Michael D Menger

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint Surgical trauma: hyperinflammation versus immunosuppression?
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Langenbecks Arch Surg 389:475-84. 2004
  2. ncbi request reprint Beyond the epithelial mucosa barrier: monitoring of microvascular perfusion dysfunction in critically endangered intestinal transplants(1,2)
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 130:20-3. 2006
  3. ncbi request reprint Experimental models to study microcirculatory dysfunction in muscle ischemia-reperfusion and osteomyocutaneous flap transfer
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Langenbecks Arch Surg 388:281-90. 2003
  4. pmc Hepatic arterial infusion but not systemic application of cetuximab in combination with oxaliplatin significantly reduces growth of CC531 colorectal rat liver metastases
    Jens Sperling
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Int J Colorectal Dis 28:555-62. 2013
  5. doi request reprint Delayed fracture healing in aged senescence-accelerated P6 mice
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Invest Surg 26:30-5. 2013
  6. ncbi request reprint Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Clin Sci (Lond) 112:429-40. 2007
  7. doi request reprint Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, Germany
    Surgery 145:372-83. 2009
  8. doi request reprint CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1
    Otto Kollmar
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Int J Cancer 126:1302-15. 2010
  9. pmc Heat shock preconditioning reduces ischemic tissue necrosis by heat shock protein (HSP)-32-mediated improvement of the microcirculation rather than induction of ischemic tolerance
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Ann Surg 242:869-78, discussion 878-9. 2005
  10. doi request reprint Gender-specific ischemic tissue tolerance in critically perfused skin
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Saarland, Germany
    Langenbecks Arch Surg 395:33-40. 2010

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Surgical trauma: hyperinflammation versus immunosuppression?
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Langenbecks Arch Surg 389:475-84. 2004
    ..Experimental and clinical studies have brought evidence that surgical trauma markedly affects the immune system, including both the specific and the non-specific immune response...
  2. ncbi request reprint Beyond the epithelial mucosa barrier: monitoring of microvascular perfusion dysfunction in critically endangered intestinal transplants(1,2)
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 130:20-3. 2006
  3. ncbi request reprint Experimental models to study microcirculatory dysfunction in muscle ischemia-reperfusion and osteomyocutaneous flap transfer
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Langenbecks Arch Surg 388:281-90. 2003
    ..The drawback of this "acute" model is that the period of analysis is restricted to a few hours only...
  4. pmc Hepatic arterial infusion but not systemic application of cetuximab in combination with oxaliplatin significantly reduces growth of CC531 colorectal rat liver metastases
    Jens Sperling
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Int J Colorectal Dis 28:555-62. 2013
    ....
  5. doi request reprint Delayed fracture healing in aged senescence-accelerated P6 mice
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Invest Surg 26:30-5. 2013
    ..However, it is still controversially discussed whether osteoporosis compromises fracture healing. Herein, we studied whether the course of healing of a femur fracture is affected by osteoporosis or age...
  6. ncbi request reprint Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Clin Sci (Lond) 112:429-40. 2007
    ..Thus aging is associated with an increased susceptibility to tissue necrosis, which is due to a loss of vascular reactivity to endogenous HO-1 expression, rather than a reduction in ischaemic tolerance...
  7. doi request reprint Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, Germany
    Surgery 145:372-83. 2009
    ..We herein studied whether Epo pretreatment can reduce cell death and ischemic necrosis in a chronic in vivo model...
  8. doi request reprint CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1
    Otto Kollmar
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Int J Cancer 126:1302-15. 2010
    ....
  9. pmc Heat shock preconditioning reduces ischemic tissue necrosis by heat shock protein (HSP)-32-mediated improvement of the microcirculation rather than induction of ischemic tolerance
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Ann Surg 242:869-78, discussion 878-9. 2005
    ....
  10. doi request reprint Gender-specific ischemic tissue tolerance in critically perfused skin
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Saarland, Germany
    Langenbecks Arch Surg 395:33-40. 2010
    ....
  11. pmc Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis
    Otto Kollmar
    Department of General, Visceral, Vascular, and Pediatric Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Neoplasia 9:862-70. 2007
    ..In a mouse model of established extrahepatic colorectal metastasis, we analyzed whether stromal cell-derived factor (SDF) 1 stimulates tumor cell migration in vitro and angiogenesis and tumor growth in vivo...
  12. pmc Excess dietary methionine does not affect fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Med Sci Monit 18:BR469-74. 2012
    ..As the essential amino acid, methionine, is a precursor of homocysteine, we aimed to investigate whether excess methionine intake affects bone repair...
  13. ncbi request reprint Microdialysis of the rectus abdominis muscle for early detection of impending abdominal compartment syndrome
    Christoph Meier
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Intensive Care Med 33:1434-43. 2007
    ....
  14. doi request reprint Ischemia-induced up-regulation of heme oxygenase-1 protects from apoptotic cell death and tissue necrosis
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 150:293-303. 2008
    ....
  15. ncbi request reprint Liver resection-associated macrophage inflammatory protein-2 stimulates engraftment but not growth of colorectal metastasis at extrahepatic sites
    Otto Kollmar
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 145:295-302. 2008
    ..Herein we studied how liver resection-associated MIP-2 affects extrahepatic tumor cell engraftment and whether MIP-2 also stimulates the growth of already established metastases...
  16. doi request reprint Endostatin inhibits Callus remodeling during fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse, 66421, Homburg Saar, Germany
    J Orthop Res 31:1579-84. 2013
    ..The results of the present study indicate endostatin promotes soft callus formation but inhibits callus remodeling during fracture healing most probably by an inhibition of angiogenesis...
  17. pmc Liver-directed chemotherapy of cetuximab and bevacizumab in combination with oxaliplatin is more effective to inhibit tumor growth of CC531 colorectal rat liver metastases than systemic chemotherapy
    Jens Sperling
    Department of General, Visceral, Vascular and Pediatric Surgery, Saarland University Hospital, Homburg Saar, Germany
    Clin Exp Metastasis 30:447-55. 2013
    ..The present study demonstrates that HAI of CE plus BE is effective to inhibit tumor growth. This effect is even more pronounced in combination with OX. Systemic application of these agents cannot achieve comparable effects...
  18. doi request reprint Darbepoetin-alpha enhances hepatectomy-associated stimulation of colorectal liver metastatic growth
    Kathrin Rupertus
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    Ann Surg 252:131-41. 2010
    ..Because EPO may promote tumor progression, we herein studied the effect of DPO on tumor growth after major hepatectomy...
  19. doi request reprint Increased osteoblast and osteoclast activity in female senescence-accelerated, osteoporotic SAMP6 mice during fracture healing
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 175:271-7. 2012
    ..There is no information, however, whether the alteration of fracture healing in osteoporosis also depends on gender...
  20. doi request reprint Sildenafil accelerates fracture healing in mice
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 29:867-73. 2011
    ..We show for the first time that sildenafil treatment accelerates fracture healing by enhancing bone formation, most probably by a CYR61-associated pathway...
  21. pmc Blockade of gC1qR/p33, a receptor for C1q, inhibits adherence of Staphylococcus aureus to the microvascular endothelium
    Shneh Sethi
    Institute for Medical Microbiology and Hygiene, University of Saarland, Homburg Saar, Germany
    Microvasc Res 82:66-72. 2011
    ..In conclusion, our findings indicate that immunological inhibition of gC1qR may be therapeutically used to decrease the interaction of S. aureus with the microvascular endothelium...
  22. doi request reprint High bone concentrations of homocysteine are associated with altered bone morphology in humans
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Br J Nutr 106:378-82. 2011
    ..The results of the present study indicate an association between altered bone morphology and elevated bone concentrations of homocysteine and S-adenosylhomocysteine, but not between altered bone morphology and methylation capacity...
  23. doi request reprint Vitalization of porous polyethylene (Medpor®) with chondrocytes promotes early implant vascularization and incorporation into the host tissue
    Susanne Ehrmantraut
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Tissue Eng Part A 18:1562-72. 2012
    ....
  24. doi request reprint Darbepoetin-α promotes neovascularization and cell proliferation in established colorectal liver metastases
    Kathrin Rupertus
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 176:517-23. 2012
    ..Because it is unknown whether DPO also enhances the growth of established tumors, we herein studied the effect of DPO on established colorectal liver metastases after Phx...
  25. ncbi request reprint Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 48:821-7. 2010
    ..This study investigated the relationship between morphological as well as biomechanical bone properties and HCY serum concentrations in humans suffering from hip osteoarthritis (OA)...
  26. ncbi request reprint Angiogenic and inflammatory host response to surgical meshes of different mesh architecture and polymer composition
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    J Biomed Mater Res B Appl Biomater 91:497-507. 2009
    ..Thus, our data demonstrate that a stronger angiogenic and inflammatory response to an implanted mesh does not necessarily result in a better incorporation into the host tissue...
  27. doi request reprint Split-liver procedure and inflammatory response: improvement by pharmacological preconditioning
    Maximilian von Heesen
    Department of General, Vascular and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 168:e125-35. 2011
    ..Herein, we hypothesized that an in situ split-liver procedure induces an inflammatory response and a deterioration of graft quality. We further studied whether graft quality can be improved by pharmacologic preconditioning...
  28. doi request reprint An internal locking plate to study intramembranous bone healing in a mouse femur fracture model
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 28:397-402. 2010
    ..The fractures that healed by intramembranous ossification showed an increased stiffness compared to fractures that healed by endochondral ossification. This model may be used to study molecular mechanisms of intramembranous bone healing...
  29. doi request reprint Heme oxygenase (HO)-1 protects from lipopolysaccharide (LPS)-mediated liver injury by inhibition of hepatic leukocyte accumulation and improvement of microvascular perfusion
    Jonas Roller
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421, Homburg Saar, Germany
    Langenbecks Arch Surg 395:387-94. 2010
    ..The mechanisms of action however, have not been clarified yet. Therefore, we analyzed in vivo the effects of HO-1 on the liver microcirculation under conditions of LPS exposure...
  30. doi request reprint Rapamycin inhibits hepatectomy-induced stimulation of metastatic tumor growth by reduction of angiogenesis, microvascular blood perfusion, and tumor cell proliferation
    Kathrin Rupertus
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg, Saarland, Germany
    Ann Surg Oncol 16:2629-37. 2009
    ..We therefore analyzed the effect of RAPA and cyclosporine A (CyA) on tumor growth characteristics after major hepatectomy using a mouse model of colorectal metastasis...
  31. doi request reprint Hepatic arterial infusion of temsirolimus inhibits tumor growth of colorectal rat liver metastases even after a growth stimulating procedure like liver resection
    Jens Sperling
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany Department of General, Visceral and Pediatric Surgery, University Medical Center, Georg August University, Gottingen, Germany Electronic address
    J Surg Res 185:587-94. 2013
    ..Herein, we studied whether HAI of temsirolimus is effective to inhibit tumor growth of colorectal liver metastases after liver resection...
  32. ncbi request reprint Role of PECAM-1 in acute rejection of fully major histocompatibility complex class II-mismatched cardiac allografts in mice
    Rene Schramm
    Department for Thoracic and Cardiovascular Surgery, University of Saarland, University Hospitals Homburg Saar, Kirrbergerstrasse, D 66421 Homburg Saar, Germany
    Transplantation 84:555-8. 2007
    ..Although deletion of PECAM-1 could not prevent rejection, it should be further evaluated as a therapeutic target in more complex settings with concomitant immunosuppression or during chronic rejection...
  33. doi request reprint Evidence for tumor cell spread during local hepatic ablation of colorectal liver metastases
    Jochen Schuld
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 178:268-79. 2012
    ..In a rat liver metastases model, evidence for tumor cell spread was analyzed comparing CRYO, radiofrequency ablation (RFA), and laser-induced thermotherapy (LITT)...
  34. doi request reprint The LockingMouseNail--a new implant for standardized stable osteosynthesis in mice
    Patric Garcia
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 169:220-6. 2011
    ..Mouse models are of increasing interest to study cellular and molecular mechanisms during fracture healing. However, unlike in large animals and in humans, stable fixation of fractures has been difficult due to the small size of the mouse...
  35. ncbi request reprint Macrophage inflammatory protein-2 promotes angiogenesis, cell migration, and tumor growth in hepatic metastasis
    Otto Kollmar
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Ann Surg Oncol 13:263-75. 2006
    ....
  36. ncbi request reprint A new model for the study of the abdominal compartment syndrome in rats
    Christoph Meier
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 139:209-16. 2007
    ..The purpose of the present study was to develop of a rodent model of abdominal compartment syndrome (ACS), which allows detailed analysis of intra-abdominal hypertension (IAH)- and decompression-associated reperfusion injury...
  37. ncbi request reprint Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung
    Takayuki Nakamura
    Department of Thoracic and Cardiovascular Surgery, University of Saarland, 66421 Homburg and Saarbrücken, Germany
    J Heart Lung Transplant 24:38-45. 2005
    ..However, the effect of this approach on alveolar macrophages in pulmonary ischemia-reperfusion injury has not yet been evaluated...
  38. ncbi request reprint Human recombinant erythropoietin protects the striated muscle microcirculation of the dorsal skinfold from postischemic injury in mice
    Claudio Contaldo
    Institute for Clinical and Experimental Surgery, University of Saarland, Hamburg Saar, Germany
    Am J Physiol Heart Circ Physiol 293:H274-83. 2007
    ..Thus our study demonstrates for the first time that EPO effectively attenuates I/R injury by preserving nutritive perfusion, reducing leukocytic inflammation, and inducing new vessel formation...
  39. doi request reprint Epigallocatechin-3-gallate inhibits estrogen-induced activation of endometrial cells in vitro and causes regression of endometriotic lesions in vivo
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Saar, Germany
    Hum Reprod 23:2308-18. 2008
    ..Herein, we studied whether EGCG may also be effective in the treatment of endometriosis...
  40. ncbi request reprint Dietary glycine does not affect physiological angiogenesis and reproductive function, but inhibits apoptosis in endometrial and ovarian tissue by down-regulation of nuclear factor-kappaB
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Fertil Steril 90:1460-9. 2008
    ..To study the effect of dietary glycine on female reproductive organs...
  41. doi request reprint Prolene-Monocryl-composite meshes do not increase microvascular Staphylococcus aureus adherence and do not sensitize for leukocytic inflammation
    Jonas Roller
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Langenbecks Arch Surg 393:349-57. 2008
    ..In this study, we analyzed whether this complication is supported by an increased interaction of bacteria and leukocytes with the microvascular endothelium at the implantation site...
  42. ncbi request reprint Simvastatin does not prevent acute cardiac allograft rejection in CD28-deficient mice
    Rene Schramm
    Department of Thoracic and Cardiovascular Surgery, University of Saarland, Saarland, Germany
    Inflamm Res 58:765-71. 2009
    ..Heterotopic cardiac transplantation in mice was used to determine whether complementary immunomodulation by statins prevents lymphocyte function-associated antigen (LFA)-1-dependent acute allograft rejection in vivo...
  43. doi request reprint Inhibition of angiogenesis: a novel antitumor mechanism of the herbal compound arctigenin
    Yuan Gu
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Anticancer Drugs 24:781-91. 2013
    ..WT tumors in the dorsal skinfold chamber model. Taken together, these results show for the first time an antiangiogenic action of arctigenin, which may contribute considerably toward its antitumor activity. ..
  44. ncbi request reprint The subepicardial microcirculation in heterotopically transplanted mouse hearts: an intravital multifluorescence microscopy study
    Rene Schramm
    Department of Thoracic and Cardiovascular Surgery, University of Saarland, Homburg Saar, Germany
    J Thorac Cardiovasc Surg 134:210-7, 217.e1. 2007
    ..We developed a model for intravital microscopic analysis of the coronary microcirculation in transplanted murine hearts and assessed the influence of cold ischemia on postischemic microcirculatory dysfunctions...
  45. doi request reprint Progenitor cell homing in the postischemic myocardium: just an unmotivated pitstop in the microcirculation?
    Fabio Tuche
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Microcirculation 19:739-48. 2012
    ..We developed a model for direct assessment of BMC sequestration in the postischemic murine myocardium after direct antegrade intracoronary injection...
  46. doi request reprint A new model to analyze metaphyseal bone healing in mice
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 178:715-21. 2012
    ..Using a special locking plate system, we herein introduce a new model, which allows the analysis of metaphyseal bone healing in mice...
  47. ncbi request reprint In vivo fluorescence microscopic imaging for dynamic quantitative assessment of intestinal mucosa permeability in mice
    Andrea Szabo
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 145:179-85. 2008
    ....
  48. doi request reprint Melatonin impairs fracture healing by suppressing RANKL-mediated bone remodeling
    Tina Histing
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 173:83-90. 2012
    ..There is no information, however, whether melatonin affects fracture healing. We therefore studied in a mouse femur fracture model the influence of melatonin on callus formation and biomechanics during fracture healing...
  49. doi request reprint Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators
    Mohammed R Moussavian
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg, Saarland, Germany
    Langenbecks Arch Surg 393:303-10. 2008
    ..Herein, we studied in isolated tubular segments of rat kidney cortex the impact of oxygen radical scavengers and an iron chelator on post-hypoxic recovery...
  50. doi request reprint Genistein does not affect vascularization and blood perfusion of endometriotic lesions and ovarian follicles in dorsal skinfold chambers of Syrian golden hamsters
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Reprod Sci 17:568-77. 2010
    ..Thus, genistein may not be considered for the development of antiangiogenic treatment strategies in the therapy of endometriosis...
  51. doi request reprint Development of a stable closed femoral fracture model in mice
    Joerg H Holstein
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 153:71-5. 2009
    ..Herein, we studied whether longitudinal fracture compression by an intramedullary screw represents a standardized, stable osteosynthesis technique in mice, and whether it may accelerate fracture healing...
  52. doi request reprint Exercise enhances angiogenesis during bone defect healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Orthop Res 29:1086-92. 2011
    ..The newly woven bone was covered by a neo-periosteum containing those blood vessels, which were visible by IVM. We conclude that exercise accelerates bone defect healing and stimulates angiogenesis during bore repair...
  53. doi request reprint IL-17C is a mediator of respiratory epithelial innate immune response
    Philipp Pfeifer
    Department of Internal Medicine V Pneumology, Allergology and Respiratory Critical Care Medicine, Saarland University Medical Center, Homburg Saar, Germany
    Am J Respir Cell Mol Biol 48:415-21. 2013
    ..These data show that IL-17C is involved in the innate immune response of respiratory epithelial cells and is suppressed by cigarette smoke...
  54. ncbi request reprint Gender differences in ischemia-reperfusion-induced microcirculatory and epithelial dysfunctions in the small intestine
    Andrea Szabo
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, D 66421 Germany
    Life Sci 78:3058-65. 2006
    ....
  55. ncbi request reprint Age-associated loss of immunomodulatory protection by granulocyte-colony stimulating factor in endotoxic rats
    Brigitte Vollmar
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Shock 18:348-54. 2002
    ....
  56. ncbi request reprint In vivo quantification of ageing changes in the rat liver from early juvenile to senescent life
    Brigitte Vollmar
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Liver 22:330-41. 2002
    ..e. the age of 1, 3, 12 and 24 months...
  57. doi request reprint Rapamycin, but not cyclosporine A, inhibits vascularization and incorporation of implanted surgical meshes
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Transpl Int 22:654-62. 2009
    ..Thus, immunosuppressed patients should not be treated with rapamycin in case of incisional hernia repair in order to guarantee adequate mesh incorporation...
  58. ncbi request reprint Heme oxygenase does not contribute to control of basal vascular tone in isolated blood-perfused rat lung
    Takayuki Nakamura
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Heart Lung Transplant 23:599-605. 2004
    ..We evaluated the significance of HO function on basal pulmonary vascular resistance (PVR) and compared it with the function of NOS...
  59. ncbi request reprint Arteriolovenular shunting critically determines shutdown of microcirculation upon cryotherapy in tumor-bearing rat liver
    Sven Richter
    Department for General, Visceral, and Vascular Surgery, University of Saarland, D 66421, Homburg Saar, Germany
    Ann Surg Oncol 12:303-12. 2005
    ..Clinicians favor repetitive cryoapplication, although there is no proven evidence for a more effective tumor eradication...
  60. ncbi request reprint Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Fertil Steril 87:163-71. 2007
    ..To investigate the effects of selective cyclo-oxygenase-2 (COX-2) inhibition on the angiogenesis and proliferation of endometrial grafts...
  61. doi request reprint 4-hydroxybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Life Sci 93:44-50. 2013
    ..Because angiogenesis is a major prerequisite for tumor growth, the aim of this study was to analyze for the first time, whether HBA may be used for anti-cancer therapy...
  62. doi request reprint Early effect of hepatic artery TNF-alpha infusion on systemic hemodynamics and inflammation: a dose-response study in pigs
    Thilo Schäfer
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Int J Colorectal Dis 25:523-32. 2010
    ..Systemic side effects, however, have not been studied yet. Therefore, we evaluated in pigs the effects of TNF-alpha hepatic artery infusion (HAI) on systemic hemodynamics, inflammation, and organ injury...
  63. doi request reprint TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation
    Shirong Liu
    Department of Neurology, University of the Saarland, 66421 Homburg Saar, Germany
    J Immunol 188:1098-107. 2012
    ..Our study demonstrated that TLR2 is a primary receptor for Aβ to trigger neuroinflammatory activation and suggested that inhibition of TLR2 in microglia could be beneficial in Alzheimer's disease pathogenesis...
  64. ncbi request reprint Impact of severity of local soft-tissue trauma on long-term manifestation of microcirculatory and microlymphatic dysfunctions
    Michaela Amon
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Trauma 61:924-32. 2006
    ....
  65. ncbi request reprint Heme oxygenase and nitric oxide synthase mediate cooling-associated protection against TNF-alpha-induced microcirculatory dysfunction and apoptotic cell death
    Michaela Amon
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    FASEB J 17:175-85. 2003
    ..Biliverdin rather than CO and NO mediates the anti-inflammatory action, whereas a coordinated function of the gaseous monoxides prevents microcirculatory dysfunction and apoptotic cell death...
  66. ncbi request reprint Protective skeletal muscle arteriolar vasomotion during critical perfusion conditions of osteomyocutaneous flaps is not mediated by nitric oxide and endothelins
    Martin Rücker
    Department of Oral and Maxillofacial Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Langenbecks Arch Surg 388:339-43. 2003
    ..The mechanisms that regulate vasomotion are still unclear; therefore, we studied the incidence of vasomotion in peripheral tissue and whether nitric oxide or endothelins are involved in regulation of vasomotion...
  67. ncbi request reprint Fibronectin binding proteins contribute to the adherence of Staphylococcus aureus to intact endothelium in vivo
    Sylvain Kerdudou
    Institute of Medical Microbiology and Hygiene, University of Saarland Hospital, Homburg Saar, Germany
    Thromb Haemost 96:183-9. 2006
    ..Accordingly, this attribution of staphylococcal FnBPs provide a rationale for novel intervention strategies such as the use of anti-FnBP antibodies in endovascular S. aureus disease...
  68. pmc Statins inhibit lymphocyte homing to peripheral lymph nodes
    Rene Schramm
    Department of Thoracic and Cardiovascular Surgery, University of Saarland, University Hospitals Homburg Saar, Germany
    Immunology 120:315-24. 2007
    ..05). We conclude that statin compounds are capable of inhibiting lymphocyte homing to murine peripheral lymph nodes in vivo. This may have novel implications for the treatment of adaptive immune responses, e.g. transplant rejection...
  69. ncbi request reprint Improvement of nutritive perfusion after free tissue transfer by local heat shock-priming-induced preservation of capillary flowmotion
    Martin Rücker
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 123:102-8. 2005
    ..Because heat shock priming protects tissue after transfer, we herein studied whether heat shock protein expression is capable to preserve critical perfusion-induced capillary flowmotion in transferred composite flaps...
  70. ncbi request reprint Improvement of vascularization of PLGA scaffolds by inosculation of in situ-preformed functional blood vessels with the host microvasculature
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Ann Surg 248:939-48. 2008
    ..We analyzed, in vivo, whether the establishment of blood supply to implanted scaffolds can be accelerated by inosculation of an in situ-preformed microvascular network with the host microvasculature...
  71. doi request reprint Short-term cultivation of in situ prevascularized tissue constructs accelerates inosculation of their preformed microvascular networks after implantation into the host tissue
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Tissue Eng Part A 17:841-53. 2011
    ..In conclusion, this study demonstrates that inosculation of in situ prevascularized tissue constructs can be easily accelerated by destabilization of preformed microvessels and angiogenic activation during short-term cultivation...
  72. doi request reprint The nightknife©: evaluation of efficiency and quality of bipolar vessel sealing
    Jochen Schuld
    Department of General, Visceral, Vascular, and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    J Laparoendosc Adv Surg Tech A 21:659-63. 2011
    ..Nightknife(©) is a novel reusable bipolar vessel sealing device. In the present study we analyzed its efficiency and quality of vessel sealing in comparison to a standard instrument (LigaSure™)...
  73. ncbi request reprint Immunostimulatory CpG-oligodeoxynucleotides (CpG-ODN) induce early hepatic injury, but provide a late window for protection against endotoxin-mediated liver damage
    Jan E Slotta
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    J Hepatol 44:576-85. 2006
    ..Herein, we studied the effect of CpG-ODN in lipopolysaccharide (LPS)-associated hepatotoxicity...
  74. ncbi request reprint Major but not minor hepatectomy accelerates engraftment of extrahepatic tumor cells
    Kathrin Rupertus
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Clin Exp Metastasis 24:39-48. 2007
    ..Herein we studied the effect of minor (30%) or major (70%) hepatectomy on engraftment of extrahepatic tumor cells, and the role of tumor neovascularization and tumor cell migration...
  75. ncbi request reprint Local platelet trapping as the cause of thrombocytopenia after hepatic cryotherapy
    Georg A Pistorius
    Department of Surgery, University of Saarland, D 66421, Homburg Saar, Germany
    World J Surg 29:657-60; discussion 661. 2005
    ..We therefore conclude that local platelet trapping represents a major cause of cryothermia-induced systemic thrombocytopenia...
  76. ncbi request reprint Blockade of in vivo VEGF-KDR/flk-1 signaling does not affect revascularization of freely transplanted pancreatic islets
    Rene Schramm
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Transplantation 75:239-42. 2003
    ....
  77. ncbi request reprint Improvement of microvascular graft equilibration and preservation in non-heart-beating donors by warm preflush with streptokinase
    Jun Ichiro Yamauchi
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Transplantation 75:449-53. 2003
    ..Temporary fibrinolytic preflush with streptokinase may represent a feasible tool to improve microvascular graft equilibration, which effectively protects the renal integrity during both cold storage and posttransplant reperfusion...
  78. pmc Endothelial progenitor cells contribute to the vascularization of endometriotic lesions
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Am J Pathol 178:442-50. 2011
    ..To our knowledge, our findings indicate for the first time that vasculogenesis (ie, de novo generation of blood vessels from EPCs) may represent an integral mechanism in the pathogenesis of endometriosis...
  79. ncbi request reprint Latent antithrombin does not affect physiological angiogenesis: an in vivo study on vascularization of grafted ovarian follicles
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Life Sci 75:203-13. 2004
    ..Thus, L-AT may be an effective drug in tumor therapy, which blocks tumor growth by selective suppression of tumor vascularization without affecting new vessel formation in the female reproductive system...
  80. ncbi request reprint n-3 Polyunsaturated fatty acid-enriched diet does not protect from liver injury but attenuates mortality rate in a rat model of systemic endotoxemia
    Brigitte Vollmar
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Crit Care Med 30:1091-8. 2002
    ..We investigated the potential of dietary fish oil containing n-3 polyunsaturated fatty acids to attenuate hepatic injury and mortality rate of rats in response to systemic endotoxemia...
  81. ncbi request reprint Evolution of a "falx lunatica" in demarcation of critically ischemic myocutaneous tissue
    Yves Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Am J Physiol Heart Circ Physiol 288:H1224-32. 2005
    ....
  82. ncbi request reprint Long-term cell survival and hemodynamic improvements after neonatal cardiomyocyte and satellite cell transplantation into healed myocardial cryoinfarcted lesions in rats
    Hanno Huwer
    Department of Thoracic and Cardiovascular Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Cell Transplant 12:757-67. 2003
    ....
  83. pmc High-resolution ultrasound imaging: a novel technique for the noninvasive in vivo analysis of endometriotic lesion and cyst formation in small animal models
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Berlin, Germany
    Am J Pathol 176:585-93. 2010
    ..Thus, high-resolution ultrasound imaging represents an important tool for future preclinical small animal studies, which address the pathophysiology of endometriosis and the development of new treatment strategies...
  84. ncbi request reprint In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Fertil Steril 84:1199-209. 2005
    ..To establish a novel endometriosis model that allows for repetitive in vivo analyses of angiogenesis in ectopic endometrial tissue...
  85. ncbi request reprint Reduction of midfacial periosteal perfusion failure by subperiosteal versus supraperiosteal dissection
    Martin Rücker
    Clinic for Oral and Maxillofacial Surgery, University of Saarland, Homburg Saar, Germany
    J Oral Maxillofac Surg 63:87-92. 2005
    ....
  86. ncbi request reprint Experimental liver metastasis: standards for local cell implantation to study isolated tumor growth in mice
    Otto Kollmar
    Department of General, Visceral and Vascular Surgery, University of Saarland, Homburg Saar, Germany
    Clin Exp Metastasis 21:453-60. 2004
    ..WT cells in a 10 microl PBS blister subcapsularly into the paramedian area of the lower surface of the left liver lobe, using a 32-gauge needle and closing the puncture site with acrylic glue...
  87. ncbi request reprint High, but not low, dietary retinoids aggravate manifestation of rat liver fibrosis
    Brigitte Vollmar
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Gastroenterol Hepatol 17:791-9. 2002
    ..The present study focuses on the role of vitamin A in carbon tetrachloride (CCl4)-induced fibrosis by chronic feeding of rats with either a vitamin A-supplemented or -depleted diet...
  88. ncbi request reprint Technetium-99m labeled 1-(4-fluorobenzyl)-4-(2-mercapto-2-methyl-4-azapentyl)-4-(2-mercapto-2-methylpropylamino)-piperidine and iodine-123 metaiodobenzylguanidine for studying cardiac adrenergic function: a comparison of the uptake characteristics in vasc
    Samuel Samnick
    Department of Nuclear Medicine, Saarland University Medical Centre, D 66421 Homburg, Germany
    Nucl Med Biol 31:511-22. 2004
    ..These data indicate that (99m)Tc-FBPBAT, like (123)I-MIBG, may be suitable for mapping cardiac adrenergic innervation by SPET, especially for alpha(1)/beta(1)-adrenoceptors as target in numerous heart diseases...
  89. ncbi request reprint Advanced hepatic tissue destruction in ablative cryosurgery: potentials of intermittent freezing and selective vascular inflow occlusion
    Otto Kollmar
    Department of General, Visceral and Vascular Surgery, D 66421 Homburg Saar, Germany
    Cryobiology 48:263-72. 2004
    ..VO-SF additionally increases the volume of the lesion and may therefore be most attractive for successful clinical application...
  90. ncbi request reprint Mechanism of the delay phenomenon: tissue protection is mediated by heme oxygenase-1
    Darius Kubulus
    Dept of Anesthesiology and Intensive Care Medicine, Univ of Saarland, D 66421 Homburg Saar, Germany
    Am J Physiol Heart Circ Physiol 287:H2332-40. 2004
    ..Thus our data indicate that the delay-induced protection from tissue necrosis is mediated by HO-1, predominantly through its carbon monoxide-associated action of adequately maintaining nutritive capillary perfusion...
  91. ncbi request reprint p-[123I]iodo-L-phenylalanine for detection of pancreatic cancer: basic investigations of the uptake characteristics in primary human pancreatic tumour cells and evaluation in in vivo models of human pancreatic adenocarcinoma
    Samuel Samnick
    Department of Nuclear Medicine, Saarland University Medical Center, 66421 Homburg Saar, Germany
    Eur J Nucl Med Mol Imaging 31:532-41. 2004
    ....
  92. pmc Macrophage inflammatory protein-2 contributes to liver resection-induced acceleration of hepatic metastatic tumor growth
    Otto Kollmar
    Department of General, Visceral, Vascular and Pediatric Surgery, University of the Saarland, D 66421 Homburg Saar, Germany
    World J Gastroenterol 12:858-67. 2006
    ..To study the role of macrophage inflammatory protein (MIP)-2 in liver resection-induced acceleration of tumor growth in a mouse model of hepatic metastasis...
  93. ncbi request reprint Injectable nanocrystalline hydroxyapatite paste for bone substitution: in vivo analysis of biocompatibility and vascularization
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg, Saar, Germany
    J Biomed Mater Res B Appl Biomater 82:494-505. 2007
    ..Thus, Ostim represents an injectable synthetic bone substitute, which may optimize the conditions for the formation of new bone at sites of bone defects by supporting a guided vascularization during biodegradation...
  94. doi request reprint Inosculation: connecting the life-sustaining pipelines
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Tissue Eng Part B Rev 15:455-65. 2009
    ....
  95. ncbi request reprint Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Germany
    Tissue Eng 12:2093-104. 2006
    ....
  96. ncbi request reprint In vitro and in vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Hum Reprod Update 13:331-42. 2007
    ..The findings resulting from all these approaches will help to provide better insights into the pathophysiology of endometriosis and to establish new anti-angiogenic treatment strategies for the future...
  97. doi request reprint The Rho-kinase inhibitor Y-27632 inhibits cholestasis-induced platelet interactions in the hepatic microcirculation
    Matthias W Laschke
    Department of Surgery, Malmo University Hospital, Malmo, Lund University, Sweden
    Microvasc Res 78:95-9. 2009
    ..Thus, targeting Rho-kinase signaling may be an effective way to protect against platelet-mediated liver injury in obstructive jaundice...
  98. doi request reprint Rho-kinase inhibitor attenuates cholestasis-induced CXC chemokine formation, leukocyte recruitment, and hepatocellular damage in the liver
    Matthias W Laschke
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    J Surg Res 159:666-73. 2010
    ....
  99. ncbi request reprint Viewing the microcirculation through the window: some twenty years experience with the hamster dorsal skinfold chamber
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Eur Surg Res 34:83-91. 2002
    ....
  100. ncbi request reprint Intravital fluorescence microscopy: a novel tool for the study of the interaction of Staphylococcus aureus with the microvascular endothelium in vivo
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Infect Dis 191:435-43. 2005
    ..The ability of Staphylococcus aureus to adhere to endothelial cells is a major prerequisite for the tissue-invasive stage of bacterial infection...
  101. ncbi request reprint Aprotinin inhibits local platelet trapping and improves tissue destruction in hepatic cryosurgery
    Otto Kollmar
    Department of General, Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Surgery 136:624-32. 2004
    ..The freeze-thaw procedure, however, may be associated with life-threatening thrombocytopenia due to local platelet trapping, and success of neoplasm ablation may be compromised by inadequate parenchymal cell destruction...