Rima Obeid

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. doi request reprint Critical evaluation of lowering the recommended dietary intake of folate
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of the Saarland, D 66421 Homburg, Germany Electronic address
    Clin Nutr 33:252-9. 2014
  2. doi request reprint Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Medical School, Saarland University, Building 57, D 66421 Homburg, Germany
    J Perinat Med 41:469-83. 2013
  3. pmc The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway
    Rima Obeid
    Department of Clinical Chemistry, University Hospital of the Saarland, D 66424, Homburg, Germany
    Nutrients 5:3481-95. 2013
  4. doi request reprint Aqueous humor glycation marker and plasma homocysteine in macular degeneration
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, 66421 Homburg Saar, Germany
    Clin Chem Lab Med 51:657-63. 2013
  5. doi request reprint Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes
    Rima Obeid
    Department of Clinical Chemistry, Saarland University Medical Centre, Homburg, Germany
    Biochimie 95:1056-61. 2013
  6. ncbi request reprint The emerging role of unmetabolized folic acid in human diseases: myth or reality?
    Rima Obeid
    University Hospital of Saarland, Department of Clinical Chemistry and Laboratory Medicine, Building 57, D 66421 Homburg Saar, Germany
    Curr Drug Metab 13:1184-95. 2012
  7. doi request reprint Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University, Medical Centre, Homburg, Germany
    Mol Nutr Food Res 56:1582-9. 2012
  8. doi request reprint Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, D 66421 Homburg Saar, Germany
    Metabolism 60:673-80. 2011
  9. doi request reprint Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine and Gynecology, University Hospital of Saarland, Homburg, Germany
    Am J Clin Nutr 92:1416-22. 2010
  10. doi request reprint Methylation status and neurodegenerative markers in Parkinson disease
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Department of Neurology, University Hospital of Saarland, Homburg, Germany
    Clin Chem 55:1852-60. 2009

Detail Information

Publications65

  1. doi request reprint Critical evaluation of lowering the recommended dietary intake of folate
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of the Saarland, D 66421 Homburg, Germany Electronic address
    Clin Nutr 33:252-9. 2014
    ..e., in Germany) supplement with the vitamin. Recommending adequate food folate intake is crucial for reaching the target protective plasma folate levels in the population...
  2. doi request reprint Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Medical School, Saarland University, Building 57, D 66421 Homburg, Germany
    J Perinat Med 41:469-83. 2013
    ..Supplemental 5-methylTHF can effectively improve folate biomarkers in young women in early pregnancy in order to prevent NTDs...
  3. pmc The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway
    Rima Obeid
    Department of Clinical Chemistry, University Hospital of the Saarland, D 66424, Homburg, Germany
    Nutrients 5:3481-95. 2013
    ..Betaine supplementation has a lowering effect on post-methionine load tHcy. Hypomethylation and tHcy elevation can be attenuated when choline or betaine is available. ..
  4. doi request reprint Aqueous humor glycation marker and plasma homocysteine in macular degeneration
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, 66421 Homburg Saar, Germany
    Clin Chem Lab Med 51:657-63. 2013
    ..In addition, we tested the association between plasma tHcy and one glycation marker in aqueous humor...
  5. doi request reprint Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes
    Rima Obeid
    Department of Clinical Chemistry, Saarland University Medical Centre, Homburg, Germany
    Biochimie 95:1056-61. 2013
    ..Metformin treatment was associated with low serum vitamin B12 and improved intracellular vitamin B12 metabolism despite low serum vitamin B12...
  6. ncbi request reprint The emerging role of unmetabolized folic acid in human diseases: myth or reality?
    Rima Obeid
    University Hospital of Saarland, Department of Clinical Chemistry and Laboratory Medicine, Building 57, D 66421 Homburg Saar, Germany
    Curr Drug Metab 13:1184-95. 2012
    ..Evidence of a negative health effect of free FA in blood is not consistent and suggests rather artificial factors. FA has no known cofactor function that would increase the likelihood of a causal role for free FA in disease development...
  7. doi request reprint Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University, Medical Centre, Homburg, Germany
    Mol Nutr Food Res 56:1582-9. 2012
    ..The study tests the metabolites of the methylation cycle in individuals with Down syndrome (DS) and applies a mathematical model in order to change this cycle by nutritional factors...
  8. doi request reprint Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, D 66421 Homburg Saar, Germany
    Metabolism 60:673-80. 2011
    ..Folic acid given to older adults is mostly converted to THF and 5-MTHF and lowered concentrations of tHcy, but caused a substantial increase in unmetabolized FA in the plasma...
  9. doi request reprint Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine and Gynecology, University Hospital of Saarland, Homburg, Germany
    Am J Clin Nutr 92:1416-22. 2010
    ..The importance of unmetabolized folic acid in maternal and fetal blood is not known...
  10. doi request reprint Methylation status and neurodegenerative markers in Parkinson disease
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Department of Neurology, University Hospital of Saarland, Homburg, Germany
    Clin Chem 55:1852-60. 2009
    ..Methylation status might link Hcy metabolism to neurodegenerative proteins in patients with PD...
  11. doi request reprint Advanced glycation end products overload might explain intracellular cobalamin deficiency in renal dysfunction, diabetes and aging
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, 66421 Homburg, Germany
    Med Hypotheses 77:884-8. 2011
    ..Transcobalamin-Cbl might retain in blood. Shedding of megalin and transcobalamin receptor under glycation conditions is also a possible mechanism of this phenomenon...
  12. doi request reprint Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg, Germany
    J Neurochem 117:1047-54. 2011
    ..The effect of the diet on P-tau and pNF-H seemed not to be explained by a lower activity or protein level of PP2A. Folate might prove protective against multiple steps in the process of neurodegeneration...
  13. ncbi request reprint Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine and Neurology, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:1129-36. 2007
    ..Increased plasma total homocysteine (tHcy) is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained...
  14. ncbi request reprint Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes
    Wolfgang Herrmann
    Department of Clinical Chemistry, Central Laboratory, Saarland University Hospital, Homburg, Germany
    Clin Chem 51:891-7. 2005
    ....
  15. ncbi request reprint The role of genetic factors in the development of hyperhomocysteinemia
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1427-34. 2003
    ..Although the TC and COMT mutations influence cellular vitamin B12 metabolism, this effect did not result in overt homocysteine elevation...
  16. ncbi request reprint Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk
    Wolfgang Herrmann
    Department of Clinical Chemistry, School of Medicine, Saarland University, Homburg, Germany
    Clin Chem Lab Med 41:1478-88. 2003
    ..In this study we investigated the diagnostic value of storage (holoTC) of vitamin B12 and functional markers (methylmalonic acid (MMA)) of vitamin B12 metabolism in populations who are at risk of vitamin B12 deficiency...
  17. ncbi request reprint Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:326-33. 2007
    ..Increased HCY has been related to neurological and psychiatric disorders. We studied the role of the B-vitamins in HCY metabolism in the brain...
  18. ncbi request reprint Comparison of the influence of volume-oriented training and high-intensity interval training on serum homocysteine and its cofactors in young, healthy swimmers
    Markus Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 41:1525-31. 2003
    ..Previous studies have suggested that endurance training influences Hcy. However, little is known about the effect of training intensity on Hcy...
  19. doi request reprint Effect of 1 year B and D vitamin supplementation on LINE-1 repetitive element methylation in older subjects
    Ulrich Hübner
    University Hospital of the Saarland, Clinical Chemistry and Laboratory Medicine Central Laboratory, 66421 Homburg, Germany
    Clin Chem Lab Med 51:649-55. 2013
    ..We tested if B and D vitamin supplementation has an effect on genomic long interspersed nuclear element-1 (LINE-1) methylation and the metabolites S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH)...
  20. ncbi request reprint The vegetarian lifestyle and DNA methylation
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 43:1164-9. 2005
    ..In conclusion, an inhibitory effect of SAH on whole-genome methylation was found, but from our data no interaction between vegetarian lifestyle and DNA methylation could be determined...
  21. ncbi request reprint Altered vitamin B12 status in recreational endurance athletes
    Markus Herrmann
    University Hospital of Saarland, Dept of Clinical Chemistry and Laboratory Medicine, Homburg Saar, Germany
    Int J Sport Nutr Exerc Metab 15:433-41. 2005
    ..51), MMA and holoTC (r = -0.36). In athletes, MMA did not correlate with vitamin B(12)and holoTC. Our data suggests an altered vitamin B(12)metabolism in recreational athletes that needs further investigation...
  22. ncbi request reprint Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians
    Wolfgang Herrmann
    Central Laboratory, Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
    Am J Clin Nutr 78:131-6. 2003
    ..Vegetarians have a lower intake of vitamin B-12 than do omnivores. Early and reliable diagnosis of vitamin B-12 deficiency is very important...
  23. doi request reprint Factors affecting the distribution of folate forms in the serum of elderly German adults
    Susanne H Kirsch
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg, Saarland, Germany
    Eur J Nutr 52:497-504. 2013
    ..We investigated the roles of age, vitamin B(12) markers, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism as determinants of folate forms in serum...
  24. ncbi request reprint The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings
    Wolfgang Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Curr Drug Metab 6:47-53. 2005
    ..Elevated MMA and normal holoTC in patients with renal insufficiency may not exclude vitamin B12 deficiency. HoloTC seems not to be a promising marker in predicting B12 status in renal patients...
  25. doi request reprint Enhanced bone metabolism in vegetarians--the role of vitamin B12 deficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 47:1381-7. 2009
    ..Vitamin B12 deficiency and bone fractures are common in vegetarians. However, a direct relationship between vitamin B12 status and bone metabolism in vegetarians has not been tested sufficiently...
  26. ncbi request reprint Vitamin B12 status in the elderly as judged by available biochemical markers
    Rima Obeid
    Department of Clinical Chemistry Central Laboratory, Saarland University Hospital, Homburg, Germany
    Clin Chem 50:238-41. 2004
  27. ncbi request reprint Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, Homburg, Germany
    Clin Chem Lab Med 42:1109-16. 2004
    ..Therefore, the demand for vitamin B6 is increased in these patients. Furthermore, renal dysfunction and low vitamin B6 levels contribute to the increase of cystathionine in pre-eclampsia and HELLP patients...
  28. doi request reprint One year B and D vitamins supplementation improves metabolic bone markers
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg Saar, Germany
    Clin Chem Lab Med 51:639-47. 2013
    ..Supplementation with these vitamins is a promising preventative strategy. The objective of this study was to evaluate the effects of vitamins D3 and B supplementation on bone turnover and metabolism in elderly people...
  29. doi request reprint Assay of whole blood (6S)-5-CH3-H4folate using ultra performance liquid chromatography tandem mass spectrometry
    Susanne H Kirsch
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg, Saarland, Germany
    Anal Bioanal Chem 404:895-902. 2012
    ..We observed a dose-dependent oxidation of (6S)-H(4)folate, which resulted in the formation of artificial folic acid in serum and WB. To minimize this effect, we recommend a fast sample preparation...
  30. ncbi request reprint Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplay
    Wolfgang Herrmann
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:547-53. 2003
    ..The influence of MTHFR 677 mutation on homocysteine (HCY) levels in relation to vitamin B12 and folate status was investigated in the current study...
  31. doi request reprint Quantification of acetylcholine, choline, betaine, and dimethylglycine in human plasma and urine using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry
    Susanne H Kirsch
    Saarland University Hospital, Department of Clinical Chemistry and Laboratory Medicine, Building 57, 66421 Homburg Saar, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 878:3338-44. 2010
    ..041) and females (r=0.621, p=0.003). The new method for the simultaneous determination of ACh, betaine, choline, and DMG is sensitive, precise, and fast enough to be used in clinical investigations related to the methylation pathway...
  32. doi request reprint Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation
    Thushari S Gomes
    Department of General Pediatrics and Neonatology, University Children s Hospital, Faculty of Medicine, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 48:1157-61. 2010
    ..We studied a total of 133 preterm neonates from normotensive mothers; SGA (n=96) and appropriate-for-gestational age (AGA, n=37)...
  33. ncbi request reprint The impact of vegetarianism on some haematological parameters
    Rima Obeid
    Department of Clinical Chemistry, University Hospital of Saarland, Homburg, Germany
    Eur J Haematol 69:275-9. 2002
    ..The current work was undertaken to investigate some haematological parameters in relation to vitamin B12 and iron status in vegetarians...
  34. doi request reprint Quantification of key folate forms in serum using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry
    Susanne H Kirsch
    Saarland University Hospital, Department of Clinical Chemistry and Laboratory Medicine, Building 57, 66421 Homburg Saar, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 878:68-75. 2010
    ..We also confirmed that MTHFR polymorphism has a significant effect on folate distribution in this small population of non-supplemented subjects...
  35. doi request reprint Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry
    Susanne H Kirsch
    Saarland University Hospital, Department of Clinical Chemistry and Laboratory Medicine, Building 57, 66421 Homburg Saar, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3865-70. 2009
    ..8). The new UPLC-MS/MS method showed very high sensitivity and selectivity for SAM and SAH, low CVs and fast sample preparation (40 samples in 60min) and analysis time (3min). This new assay can be used for large-scale clinical studies...
  36. ncbi request reprint Response of homocysteine, cystathionine, and methylmalonic acid to vitamin treatment in dialysis patients
    Rima Obeid
    Department of Clinical Chemistry, Central Laboratory, Saarland University Hospital, 66421 Homburg, Germany
    Clin Chem 51:196-201. 2005
    ..Vitamin treatment lowers total homocysteine (tHcy) concentrations in plasma and may therefore reduce the associated risk. Current treatment strategies have not achieved normalization of tHcy in the majority of dialysis patients...
  37. ncbi request reprint Priorities in the discovery of the implications of water channels in epilepsy and Duchenne muscular dystrophy
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Cell Mol Biol (Noisy-le-grand) 52:16-20. 2006
    ..This review discusses the relationship between brain and blood levels of key vitamins and metabolites related to one carbon metabolism...
  38. ncbi request reprint Biochemical indexes of the B vitamins in cord serum are predicted by maternal B vitamin status
    Rima Obeid
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Am J Clin Nutr 82:133-9. 2005
    ..Vitamin B-12 is the major determinant of tHcy in newborns. Maternal status of folate, vitamin B-12, and vitamin B-6 during pregnancy may affect the biochemical markers of these micronutrients in newborns...
  39. ncbi request reprint The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth
    Rima Obeid
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 52:263-9. 2006
    ..Transcobalamin (TC) carries approximately 25% of total plasma vitamin B12 and is 6% to 20% saturated with cobalamin. Haptocorrin (HC) binds approximately 80% of total cobalamin and is largely saturated with cobalamin...
  40. ncbi request reprint Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status
    Wolfgang Herrmann
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 43:1139-46. 2005
    ..Asymmetric dimethylarginine (ADMA) is an inhibitor of NO-synthase that may adversely affect the endothelium...
  41. ncbi request reprint Hyperhomocysteinaemia: a critical review of old and new aspects
    Wolfgang Herrmann
    Clinical Chemistry and Laboratory Medicine Central Laboratory, Saarland University Medical School, 66421 Homburg, Germany
    Curr Drug Metab 8:17-31. 2007
    ..HHCY and low folate are causal factors for pregnancy complications. In addition to the recommended folate supplementation, vitamin B12 supplementation may also decrease pregnancy complications...
  42. ncbi request reprint Cellular uptake of vitamin B12 in patients with chronic renal failure
    Rima Obeid
    Department of Clinical Chemistry, Central Laboratory, Saarland University Hospital, Homburg, Germany
    Nephron Clin Pract 99:c42-8. 2005
    ..Elevated concentration of plasma homocysteine (tHcy) is common in renal patients, however, the reason behind the resistance to vitamin B(12) and folate therapy are poorly understood...
  43. ncbi request reprint Hyperhomocysteinemia and response of methionine cycle intermediates to vitamin treatment in renal patients
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, School of Medicine, Saarland University, Germany
    Clin Chem Lab Med 43:1039-47. 2005
    ..Future studies may consider extending the duration of vitamin treatment, as well as agents that may enhance the hydrolysis of SAH and cystathionine...
  44. ncbi request reprint Homocysteine increases during endurance exercise
    Markus Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 41:1518-24. 2003
    ..Furthermore, about 25% of recreational endurance athletes exhibited hyperhomocysteinemia in association with low vitamin B12 and folate levels...
  45. doi request reprint Quantification of plasma phospholipids by ultra performance liquid chromatography tandem mass spectrometry
    Yannick Rabagny
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Building 57, 66421 Homburg Saar, Germany
    Anal Bioanal Chem 401:891-9. 2011
    ..Quantification was linear over the physiological ranges for PE, LPC, and SM and up to 500 μmol/L for PC. The concentrations of PLs in the plasma of healthy donors yielded results that were comparable with those of previous works...
  46. doi request reprint Utility and limitations of biochemical markers of vitamin B12 deficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg Saar, Germany
    Eur J Clin Invest 43:231-7. 2013
    ..We worked out a diagnostic algorithm that provides a two-step detection of vitamin B12 deficiency using holotranscobalamin as a first line marker and methylmalonic acid (MMA) as a second line marker...
  47. ncbi request reprint Hyperhomocysteinemia and vitamin B-12 deficiency are more striking in Syrians than in Germans--causes and implications
    Wolfgang Herrmann
    Department of Clinical Chemistry, Saarland Medical School, Building 40, Kirrberger Str, D 66421 Homburg, Germany
    Atherosclerosis 166:143-50. 2003
    ..Vitamin B-12 deficiency induces folate trapping. Besides lifestyle, other presently unknown factors may contribute to hyperhomocysteinemia and vitamin B-12 deficiency in Syrians...
  48. ncbi request reprint The measurement of complexed prostate-specific antigen has a better performance than total prostate-specific antigen
    Wolfgang Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 42:1051-7. 2004
    ..Thus, cPSA might be seen as the superior first-line parameter in screening for prostate cancer. Using lower cut-off values for tPSA or cPSA than the commonly accepted values seems reasonable for screening purposes...
  49. doi request reprint Homocysteine: a biomarker in neurodegenerative diseases
    Wolfgang Herrmann
    Department of Clinical Chemistry, Medical School, Saarland University, Homburg, Germany
    Clin Chem Lab Med 49:435-41. 2011
    ..Therefore, it seems prudent to identify B vitamin deficient subjects and to ensure sufficient vitamin intake. Therefore, recent evidence supports the role of Hcy as a potential biomarker in age-related neurodegenerative diseases...
  50. ncbi request reprint Biomarkers of folate and vitamin B(12) status in cerebrospinal fluid
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1614-20. 2007
    ..This review discusses the relationship between brain and blood levels of key vitamins and metabolites related to one carbon metabolism...
  51. ncbi request reprint Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acid
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1746-50. 2007
    ..Serum concentration of holoTC is a new marker in laboratory diagnosis of cobalamin deficiency. We tested the utility of holoTC in assessing vitamin B(12) status...
  52. doi request reprint Homocysteine and lipids: S-adenosyl methionine as a key intermediate
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Central Laboratory, University Hospital, Saarland University, D 66424 Homburg Saar, Germany
    FEBS Lett 583:1215-25. 2009
    ..The effect of Hcy on HDL-cholesterol is probably related to inhibiting enzymes or molecules participating in HDL-particle assembly...
  53. doi request reprint Genetic defects in folate and cobalamin pathways affecting the brain
    Susanne H Kirsch
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    Clin Chem Lab Med 51:139-55. 2013
    ....
  54. ncbi request reprint Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects
    Rima Obeid
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 43:1052-7. 2005
    ..Concentrations of tHcy and MMA are useful indicators of B-vitamin status in the pediatric laboratory. Using these functional markers may facilitate detecting sub-optimal B-vitamin status in children...
  55. ncbi request reprint [Hyperhomocysteinemia and B-vitamin deficiency. Current clinical aspects]
    Wolfgang Herrmann
    Klinische Chemie Zentrallabor, Universitatsklinikum des Saarlandes, Homburg
    Med Monatsschr Pharm 29:291-302. 2006
    ..Current recommendations stress the importance of measurement of plasma concentrations of homocysteine in patients with multiple risk factors. This allow early intervention with B-vitamins...
  56. doi request reprint Measurement of concentrations of whole blood levels of choline, betaine, and dimethylglycine and their relations to plasma levels
    Hussain Mohamad Awwad
    Saarland University Hospital, Department of Clinical Chemistry and Laboratory Medicine, Building 57, 66421 Homburg Saar, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 957:41-5. 2014
    ..In conclusion, we have established a reliable method for measuring choline metabolites in WB. The concentrations of WB choline, betaine, and DMG seem to reflect intracellular concentrations of these metabolites. ..
  57. doi request reprint The role of choline in prostate cancer
    Hussain Mohamad Awwad
    Saarland University Hospital, Department of Clinical Chemistry and Laboratory Medicine, Building 57, 66421 Homburg Saar, Germany
    Clin Biochem 45:1548-53. 2012
    ..This review summarizes the potential role of choline metabolism in cancer, especially in prostate cancer...
  58. ncbi request reprint Cobalamin status (holo-transcobalamin, methylmalonic acid) and folate as determinants of homocysteine concentration
    Rima Obeid
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Clin Chem 48:2064-5. 2002
  59. ncbi request reprint The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status
    Rima Obeid
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1357-62. 2003
    ..The increased risk of VTE, accompanied by factor V Leiden, may be related to confounding environmental factors...
  60. ncbi request reprint Stimulatory effect of homocysteine on interleukin-8 expression in human endothelial cells
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1045-8. 2003
    ..The formation of homocysteine-induced oxidation products might serve as one of the underlying mechanisms of this effect...
  61. ncbi request reprint Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Kirrberger Strasse, Gebaude 57, 66421 Homburg Saar, Germany
    FEBS Lett 580:2994-3005. 2006
    ..This review describes the most important mechanisms of Hcy neurotoxicity and pharmacological agents known to reverse Hcy effects...
  62. ncbi request reprint The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1590-606. 2007
    ..Treatment with folic acid, B(12) and B(6) lowers tHcy. For secondary and primary prevention from several neuropsychiatric disorders, it seems prudent to actively identify deficient subjects and ensure sufficient vitamin intake...
  63. ncbi request reprint Clinical validation of a new blood collection tube for the accuracy of total homocysteine measurement by different methods
    Emmanuel Bisse
    Department of Clinical Chemistry, University Medical Center Freiburg, Hugstetterstrasse 55, D 79106 Freiburg, Germany
    Clin Biochem 40:739-43. 2007
    ..To evaluate the clinical use of Homocysteine-Primavette, a new blood collection medium for total homocysteine (tHcy) assay...
  64. ncbi request reprint Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease
    Frank Gerald Pajonk
    Department for Psychiatry, Saarland University, Building 90, 66421 Homburg Saar, Germany
    J Alzheimers Dis 8:23-7. 2005
    ..5% of the patients revealed a significant negative correlation between plasma Cu and ADAS-cog. This finding supports the hypothesis of a mild Cu deficiency in most AD patients...
  65. doi request reprint Cobalamin deficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University of Saarland, 66421, Homburg, Germany
    Subcell Biochem 56:301-22. 2012
    ..Because Cbl deficiency is a risk factor for neurodegenerative diseases an early diagnosis of a low B12 status is required which should be followed by an effective treatment in order to prevent irreversible damages...