Research Topics
Species | Jurgen GeiselSummaryAffiliation: Saarland University Country: Germany Publications
| Collaborators
|
Detail Information
Publications
The impact of hyperhomocysteinemia as a cardiovascular risk factor in the prediction of coronary heart diseaseJurgen Geisel
Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
Clin Chem Lab Med 41:1513-7. 2003..6 micromol/l. This data strongly suggests that plasma homocysteine helps identify individuals at risk, especially among those with elevated C-reactive protein levels...- Decreased p66Shc promoter methylation in patients with end-stage renal diseaseJurgen Geisel
Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
Clin Chem Lab Med 45:1764-70. 2007..First, patients with ESRD have a disturbed homocysteine metabolism, and second an increased risk of morbidity and mortality from cardiovascular disease is a constant finding in these patients... - The vegetarian lifestyle and DNA methylationJurgen Geisel
Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
Clin Chem Lab Med 43:1164-9. 2005..In conclusion, an inhibitory effect of SAH on whole-genome methylation was found, but from our data no interaction between vegetarian lifestyle and DNA methylation could be determined... - Stimulatory effect of homocysteine on interleukin-8 expression in human endothelial cellsJurgen Geisel
Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
Clin Chem Lab Med 41:1045-8. 2003..The formation of homocysteine-induced oxidation products might serve as one of the underlying mechanisms of this effect... - The role of genetic factors in the development of hyperhomocysteinemiaJurgen Geisel
Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
Clin Chem Lab Med 41:1427-34. 2003..Although the TC and COMT mutations influence cellular vitamin B12 metabolism, this effect did not result in overt homocysteine elevation... - Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at riskWolfgang Herrmann
Department of Clinical Chemistry, School of Medicine, Saarland University, Homburg, Germany
Clin Chem Lab Med 41:1478-88. 2003..In this study we investigated the diagnostic value of storage (holoTC) of vitamin B12 and functional markers (methylmalonic acid (MMA)) of vitamin B12 metabolism in populations who are at risk of vitamin B12 deficiency... - Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetariansWolfgang Herrmann
Central Laboratory, Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
Am J Clin Nutr 78:131-6. 2003..Vegetarians have a lower intake of vitamin B-12 than do omnivores. Early and reliable diagnosis of vitamin B-12 deficiency is very important... - The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settingsWolfgang Herrmann
Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
Curr Drug Metab 6:47-53. 2005..Elevated MMA and normal holoTC in patients with renal insufficiency may not exclude vitamin B12 deficiency. HoloTC seems not to be a promising marker in predicting B12 status in renal patients... - Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiencyWolfgang Herrmann
Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, Homburg, Germany
Clin Chem Lab Med 42:1109-16. 2004..Therefore, the demand for vitamin B6 is increased in these patients. Furthermore, renal dysfunction and low vitamin B6 levels contribute to the increase of cystathionine in pre-eclampsia and HELLP patients... 
Assay of whole blood (6S)-5-CH3-H4folate using ultra performance liquid chromatography tandem mass spectrometrySusanne H Kirsch
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg, Saarland, Germany
Anal Bioanal Chem 404:895-902. 2012..We observed a dose-dependent oxidation of (6S)-H(4)folate, which resulted in the formation of artificial folic acid in serum and WB. To minimize this effect, we recommend a fast sample preparation...- Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplayWolfgang Herrmann
Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
Clin Chem Lab Med 41:547-53. 2003..The influence of MTHFR 677 mutation on homocysteine (HCY) levels in relation to vitamin B12 and folate status was investigated in the current study... - The measurement of complexed prostate-specific antigen has a better performance than total prostate-specific antigenWolfgang Herrmann
Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
Clin Chem Lab Med 42:1051-7. 2004..Thus, cPSA might be seen as the superior first-line parameter in screening for prostate cancer. Using lower cut-off values for tPSA or cPSA than the commonly accepted values seems reasonable for screening purposes... - Vegetarian lifestyle and monitoring of vitamin B-12 statusWolfgang Herrmann
Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, Bld 40, D 66421 Homburg Saar, Germany
Clin Chim Acta 326:47-59. 2002..In our investigations, we have found stage III of vitamin B-12 deficiency in over 60% of vegetarians, thus underlining the importance of cobalamin monitoring in this dietary group... - Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometrySusanne H Kirsch
Saarland University Hospital, Department of Clinical Chemistry and Laboratory Medicine, Building 57, 66421 Homburg Saar, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 877:3865-70. 2009..8). The new UPLC-MS/MS method showed very high sensitivity and selectivity for SAM and SAH, low CVs and fast sample preparation (40 samples in 60min) and analysis time (3min). This new assay can be used for large-scale clinical studies... - Evaluation of alkaline phosphatase activity assay for the Reflotron system after substitution of the comparison methodUlrich Hübner
Department of Clinical Chemistry Central Laboratory, Saarland University Hospital, Homburg, Germany
Clin Lab 51:49-53. 2005..The ALP Reflotron assay is an adequate method for decentralized testing. It shows a good precision and agreement with the comparison method, although the systematic differences for placental and bone ALP isoenzymes have to be considered... - Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical modelRima Obeid
Department of Clinical Chemistry and Laboratory Medicine, Saarland University, Medical Centre, Homburg, Germany
Mol Nutr Food Res 56:1582-9. 2012..The study tests the metabolites of the methylation cycle in individuals with Down syndrome (DS) and applies a mathematical model in order to change this cycle by nutritional factors... - Apolipoprotein E2/E2 genotype in combination with mutations in the LDL receptor gene causes type III hyperlipoproteinemiaJurgen Geisel
Klinisch Chemisches Zentrallabor, Universitatskliniken des Saarlandes, Homburg, Germany
Clin Chem Lab Med 40:475-9. 2002.... - The effect of a pneumatic tube transport system on platelet aggregation using optical aggregometry and the PFA-100Ulrich Hübner
University Hospital of the Saarland, Clinical Chemistry and Laboratory Medicine Central Laboratory, Homburg, Germany
Clin Lab 56:59-64. 2010..However, the preanalytical effects of pneumatic tube transport of blood samples on platelet function analysis are not fully understood...