Affiliation: Saarland University
- The Sec63p J-Domain Is Required for ERAD of Soluble Proteins in YeastChristina Servas
Department of Microbiology, Faculty of Natural Sciences and Technology VIII, Saarland University, Saarbrucken, Germany
PLoS ONE 8:e82058. 2013..In contrast to mammalian cells where SEC63 expression levels affect steady-state levels of multi-spanning transmembrane proteins, the sec63 J-domain mutant was only defective in ERAD of soluble substrates. ..
- ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7Thomas Tretter
Department of Microbiology, Faculty of Natural Sciences and Technology VIII, Saarland University, Campus A1, 5, 66123 Saarbrucken, Germany
BMC Cell Biol 14:56. 2013..The mechanisms of channel opening for the different modes of translocation are not understood so far, but the position of the large ER-lumenal loop 7 of Sec61p suggests a decisive role...
- N-acetylation and phosphorylation of Sec complex subunits in the ER membraneChristina Soromani
Department of Clinical Biochemistry, University College London Hospital, London, UK
BMC Cell Biol 13:34. 2012..Little is known about the biogenesis and regulation of individual Sec complex subunits...
- Analysis of Sec61p and Ssh1p interactions in the ER membrane using the split-ubiquitin systemCarol Harty
Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK
BMC Cell Biol 14:14. 2013..Generation of fusion proteins is, however, rife with problems, and particularly in transmembrane proteins often disturbs topology, structure and function...