we demonstrate that the conserved residues of the metal ion binding domain are crucial for MMR activity of MutLalpha in vitro...
  11. ncbi Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system
    Joerg Trojan
    Second Department of Medicine, Johann Wolfgang Goethe University, Frankfurt a M, Germany
    Gastroenterology 122:211-9. 2002
    ..To date, functional analysis of missense mutations has been performed primarily in Saccharomyces cerevisiae. The aim of this study was to examine the biochemical properties of hMLH1 protein variants in a human expression system...
  12. ncbi Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis
    Guido Plotz
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Inflamm Bowel Dis 14:605-11. 2008
    ....