Michael Bohm

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi Overview of the i-SEARCH Global Study : Cardiovascular Risk Factors and Microalbuminuria in Hypertensive Individuals
    Michael Bohm
    Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, 66421, Homburg, Saar, Germany
    High Blood Press Cardiovasc Prev 15:217-24. 2008
  2. ncbi Hotline update of clinical trials and registries presented at the German Cardiac Society Meeting 2009
    L S Maier
    Abt Kardiologie and Pneumologie Herzzentrum, Georg August Universitat Gottingen, Gottingen, Germany
    Clin Res Cardiol 98:413-9. 2009
  3. ncbi Patterns and predictors of statin prescription in patients with type 2 diabetes
    Heiner K Berthold
    Charite University Medicine Berlin, Virchow Clinic Campus, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany
    Cardiovasc Diabetol 8:25. 2009
  4. ncbi Biomarkers: optimizing treatment guidance in heart failure
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 100:973-81. 2011
  5. ncbi Treating to protect: current cardiovascular treatment approaches and remaining needs
    Michael Bohm
    Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg Saar, Germany
    Medscape J Med 10:S3. 2008
  6. ncbi Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH
    Michael Bohm
    Klinik für Innere Medizin III Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Homburg Saar, Germany
    J Hypertens 26:18-25. 2008
  7. ncbi Association of cardiovascular risk factors with microalbuminuria in hypertensive individuals: the i-SEARCH global study
    Michael Bohm
    Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Homburg, Saar, Germany
    J Hypertens 25:2317-24. 2007
  8. ncbi Angiotensin receptor blockers versus angiotensin-converting enzyme inhibitors: where do we stand now?
    Michael Bohm
    Department of Internal Medicine III, Cardiology Angiology and Intensive Cardiac Medicine, University of Saarland, Homburg Saar, Germany
    Am J Cardiol 100:38J-44J. 2007
  9. ncbi [Peace-study. Coronary heart disease: additive therapy with ACE-inhibitors?]
    M Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes
    Internist (Berl) 46:592-4. 2005
  10. ncbi Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Atherosclerosis 212:55-62. 2010

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi Overview of the i-SEARCH Global Study : Cardiovascular Risk Factors and Microalbuminuria in Hypertensive Individuals
    Michael Bohm
    Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, 66421, Homburg, Saar, Germany
    High Blood Press Cardiovasc Prev 15:217-24. 2008
    ..This article discusses the main results of the study and the potential implications of ongoing analyses included in the core clinical study programme...
  2. ncbi Hotline update of clinical trials and registries presented at the German Cardiac Society Meeting 2009
    L S Maier
    Abt Kardiologie and Pneumologie Herzzentrum, Georg August Universitat Gottingen, Gottingen, Germany
    Clin Res Cardiol 98:413-9. 2009
    ..in Clin Res Cardiol 96:457-468, 9; Maier et al. in Clin Res Cardiol 97:356-363, 3)...
  3. ncbi Patterns and predictors of statin prescription in patients with type 2 diabetes
    Heiner K Berthold
    Charite University Medicine Berlin, Virchow Clinic Campus, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany
    Cardiovasc Diabetol 8:25. 2009
    ..The aim of the study was to identify patient-related factors predicting statin prescription...
  4. ncbi Biomarkers: optimizing treatment guidance in heart failure
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 100:973-81. 2011
    ..Taken together the data indicate that biomarkers are evolving into a valuable addendum to the diagnostic and therapeutic armamentarium...
  5. ncbi Treating to protect: current cardiovascular treatment approaches and remaining needs
    Michael Bohm
    Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg Saar, Germany
    Medscape J Med 10:S3. 2008
    ..Educating patients, raising physicians' awareness, and implementing effective and safe treatment regimens are all necessary steps to bring about the much-needed improvements in cardiac health outcomes...
  6. ncbi Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH
    Michael Bohm
    Klinik für Innere Medizin III Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Homburg Saar, Germany
    J Hypertens 26:18-25. 2008
    ..In patients in sinus rhythm (n = 18 900) the relationship between increased heart rate and the prevalence of MAU was analysed...
  7. ncbi Association of cardiovascular risk factors with microalbuminuria in hypertensive individuals: the i-SEARCH global study
    Michael Bohm
    Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Homburg, Saar, Germany
    J Hypertens 25:2317-24. 2007
    ..A secondary objective was to establish a correlation between MAU and known cardiovascular risk factors...
  8. ncbi Angiotensin receptor blockers versus angiotensin-converting enzyme inhibitors: where do we stand now?
    Michael Bohm
    Department of Internal Medicine III, Cardiology Angiology and Intensive Cardiac Medicine, University of Saarland, Homburg Saar, Germany
    Am J Cardiol 100:38J-44J. 2007
    ....
  9. ncbi [Peace-study. Coronary heart disease: additive therapy with ACE-inhibitors?]
    M Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes
    Internist (Berl) 46:592-4. 2005
  10. ncbi Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Atherosclerosis 212:55-62. 2010
    ..To determine the effect of heart rate reduction with ivabradine on atherosclerotic lesions and erectile dysfunction...
  11. ncbi Improvement of endothelial function of the corpus cavernosum in apolipoprotein E knockout mice treated with irbesartan
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Pharmacol Exp Ther 327:692-8. 2008
    ..This result emphasizes the beneficial effect of inhibition of the renin-angiotensin system even in terms of erectile function...
  12. ncbi Role of Rac1 GTPase activation in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 50:359-67. 2007
    ..We aimed to study the role of Rac1 GTPase in atrial fibrillation (AF)...
  13. ncbi Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Hypertension 61:225-31. 2013
    ..Modulation of the autonomic nervous system by RDN might provide rate control and reduce susceptibility to AF. Whether RDN may provide rate control in a larger number of patients with AF deserves further clinical studies...
  14. ncbi Paclitaxel and sirolimus differentially affect growth and motility of endothelial progenitor cells and coronary artery smooth muscle cells
    Yvonne P Clever
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 7:K32-42. 2011
    ..This study investigates the time-dependent influence on growth and motility of paclitaxel and sirolimus alone and combined with the coating additive iopromide on EPC and hCASMC...
  15. ncbi Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Homburg Saar D 66421, Germany
    Cardiovasc Res 87:485-93. 2010
    ..The small GTPase Rac1 seems to play a role in the pathogenesis of atrial fibrillation (AF). The aim of the present study was to characterize the effects of Rac1 overexpression on atrial electrophysiology...
  16. ncbi Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Atherosclerosis 216:23-34. 2011
    ..PPAR-γ agonists may mediate vascular effects in addition to insulin sensitizing. We therefore examined whether pioglitazone regulates vascular telomere biology...
  17. ncbi Physical activity is inversely associated with microalbuminuria in hypertensive patients at high cardiovascular risk: data from I-SEARCH
    Janine Pöss
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Eur J Prev Cardiol 19:1066-73. 2012
    ..Physical activity improves endothelial function. This analysis aims to explore the impact of regular physical exercise on the prevalence and the degree of MAU in hypertensive individuals at high cardiovascular risk...
  18. ncbi Two year follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter
    Bruno Scheller
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Clin Res Cardiol 97:773-81. 2008
    ..We are presenting an extension of a previously published trial on the efficacy and safety of a paclitaxel-coated balloon in coronary ISR in a larger patient population and after a complete follow-up of 2 years...
  19. ncbi Long-term follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter
    Bruno Scheller
    Klinik fur Innere Medizin, III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    JACC Cardiovasc Interv 5:323-30. 2012
    ..This study presents long-term clinical follow-up, including binary restenosis rate and major adverse cardiovascular events, of the PACCOCATH-ISR (Treatment of In-Stent Restenosis by Paclitaxel Coated PTCA Balloons) I and II trial...
  20. ncbi Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE-/- mice
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 40, 66421 Homburg Saar, Germany
    Cardiovasc Res 90:484-92. 2011
    ..However, their effects on blood monocytes, endothelial function, atherogenesis, and sterol tissue concentrations are poorly understood...
  21. ncbi ACE inhibition promotes upregulation of endothelial progenitor cells and neoangiogenesis in cardiac pressure overload
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 83:106-14. 2009
    ..We hypothesized that ACE inhibitors may exert beneficial effects during pressure-induced myocardial hypertrophy by regulating progenitor cell function...
  22. ncbi Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Chem Phys Lipids 164:451-6. 2011
    ..The aim of the present study was to evaluate markers of cholesterol metabolism and determine their relationship with CVD in patients without diabetes mellitus who were not receiving statin treatment...
  23. ncbi Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 60:419-24. 2012
    ....
  24. ncbi Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:172-8. 2012
    ..Renal denervation displays antiarrhythmic effects by reducing NTP-induced AERP shortening and inhibits postapneic BP rises associated with obstructive events...
  25. ncbi Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Circulation 117:2377-87. 2008
    ..We hypothesized that selective heart rate reduction may influence endothelial function and atherogenesis and tested the effects of the I(f) current inhibitor ivabradine in apolipoprotein E-deficient mice...
  26. ncbi Drug-eluting balloon: very short-term exposure and overlapping
    Bodo Cremers
    University of Saarland, Homburg Saar, Department of Internal Medicine III, Germany
    Thromb Haemost 101:201-6. 2009
    ..DEB were found to effectively reduce neointimal proliferation regardless of inflation time and dose within the tested range. No adverse reactions were seen as dose was increased to more than three times the clinically tested dose...
  27. ncbi The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in mice
    Janine Pöss
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstr, 66421, Homburg, Saar, Germany
    Basic Res Cardiol 105:725-35. 2010
    ..Aliskiren increased number and function of PAC in mice and prevented atherosclerotic lesion formation. The effects were observed independent of blood pressure lowering...
  28. ncbi Alterations in cholesterol homeostasis are associated with coronary heart disease in patients with aortic stenosis
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Coron Artery Dis 20:376-82. 2009
    ..Therefore, the aim of this study was to investigate differences in cholesterol metabolism in relation to vascular diseases in this subset of patients...
  29. ncbi Aldosterone promotes atrial fibrillation
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, D 66421 Homburg Saar, Germany
    Eur Heart J 33:2098-108. 2012
    ..However, it is unclear whether this is the consequence of altered haemodynamics or a direct aldosterone effect. It was the aim of the study to demonstrate load-independent effects of aldosterone on atrial structure and electrophysiology...
  30. ncbi Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Circulation 120:2438-47. 2009
    ..This study examines the effects of exercising on vascular telomere biology and endothelial apoptosis in mice and the effects of long-term endurance training on telomere biology in humans...
  31. ncbi Heart rate reduction in cardiovascular disease and therapy
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg Saar, Germany
    Clin Res Cardiol 100:11-9. 2011
    ..Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy...
  32. ncbi Cardiorespiratory response to exercise after renal sympathetic denervation in patients with resistant hypertension
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 58:1176-82. 2011
    ..This study sought to investigate the effects of interventional renal sympathetic denervation (RD) on cardiorespiratory response to exercise...
  33. ncbi Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Mol Cell Cardiol 50:678-85. 2011
    ..In cardiac fibroblasts, Rac1 GTPase mediates upregulation of fibronectin via LOX and CTGF. Inhibition of this signaling pathway may therefore represent a target for the prevention of fibrotic atrial remodeling...
  34. ncbi Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Pharmacol Exp Ther 325:818-23. 2008
    ..These effects may be related to a reduction of ROS production, which is independent of heart rate reduction, because metoprolol did not increase endothelial function...
  35. ncbi Short- and long-term effects of a novel paclitaxel coated stent in the porcine coronary model
    Bruno Scheller
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 97:118-23. 2008
    ..The aim of the present animal studies was to evaluate the novel paclitaxel coated Coroflex. Please stent in the porcine coronary model...
  36. ncbi Microalbuminuria independently correlates to cardiovascular comorbidity burden in patients with hypertension
    Felix Mahfoud
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 101:761-6. 2012
    ..Microalbuminuria (MAU) is a marker for endothelial dysfunction and a predictor of cardiovascular events. Cardiovascular risk and mortality are mainly influenced by associated morbidities and risk factors...
  37. ncbi Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis
    Andrey Kazakov
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Cardiovasc Res 93:397-405. 2012
    ..We hypothesized that eNOS of the bone marrow (BM) affects cardiac remodelling during myocardial hypertrophy via the regulation of BM-derived vascular progenitor cells...
  38. ncbi Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Kirrbergerstraße, Homburg Saar, Germany
    Eur J Heart Fail 14:404-13. 2012
    ..Cognitive function and psychological co-morbidities are associated with hospitalization, disability, and mortality...
  39. ncbi Update on myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Strasse 1, Homburg Saar, Germany
    J Am Coll Cardiol 59:779-92. 2012
    ..Further investigations by controlled, randomized studies are needed to definitively determine their role in the treatment of myocarditis...
  40. ncbi Role of integrin-linked kinase for functional capacity of endothelial progenitor cells in patients with stable coronary artery disease
    Christian Werner
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 377:331-6. 2008
    ..Functionally, ILK is necessary and sufficient for SDF-1-triggered migration and adhesion in EPCs. These data extend current knowledge about the role of ILK in EPC biology and implicate ILK as a therapeutic target in CAD...
  41. ncbi The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance
    Christian Werner
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Diabetes 56:2609-15. 2007
    ..The effect represents a potential regenerative mechanism in atherosclerosis and is observed in normoglycemic individuals with stable coronary artery disease...
  42. ncbi Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarland, Homburg Saar, Germany
    J Am Coll Cardiol 55:469-80. 2010
    ..We studied the signal transduction of atrial structural remodeling that contributes to the pathogenesis of atrial fibrillation (AF)...
  43. ncbi Heart failure with normal left ventricular ejection fraction: what is the evidence?
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Trends Cardiovasc Med 18:280-92. 2008
    ..In contrast to heart failure with reduced ejection fraction, large-scale randomized controlled drug trials for HFNEF are scarce and could not demonstrate mortality reduction so far...
  44. ncbi Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    Ulrich Laufs
    Klinik fur Innere Medizin III, niversitätsklinikum des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 25:809-14. 2005
    ..The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase...
  45. ncbi Cardiomyocytes of noncardiac origin in myocardial biopsies of human transplanted hearts
    Patrick Muller
    Departments of Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 106:31-5. 2002
    ....
  46. ncbi Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, Homburg Saar, Germany
    Eur Heart J 33:1223-31. 2012
    ..Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth...
  47. ncbi Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy
    Stephanie I Bettink
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 397:208-13. 2010
    ..We conclude that in both SDF-1- and angiotensin II-triggered signaling, ILK is a central mediator of rac1-induced oxidative stress and myocardial hypertrophy...
  48. ncbi Rapid immunomodulation by rosuvastatin in patients with acute coronary syndrome
    Andreas Link
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421Homburg Saar, Germany
    Eur Heart J 27:2945-55. 2006
    ..It is unclear how rapidly the beneficial effects of statins occur in patients with ACS and whether these drug properties are related to lipid lowering...
  49. ncbi Prognostic electrocardiographic parameters in patients with suspected myocarditis
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstraße, 66421 Homburg Saar, Germany
    Eur J Heart Fail 13:398-405. 2011
    ..The objective of this study was to investigate the prognostic value of electrocardiographic (ECG) parameters for outcome in patients acutely admitted with myocarditis without previous heart failure who underwent endomyocardial biopsy...
  50. ncbi Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study
    Felix Mahfoud
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 123:1940-6. 2011
    ..We investigated the effect of catheter-based renal sympathetic denervation on glucose metabolism and blood pressure control in patients with resistant hypertension...
  51. ncbi Relationship between cholesterol synthesis and intestinal absorption is associated with cardiovascular risk
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 40, D 66421 Homburg Saar, Germany
    Atherosclerosis 210:362-5. 2010
    ..Therefore, prospective clinical trials are needed to evaluate whether subjects with altered cholesterol homeostasis may benefit from treatment strategies that reduce cholesterol absorption in addition to statin treatment...
  52. ncbi RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection
    Christian Werner
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 97:418-31. 2008
    ....
  53. ncbi Virus serology in patients with suspected myocarditis: utility or futility?
    Felix Mahfoud
    Klinik fur Innere Medizin III, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse 1, Homburg Saar, Germany
    Eur Heart J 32:897-903. 2011
    ..We determined prospectively the diagnostic value of virus serology in comparison with endomyocardial biopsy (EMB) including viral genome detection and immunohistochemistry in patients with clinically suspected myocarditis...
  54. ncbi Procollagen propeptides: serum markers for atrial fibrosis?
    Hans Ruprecht Neuberger
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:655-61. 2012
    ..During collagen synthesis and degradation, collagen propeptides and telopeptides are released into the blood. This study tested the hypothesis that serum markers of collagen turnover correlate with atrial fibrosis...
  55. ncbi The effects of direct thrombin inhibition with dabigatran on plaque formation and endothelial function in apolipoprotein e-deficient mice
    Illkyu O Lee
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Pharmacol Exp Ther 343:253-7. 2012
    ..Interference with the coagulation system might provide a therapeutic target to modify atherosclerotic disease progression...
  56. ncbi Images in cardiovascular medicine. Cardiac imaging in isolated noncompaction of ventricular myocardium
    Magnus Baumhakel
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circulation 106:e16-7. 2002
  57. ncbi Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice
    Florian Custodis
    Kliniken für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Vasc Res 49:432-40. 2012
    ..Therefore, we characterized effects of heart rate reduction (HRR) by I(f) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein E-deficient (ApoE(-)/(-)) mice...
  58. ncbi Drug coated balloons in acute coronary syndromes--opportunities and limitations
    Bruno Scheller
    Clinical and Experimental Interventional Cardiology, Internal Medicine III, University Hospital of Saarland, Homburg Saar, Germany
    Curr Vasc Pharmacol 10:472-5. 2012
    ..Patients in hemodynamic critical situations under catecholamine therapy may present with too small vessel diameters. Another clinically relevant scenario represents in-stent restenosis (ISR) which is frequently associated with ACS...
  59. ncbi Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: data from EPHESUS
    Christian Ukena
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Card Fail 18:439-45. 2012
    ..The present analysis investigated the prognostic value of postadmission blood glucose (BG) concentration on clinical outcomes in high-risk patients with heart failure after acute myocardial infarction...
  60. ncbi Inhibition of neointimal hyperplasia with a novel zotarolimus coated balloon catheter
    Bodo Cremers
    Department of Internal Medicine III, University of Saarland, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:469-76. 2012
    ..Drug content of the vessel wall (n = 9) was measured about 10-30 min post intervention with ZCB in additional pigs...
  61. ncbi Addition of paclitaxel to contrast media prevents restenosis after coronary stent implantation
    Bruno Scheller
    Internal Medicine III Cardiology Angiology, University of Saarland, Homburg Saar, Germany
    J Am Coll Cardiol 42:1415-20. 2003
    ..The present study was designed to test the efficacy of paclitaxel added to the contrast agent iopromide in the prevention of restenosis...
  62. ncbi Beneficial association of β-blocker therapy on recovery from severe acute heart failure treatment: data from the Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support trial
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Crit Care Med 39:940-4. 2011
    ..The aim is to determine whether β-blocker use at study entry and/or at discharge has an impact on 31- and 180-day survival...
  63. ncbi Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtoler
    Michael Bohm
    Department of Cardiology, University of the Saarland, Saarbrucken, Germany
    Circulation 121:1439-46. 2010
    ....
  64. ncbi Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, 66424 Homburg Saar, Germany
    Stroke 42:1742-9. 2011
    ..Vascular effects of mental stress are only partially understood. Therefore, we studied effects of chronic stress and heart rate (HR) on endothelial function and cerebral ischemia...
  65. ncbi Myocardial regeneration by endogenous adult progenitor cells
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie and Internistische Intensivmedizin, Universitat des Saarlandes, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    J Mol Cell Cardiol 39:377-87. 2005
    ..This review critically discusses the recent findings in the field of endogenous adult progenitor cells and proposes new areas for future research...
  66. ncbi BEAUTIFUL results--the slower, the better?
    Jan Christian Reil
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, 66421 Homburg Saar, Germany
    Lancet 372:779-80. 2008
  67. ncbi Blood pressure and heart rate predict outcome in patients acutely admitted with suspected myocarditis without previous heart failure
    Felix Mahfoud
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Hypertens 30:1217-24. 2012
    ..The study investigated the prognostic impact of blood pressure and heart rate in patients acutely admitted with suspected myocarditis without previous heart failure who underwent endomyocardial biopsy...
  68. ncbi From evidence to rationale: cardiovascular protection by angiotensin II receptor blockers compared with angiotensin-converting enzyme inhibitors
    Michael Bohm
    Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg Saar, Germany
    Cardiology 117:163-73. 2010
    ....
  69. ncbi Long-term follow-up of early versus delayed invasive approach after fibrinolysis in acute myocardial infarction
    Yvonne P Clever
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circ Cardiovasc Interv 4:342-8. 2011
    ..The Southwest German Interventional Study in Acute Myocardial Infarction (SIAM III) evaluated the effects of transfer for early PCI in acute ST-elevation-myocardial infarction compared with a delayed PCI strategy...
  70. ncbi HMG-CoA reductase inhibitors in chronic heart failure: potential mechanisms of benefit and risk
    Ulrich Laufs
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Drugs 66:145-54. 2006
    ....
  71. ncbi Telmisartan prevents cardiovascular events in a broad group of at-risk patients
    Magnus Baumhakel
    University Hospital of the Saarland, Department of Cardiology, Homburg Saar, Germany
    Expert Opin Pharmacother 10:3113-7. 2009
    ..In these patients who are intolerant to ACE-Is or who do not achieve blood pressure control, the ARB with the best evidence for secondary prevention is telmisartan according to the results of the ONTARGET trial...
  72. ncbi Pressure-induced cardiac overload induces upregulation of endothelial and myocardial progenitor cells
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Cardiovasc Res 77:151-9. 2008
    ..Bone-marrow-derived progenitor cells have been shown to contribute to endothelial homeostasis, repair, and new blood vessel formation. We therefore studied the effects of pressure overload on angiogenesis and progenitor cells...
  73. ncbi Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy
    Florian Custodis
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 71:342-51. 2006
    ..NADPH oxidase is a major source of ROS production. The small GTPase Rac1 mediates the activation of NADPH oxidase; however, the mechanism of Rac1 activation is incompletely understood...
  74. ncbi Ischaemia-induced up-regulation of Toll-like receptor 2 in circulating monocytes in cardiogenic shock
    Simina Selejan
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Eur Heart J 33:1085-94. 2012
    ..To investigate the role of Toll-like receptor 2 (TLR2) in uncomplicated acute myocardial infarction (AMI) and in cardiogenic shock (CS)...
  75. ncbi Carvedilol but not metoprolol reduces beta-adrenergic responsiveness after complete elimination from plasma in vivo
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 109:3182-90. 2004
    ..Here, we determined the significance of this phenomenon on human beta-ARs in vitro and in vivo...
  76. ncbi Functional effects of β₁-adrenoceptor polymorphisms on the hemodynamic response to dobutamine with and without β-blocker administration
    Michael Kindermann
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg Saar, Germany
    Clin Res Cardiol 100:129-37. 2011
    ..The relevance of the Arg389Gly- and Ser49Gly-β₁-adrenoceptor (AR) polymorphisms for cardiovascular function and pharmacotherapy is controversial...
  77. ncbi Biventricular versus conventional right ventricular stimulation for patients with standard pacing indication and left ventricular dysfunction: the Homburg Biventricular Pacing Evaluation (HOBIPACE)
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 47:1927-37. 2006
    ....
  78. ncbi [Erectile dysfunction: indicator of end-organ damage in cardiovascular patients]
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421, Homburg Saar
    Med Klin (Munich) 104:309-13. 2009
    ..Furthermore, different trials suggest erectile function as a strong predictor of cardiovascular events like myocardial infarction or stroke...
  79. ncbi Paclitaxel balloon coating, a novel method for prevention and therapy of restenosis
    Bruno Scheller
    Department of Internal Medicine III Cardiology Angiology, University of Saarland, Homburg Saar, Germany
    Circulation 110:810-4. 2004
    ..The aim of the present study was to evaluate a novel method of local drug delivery based on angioplasty balloons...
  80. ncbi Treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter
    Bruno Scheller
    Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    N Engl J Med 355:2113-24. 2006
    ..Treatment of coronary in-stent restenosis is hampered by a high incidence of recurrent in-stent restenosis. We assessed the efficacy and safety of a paclitaxel-coated balloon in this setting...
  81. ncbi Hotline update of clinical trials and registries presented at the ACC and SCAI-ACCi2 meeting 2008 in Chicago
    Yvonne P Clever
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 97:409-17. 2008
    ..These comprehensive summaries should provide the readers with the most recent data on diagnostic and therapeutic developments in cardiovascular medicine...
  82. ncbi Renal sympathetic denervation for treatment of electrical storm: first-in-man experience
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:63-7. 2012
    ..Catheter-based renal sympathetic denervation (RDN) is a novel treatment option for patients with resistant hypertension, proved to reduce local and whole-body sympathetic activity...
  83. ncbi Heart-focused anxiety in the general population
    Denise Fischer
    Universitatsklinikum des Saarlandes, Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Strase, 66421, Homburg Saar, Germany
    Clin Res Cardiol 101:109-16. 2012
    ..Furthermore, we assessed the reliability of the CAQ and investigated the influence of social variables on heart-focused anxiety...
  84. ncbi Predictors of outcome in patients with suspected myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Circulation 118:639-48. 2008
    ..The objective of this study was to identify the prognostic indicators in patients with suspected myocarditis who underwent endomyocardial biopsy...
  85. ncbi Cardiological evaluation after cerebral ischaemia : Consensus statement of the Working Group Heart and Brain of the German Cardiac Society-Cardiovascular Research (DGK) and the German Stroke Society (DSG)
    Ulrich Laufs
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Germany
    Clin Res Cardiol 99:609-25. 2010
    ....
  86. ncbi Endogenous activation of mitochondrial KATP channels protects human failing myocardium from hydroxyl radical-induced stunning
    Christoph Maack
    Medizinische Klinik und Poliklinik, Innere Medizin III Kardiologie Angiologie, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circ Res 105:811-7. 2009
    ..Furthermore, although ATP-dependent K+ channels (K(ATP) channels) are implicated in myocardial protection during ischemia/reperfusion ("ischemic preconditioning"), their role in heart failure has hardly been elucidated...
  87. ncbi Sexual function, satisfaction, and association of erectile dysfunction with cardiovascular disease and risk factors in cardiovascular high-risk patients: substudy of the ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telm
    Michael Bohm
    Klinik für Innere Medizin III des Universitätsklinikum des Saarlandes, Saarland, Homburg, Germany
    Am Heart J 154:94-101. 2007
    ..The effects of treatment with telmisartan and ramipril, alone or in combination, including a telmisartan versus placebo arm will be determined prospectively during a follow-up of 4 years...
  88. ncbi Telmisartan inhibits beta2-integrin MAC-1 expression in human T-lymphocytes
    Andreas Link
    Klinik fur Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hypertens 24:1891-8. 2006
    ..Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are well known, the underlying mechanisms are poorly understood...
  89. ncbi Randomized comparison of anterolateral versus anteroposterior electrode position for biphasic external cardioversion of atrial fibrillation
    Stephanos Siaplaouras
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische, Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am Heart J 150:150-2. 2005
    ..This study compared anteroposterior (AP) vs anterolateral (AL) electrode positioning...
  90. ncbi Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Am J Cardiol 93:84-8. 2004
    ..Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation...
  91. ncbi Atrial fibrillation in heart failure: current treatment of patients with remodeled atria
    Hans Ruprecht Neuberger
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421, Homburg Saar, Germany
    Curr Heart Fail Rep 5:219-25. 2008
    ..Thus, prevention of AF entirely is an important goal. This review summarizes recent data concerning prognostic relevance, treatment, and means of primary and secondary prevention of AF in patients with CHF...
  92. ncbi Inhibitory effect of estrogen on Rac1-expression in monocytes
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, D 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 386:45-9. 2009
    ..In summary, the data show that down-regulation of Rac1-GTPase contributes to the inhibition of angiotensin II-mediated superoxide release by 17beta-estradiol in monocytes...
  93. ncbi Blocking interferon {beta} stimulates vascular smooth muscle cell proliferation and arteriogenesis
    Stephan H Schirmer
    Department of Cardiology, Saarland University Hospital, 66421 Homburg Saar, Germany
    J Biol Chem 285:34677-85. 2010
    ..Inhibition of IFNβ stimulates VSMC proliferation and collateral artery growth...
  94. ncbi Heart rate reduction by I(f)-channel inhibition and its potential role in heart failure with reduced and preserved ejection fraction
    Jan Christian Reil
    Klinik fur Innere Medizin III, University of the Saarland, Homburg Saar, Germany
    Trends Cardiovasc Med 19:152-7. 2009
    ....
  95. ncbi The PPAR-gamma agonist pioglitazone increases neoangiogenesis and prevents apoptosis of endothelial progenitor cells
    Christoph Gensch
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Atherosclerosis 192:67-74. 2007
    ..Pioglitazone prevents apoptosis of EPC in mice as well as in human EPC in a PI3K-dependent but NO-independent manner. Reduction of EPC apoptosis by TZD may be a potentially beneficial mechanism for patients with vascular diseases...
  96. ncbi Vascular pathophysiology in response to increased heart rate
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 56:1973-83. 2010
    ....
  97. ncbi Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Heart Rhythm 8:1436-43. 2011
    ..Obstructive sleep apnea (OSA) causes negative tracheal pressure (NTP) and is associated with atrial fibrillation (AF)...
  98. ncbi Optimal antagonism of the Renin-Angiotensin-aldosterone system: do we need dual or triple therapy?
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Drugs 70:1215-30. 2010
    ..Finally, novel pharmacological agents such as the direct renin inhibitor aliskiren may provide additional therapeutic tools, but their role has yet to be established...
  99. ncbi Blood pressure reduction with olmesartan in mild-to-moderate essential hypertension: a planned interim analysis of an open label sub-study in German patients
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Curr Med Res Opin 22:1375-80. 2006
    ....
  100. ncbi Contrast media as carriers for local drug delivery. Successful inhibition of neointimal proliferation in the porcine coronary stent model
    Bruno Scheller
    Internal Medicine III, University of Saarland, D 66421 Homburg Saar, Germany
    Eur Heart J 24:1462-7. 2003
    ..The aim of this study was to test a novel taxane-contrast agent formulation for this new approach in the setting of coronary stenting...
  101. ncbi ACE inhibition in secondary prevention: are the results controversial?
    Erik B Friedrich
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421 Homburg Saar, Germany
    Clin Res Cardiol 95:61-7. 2006
    ..Further studies are needed to try to resolve this issue. In the meantime, the overwhelming data still support the use of ACE inhibitors in patients with coronary artery disease with preserved left ventricular function...