Georg Nickenig

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint Should angiotensin II receptor blockers and statins be combined?
    Georg Nickenig
    Department of Internal Medicine III, University Hospital of the Saarland, Homburg Saar, Germany
    Circulation 110:1013-20. 2004
  2. ncbi request reprint Mechanisms of increased vascular superoxide production in an experimental model of idiopathic dilated cardiomyopathy
    Hanke Mollnau
    Medizinische Klinik II, Johannes Gutenberg Universitat, Mainz, Germany
    Arterioscler Thromb Vasc Biol 25:2554-9. 2005
  3. ncbi request reprint Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    Ulrich Laufs
    Klinik fur Innere Medizin III, niversitätsklinikum des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 25:809-14. 2005
  4. ncbi request reprint Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circulation 105:2083-91. 2002
  5. ncbi request reprint AT1 receptor antagonism improves endothelial dysfunction in postmenopausal women
    Kerstin Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Maturitas 53:176-83. 2006
  6. ncbi request reprint Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Am J Cardiol 93:84-8. 2004
  7. ncbi request reprint Angiotensin II type 1 receptor antagonism improves hypercholesterolemia-associated endothelial dysfunction
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1208-12. 2002
  8. ncbi request reprint Paclitaxel balloon coating, a novel method for prevention and therapy of restenosis
    Bruno Scheller
    Department of Internal Medicine III Cardiology Angiology, University of Saarland, Homburg Saar, Germany
    Circulation 110:810-4. 2004
  9. ncbi request reprint Telmisartan inhibits beta2-integrin MAC-1 expression in human T-lymphocytes
    Andreas Link
    Klinik fur Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hypertens 24:1891-8. 2006
  10. ncbi request reprint CD34-/CD133+/VEGFR-2+ endothelial progenitor cell subpopulation with potent vasoregenerative capacities
    Erik B Friedrich
    Department for Internal Medicine III, University Hospital of the Saarland, Germany
    Circ Res 98:e20-5. 2006

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Should angiotensin II receptor blockers and statins be combined?
    Georg Nickenig
    Department of Internal Medicine III, University Hospital of the Saarland, Homburg Saar, Germany
    Circulation 110:1013-20. 2004
  2. ncbi request reprint Mechanisms of increased vascular superoxide production in an experimental model of idiopathic dilated cardiomyopathy
    Hanke Mollnau
    Medizinische Klinik II, Johannes Gutenberg Universitat, Mainz, Germany
    Arterioscler Thromb Vasc Biol 25:2554-9. 2005
    ..In the present study, we sought to identify mechanisms underlying increased oxidative stress in vascular tissue in an experimental animal model of chronic congestive heart failure (CHF)...
  3. ncbi request reprint Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    Ulrich Laufs
    Klinik fur Innere Medizin III, niversitätsklinikum des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 25:809-14. 2005
    ..The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase...
  4. ncbi request reprint Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circulation 105:2083-91. 2002
    ..It has not been completely clarified whether selective estrogen receptor modulators (SERMs) such as raloxifene exert vasoprotective effects similar to those of estrogens...
  5. ncbi request reprint AT1 receptor antagonism improves endothelial dysfunction in postmenopausal women
    Kerstin Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Maturitas 53:176-83. 2006
    ..AT1 receptor antagonism improves vascular function in postmenopausal women without HRT. Thus, AT1 receptor blockade may resemble an efficient approach for the prevention of vascular dysfunction in estrogen-deficient women...
  6. ncbi request reprint Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Am J Cardiol 93:84-8. 2004
    ..Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation...
  7. ncbi request reprint Angiotensin II type 1 receptor antagonism improves hypercholesterolemia-associated endothelial dysfunction
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1208-12. 2002
    ..Hypercholesterolemia-induced angiotensin II type 1 (AT1) receptor overexpression is thought to be a key event in the development of endothelial dysfunction...
  8. ncbi request reprint Paclitaxel balloon coating, a novel method for prevention and therapy of restenosis
    Bruno Scheller
    Department of Internal Medicine III Cardiology Angiology, University of Saarland, Homburg Saar, Germany
    Circulation 110:810-4. 2004
    ..The aim of the present study was to evaluate a novel method of local drug delivery based on angioplasty balloons...
  9. ncbi request reprint Telmisartan inhibits beta2-integrin MAC-1 expression in human T-lymphocytes
    Andreas Link
    Klinik fur Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hypertens 24:1891-8. 2006
    ..Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are well known, the underlying mechanisms are poorly understood...
  10. ncbi request reprint CD34-/CD133+/VEGFR-2+ endothelial progenitor cell subpopulation with potent vasoregenerative capacities
    Erik B Friedrich
    Department for Internal Medicine III, University Hospital of the Saarland, Germany
    Circ Res 98:e20-5. 2006
    ..We identified a new CD34-/133+ EPC subpopulation, which is apparently a precursor of "classical" CD34+/133+ EPC, and functionally more potent than these with respect to homing and vascular repair...
  11. ncbi request reprint Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment
    Christoph Maack
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 108:1567-74. 2003
    ..Isoprenylation of rac1 can be inhibited by statin therapy. Thus, we examined ROS and rac1 in human failing myocardium and tested their regulation by statins in vivo...
  12. ncbi request reprint Modulation of antioxidant enzyme expression and function by estrogen
    Kerstin Strehlow
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circ Res 93:170-7. 2003
    ..Estrogen acts antioxidative at least to some extent via stimulation of MnSOD and ecSOD expression and activity, which may contribute to its vasoprotective effects...
  13. ncbi request reprint Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice
    Sven Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 110:3062-7. 2004
    ..Angiotensin II type 1 (AT1) receptor activation is potentially involved in the multifactorial pathogenesis of atherosclerosis...
  14. ncbi request reprint 17Beta-estradiol inhibits monocyte adhesion via down-regulation of Rac1 GTPase
    Erik B Friedrich
    Department for Internal Medicine III, University Hospital of the Saarland, 66421 Homburg Saar, Germany
    J Mol Cell Cardiol 40:87-95. 2006
    ..These studies extend current knowledge about the mechanisms responsible for the vascular recruitment of pro-inflammatory cells, and potentially open up new avenues for the therapy of atherosclerosis...
  15. ncbi request reprint Interrelationship of free oxygen radicals and endothelial dysfunction--modulation by statins
    Sven Wassmann
    Medizinische Klinik und Poliklinik Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Endothelium 10:23-33. 2003
    ....
  16. ncbi request reprint Modulation of oxidant and antioxidant enzyme expression and function in vascular cells
    Sven Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Hypertension 44:381-6. 2004
    ..This review focuses on the modulation of expression and activity of major antioxidant and oxidant enzymes expressed in vascular cells...
  17. ncbi request reprint Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1567-72. 2002
    ..Despite the anticipated stem cell plasticity, the role of bone marrow-derived endothelial progenitor cells has not been clarified in vascular lesion development...
  18. ncbi request reprint The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: Part II: AT(1) receptor regulation
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 105:530-6. 2002
  19. ncbi request reprint Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  20. ncbi request reprint Pleiotropic effects of HMG-CoA reductase inhibitors
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Basic Res Cardiol 97:105-16. 2002
    ..These pleiotropic properties of statins may have important clinical implications in addition to lowering serum cholesterol...
  21. ncbi request reprint Cellular antioxidant effects of atorvastatin in vitro and in vivo
    Sven Wassmann
    Medizinische Klinik und Poliklinik Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:300-5. 2002
    ..These effects of atorvastatin may contribute to the vasoprotective effects of statins...
  22. ncbi request reprint Addition of paclitaxel to contrast media prevents restenosis after coronary stent implantation
    Bruno Scheller
    Internal Medicine III Cardiology Angiology, University of Saarland, Homburg Saar, Germany
    J Am Coll Cardiol 42:1415-20. 2003
    ..The present study was designed to test the efficacy of paclitaxel added to the contrast agent iopromide in the prevention of restenosis...
  23. ncbi request reprint The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 105:393-6. 2002
  24. ncbi request reprint Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction
    Bruno Scheller
    Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 42:634-41. 2003
    ..The Southwest German Interventional Study in Acute Myocardial Infarction (SIAM III) investigated potentially beneficial effects of immediate stenting after thrombolysis as opposed to a more conservative treatment regimen...
  25. ncbi request reprint Effect of intensive versus moderate lipid lowering on endothelial function and vascular responsiveness to angiotensin II in stable coronary artery disease
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 96:1361-4. 2005
    ..05). Endothelium improvement was accompanied by decreased vascular response to angiotensin II (p = 0.039). These findings suggest a mechanism for the clinical benefit of intensive lipid-lowering treatment in coronary heart disease...
  26. ncbi request reprint Clinical evidence for the cardiovascular benefits of angiotensin receptor blockers
    Georg Nickenig
    University of Saarland, Homburg, Germany
    J Renin Angiotensin Aldosterone Syst 7:S1-7. 2006
    ..Ongoing trials are aiming to define the place of such agents in lessening morbidity and mortality from CVD...
  27. ncbi request reprint Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, Homburg, Germany
    Circulation 109:220-6. 2004
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to exert beneficial effects on atherosclerosis, angiogenesis, and vascular repair...
  28. ncbi request reprint Progesterone antagonizes the vasoprotective effect of estrogen on antioxidant enzyme expression and function
    Kerstin Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 97:1046-54. 2005
    ..These findings may in part explain why hormone replacement therapy with estrogen plus progesterone displayed no beneficial effect on cardiovascular event rates in the prospective clinical trials...
  29. ncbi request reprint [Acute coronary syndrome--better risk stratification by determination of inflammatory parameters?]
    Andreas Link
    Innere Medizin III Kardiologie Angiologie, Universitatskliniken des Saarlandes, Homburg Saar
    Med Klin (Munich) 97:63-9. 2002
    ..In the past years coronary atherosclerosis and plaque rupture have been characterized not only as a problem of growth of smooth vascular cells, of activated thrombocytes and coagulation but also of inflammation...
  30. ncbi request reprint Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg, Germany
    Brain Res 942:23-30. 2002
    ..The effects are independent of changes in cholesterol levels and are equivalent or even superior to the protective effects by simvastatin and atorvastatin in this animal model...
  31. ncbi request reprint Impact of HMG CoA reductase inhibition on small GTPases in the heart
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg Saar, Germany
    Cardiovasc Res 53:911-20. 2002
    ..Therefore, it was tested if these drugs inhibit Rac1 and RhoA activity in cardiomyocytes and, thereby, prevent angiotensin II-mediated expression of atrial natriuretic factor (ANF) and myosin light chain (MLC)-2 in the heart...
  32. ncbi request reprint Differential antiplatelet effects of angiotensin converting enzyme inhibitors: comparison of ex vivo platelet aggregation in cardiovascular patients with ramipril, captopril and enalapril
    Dirk Skowasch
    Department of Internal Medicine II, Cardiology, Heart Center University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Clin Res Cardiol 95:212-6. 2006
    ....
  33. ncbi request reprint Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo
    Georg Nickenig
    Universitatskliniken des Saarlandes, Medizinische Klinik und Poliklinik, Innere Medizin III, 66424 Homburg Saar, Germany
    FASEB J 16:1077-86. 2002
    ..These findings reveal novel mechanisms of redox-controlled cellular proliferation involving GKLF and Id3 that may have general implications for our understanding of vascular and nonvascular growth control...
  34. ncbi request reprint Improvement of endothelial function by systemic transfusion of vascular progenitor cells
    Sven Wassmann
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Circ Res 99:e74-83. 2006
    ..More than 1 subpopulation of the MNC fraction seems to be involved in this effect...
  35. ncbi request reprint Rapid immunomodulation by rosuvastatin in patients with acute coronary syndrome
    Andreas Link
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421Homburg Saar, Germany
    Eur Heart J 27:2945-55. 2006
    ..It is unclear how rapidly the beneficial effects of statins occur in patients with ACS and whether these drug properties are related to lipid lowering...
  36. ncbi request reprint Rapid effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition on coronary endothelial function
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 93:e98-103. 2003
    ..Statin treatment improves endothelium-dependent coronary vasomotion within 24 hours in the absence of significant cholesterol reduction. The full text of this article is available online at http://www.circresaha.org...
  37. ncbi request reprint Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 94:534-41. 2004
    ..This interaction of the proinflammatory cytokine IL-6 with the renin-angiotensin system may represent an important pathogenetic mechanism in the atherosclerotic process...
  38. ncbi request reprint From fat fighter to risk factor: the zigzag trek of leptin
    Nikos Werner
    Arterioscler Thromb Vasc Biol 24:7-9. 2004
  39. ncbi request reprint Pathophysiological regulation of the AT1-receptor and implications for vascular disease
    Sven Wassmann
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    J Hypertens Suppl 24:S15-21. 2006
    ..Numerous studies have demonstrated that activation of the angiotensin II type 1 (AT1) receptor plays an important role in the pathogenesis of cardiovascular diseases...
  40. ncbi request reprint Withdrawal of statin treatment abrogates stroke protection in mice
    Karen Gertz
    Klinik und Poliklinik fur Neurologie, Charite, Humboldt Universitat Berlin, Berlin, Germany
    Stroke 34:551-7. 2003
    ..Acute withdrawal of statin treatment may suppress endothelial NO production and impair vascular function...
  41. ncbi request reprint One-year results of the SCORPIUS study: a German multicenter investigation on the effectiveness of sirolimus-eluting stents in diabetic patients
    Dietrich Baumgart
    Department of Cardiology, West German Heart Center, University Clinic Essen, University Duisburg Essen, Essen, Germany
    J Am Coll Cardiol 50:1627-34. 2007
    ..Previously, this had been analyzed only in substudies of larger trials or in clinical investigations enrolling a small number of patients...
  42. ncbi request reprint Endothelial progenitor cells in health and atherosclerotic disease
    Nikos Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    Ann Med 39:82-90. 2007
    ..We discuss new insights into vascular stem cell biology derived from experimental and clinical studies...
  43. ncbi request reprint Angiotensin II: one driving force behind atherogenesis
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Hypertension 51:175-6. 2008
  44. ncbi request reprint Is the degeneration of aortic valve bioprostheses similar to that of native aortic valves? Insights into valvular pathology
    Dirk Skowasch
    University of Bonn, Department of Internal Medicine II Cardiology, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Expert Rev Med Devices 3:453-62. 2006
    ..Recent studies suggest a similar valvular pathology, that underlies both types of valvular degeneration, but also an even more important role of inflammatory and repair processes in the case of BP degeneration...
  45. pmc Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization
    Vincent Fontaine
    INSERM U589, Institut L Bugnard, Centre Hospitalier Universitaire Rangueil, Toulouse Cedex, France
    Am J Pathol 169:1855-62. 2006
    ..In conclusion, FGF2, specifically medullary FGF2, is necessary and sufficient to mediate the accelerative effect of E2 on both reendothelialization and EPC mobilization...
  46. ncbi request reprint Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging
    Albrecht Stroh
    Department of Radiology, Charite Universitaetsmedizin Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Neuroimage 33:886-97. 2006
    ..Taken together, our results demonstrate that brain engraftment of systemically administered mononuclear cells can be visualized non-invasively over time and space using high-resolution MRI...
  47. ncbi request reprint Circulating endothelial progenitor cells correlate with erectile function in patients with coronary heart disease
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Eur Heart J 27:2184-8. 2006
    ..The aim of the study was to determine the influence of endothelial progenitor cells (EPC) on erectile dysfunction (ED). EPC play a major role in repair mechanisms of the endothelial monolayer, but the role of EPC in ED is unclear...
  48. ncbi request reprint Regulation of antioxidant and oxidant enzymes in vascular cells and implications for vascular disease
    Sven Wassmann
    Medizinische Klinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Curr Hypertens Rep 8:69-78. 2006
    ..Identification of key enzymes and mechanisms of vascular oxidative stress is important for the development of novel, specific pharmacologic interventions...
  49. ncbi request reprint Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury
    Nikos Werner
    Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, 66421 Homburg Saar, Germany
    Circ Res 93:e17-24. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  50. ncbi request reprint Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation
    Kerstin Strehlow
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, 66421 Homburg Saar, Germany
    Circulation 107:3059-65. 2003
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to positively influence endothelialization, vascular repair, and angiogenesis...
  51. ncbi request reprint Identification of a novel redox-sensitive gene, Id3, which mediates angiotensin II-induced cell growth
    Cornelius Mueller
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg, Germany
    Circulation 105:2423-8. 2002
    ..Angiotensin II (Ang II) is one of the most potent inducers of oxidative stress in the vasculature. The molecular events involved in Ang II-induced proliferation of vascular smooth muscle cells (VSMCs) are only partially understood...
  52. ncbi request reprint Vascular response to angiotensin II predicts long-term prognosis in patients undergoing coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, University Hospital Groningen, The Netherlands
    Hypertension 44:930-4. 2004
    ..In conclusion, these results suggest that in patients undergoing CABG, a diminished vascular responsiveness of the thoracic artery to exogenous angiotensin II is related to an increased risk of future cardiovascular events...
  53. ncbi request reprint Down-regulation of Rac-1 GTPase by Estrogen
    Ulrich Laufs
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, 66421 Homburg Saar, Germany
    J Biol Chem 278:5956-62. 2003
    ..Rac1 GTPase gene-transcription and activity is regulated by 17 beta-estradiol, which may be an important molecular mechanism contributing to the cardiovascular effects of estrogens...
  54. ncbi request reprint The role of the AUUUUA hexamer for the posttranscriptional regulation of the AT1 receptor mRNA stability
    Anja Berger
    Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, 66421 Homburg, Saarland, Germany
    Biochem Biophys Res Commun 330:805-12. 2005
    ..These findings indicate that the AUUUUA hexamer is essential for the posttranscriptional modulation of the AT1 receptor mRNA expression...
  55. ncbi request reprint In vitro differentiation characteristics of cultured human mononuclear cells-implications for endothelial progenitor cell biology
    Katrin Walenta
    Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 333:476-82. 2005
    ..Careful surface marker analysis might be necessary when using in vitro EPC differentiation systems...
  56. ncbi request reprint Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg, Germany
    Eur J Cardiovasc Prev Rehabil 12:407-14. 2005
    ..Exercise is a central component of the primary prevention of vascular diseases. The effect of physical activity on circulating EPC in healthy individuals is not known...
  57. ncbi request reprint Circulating CD31+/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease
    Nikos Werner
    Klinik fur Innere Medizin II, Universitatsklinikum Bonn, Bonn, Germany
    Arterioscler Thromb Vasc Biol 26:112-6. 2006
    ..Endothelial dysfunction predicts morbidity and mortality in patients at cardiovascular risk. Endothelial function may be decisively influenced by the degree of endothelial cell apoptosis...
  58. ncbi request reprint Mechanisms of stroke protection by physical activity
    Matthias Endres
    Klinik und Poliklinik fur Neurologie, Charite, Humboldt Universitat zu Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Ann Neurol 54:582-90. 2003
    ..Our results suggest that physical activity not only decreases stroke risk, but also provides a prophylactic treatment strategy for increasing blood flow and reducing brain injury during cerebral ischemia...
  59. ncbi request reprint Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy?
    Nikos Werner
    Medizinischen Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    Arterioscler Thromb Vasc Biol 26:257-66. 2006
    ....
  60. doi request reprint Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Circulation 117:2912-8. 2008
    ..To test this hypothesis, we investigated the effects of MRP1 inhibition and LTC(4) receptor blockade (Cys-LT1 receptor) in vitro and in vivo...