M W Laschke

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Germany
    Tissue Eng 12:2093-104. 2006
  2. pmc High-resolution ultrasound imaging: a novel technique for the noninvasive in vivo analysis of endometriotic lesion and cyst formation in small animal models
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Berlin, Germany
    Am J Pathol 176:585-93. 2010
  3. doi request reprint In vitro and in vivo evaluation of a novel nanosize hydroxyapatite particles/poly(ester-urethane) composite scaffold for bone tissue engineering
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Acta Biomater 6:2020-7. 2010
  4. doi request reprint Angiogenic and inflammatory host response to surgical meshes of different mesh architecture and polymer composition
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    J Biomed Mater Res B Appl Biomater 91:497-507. 2009
  5. ncbi request reprint Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Fertil Steril 87:163-71. 2007
  6. doi request reprint The Rho-kinase inhibitor Y-27632 inhibits cholestasis-induced platelet interactions in the hepatic microcirculation
    Matthias W Laschke
    Department of Surgery, Malmo University Hospital, Malmo, Lund University, Sweden
    Microvasc Res 78:95-9. 2009
  7. ncbi request reprint Injectable nanocrystalline hydroxyapatite paste for bone substitution: in vivo analysis of biocompatibility and vascularization
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg, Saar, Germany
    J Biomed Mater Res B Appl Biomater 82:494-505. 2007
  8. ncbi request reprint In vitro and in vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Hum Reprod Update 13:331-42. 2007
  9. ncbi request reprint Incorporation of growth factor containing Matrigel promotes vascularization of porous PLGA scaffolds
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    J Biomed Mater Res A 85:397-407. 2008
  10. ncbi request reprint Dietary glycine does not affect physiological angiogenesis and reproductive function, but inhibits apoptosis in endometrial and ovarian tissue by down-regulation of nuclear factor-kappaB
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Fertil Steril 90:1460-9. 2008

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Germany
    Tissue Eng 12:2093-104. 2006
    ....
  2. pmc High-resolution ultrasound imaging: a novel technique for the noninvasive in vivo analysis of endometriotic lesion and cyst formation in small animal models
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Berlin, Germany
    Am J Pathol 176:585-93. 2010
    ..Thus, high-resolution ultrasound imaging represents an important tool for future preclinical small animal studies, which address the pathophysiology of endometriosis and the development of new treatment strategies...
  3. doi request reprint In vitro and in vivo evaluation of a novel nanosize hydroxyapatite particles/poly(ester-urethane) composite scaffold for bone tissue engineering
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Acta Biomater 6:2020-7. 2010
    ..Thus, nHA/PU composite scaffolds represent a promising new type of scaffold for bone tissue engineering, combining the flexible material properties of PU with the advantage of an osteoconductive surface...
  4. doi request reprint Angiogenic and inflammatory host response to surgical meshes of different mesh architecture and polymer composition
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    J Biomed Mater Res B Appl Biomater 91:497-507. 2009
    ..Thus, our data demonstrate that a stronger angiogenic and inflammatory response to an implanted mesh does not necessarily result in a better incorporation into the host tissue...
  5. ncbi request reprint Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Fertil Steril 87:163-71. 2007
    ..To investigate the effects of selective cyclo-oxygenase-2 (COX-2) inhibition on the angiogenesis and proliferation of endometrial grafts...
  6. doi request reprint The Rho-kinase inhibitor Y-27632 inhibits cholestasis-induced platelet interactions in the hepatic microcirculation
    Matthias W Laschke
    Department of Surgery, Malmo University Hospital, Malmo, Lund University, Sweden
    Microvasc Res 78:95-9. 2009
    ..Thus, targeting Rho-kinase signaling may be an effective way to protect against platelet-mediated liver injury in obstructive jaundice...
  7. ncbi request reprint Injectable nanocrystalline hydroxyapatite paste for bone substitution: in vivo analysis of biocompatibility and vascularization
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg, Saar, Germany
    J Biomed Mater Res B Appl Biomater 82:494-505. 2007
    ..Thus, Ostim represents an injectable synthetic bone substitute, which may optimize the conditions for the formation of new bone at sites of bone defects by supporting a guided vascularization during biodegradation...
  8. ncbi request reprint In vitro and in vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Hum Reprod Update 13:331-42. 2007
    ..The findings resulting from all these approaches will help to provide better insights into the pathophysiology of endometriosis and to establish new anti-angiogenic treatment strategies for the future...
  9. ncbi request reprint Incorporation of growth factor containing Matrigel promotes vascularization of porous PLGA scaffolds
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    J Biomed Mater Res A 85:397-407. 2008
    ..These findings demonstrate that the combination of proangiogenic extracellular matrices with solid scaffold biomaterials may represent a novel approach to accelerate adequate vascularization of tissue engineering constructs...
  10. ncbi request reprint Dietary glycine does not affect physiological angiogenesis and reproductive function, but inhibits apoptosis in endometrial and ovarian tissue by down-regulation of nuclear factor-kappaB
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Fertil Steril 90:1460-9. 2008
    ..To study the effect of dietary glycine on female reproductive organs...
  11. doi request reprint Inosculation: connecting the life-sustaining pipelines
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Tissue Eng Part B Rev 15:455-65. 2009
    ....
  12. doi request reprint In vivo biocompatibility and vascularization of biodegradable porous polyurethane scaffolds for tissue engineering
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Acta Biomater 5:1991-2001. 2009
    ..However, the scaffolds should be further modified or conditioned in order to accelerate and improve the process of vascularization...
  13. doi request reprint Rapamycin, but not cyclosporine A, inhibits vascularization and incorporation of implanted surgical meshes
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Transpl Int 22:654-62. 2009
    ..Thus, immunosuppressed patients should not be treated with rapamycin in case of incisional hernia repair in order to guarantee adequate mesh incorporation...
  14. doi request reprint Rho-kinase inhibitor attenuates cholestasis-induced CXC chemokine formation, leukocyte recruitment, and hepatocellular damage in the liver
    Matthias W Laschke
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    J Surg Res 159:666-73. 2010
    ....
  15. doi request reprint Epigallocatechin-3-gallate inhibits estrogen-induced activation of endometrial cells in vitro and causes regression of endometriotic lesions in vivo
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Saar, Germany
    Hum Reprod 23:2308-18. 2008
    ..Herein, we studied whether EGCG may also be effective in the treatment of endometriosis...
  16. pmc Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Br J Pharmacol 149:137-44. 2006
    ..Rapamycin is a widely used drug with antifungal, immunosuppressant and antiangiogenic effects. Herein, we studied whether immunosuppressive doses of rapamycin are capable of influencing endometriotic lesions...
  17. pmc Endothelial progenitor cells contribute to the vascularization of endometriotic lesions
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Am J Pathol 178:442-50. 2011
    ..To our knowledge, our findings indicate for the first time that vasculogenesis (ie, de novo generation of blood vessels from EPCs) may represent an integral mechanism in the pathogenesis of endometriosis...
  18. ncbi request reprint Promoting external inosculation of prevascularised tissue constructs by pre-cultivation in an angiogenic extracellular matrix
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Eur Cell Mater 20:356-66. 2010
    ....
  19. doi request reprint Short-term cultivation of in situ prevascularized tissue constructs accelerates inosculation of their preformed microvascular networks after implantation into the host tissue
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Tissue Eng Part A 17:841-53. 2011
    ..In conclusion, this study demonstrates that inosculation of in situ prevascularized tissue constructs can be easily accelerated by destabilization of preformed microvessels and angiogenic activation during short-term cultivation...
  20. doi request reprint Improvement of vascularization of PLGA scaffolds by inosculation of in situ-preformed functional blood vessels with the host microvasculature
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Ann Surg 248:939-48. 2008
    ..We analyzed, in vivo, whether the establishment of blood supply to implanted scaffolds can be accelerated by inosculation of an in situ-preformed microvascular network with the host microvasculature...
  21. pmc In vitro and in vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Br J Pharmacol 163:835-44. 2011
    ..4-Hydroxybenzyl alcohol (HBA) is a phenolic plant compound, which has been shown to influence many cellular mechanisms. In the present study, we analysed in vitro and in vivo the anti-angiogenic actions of this pleiotropic agent...
  22. ncbi request reprint Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Hum Reprod 21:262-8. 2006
    ....
  23. doi request reprint Genistein does not affect vascularization and blood perfusion of endometriotic lesions and ovarian follicles in dorsal skinfold chambers of Syrian golden hamsters
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Reprod Sci 17:568-77. 2010
    ..Thus, genistein may not be considered for the development of antiangiogenic treatment strategies in the therapy of endometriosis...
  24. doi request reprint Three-dimensional spheroids of adipose-derived mesenchymal stem cells are potent initiators of blood vessel formation in porous polyurethane scaffolds
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Acta Biomater 9:6876-84. 2013
    ..Thus, adMSC spheroids may be used to increase the efficacy of MSC-based vascularization strategies in future tissue engineering applications...
  25. pmc Rapamycin affects early fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, Homburg Saar, Germany
    Br J Pharmacol 154:1055-62. 2008
    ....
  26. doi request reprint Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy
    J E Slotta
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Br J Surg 95:976-84. 2008
    ..This experimental study investigated the role of Rho-kinase in hepatectomy-induced sensitization to endotoxin...
  27. pmc Simvastatin protects against cholestasis-induced liver injury
    S Dold
    Department of Surgery, Malmo University Hospital, Lund University, Sweden
    Br J Pharmacol 156:466-74. 2009
    ..Bile duct obstruction is associated with hepatic accumulation of leukocytes and liver injury. The aim of this study was to evaluate the effect of simvastatin on cholestasis-induced liver inflammation and tissue damage...
  28. pmc Platelet-dependent accumulation of leukocytes in sinusoids mediates hepatocellular damage in bile duct ligation-induced cholestasis
    M W Laschke
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Br J Pharmacol 153:148-56. 2008
    ..The aim of the present study was to evaluate the role of platelets and P-selectin in cholestasis-induced liver injury...
  29. doi request reprint Intravital microscopic studies of angiogenesis during bone defect healing in mice calvaria
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Injury 42:765-71. 2011
    ..Herein, we introduce a calvarian defect model in mice that allows the repetitive analysis of blood vessel formation during bone repair by intravital microscopy...
  30. doi request reprint Low dose erythropoietin stimulates bone healing in mice
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 29:165-72. 2011
    ..The herein shown acceleration of healing by EPO may represent a promising novel treatment strategy for fractures with delayed healing and non-union formation...
  31. ncbi request reprint Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury
    Karin Thorlacius
    Department of Anesthesiology, Lund University, Malmo, Sweden
    J Leukoc Biol 79:923-31. 2006
    ..Based on the present findings, it is suggested that inhibition of the Rho-kinase signaling pathway may be a useful target in the treatment of septic liver injury...
  32. doi request reprint Direct in vivo observations of P-selectin glycoprotein ligand-1-mediated leukocyte-endothelial cell interactions in the pulmonary microvasculature in abdominal sepsis in mice
    J Roller
    Department of Clinical Sciences, Section of Surgery, Lund University, 20502 Malmo, Sweden
    Inflamm Res 62:275-82. 2013
    ..We have developed a method based on intravital fluorescence microscopy of the lung microcirculation to examine the role of PSGL-1 in the extravasation process of leukocytes in septic lung damage...
  33. ncbi request reprint Vascularisation of porous scaffolds is improved by incorporation of adipose tissue-derived microvascular fragments
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Eur Cell Mater 24:266-77. 2012
    ..Accordingly, this approach may markedly contribute to the success of future tissue engineering applications in clinical practice...
  34. ncbi request reprint The dorsal skinfold chamber: window into the dynamic interaction of biomaterials with their surrounding host tissue
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Eur Cell Mater 22:147-64; discussion 164-7. 2011
    ....
  35. ncbi request reprint Perioperative steroid administration inhibits angiogenic host tissue response to porous polyethylene (Medpor) implants
    S Ehrmantraut
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421, Homburg Saar, Germany
    Eur Cell Mater 19:107-16. 2010
    ..Therefore, perioperative steroid therapy should be avoided in case of Medpor implantation to achieve a rapid incorporation of the biomaterial at the implantation site...
  36. pmc In vivo imaging of physiological angiogenesis from immature to preovulatory ovarian follicles
    B Vollmar
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Am J Pathol 159:1661-70. 2001
    ....
  37. ncbi request reprint New experimental approach to study host tissue response to surgical mesh materials in vivo
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg, Saar, Germany
    J Biomed Mater Res A 74:696-704. 2005
    ..We conclude that this novel model of surgical mesh implantation is a useful experimental approach to analyze host tissue response and vascular ingrowth of newly devised materials for hernia repair...
  38. doi request reprint P-selectin glycoprotein ligand-1-mediated leukocyte recruitment regulates hepatocellular damage in acute obstructive cholestasis in mice
    Stefan Dold
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Inflamm Res 59:291-8. 2010
    ..Leukocytes mediate hepatocellular injury in obstructive cholestasis. The aim of the present study was to define the role of P-selectin glycoprotein ligand-1 (PSGL-1) in cholestasis-induced leukocyte recruitment and liver damage...
  39. ncbi request reprint Immunoglobulin M-enriched human intravenous immunoglobulins reduce leukocyte-endothelial cell interactions and attenuate microvascular perfusion failure in normotensive endotoxemia
    Johannes N Hoffman
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Shock 29:133-9. 2008
    ..Our findings can explain better efficacy of IgM-enriched Igs in patients with severe sepsis...
  40. doi request reprint Anti-angiogenic treatment strategies for the therapy of endometriosis
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Hum Reprod Update 18:682-702. 2012
    ..Further experimental studies, controlled clinical trials in particular, are required now to clarify which compounds fulfil these expectations without inducing severe side effects in patients with endometriosis...
  41. doi request reprint Resveratrol is a potent inhibitor of vascularization and cell proliferation in experimental endometriosis
    J Rudzitis-Auth
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar D66421, Germany
    Hum Reprod 28:1339-47. 2013
    ..Does the phytochemical compound resveratrol inhibit vascularization of endometriotic lesions?..
  42. doi request reprint Small animal bone healing models: standards, tips, and pitfalls results of a consensus meeting
    T Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Bone 49:591-9. 2011
    ..This review discusses distinct requirements for the experimental setups as well as the advantages and pitfalls of the different fixation techniques in rats and mice...
  43. ncbi request reprint Ovariectomy improves neovascularization and microcirculation of freely transplanted ovarian follicles
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    J Endocrinol 172:535-44. 2002
    ..In conclusion, the study demonstrates that ovariectomy improves neovascularization and microcirculation of freely transplanted ovarian follicles...
  44. doi request reprint Vasculogenesis: a new piece of the endometriosis puzzle
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Hum Reprod Update 17:628-36. 2011
    ..CONCLUSIONS ; The involvement of vasculogenesis in endometriosis may offer the exciting opportunity for the future establishment of novel diagnostic and therapeutic strategies for this frequent gynaecological disease...
  45. doi request reprint Intravital fluorescent microscopic evaluation of bacterial cellulose as scaffold for vascular grafts
    Maricris Esguerra
    Department of Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    J Biomed Mater Res A 93:140-9. 2010
    ..In conclusion, BC offers good biocompatibility and material incorporation compared with commonly used materials in vascular surgery. Thus, BC represents a promising new biomaterial for tissue engineering of vascular grafts...
  46. ncbi request reprint Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia
    Johannes N Hoffmann
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Crit Care Med 32:1011-7. 2004
    ..To characterize microcirculatory actions of activated protein C in an endotoxemia rodent model that allows in vivo studies of microvascular inflammation and perfusion dysfunction...
  47. ncbi request reprint Latent antithrombin does not affect physiological angiogenesis: an in vivo study on vascularization of grafted ovarian follicles
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Life Sci 75:203-13. 2004
    ..Thus, L-AT may be an effective drug in tumor therapy, which blocks tumor growth by selective suppression of tumor vascularization without affecting new vessel formation in the female reproductive system...
  48. doi request reprint Xanthohumol inhibits growth and vascularization of developing endometriotic lesions
    J Rudzitis-Auth
    Institute for Clinical and Experimental Surgery, University of Saarland, Saar, Germany
    Hum Reprod 27:1735-44. 2012
    ..In the present study, we analyzed, for the first time, whether this dietary compound may also be used for the treatment of endometriosis...
  49. ncbi request reprint Experimental models to study microcirculatory dysfunction in muscle ischemia-reperfusion and osteomyocutaneous flap transfer
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Langenbecks Arch Surg 388:281-90. 2003
    ..The drawback of this "acute" model is that the period of analysis is restricted to a few hours only...
  50. ncbi request reprint In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Fertil Steril 84:1199-209. 2005
    ..To establish a novel endometriosis model that allows for repetitive in vivo analyses of angiogenesis in ectopic endometrial tissue...
  51. doi request reprint Heme oxygenase (HO)-1 protects from lipopolysaccharide (LPS)-mediated liver injury by inhibition of hepatic leukocyte accumulation and improvement of microvascular perfusion
    Jonas Roller
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421, Homburg Saar, Germany
    Langenbecks Arch Surg 395:387-94. 2010
    ..The mechanisms of action however, have not been clarified yet. Therefore, we analyzed in vivo the effects of HO-1 on the liver microcirculation under conditions of LPS exposure...
  52. doi request reprint p38 MAPK regulates ischemia-reperfusion-induced recruitment of leukocytes in the colon
    Stefan Santen
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Surgery 145:303-12. 2009
    ..Our objective was to examine the role of p38 mitogen-activated protein kinase (MAPK) in ischemia-reperfusion (I/R)-induced recruitment or leukocytes in the colon...
  53. doi request reprint Rho-kinase signalling regulates CXC chemokine formation and leukocyte recruitment in colonic ischemia-reperfusion
    Stefan Santen
    Department of Surgery, Malmo University Hospital, Lund University, 205 02 Malmo, Sweden
    Int J Colorectal Dis 25:1063-70. 2010
    ..Leukocyte recruitment is a key feature in ischemia-reperfusion (I/R)-induced tissue injury. The aim of the present study was to investigate the effect of Rho-kinase inhibition on I/R-provoked leukocyte recruitment in the colon...
  54. ncbi request reprint Impact of severity of local soft-tissue trauma on long-term manifestation of microcirculatory and microlymphatic dysfunctions
    Michaela Amon
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Trauma 61:924-32. 2006
    ....
  55. doi request reprint Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury
    Jan E Slotta
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    J Investig Med 57:645-9. 2009
    ..The aim of the present study was to examine the effects of simvastatin on endotoxemic liver injury...
  56. doi request reprint Prolene-Monocryl-composite meshes do not increase microvascular Staphylococcus aureus adherence and do not sensitize for leukocytic inflammation
    Jonas Roller
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Langenbecks Arch Surg 393:349-57. 2008
    ..In this study, we analyzed whether this complication is supported by an increased interaction of bacteria and leukocytes with the microvascular endothelium at the implantation site...
  57. doi request reprint Cholestatic liver damage is mediated by lymphocyte function antigen-1-dependent recruitment of leukocytes
    Stefan Dold
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Surgery 144:385-93. 2008
    ..Therefore, the aim of our experimental study was to evaluate the role of lymphocyte function antigen-1 (LFA-1) in cholestatic liver injury...
  58. doi request reprint Simvastatin attenuates hepatic sensitization to lipopolysaccharide after partial hepatectomy
    Jan E Slotta
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    J Surg Res 162:184-92. 2010
    ..Herein, we hypothesized that pretreatment with simvastatin may protect against lipopolysaccharide (LPS)-induced liver damage after partial hepatectomy...
  59. ncbi request reprint Viewing the microcirculation through the window: some twenty years experience with the hamster dorsal skinfold chamber
    Michael D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Eur Surg Res 34:83-91. 2002
    ....
  60. doi request reprint Combined blockade of angiotensin II type 1 receptor and activation of peroxisome proliferator-activated receptor-γ by telmisartan effectively inhibits vascularization and growth of murine endometriosis-like lesions
    A Nenicu
    Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Hum Reprod 29:1011-24. 2014
    ..Is telmisartan effective in the treatment of endometriosis?..
  61. doi request reprint A comparative evaluation of ablations produced by high-frequency coagulation-, argon plasma coagulation-, and cryotherapy devices in porcine liver
    J Sperling
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    Int J Colorectal Dis 27:1229-35. 2012
    ..Using a porcine in vivo model, we therefore analyzed the effect of different ablation devices on depth and completeness of hepatic parenchymal cell destruction...
  62. doi request reprint Vascularization in tissue engineering: angiogenesis versus inosculation
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Eur Surg Res 48:85-92. 2012
    ..The present review provides an overview of these two concepts applied in tissue engineering...
  63. doi request reprint An old dream revitalised: preconditioning strategies to protect surgical flaps from critical ischaemia and ischaemia-reperfusion injury
    Y Harder
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Plast Reconstr Aesthet Surg 61:503-11. 2008
    ..In view of successful translational research, it is now time that the efficacy of these novel preconditioning procedures is proven in prospective randomised clinical trials...
  64. ncbi request reprint Adverse effect of heparin on antithrombin action during endotoxemia: microhemodynamic and cellular mechanisms
    Johannes N Hoffmann
    Department of Surgery, Chirurgische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistr 15, D 81377 Munchen, Germany
    Thromb Haemost 88:242-52. 2002
    ..These results indicate that heparin should be avoided to permit AT to modulate LPS-induced inflammatory responses...
  65. ncbi request reprint Intravital fluorescence microscopy: a novel tool for the study of the interaction of Staphylococcus aureus with the microvascular endothelium in vivo
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Infect Dis 191:435-43. 2005
    ..The ability of Staphylococcus aureus to adhere to endothelial cells is a major prerequisite for the tissue-invasive stage of bacterial infection...
  66. ncbi request reprint Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia
    Johannes N Hoffmann
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 97:460-70. 2002
    ....
  67. pmc Microcirculatory alterations in ischemia-reperfusion injury and sepsis: effects of activated protein C and thrombin inhibition
    Johannes N Hoffmann
    Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany
    Crit Care 9:S33-7. 2005
    ..Thus, the action of APC on the microcirculatory level in systemic endotoxemia is unlikely to be caused by a thrombin inhibition-associated anticoagulatory action...
  68. doi request reprint Local preconditioning by thermal stress accelerates microvascular thrombus formation
    Martin Rücker
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Shock 31:627-33. 2009
    ..Thus, preconditioning with local stress cannot be considered as a strategy to prevent thrombus formation...
  69. ncbi request reprint Angiogenic and inflammatory response to biodegradable scaffolds in dorsal skinfold chambers of mice
    Martin Rücker
    Department of Oral and Maxillofacial Surgery, Hannover Medical School, D 30625 Hannover, Germany
    Biomaterials 27:5027-38. 2006
    ..PLGA scaffolds show a better biocompatibility than hydrogel scaffolds and promote vascular ingrowth, guaranteeing adequate engraftment within the host tissue...
  70. ncbi request reprint Fibronectin binding proteins contribute to the adherence of Staphylococcus aureus to intact endothelium in vivo
    Sylvain Kerdudou
    Institute of Medical Microbiology and Hygiene, University of Saarland Hospital, Homburg Saar, Germany
    Thromb Haemost 96:183-9. 2006
    ..Accordingly, this attribution of staphylococcal FnBPs provide a rationale for novel intervention strategies such as the use of anti-FnBP antibodies in endovascular S. aureus disease...
  71. ncbi request reprint Vascularization and biocompatibility of scaffolds consisting of different calcium phosphate compounds
    Martin Rücker
    Department of Oral and Maxillofacial Surgery, Hannover Medical School, 30625 Hannover, Germany
    J Biomed Mater Res A 86:1002-11. 2008
    ..Hydroxyapatite and, in particular, dentin scaffolds promote vascularization and exhibit a biocompatibility comparable to that of isogeneic bone. This may guarantee the rapid incorporation of these materials into the host tissue...
  72. ncbi request reprint Cryopreservation does not affect neovascularization of freely transplanted ovarian follicles
    Matthias W Laschke
    Fertil Steril 79:1458-60. 2003
  73. ncbi request reprint Sepsis-associated cholestasis is critically dependent on P-selectin-dependent leukocyte recruitment in mice
    Matthias W Laschke
    Dept of Surgery, Malmö Univ Hospital, Lund Univ, S 205 02 Malmo, Sweden
    Am J Physiol Gastrointest Liver Physiol 292:G1396-402. 2007
    ..Our study demonstrates for the first time that P-selectin-mediated recruitment of leukocytes, but not the local production of proinflammatory mediators, is the primary cause of cholestasis in septic liver injury...