Peter Falkai

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg Saar, Germany
    Eur Arch Psychiatry Clin Neurosci 253:92-9. 2003
  2. doi request reprint Cortical neurochemistry in euthymic patients with bipolar I disorder
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, 37075 Goettingen, Germany
    World J Biol Psychiatry 10:285-94. 2009
  3. ncbi request reprint Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
  4. ncbi request reprint Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia
    Berend Malchow
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University LMU Munich, Nußbaumstraße 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:S155-68. 2013
  5. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
  6. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
  7. pmc Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:565-77. 2012
  8. doi request reprint Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm 115:1651-9. 2008
  9. doi request reprint Cognitive impairment of executive function as a core symptom of schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 10:442-51. 2009
  10. doi request reprint Early onset of obsessive-compulsive disorder and associated comorbidity
    Deborah Janowitz
    Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
    Depress Anxiety 26:1012-7. 2009

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg Saar, Germany
    Eur Arch Psychiatry Clin Neurosci 253:92-9. 2003
    ..Genetic loading seems to have an impact on frontal regions as the interhemispheric fissure and on the temporal horn...
  2. doi request reprint Cortical neurochemistry in euthymic patients with bipolar I disorder
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, 37075 Goettingen, Germany
    World J Biol Psychiatry 10:285-94. 2009
    ..The aim of this study was to re-investigate prefrontal and anterior cingulate neurochemistry in a sample of euthymic patients with bipolar I disorder...
  3. ncbi request reprint Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
    ....
  4. ncbi request reprint Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia
    Berend Malchow
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University LMU Munich, Nußbaumstraße 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:S155-68. 2013
    ..Future longitudinal studies in first-episode patients with quantification of cannabis abuse and assessment of schizophrenia risk genes are warranted...
  5. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
    ..BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus...
  6. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
    ..In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD...
  7. pmc Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:565-77. 2012
    ..It is hypothesized that abnormal expression of these and related genes has a major impact on the pathophysiology of schizophrenia...
  8. doi request reprint Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm 115:1651-9. 2008
    ..Finally, CSF Abeta42 levels declined significantly in both groups within 12 months supporting the notion that CSF Abeta42 may be valid not only for diagnostic but also for prognostic purposes in AD...
  9. doi request reprint Cognitive impairment of executive function as a core symptom of schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 10:442-51. 2009
    ..In conclusion, these results may suggest a cognitive endophenotype in schizophrenia and underline the role of the prefrontal cortex in schizophrenic pathophysiology...
  10. doi request reprint Early onset of obsessive-compulsive disorder and associated comorbidity
    Deborah Janowitz
    Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
    Depress Anxiety 26:1012-7. 2009
    ..This study was undertaken to discriminate the subtypes of OCD in different AOO levels and to test the hypothesis that different AOO bands are associated with a differential pattern of comorbidity...
  11. pmc Internal capsule size associated with outcome in first-episode schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:278-83. 2009
    ..In conclusion, reduced maximal area of ALIC, which can be interpreted as a disturbance of fronto-thalamic connectivity, is associated with poor outcome during the 1 year course of first-episode schizophrenia...
  12. ncbi request reprint Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: relation to performance and clinical symptoms
    Ilona Henseler
    Centre for Translational Research in Systems Neuroscience and Clinical Psychiatry, Department of Psychiatry and Psychotherapy, Georg August University, D 37075 Goettingen, Germany
    J Psychiatr Res 44:364-72. 2010
    ..The relationship between working memory (WM) impairment, disturbed functional connectivity, and the characteristic symptoms of schizophrenia, however, remains elusive...
  13. pmc Comorbid substance abuse and brain morphology in recent-onset psychosis
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:28-36. 2009
    ....
  14. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 16:1951-8. 2013
    ..In agreement with preclinical research, we suggest that NPS may be a promising pharmacological candidate with anti-obsessional properties...
  15. pmc Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm 115:1181-7. 2008
    ..Despite a number of findings supporting the hypothesis of environmental Cu modulating AD, our results demonstrate that oral Cu intake has neither a detrimental nor a promoting effect on the progression of AD...
  16. pmc Compensatory hyperactivations as markers of latent working memory dysfunctions in patients with obsessive-compulsive disorder: an fMRI study
    Ilona Henseler
    Systems Neuroscience Unit, Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    J Psychiatry Neurosci 33:209-15. 2008
    ..To test this hypothesis, we examined patients without a behavioural deficit in WM during performance of different WM tasks using functional magnetic resonance imaging (fMRI)...
  17. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
    ....
  18. doi request reprint Neuropsychological impairments predict the clinical course in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Düsseldorf Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:28-34. 2008
    ....
  19. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  20. doi request reprint Deficient inhibitory cortical networks in antipsychotic-naive subjects at risk of developing first-episode psychosis and first-episode schizophrenia patients: a cross-sectional study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Biol Psychiatry 72:744-51. 2012
    ..However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis...
  21. doi request reprint Pathological amygdala activation during working memory performance: Evidence for a pathophysiological trait marker in bipolar affective disorder
    Oliver Gruber
    Centre for Translational Research in Systems Neuroscience and Clinical Psychiatry, Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Hum Brain Mapp 31:115-25. 2010
    ..This pathophysiological abnormality appears to be a trait marker in bipolar disorders that can be observed even in the euthymic state and that seems to be largely independent of task performance and medication...
  22. doi request reprint Functional interactions guiding adaptive processing of behavioral significance
    Esther Kristina Diekhof
    Systems Neuroscience Unit, Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Hum Brain Mapp 30:3325-31. 2009
    ....
  23. ncbi request reprint Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...
  24. doi request reprint Impaired long-term depression in schizophrenia: a cathodal tDCS pilot study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Brain Stimul 5:475-83. 2012
    ..However, glutamate-dependent long-term depression (LTD)-like cortical plasticity has not yet been investigated...
  25. doi request reprint The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls--a randomized placebo-controlled, double-blind fMRI study
    Birgit Guse
    University Medical Centre, Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Str 5, D 37075 Gottingen, Germany
    Behav Brain Res 237:300-7. 2013
    ..This is the first fMRI study that has systematically investigated this topic within a randomized, placebo-controlled, double-blind design, contrasting the effects in schizophrenia patients and healthy controls...
  26. doi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 14:2-44. 2013
    ..These guidelines are primarily concerned with the biological treatment (including antipsychotic medication and other pharmacological treatment options) of adults suffering from schizophrenia...
  27. pmc Reduced prefrontal gyrification in obsessive-compulsive disorder
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:455-64. 2010
    ..In conclusion, prefrontal hypogyrification in OCD patients may be a structural correlate of the impairment in executive function of this patient group and may point to a neurodevelopmental origin of this disease...
  28. doi request reprint Planum temporale asymmetry to the right hemisphere in first-episode schizophrenia
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Street 5, 37075 Goettingen, Germany
    Psychiatry Res 193:56-9. 2011
    ..We investigated planum temporale (PT) volume and asymmetry in 23 first-episode schizophrenia patients compared to healthy controls and found for the first time an in vivo volume asymmetry of PT to the right hemisphere...
  29. doi request reprint Impulsive personality and the ability to resist immediate reward: an fMRI study examining interindividual differences in the neural mechanisms underlying self-control
    Esther Kristina Diekhof
    Department of Psychiatry and Psychotherapy, Center for Translational Research in Systems Neuroscience and Psychiatry, Georg August University, Von Siebold Strasse 5, Goettingen, Germany
    Hum Brain Mapp 33:2768-84. 2012
    ..Collectively, these results suggest trait-specific neural mechanisms that allow HI individuals to control their desire for immediate reward...
  30. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: long-term treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 7:5-40. 2006
    ....
  31. ncbi request reprint SNAP-25 genotype influences NAA/Cho in left hippocampus
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    J Neural Transm 115:1513-8. 2008
    ..The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus...
  32. pmc Patients with schizophrenia show deficits of working memory maintenance components in circuit-specific tasks
    David Zilles
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:519-25. 2010
    ..In contrast to a seemingly global working memory deficit, individual analysis revealed differential patterns of working memory impairments in patients with schizophrenia...
  33. ncbi request reprint Neuregulin-1 haplotype HAP(ICE) is associated with lower hippocampal volumes in schizophrenic patients and in non-affected family members
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    J Psychiatr Res 43:1-6. 2008
    ..This preliminary evidence may help to guide further research into the pathophysiological pathways that underlie this genetic susceptibility for schizophrenia...
  34. doi request reprint Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment
    Martina Von Wilmsdorff
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    World J Biol Psychiatry 14:490-9. 2013
    ..The influence of the neuregulin-1 (NRG1) risk genotype or effects of antipsychotics on expression of EAATs are unknown...
  35. doi request reprint The effect of aerobic exercise on cortical architecture in patients with chronic schizophrenia: a randomized controlled MRI study
    Peter Falkai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nußbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:469-73. 2013
    ..However, respective exercise effects might be attenuated in chronic schizophrenia, which should be verified in a larger sample...
  36. ncbi request reprint Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia
    Thomas Schneider-Axmann
    Department of Psychiatry and Psychotherapy, University of Saarland, D 66421 Homburg Saar, Germany
    J Psychiatr Res 40:646-55. 2006
    ..The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as schizophrenic patients and how state of genetic loading contribute to these abnormalities...
  37. doi request reprint A similar but distinctive pattern of impaired cortical excitability in first-episode schizophrenia and ADHD
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Neuropsychobiology 67:74-83. 2013
    ..Studies on cortical excitability comparing these two diseases directly are lacking...
  38. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 13:318-78. 2012
    ..This first part of the updated guidelines covers the general descriptions of antipsychotics and their side effects, the biological treatment of acute schizophrenia and the management of treatment-resistant schizophrenia...
  39. ncbi request reprint Evidence for specific cognitive deficits in visual information processing in patients with OCD compared to patients with unipolar depression
    Friederike Rampacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, DE 53105 Bonn, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 34:984-91. 2010
    ..As yet, it has not been substantiated whether deficits in visual organization and complex visual memory are also specific to OCD and are not shared by MDD...
  40. doi request reprint Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Strasse 5, D 37075, Goettingen, Germany
    Behav Brain Res 224:15-22. 2011
    ..Disturbances of N-methyl-d-aspartate, gamma-aminobutyric acid and dopamine receptors may account for this plasticity deficit. LTP-like plasticity deficits might be related to disturbed information processing in schizophrenia patients...
  41. pmc Diagnosis-specific effect of familial loading on verbal working memory in schizophrenia
    David Zilles
    Department of Psychiatry and Psychotherapy, Georg August University, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:309-15. 2009
    ..Working memory dysfunctions have been shown to be heritable and have been proposed to represent a promising endophenotype of schizophrenic psychoses...
  42. pmc Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence
    Berend Malchow
    Department of Psychiatry and Psychotherapy, University Medical Center Gottingen, Georg August University, Germany
    Eur Arch Psychiatry Clin Neurosci 263:3-13. 2013
    ..There is some weak evidence that cannabis abuse could affect brain structures in high-risk subjects, but replication of these studies is needed...
  43. pmc Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:415-23. 2012
    ..Dysfunctional N-methyl D-aspartate receptors or modulation of dopaminergic transmission can explain these findings. Nevertheless, the effects of antipsychotic medication still need to be considered...
  44. pmc Prefrontal cortex gyrification index in twins: an MRI study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:459-65. 2011
    ..The nonexistence of a pronounced similarity in MZ twins compared to DZ twins concerning prefrontal GI raises questions about the extent of genetic influence on GI...
  45. doi request reprint Automated gray level index measurements reveal only minor cytoarchitectonic changes of Brodmann area 9 in schizophrenia
    Ralf Tepest
    Department of Psychiatry and Psychotherapy, University of Cologne, Köln Cologne, Germany
    Psychiatry Res 163:183-92. 2008
    ..Since increases in GLI were found only in selected layers (V and VI) of BA9, these findings do not support a generalized neuropil reduction across all cortical layers...
  46. doi request reprint Hippocampal integrity and neurocognition in first-episode schizophrenia: a multidimensional study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 15:188-99. 2014
    ..However, the association between hippocampal morphometry, neurochemistry and function is controversial. Therefore, we aimed to investigate the relationship between hippocampal anomalies and their functional relevance...
  47. pmc Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosi
    Andreas Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Bull 37:S111-21. 2011
    ..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis...
  48. pmc S100B and homocysteine in the acute alcohol withdrawal syndrome
    Dirk Wedekind
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, 37075 Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:133-8. 2011
    ..S100B could be of relevance in the neurobiology of alcohol withdrawal syndromes. It may be indirectly related to the level of stress level or glutamatergic activity during alcohol withdrawal...
  49. doi request reprint Fear is only as deep as the mind allows: a coordinate-based meta-analysis of neuroimaging studies on the regulation of negative affect
    Esther Kristina Diekhof
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Germany
    Neuroimage 58:275-85. 2011
    ..In addition, higher-level regulation strategies may further engage complementary neural resources to effectively deal with the emotion-eliciting events...
  50. ncbi request reprint CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia
    Claudia Wolf
    Department of Psychiatry and Psychotherapy, Center for Translational Research in Systems Neuroscience and Psychiatry, Georg August University Gottingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 264:93-102. 2014
    ....
  51. ncbi request reprint Predictors of symptomatic remission in first-episode psychosis outpatients treated with quetiapine: a naturalistic study
    Katrin Gade
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Int J Psychiatry Clin Pract 17:148-53. 2013
    ..The aim of this naturalistic study was to assess course and predictors of symptomatic remission in outpatients with first-episode psychosis during quetiapine monotherapy...
  52. doi request reprint The effects of physical exercise in schizophrenia and affective disorders
    Berend Malchow
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nußbaumstraße 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:451-67. 2013
    ....
  53. doi request reprint Reduction of gyrification index in the cerebellar vermis in schizophrenia: a post-mortem study
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    World J Biol Psychiatry 12:99-103. 2011
    ..Cerebellar regions have been implicated in the pathophysiology of schizophrenia; however, the GI has not been investigated here so far...
  54. pmc Schizophrenia as a disorder of disconnectivity
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S150-4. 2011
    ..The specificity and the neurobiological origin of these connectivity deficits and the relation to the symptom complex of schizophrenia and the glutamatergic and GABAergic system are discussed...
  55. pmc No change to grey and white matter volumes in bipolar I disorder patients
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University of Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:345-9. 2008
    ..The aim of this study was to investigate grey and white matter volumes in a large sample of patients with bipolar I disorder...
  56. ncbi request reprint Obsessive-compulsive disorder and posttraumatic stress disorder
    Hans Joergen Grabe
    Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany
    Psychopathology 41:129-34. 2008
    ..This study investigates the hypothesis that traumatic events and posttraumatic stress disorders (PTSD) precede the onset of OCD...
  57. pmc Disturbed anterior prefrontal control of the mesolimbic reward system and increased impulsivity in bipolar disorder
    Sarah Trost
    Department of Psychiatry and Psychotherapy, Centre for Translational Research in Systems Neuroscience and Clinical Psychiatry, Georg August University, Goettingen, Germany
    Neuropsychopharmacology 39:1914-23. 2014
    ..The disturbed top-down control of mesolimbic reward signals by prefrontal brain regions in BD can be interpreted in terms of a disease-related enhanced impulsivity, a trait marker of BD. ..
  58. ncbi request reprint Correlation between amygdala volume and age in bipolar disorder - a systematic review and meta-analysis of structural MRI studies
    Juliana Usher
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Germany
    Psychiatry Res 182:1-8. 2010
    ..A meta-regression analysis revealed a positive correlation between mean age and amygdala volume in patients with BD. We speculate that amygdala volume is reduced at the onset of the disease and increases with age...
  59. ncbi request reprint Articulatory rehearsal in verbal working memory: a possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder
    Oliver Gruber
    Cognitive Neuroscience Unit, Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    Neurosci Lett 405:24-8. 2006
    ..The findings provide first evidence that dysfunction of a brain system subserving articulatory rehearsal could represent a biological marker which differentiates between schizophrenia and schizoaffective disorder...
  60. ncbi request reprint Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    J Clin Psychopharmacol 30:190-2. 2010
    ....
  61. ncbi request reprint Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Rhineland State Clinics Düsseldorf, Dusseldorf, Germany
    J Clin Psychiatry 68:1763-74. 2007
    ..Accordingly, the hypothesis of whether 1-year relapse rate in first-episode schizophrenia under maintenance treatment with risperidone is lower compared to haloperidol in low dose was tested...
  62. pmc Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Psychopharmacology (Berl) 208:353-63. 2010
    ..Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking...
  63. ncbi request reprint Harm avoidance in subjects with obsessive-compulsive disorder and their families
    Susan Ettelt
    Department of Psychiatry and Psychotherapy, University of Greifswald, Germany
    J Affect Disord 107:265-9. 2008
    ..HA is considered to be a genetically influenced personality trait with an increasingly understood neuroanatomical basis...
  64. pmc Cognitive effects of high-frequency repetitive transcranial magnetic stimulation: a systematic review
    Birgit Guse
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    J Neural Transm 117:105-22. 2010
    ....
  65. pmc Posttraumatic stress disorder (PTSD) in the German Armed Forces: a retrospective study in inpatients of a German army hospital
    Borwin Bandelow
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:459-67. 2012
    ..8% vs. 5.17%). A careful psychiatric screening before recruitment might help to identify persons at risk of PTSD...
  66. doi request reprint The effects of combined acamprosate and integrative behaviour therapy in the outpatient treatment of alcohol dependence: a randomized controlled trial
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Drug Alcohol Depend 118:417-22. 2011
    ..The aim of this randomized, controlled, multisite trial was to evaluate the efficacy of combined treatment with integrative behaviour therapy (IBT) and acamprosate on drinking behaviour in detoxified alcohol-dependent patients...
  67. doi request reprint Borderline personality disorder: a dysregulation of the endogenous opioid system?
    Borwin Bandelow
    Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany
    Psychol Rev 117:623-36. 2010
    ..An understanding of the neurobiology of BPD may help in developing new treatments for patients with this severe disorder...
  68. doi request reprint Cognition in hepatitis C patients treated with pegylated interferon
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    World J Biol Psychiatry 10:819-26. 2009
    ..We conclude that neurocognitive performance was influenced by antiviral IFN-alpha-based combination treatment only in single domains and not to a clinically relevant extent in contrast to the significant worsening of depression...
  69. ncbi request reprint Effects of antipsychotics on brain structure
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany
    Curr Opin Psychiatry 19:145-50. 2006
    ..This review highlights the recent findings of different effects of typical and atypical antipsychotics on brain structure...
  70. ncbi request reprint Neural substrates of olfactory processing in schizophrenia patients and their healthy relatives
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Psychiatry Res 155:103-12. 2007
    ..Results point to a differentiation between trait and state components in cerebral dysfunctions during emotional olfactory processing in schizophrenia...
  71. ncbi request reprint Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia
    Thomas Wobrock
    Dept of Psychiatry and Psychotherapy, University Hospital of Saarland, 66421 Homburg Saar, Germany
    Eur Arch Psychiatry Clin Neurosci 257:203-10. 2007
    ..The lack of higher cognitive disturbance in young schizophrenic patients with comorbid substance abuse may encourage clinicians to develop integrated treatment programmes using cognitive strategies of drug therapy...
  72. ncbi request reprint Limitations of current therapies: why do patients switch therapies?
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    Eur Neuropsychopharmacol 18:S135-9. 2008
    ....
  73. ncbi request reprint Functional brain abnormalities in psychiatric disorders: neural mechanisms to detect and resolve cognitive conflict and interference
    Tobias Melcher
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Brain Res Rev 59:96-124. 2008
    ..Taken together, interference resolution and performance monitoring appeared to be fruitful concepts in the investigation of neurocognitive deficits in psychiatric disorders...
  74. ncbi request reprint Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease
    Oliver Wirths
    Department of Psychiatry, University of the Saarland, 66421 Homburg Saar, Germany
    Exp Gerontol 41:220-4. 2006
    ..Furthermore, statistical analysis revealed a significant negative correlation between plasma cholesterol and brain Abeta42 levels during aging in the mice expressing both APP and PS1...
  75. ncbi request reprint MRI of the brainstem in patients with major depression, bipolar affective disorder and normal controls
    Tillmann Supprian
    Dept of Psychiatry, The Saarland University Hospital, D 66421 Homburg Saar, Germany
    Psychiatry Res 131:269-76. 2004
    ..This finding needs to be replicated in a larger sample with more elaborated MRI techniques (multi-echo sequences) for the determination of T2-relaxation times...
  76. ncbi request reprint Functional neuroimaging of reward processing and decision-making: a review of aberrant motivational and affective processing in addiction and mood disorders
    Esther Kristina Diekhof
    Systems Neuroscience Unit, Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Strasse 5, D 37075 Goettingen, Germany
    Brain Res Rev 59:164-84. 2008
    ..The overall goal is to critically evaluate the specificity of neurophysiological alterations identified in these psychiatric disorders and associated symptoms, and to make suggestions concerning future research...
  77. doi request reprint Insertion/deletion polymorphism in the gene for angiotensin converting enzyme (ACE) in panic disorder: A gender-specific effect?
    Borwin Bandelow
    Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany
    World J Biol Psychiatry 11:66-70. 2010
    ..0195), respectively, was observed. The present results provide further support for a potentially male-specific role of the less active ACE I allele in the pathogenesis of panic disorder, possibly by altering substance P levels...
  78. ncbi request reprint Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal view
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, D 66421 Homburg Saar, Germany
    Psychiatry Res 132:261-71. 2004
    ..As the frontal lobe takes shape late in brain development, underlying genetic mechanisms may be dysregulated in schizophrenic patients and subjects at risk to develop the disorder...
  79. doi request reprint Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 12:201-15. 2011
    ..This may be partly ascribed to the origin of the materials (CSF, blood, brain tissue) or to the genes selected for the respective studies. Moreover, in some locations, inflammatory genes may be up-regulated, others may be down-regulated...
  80. ncbi request reprint Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients
    Ute Habel
    Department of Psychiatry and Psychotherapy, University of Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Am J Psychiatry 161:1806-13. 2004
    ..Brain activity was measured during mood induction in patients with schizophrenia and their first-degree nonaffected relatives...
  81. doi request reprint A roadmap to disentangle the molecular etiology of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, 37075 Goettingen, Germany
    Eur Psychiatry 23:224-32. 2008
    ..The coming calls of the frame work program will be used to strengthen this network in order to achieve substantial progress in understanding and treating this devastating illness...
  82. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 1: acute treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 6:132-91. 2005
    ....
  83. doi request reprint Acute treatment with cannabinoid receptor agonist WIN55212.2 improves prepulse inhibition in psychosocially stressed mice
    Magdalena M Brzózka
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    Behav Brain Res 218:280-7. 2011
    ..Taken together, our data imply that CB1-receptors might play a crucial role in the synergistic effects of psychosocial stress and cannabinoids in brain...
  84. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  85. ncbi request reprint Antidepressive treatment in patients with temporal lobe epilepsy and major depression: a prospective study with three different antidepressants
    Kai Uwe Kuhn
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Epilepsy Behav 4:674-9. 2003
    ..At endpoint the dropout rate for mirtazapine was significantly higher than that for reboxetine or citalopram. Reboxetine showed a trend to be more efficacious than citalopram but not mirtazapine at Week 4...
  86. ncbi request reprint Hippocampal deformities in the unaffected siblings of schizophrenia subjects
    Ralf Tepest
    Department of Psychiatry RT, University of Bonn Medical Center, Bonn, Germany
    Biol Psychiatry 54:1234-40. 2003
    ..The objective of this study was to further elucidate hippocampal deformities as a marker of genetic vulnerability for schizophrenia...
  87. ncbi request reprint Trait characteristic of impaired visuomotor integration during Trail-Making Test B performance in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Neuropsychobiology 48:59-67. 2003
    ..Thus, the abnormalities in the process of TMT-B performance proved to be reliable and stable trait characteristics in schizophrenia...
  88. ncbi request reprint Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophrenia
    Kai Vogeley
    Research Center Juelich, Institute of Medicine, 52425 Juelich, Germany
    Schizophr Res 62:133-40. 2003
    ..The described automated image analysis method providing cytoarchitectonic profiles can be applied as a fast and observer-independent scanning tool to detect cytoarchitectonic abnormalities in multiple brain regions...
  89. ncbi request reprint Volumes of association thalamic nuclei in schizophrenia: a postmortem study
    Peter Danos
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Schizophr Res 60:141-55. 2003
    ..However, the findings of a substantial volume reduction of the THAL suggest that the volumes of additional thalamic nuclei may be also reduced in schizophrenia...
  90. ncbi request reprint Reductions in cholesterol and synaptic markers in association cortex in mood disorders
    Clare L Beasley
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Bipolar Disord 7:449-55. 2005
    ..The aim of this study was to quantify sterol levels in the brains of patients with major psychiatric disorders and further to relate these levels to markers of myelin and synapses...
  91. ncbi request reprint Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:519-23. 2005
    ....
  92. ncbi request reprint Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness
    William G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Cereb Cortex 12:349-56. 2002
    ..These abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders...
  93. ncbi request reprint Clozapine alone versus clozapine and risperidone with refractory schizophrenia
    William G Honer
    Centre for Complex Disorders and the Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, Vancouver, Canada
    N Engl J Med 354:472-82. 2006
    ..The treatment of schizophrenia with multiple antipsychotic drugs is common, but the benefits and risks are not known...
  94. ncbi request reprint Increased serum S100B in elderly, chronic schizophrenic patients: negative correlation with deficit symptoms
    Andrea Schmitt
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Schizophr Res 80:305-13. 2005
    ..Correlations point to the impact of S100B in neuroplasticity and ageing. Post-mortem studies should clarify the presence of altered S100B function in the brain and its relationship to neuroplastic or neurodegenerative processes...
  95. doi request reprint Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review
    Mirko Bibl
    Klinik fur Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universitat Duisburg Essen, Essen, Germany
    Dement Geriatr Cogn Disord 25:256-65. 2008
    ..The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid-beta (Abeta) peptides, total tau and phospho-tau among Alzheimer's disease (AD) and vascular dementias (VAD)...
  96. doi request reprint [Development of the evidence-based S3 guideline for diagnosis and therapy of bipolar disorders]
    Andrea Pfennig
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinik kum Carl Gustav Carus, Technische Universitat Dresden
    Nervenarzt 79:500-4. 2008
  97. ncbi request reprint Intact hippocampal gray matter in schizophrenia as revealed by automatized image analysis postmortem
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:513-7. 2005
    ..Results showed no significant differences between diagnostic groups with respect to the dependent variables, supporting the view that there is no primary alteration of hippocampal gray matter in schizophrenia...
  98. pmc Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches
    Martin Begemann
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 14:546-52. 2008
    ..This case suggests that rapid cycling is a systemic disease, resembling hibernation, with prostaglandins playing a mediator role...
  99. ncbi request reprint Cardiac risk of psychotropic drugs
    David Ames
    Aust N Z J Psychiatry 36:819-20. 2002
  100. ncbi request reprint The dichotomy of schizophrenia and affective disorders in extended pedigrees
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105, Bonn, Germany
    Schizophr Res 57:259-66. 2002
    ..In relatives, the risk of schizophrenia was maximal in absence of a family history of affective disorder. This constellation holds true even if only families of index cases without any affective syndrome during lifetime are considered...
  101. ncbi request reprint The temporal lobe in schizophrenia from uni- and multiply affected families
    Peter Falkai
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 325:25-8. 2002
    ..Comparing subjects from uni- and multiply affected families may be a useful strategy to reduce variability for future studies of environmental interactions with genetic risk for schizophrenia...