Jurgen Geisel

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint Stimulatory effect of homocysteine on interleukin-8 expression in human endothelial cells
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1045-8. 2003
  2. ncbi request reprint Decreased p66Shc promoter methylation in patients with end-stage renal disease
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
    Clin Chem Lab Med 45:1764-70. 2007
  3. ncbi request reprint The vegetarian lifestyle and DNA methylation
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 43:1164-9. 2005
  4. ncbi request reprint The impact of hyperhomocysteinemia as a cardiovascular risk factor in the prediction of coronary heart disease
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1513-7. 2003
  5. ncbi request reprint The role of genetic factors in the development of hyperhomocysteinemia
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1427-34. 2003
  6. ncbi request reprint Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk
    Wolfgang Herrmann
    Department of Clinical Chemistry, School of Medicine, Saarland University, Homburg, Germany
    Clin Chem Lab Med 41:1478-88. 2003
  7. ncbi request reprint Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians
    Wolfgang Herrmann
    Central Laboratory, Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
    Am J Clin Nutr 78:131-6. 2003
  8. ncbi request reprint The impact of vegetarianism on some haematological parameters
    Rima Obeid
    Department of Clinical Chemistry, University Hospital of Saarland, Homburg, Germany
    Eur J Haematol 69:275-9. 2002
  9. doi request reprint One year B and D vitamins supplementation improves metabolic bone markers
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg Saar, Germany
    Clin Chem Lab Med 51:639-47. 2013
  10. ncbi request reprint The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings
    Wolfgang Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Curr Drug Metab 6:47-53. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Stimulatory effect of homocysteine on interleukin-8 expression in human endothelial cells
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1045-8. 2003
    ..The formation of homocysteine-induced oxidation products might serve as one of the underlying mechanisms of this effect...
  2. ncbi request reprint Decreased p66Shc promoter methylation in patients with end-stage renal disease
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
    Clin Chem Lab Med 45:1764-70. 2007
    ..First, patients with ESRD have a disturbed homocysteine metabolism, and second an increased risk of morbidity and mortality from cardiovascular disease is a constant finding in these patients...
  3. ncbi request reprint The vegetarian lifestyle and DNA methylation
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 43:1164-9. 2005
    ..In conclusion, an inhibitory effect of SAH on whole-genome methylation was found, but from our data no interaction between vegetarian lifestyle and DNA methylation could be determined...
  4. ncbi request reprint The impact of hyperhomocysteinemia as a cardiovascular risk factor in the prediction of coronary heart disease
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1513-7. 2003
    ..6 micromol/l. This data strongly suggests that plasma homocysteine helps identify individuals at risk, especially among those with elevated C-reactive protein levels...
  5. ncbi request reprint The role of genetic factors in the development of hyperhomocysteinemia
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1427-34. 2003
    ..Although the TC and COMT mutations influence cellular vitamin B12 metabolism, this effect did not result in overt homocysteine elevation...
  6. ncbi request reprint Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk
    Wolfgang Herrmann
    Department of Clinical Chemistry, School of Medicine, Saarland University, Homburg, Germany
    Clin Chem Lab Med 41:1478-88. 2003
    ..In this study we investigated the diagnostic value of storage (holoTC) of vitamin B12 and functional markers (methylmalonic acid (MMA)) of vitamin B12 metabolism in populations who are at risk of vitamin B12 deficiency...
  7. ncbi request reprint Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians
    Wolfgang Herrmann
    Central Laboratory, Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
    Am J Clin Nutr 78:131-6. 2003
    ..Vegetarians have a lower intake of vitamin B-12 than do omnivores. Early and reliable diagnosis of vitamin B-12 deficiency is very important...
  8. ncbi request reprint The impact of vegetarianism on some haematological parameters
    Rima Obeid
    Department of Clinical Chemistry, University Hospital of Saarland, Homburg, Germany
    Eur J Haematol 69:275-9. 2002
    ..The current work was undertaken to investigate some haematological parameters in relation to vitamin B12 and iron status in vegetarians...
  9. doi request reprint One year B and D vitamins supplementation improves metabolic bone markers
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg Saar, Germany
    Clin Chem Lab Med 51:639-47. 2013
    ..Supplementation with these vitamins is a promising preventative strategy. The objective of this study was to evaluate the effects of vitamins D3 and B supplementation on bone turnover and metabolism in elderly people...
  10. ncbi request reprint The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings
    Wolfgang Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Curr Drug Metab 6:47-53. 2005
    ..Elevated MMA and normal holoTC in patients with renal insufficiency may not exclude vitamin B12 deficiency. HoloTC seems not to be a promising marker in predicting B12 status in renal patients...
  11. ncbi request reprint Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, Homburg, Germany
    Clin Chem Lab Med 42:1109-16. 2004
    ..Therefore, the demand for vitamin B6 is increased in these patients. Furthermore, renal dysfunction and low vitamin B6 levels contribute to the increase of cystathionine in pre-eclampsia and HELLP patients...
  12. ncbi request reprint Factors affecting the distribution of folate forms in the serum of elderly German adults
    Susanne H Kirsch
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg, Saarland, Germany
    Eur J Nutr 52:497-504. 2013
    ..We investigated the roles of age, vitamin B(12) markers, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism as determinants of folate forms in serum...
  13. doi request reprint Assay of whole blood (6S)-5-CH3-H4folate using ultra performance liquid chromatography tandem mass spectrometry
    Susanne H Kirsch
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg, Saarland, Germany
    Anal Bioanal Chem 404:895-902. 2012
    ..We observed a dose-dependent oxidation of (6S)-H(4)folate, which resulted in the formation of artificial folic acid in serum and WB. To minimize this effect, we recommend a fast sample preparation...
  14. ncbi request reprint Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplay
    Wolfgang Herrmann
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:547-53. 2003
    ..The influence of MTHFR 677 mutation on homocysteine (HCY) levels in relation to vitamin B12 and folate status was investigated in the current study...
  15. doi request reprint Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes
    Rima Obeid
    Department of Clinical Chemistry, Saarland University Medical Centre, Homburg, Germany
    Biochimie 95:1056-61. 2013
    ..Metformin treatment was associated with low serum vitamin B12 and improved intracellular vitamin B12 metabolism despite low serum vitamin B12...
  16. doi request reprint Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University, Medical Centre, Homburg, Germany
    Mol Nutr Food Res 56:1582-9. 2012
    ..The study tests the metabolites of the methylation cycle in individuals with Down syndrome (DS) and applies a mathematical model in order to change this cycle by nutritional factors...
  17. ncbi request reprint The measurement of complexed prostate-specific antigen has a better performance than total prostate-specific antigen
    Wolfgang Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 42:1051-7. 2004
    ..Thus, cPSA might be seen as the superior first-line parameter in screening for prostate cancer. Using lower cut-off values for tPSA or cPSA than the commonly accepted values seems reasonable for screening purposes...
  18. ncbi request reprint Vegetarian lifestyle and monitoring of vitamin B-12 status
    Wolfgang Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, Bld 40, D 66421 Homburg Saar, Germany
    Clin Chim Acta 326:47-59. 2002
    ..In our investigations, we have found stage III of vitamin B-12 deficiency in over 60% of vegetarians, thus underlining the importance of cobalamin monitoring in this dietary group...
  19. doi request reprint SuperTAG methylation-specific digital karyotyping reveals uremia-induced epigenetic dysregulation of atherosclerosis-related genes
    Adam M Zawada
    Department of Internal Medicine IV, Saarland University Medical Center, Homburg, Germany
    Circ Cardiovasc Genet 5:611-20. 2012
    ..We hypothesized that gene-specific epigenetic dysregulation in CKD exists, affecting genes pertinent to inflammation and atherosclerosis...
  20. doi request reprint Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry
    Susanne H Kirsch
    Saarland University Hospital, Department of Clinical Chemistry and Laboratory Medicine, Building 57, 66421 Homburg Saar, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3865-70. 2009
    ..8). The new UPLC-MS/MS method showed very high sensitivity and selectivity for SAM and SAH, low CVs and fast sample preparation (40 samples in 60min) and analysis time (3min). This new assay can be used for large-scale clinical studies...
  21. ncbi request reprint Evaluation of alkaline phosphatase activity assay for the Reflotron system after substitution of the comparison method
    Ulrich Hübner
    Department of Clinical Chemistry Central Laboratory, Saarland University Hospital, Homburg, Germany
    Clin Lab 51:49-53. 2005
    ..The ALP Reflotron assay is an adequate method for decentralized testing. It shows a good precision and agreement with the comparison method, although the systematic differences for placental and bone ALP isoenzymes have to be considered...
  22. ncbi request reprint Apolipoprotein E2/E2 genotype in combination with mutations in the LDL receptor gene causes type III hyperlipoproteinemia
    Jurgen Geisel
    Klinisch Chemisches Zentrallabor, Universitatskliniken des Saarlandes, Homburg, Germany
    Clin Chem Lab Med 40:475-9. 2002
    ....
  23. doi request reprint Common genetic variation in vitamin D metabolism is associated with liver stiffness
    Frank Grunhage
    Department of Medicine II, Saarland University Medical Center, Homburg, Germany
    Hepatology 56:1883-91. 2012
    ..0 kPa and TE between 7.0 and 9.5 kPa. 25(OH)-vitamin D levels correlated with sunshine hours at the time of inclusion (P < 0.001)...
  24. ncbi request reprint The effect of a pneumatic tube transport system on platelet aggregation using optical aggregometry and the PFA-100
    Ulrich Hübner
    University Hospital of the Saarland, Clinical Chemistry and Laboratory Medicine Central Laboratory, Homburg, Germany
    Clin Lab 56:59-64. 2010
    ..However, the preanalytical effects of pneumatic tube transport of blood samples on platelet function analysis are not fully understood...