Research Topics
Genomes and GenesSpecies | Andreas KellerSummaryAffiliation: Saarland University Country: Germany Publications
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Detail Information
Publications
Toward the blood-borne miRNome of human diseasesAndreas Keller
Biomarker Discovery Center, Heidelberg, Germany
Nat Methods 8:841-3. 2011..We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs...- Combining gene expression signatures and autoantibody profiles in human meningiomaA Keller
Center for Bioinformatics, Saarland University, Saarbrucken, Germany
Gene Ther 16:184-9. 2009.... 
SePaCS--a web-based application for classification of seroreactivity profilesAndreas Keller
Center for Bioinformatics, Saarland University, Building E1 1, 66041 Saarbrucken, Germany
Nucleic Acids Res 35:W683-7. 2007..As a second example, we evaluated SePaCS on glioma, a malignant brain tumor. SePaCS is freely available at http://www.bioinf.uni-sb.de/sepacs...- A novel algorithm for detecting differentially regulated paths based on gene set enrichment analysisAndreas Keller
Center for Bioinformatics, Saarland University, Building E 1 1, Saarbrucken, Germany
Bioinformatics 25:2787-94. 2009.... - Computation of significance scores of unweighted Gene Set Enrichment AnalysesAndreas Keller
Center for Bioinformatics, Saarland University, Building E1 1, 66804 Saarbrücken, Germany
BMC Bioinformatics 8:290. 2007..To test our algorithm, we applied it not only to simulated data sets, but additionally evaluated expression profiles of squamous cell lung cancer tissue and autologous unaffected tissue... - GeneTrailExpress: a web-based pipeline for the statistical evaluation of microarray experimentsAndreas Keller
Center for Bioinformatics, Saarland University, Saarbrucken, Germany
BMC Bioinformatics 9:552. 2008..While a variety of tools for normalizing, analysing, or visualizing expression profiles has been developed in the last years, most of these tools offer only functionality for accomplishing certain steps of the evaluation pipeline... - A minimally invasive multiple marker approach allows highly efficient detection of meningioma tumorsAndreas Keller
Center for Bioinformatics, Saarland University, Building 3, 11, 66041 Saarbrucken, Germany
BMC Bioinformatics 7:539. 2006..For validation purposes we choose the intracranial meningioma tumors as model system since they occur very frequently, are mostly benign, and are genetically stable... - Genome wide expression profiling identifies specific deregulated pathways in meningiomaAndreas Keller
Center for Bioinformatics, Saarland University, Building E 1 1, Saarbrücken 66041, Germany
Int J Cancer 124:346-51. 2009..0001). Pathways with increased expression included several metabolic pathways. Extended expression profiling by a novel statistical gene set enrichment identified pathways that have previously not been associated with meningioma... - Novel immunogenic antigens increase classification accuracy in meningioma to 93.84%Nicole Ludwig
Department of Human Genetics, Medical School, Saarland University, Homburg Saar, Germany
Int J Cancer 128:1493-501. 2011..normal sera as shown by their AUC values. These results demonstrate that the accuracy of a serum-based diagnostic can be readily and considerably improved by screening extended sets of proteins... - miRTrail--a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseasesCedric Laczny
Center for Bioinformatics, Saarland University, Campus E2 1, 66041 Saarbrucken, Germany
BMC Bioinformatics 13:36. 2012..To understand the regulatory processes of miRNAs on genes, integrative computer-aided approaches are essential, especially in the light of complex human diseases as cancer... - miRNAs in lung cancer - studying complex fingerprints in patient's blood cells by microarray experimentsAndreas Keller
febit biomed gmbh, Heidelberg, Germany
BMC Cancer 9:353. 2009..Here we addressed the question whether there is a sufficient number of miRNAs deregulated in blood cells of cancer patients to be able to distinguish between cancer patients and controls... - Is there a general autoantibody signature for cancer?Nicole Ludwig
Department of Human Genetics, Medical School, Saarland University, Building 60, 66421 Homburg Saar, Germany
Eur J Cancer 48:2451-61. 2012..Here we address the question whether cancer specific signatures exist... - Multicenter study identified molecular blood-born protein signatures for Wilms TumorJana Schmitt
Department of Human Genetics, Medical School, Saarland University, 66421 Homburg, Germany
Int J Cancer 131:673-82. 2012..We present the first multicenter study of autoantibody signatures in patients with WT. We established an autoantibody signature that separates patients with WT from controls... - High-throughput miRNA profiling of human melanoma blood samplesPetra Leidinger
Institute of Human Genetics, Medical School, Saarland University, Building 60, 66421 Homburg Saar, Germany
BMC Cancer 10:262. 2010..MicroRNA (miRNA) signatures are not only found in cancer tissue but also in blood of cancer patients. Specifically, miRNA detection in blood offers the prospect of a non-invasive analysis tool... - Identification of lung cancer with high sensitivity and specificity by blood testingPetra Leidinger
Department of Human Genetics, Medical School, Saarland University, Building 60, 66421 Homburg Saar, Germany
Respir Res 11:18. 2010..Cytological analysis and chest X-ray failed to reduce mortality, and CT screenings are still controversially discussed. Recent studies provided first evidence for the potential usefulness of autoantigens as markers for lung cancer... - MicroRNA expression changes after lung cancer resection: a follow-up studyPetra Leidinger
Institute of Human Genetics, Saarland University, Medical School, Homburg, Germany
RNA Biol 9:900-10. 2012..Our data underline the importance of studies that follow the fate of miRNAs over time, both to further our understanding of the biology of miRNA signatures and to establish these signatures as biomarkers... - Pattern of serum autoantibodies allows accurate distinction between a tumor and pathologies of the same organNicole Ludwig
Department of Human Genetics, Medical School, Saarland University, Homburg Saar, Germany
Clin Cancer Res 14:4767-74. 2008..One of the major challenges toward this goal is to prove that seroreactivity profiles do not only allow for identifying a tumor but also allow for distinguishing tumors from other pathologies of the same organ... - Treatment-independent miRNA signature in blood of wilms tumor patientsJana Schmitt
Department of Human Genetics, Saarland University, 66421 Homburg Saar, Germany
BMC Genomics 13:379. 2012..Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001... - A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in gliomaUlrike Fischer
Department of Human Genetics, Saarland University, 66421 Homburg Saar, Germany
Mol Cancer Res 6:576-84. 2008..Our data indicate that amplifications on 12q13-21 (a) are more frequent than previously thought and present in low-grade tumors and (b) are maintained as extended regions over long periods of time... - Specific peripheral miRNA profiles for distinguishing lung cancer from COPDPetra Leidinger
Institute of Human Genetics, Saarland University, Medical School, Homburg, Germany
Lung Cancer 74:41-7. 2011..In conclusion, we showed that blood miRNA signatures are suitable to distinguish lung cancer from COPD... - Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controlsAndreas Keller
febit biomed gmbh, Heidelberg, Germany
PLoS ONE 4:e7440. 2009..The implications of our study are twofold. The miRNA expression profiles in blood cells may serve as a biomarker for MS, and deregulation of miRNA expression may play a role in the pathogenesis of MS... - Improving seroreactivity-based detection of gliomaNicole Ludwig
Department of Human Genetics, Medical School, Saarland University, Building 60, Homburg Saar, Germany
Neoplasia 11:1383-9. 2009..In the future, autoantibody signatures in glioma not only may prove useful for diagnosis but also offer the prospect for a personalized immune-based therapy... - Toward an early diagnosis of lung cancer: an autoantibody signature for squamous cell lung carcinomaPetra Leidinger
Department of Human Genetics, Medical School, Saarland University, 66421 Homburg Saar, Germany
Int J Cancer 123:1631-6. 2008.... - GeneTrail--advanced gene set enrichment analysisChristina Backes
Center for Bioinformatics, Saarland University, Building E1 1, 66041 Saarbrucken, Germany
Nucleic Acids Res 35:W186-92. 2007..GeneTrail is freely accessible at http://genetrail.bioinf.uni-sb.de... - Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in acute myocardial infarctionBritta Vogel
Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
Clin Chem 59:410-8. 2013..However, the kinetics of the time-dependent sensitivity of these novel miRNA biomarkers remained unknown... - GAS41 amplification results in overexpression of a new spindle pole proteinJana Schmitt
Department of Human Genetics, Saarland University, Medical School, Homburg, Germany
Genes Chromosomes Cancer 51:868-80. 2012..We propose that GAS41 amplification may have an effect on the highly altered karyotype of glioblastoma via its role during spindle pole formation... - An integer linear programming approach for finding deregulated subgraphs in regulatory networksChristina Backes
Department of Human Genetics, Saarland University, 66421 Homburg Saar, Germany
Nucleic Acids Res 40:e43. 2012..In summary, our approach opens new avenues for the elucidation of pathogenic mechanisms and for the detection of molecular key players... - Immunogenicity of autoantigensChristina Backes
Center for Bioinformatics, Saarland University, 66041 Saarbrucken, Germany
BMC Genomics 12:340. 2011..To this end, we have carried out the most comprehensive in-silicio study of different groups of autoantigens including large antigen sets identified by our groups combined with publicly available antigen sets... - Novel autoantigens immunogenic in COPD patientsPetra Leidinger
Department of Human Genetics, Medical School, Saarland University, Building 60, 66421 Homburg Saar, Germany
Respir Res 10:20. 2009..In this study we analyze the complexity of the autoantibody response and reveal the nature of the antigens that are recognized by autoantibodies in COPD patients... - Amplicons on chromosome 12q13-21 in glioblastoma recurrencesUlrike Fischer
Department of Human Genetics, Saarland University, 66421 Homburg Saar, Germany
Int J Cancer 126:2594-602. 2010..We recognized a significant longer survival time in glioblastoma patients that lack amplifications of either CDK4, CYP27B1, XRCC6BP1 (KUB3), or MDM2... 
Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosisAndreas Keller
Biomarker Discovery Center Heidelberg, Heidelberg, Germany
RNA Biol 8:506-16. 2011..Our findings support the idea that a developing lung cancer might be detectable years prior to diagnosis through a specific miRNA signature and that this signature changes during tumor development...- A dictionary on microRNAs and their putative target pathwaysChristina Backes
Center for Bioinformatics, Saarland University, Germany
Nucleic Acids Res 38:4476-86. 2010..Our target pathways analysis provides a 'miRNA-target pathway' dictionary, which enables researchers to identify target pathways of differentially regulated miRNAs... - Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lungNicole Comtesse
Department of Human Genetics, Medical School, Saarland University, Homburg, Germany
Int J Cancer 120:2538-44. 2007..Our results contribute to the understanding of the frequent amplification processes in squamous cell carcinomas of the lung and to the understanding of the translation initiation that appears not to require eIF4E in lung carcinogenesis... - Identification of novel SNPs in glioblastoma using targeted resequencingAndreas Keller
Biomarker Discovery Center Heidelberg, Heidelberg, Germany
PLoS ONE 6:e18158. 2011..In addition, we identified SNPs in 20 of 21 GBM associated antigens providing further evidence that genetic variations are significantly associated with the immunogenicity of antigens... - MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarctionBenjamin Meder
Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany
Basic Res Cardiol 106:13-23. 2011..The here presented study shows that single miRNAs and especially miRNA signatures derived from peripheral blood, could be valuable novel biomarkers for cardiovascular diseases... - Genome-wide gene amplification during differentiation of neural progenitor cells in vitroUlrike Fischer
Department of Human Genetics, Saarland University, Homburg Saar, Germany
PLoS ONE 7:e37422. 2012..Gene amplifications in normal human cells as physiological process has not been reported yet and may bear resemblance to developmental gene amplifications in amphibians and insects... - Autoantibody signature differentiates Wilms tumor patients from neuroblastoma patientsJana Schmitt
Department of Human Genetics, Medical School, Saarland University, Homburg, Germany
PLoS ONE 6:e28951. 2011..In summary, neuroblastoma appears as a highly immunogenic tumor as demonstrated by the extended number of antigens that separate this tumor from Wilms tumor... - Increased seroreactivity to glioma-expressed antigen 2 in brain tumor patients under radiationSabrina M Heisel
Department of Human Genetics, Saarland University Medical School, Homburg Saar, Germany
PLoS ONE 3:e2164. 2008..Most recently, cell culture and animal studies provided the first convincing evidence that radiation not only eliminates tumor cells, but also modulates the immune response and likely improves anti-tumor immunotherapy... - Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targetsNicole Comtesse
Department of Human Genetics, Medical School, University of Saarland, Building 60, 66421 Homburg Saar, Germany
Proc Natl Acad Sci U S A 102:9601-6. 2005..The frequent antibody response against specific antigens offers new diagnostic and therapeutic targets for meningioma. We developed a statistical learning method to differentiate sera of meningioma patients from sera of healthy donors... - New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencingAndreas Keller
Department of Human Genetics, Saarland University, 66421 Homburg, Saar, Germany
Nat Commun 3:698. 2012..Sequences corresponding to ~60% of the genome of Borrelia burgdorferi are indicative of the earliest human case of infection with the pathogen for Lyme borreliosis... - Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathiesBenjamin Meder
Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany
Circ Cardiovasc Genet 4:110-22. 2011.... - Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycinYasser A Elnakady
Department of Pharmaceutical Biotechnology, Saarland University, P O Box 151150, 66041 Saarbrucken, Germany
Chembiochem 8:1261-72. 2007..This study therefore provides evidence that kendomycin mediates its cytotoxic effects, at least in part, through proteasome inhibition... - Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairmentsMasood Abu-Halima
Department of Human Genetics, Saarland University, Homburg Saar, Germany
Fertil Steril 99:1249-1255.e16. 2013..To determine whether microRNAs are differentially expressed in men with normal versus impaired spermatogenesis, and to find a biomarker for accurate diagnosis of male infertility... - Alterations in cardiac DNA methylation in human dilated cardiomyopathyJan Haas
Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany
EMBO Mol Med 5:413-29. 2013..In vivo studies of orthologous ly75 and adora2a in zebrafish demonstrate a functional role of these genes in adaptive or maladaptive pathways in heart failure... - Diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis by measurement of microRNA abundance in blood and tissueAndrea S Bauer
Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
PLoS ONE 7:e34151. 2012..The results could have an immediate diagnostic value for the evaluation of tumor reoccurrence in patients, who have undergone curative surgical resection, and for people with a familial risk of pancreatic cancer... - Proteomic study of human glioblastoma multiforme tissue employing complementary two-dimensional liquid chromatography- and mass spectrometry-based approachesKatja Melchior
Department of Chemistry, Instrumental Analysis and Bioanalysis, Saarland University, 66123 Saarbrucken, Germany
J Proteome Res 8:4604-14. 2009..The results indicate the usefulness of the semi-top-down approach for the investigation of immunogenic antigens in human tumor tissue samples... - A set of specific miRNAs is connected with murine and human gastric cancerAftab Ali Shah
Division of Molecular Genetics, Institute of Human Genetics, University of Tubingen, Germany Department of Biotechnology, University of Malakand, Pakistan Institute of Human Genetics, Saarland University, Homburg, Germany
Genes Chromosomes Cancer 52:237-49. 2013..If confirmed in a larger patient pool, these miRNAs could constitute appropriate blood-born biomarkers for GC. © 2012 Wiley Periodicals, Inc... - High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencingMark Matzas
Febit group, Heidelberg, Germany
Nat Biotechnol 28:1291-4. 2010..We use DNA obtained by megacloning to assemble synthetic genes. In principle, millions of DNA fragments can be sequenced, characterized and sorted in a single megacloner run, enabling constructive biology up to the megabase scale...