Michael Bohm

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint Effect of bisoprolol on perioperative complications in chronic heart failure after surgery (Cardiac Insufficiency Bisoprolol Study II (CIBIS II))
    M Bohm
    Universitatskliniken des Saarlandes, Medizinische Klinik und Poliklinik, Innere Medizin III, 66421 Homburg Saar, Germany
    Z Kardiol 92:668-76. 2003
  2. ncbi request reprint Treatment of heart failure with beta-blockers. Mechanisms and results
    M Bohm
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, Homburg Saar, Germany
    Basic Res Cardiol 95:I15-24. 2000
  3. ncbi request reprint [Indications for renal angiography and for percutaneous transluminal renal artery dilatation: interdisciplinary consensus statement regarding renal artery stenosis]
    M Bohm
    Medizinische Universitätsklinik und Poliklinik, Innere Medizin III, Kardiologie, Universitatskliniken des Saarlandes, Homburg Saar
    Dtsch Med Wochenschr 128:150-6. 2003
  4. ncbi request reprint Does statin therapy influence steroid hormone synthesis?
    M Bohm
    Klinik fur Innere Medizin III, Universitatskliniken des Saarlandes, Kirrberger Strasse, 66421 Homburg, Germany
    Z Kardiol 93:43-8. 2004
  5. ncbi request reprint Sexual function, satisfaction, and association of erectile dysfunction with cardiovascular disease and risk factors in cardiovascular high-risk patients: substudy of the ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telm
    Michael Bohm
    Klinik für Innere Medizin III des Universitätsklinikum des Saarlandes, Saarland, Homburg, Germany
    Am Heart J 154:94-101. 2007
  6. ncbi request reprint [Drug treatment of chronic heart failure]
    M Bohm
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar
    Clin Res Cardiol 95:36-54; quiz 55-6. 2006
  7. ncbi request reprint Perspectives of I(f) inhibition by ivabradine in cardiology
    Michael Bohm
    Klinik für Innere Medizin III Kardiologie Angiologie Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Drugs 67:43-9. 2007
  8. ncbi request reprint Heart failure and statins--why do we need a clinical trial?
    M Bohm
    Klinik fur Innere Medizin III, Universitätsklinik des Saarlandes, Kirrberger Strasse, 66421 Homburg, Gemany
    Z Kardiol 94:223-30. 2005
  9. ncbi request reprint [ACE-inhibitor effects on the stabilization of coronary heart disease. EUROPA study]
    M Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum, Homburg Saar
    Internist (Berl) 45:1196-8. 2004
  10. ncbi request reprint Alcohol and red wine: impact on cardiovascular risk
    Michael Bohm
    Medizinische Universitätsklinik und Poliklinik, Innere Medizin III, Kardiologie Angiologie, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Nephrol Dial Transplant 19:11-6. 2004

Collaborators

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint Effect of bisoprolol on perioperative complications in chronic heart failure after surgery (Cardiac Insufficiency Bisoprolol Study II (CIBIS II))
    M Bohm
    Universitatskliniken des Saarlandes, Medizinische Klinik und Poliklinik, Innere Medizin III, 66421 Homburg Saar, Germany
    Z Kardiol 92:668-76. 2003
    ..Therefore, a controlled randomized trial with perioperative beta-blocker treatment in heart failure patients is warranted to further test this hypothesis...
  2. ncbi request reprint Treatment of heart failure with beta-blockers. Mechanisms and results
    M Bohm
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, Homburg Saar, Germany
    Basic Res Cardiol 95:I15-24. 2000
    ..The mechanism of beta-blocker effects in heart failure are cardiac protection from beta1-adrenoceptor overstimulation, antiarrhythmic effects, reduction in heart rate and positive energetic effects or a combination thereof...
  3. ncbi request reprint [Indications for renal angiography and for percutaneous transluminal renal artery dilatation: interdisciplinary consensus statement regarding renal artery stenosis]
    M Bohm
    Medizinische Universitätsklinik und Poliklinik, Innere Medizin III, Kardiologie, Universitatskliniken des Saarlandes, Homburg Saar
    Dtsch Med Wochenschr 128:150-6. 2003
  4. ncbi request reprint Does statin therapy influence steroid hormone synthesis?
    M Bohm
    Klinik fur Innere Medizin III, Universitatskliniken des Saarlandes, Kirrberger Strasse, 66421 Homburg, Germany
    Z Kardiol 93:43-8. 2004
    ..There was no compensatory change in FSH or LH. It is concluded that pravastatin does not alter steroid hormones or gonadotropins in a clinically applicable dose, which significantly reduces total and LDL cholesterol...
  5. ncbi request reprint Sexual function, satisfaction, and association of erectile dysfunction with cardiovascular disease and risk factors in cardiovascular high-risk patients: substudy of the ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telm
    Michael Bohm
    Klinik für Innere Medizin III des Universitätsklinikum des Saarlandes, Saarland, Homburg, Germany
    Am Heart J 154:94-101. 2007
    ..The effects of treatment with telmisartan and ramipril, alone or in combination, including a telmisartan versus placebo arm will be determined prospectively during a follow-up of 4 years...
  6. ncbi request reprint [Drug treatment of chronic heart failure]
    M Bohm
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar
    Clin Res Cardiol 95:36-54; quiz 55-6. 2006
    ..Treatment has to be adjusted to current guidelines. The state of the art of medical treatment of chronic heart failure is addressed in this report...
  7. ncbi request reprint Perspectives of I(f) inhibition by ivabradine in cardiology
    Michael Bohm
    Klinik für Innere Medizin III Kardiologie Angiologie Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Drugs 67:43-9. 2007
    ..Further clinical and mechanistic studies to clarify the pathophysiological background are needed to fully define the role of heart rate reduction in the broad spectrum of cardiovascular interventions...
  8. ncbi request reprint Heart failure and statins--why do we need a clinical trial?
    M Bohm
    Klinik fur Innere Medizin III, Universitätsklinik des Saarlandes, Kirrberger Strasse, 66421 Homburg, Gemany
    Z Kardiol 94:223-30. 2005
    ..Since there are no safety data on the use of statins in chronic heart failure, a controlled randomized and placebo-controlled trial is urgently needed...
  9. ncbi request reprint [ACE-inhibitor effects on the stabilization of coronary heart disease. EUROPA study]
    M Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum, Homburg Saar
    Internist (Berl) 45:1196-8. 2004
  10. ncbi request reprint Alcohol and red wine: impact on cardiovascular risk
    Michael Bohm
    Medizinische Universitätsklinik und Poliklinik, Innere Medizin III, Kardiologie Angiologie, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Nephrol Dial Transplant 19:11-6. 2004
  11. ncbi request reprint [The "French Paradox"--effects of alcohol, wine and wine polyphenols on the heart]
    M Bohm
    Medizinische Universitätsklinik und Poliklinik, Innere Medizin III, Kardiologie Angiologie, Homburg Saar, Germany
    Dtsch Med Wochenschr 127:2748-56. 2002
  12. ncbi request reprint [Pathophysiology of heart failure today]
    Michael Bohm
    Medizinische Universitätsklinik und Poliklinik, Innere Medizin III, Homburg Saar
    Herz 27:75-91. 2002
    ..Angiotensin II and norepinephrine induce programmed cell death (apoptosis) in myocardial cells, thereby contributing to the progression of left ventricular function to heart failure...
  13. ncbi request reprint Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Atherosclerosis 212:55-62. 2010
    ..To determine the effect of heart rate reduction with ivabradine on atherosclerotic lesions and erectile dysfunction...
  14. ncbi request reprint Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1567-72. 2002
    ..Despite the anticipated stem cell plasticity, the role of bone marrow-derived endothelial progenitor cells has not been clarified in vascular lesion development...
  15. ncbi request reprint Effects of renal sympathetic denervation on exercise blood pressure, heart rate, and capacity in patients with resistant hypertension
    Sebastian Ewen
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 63:839-45. 2014
    ..No changes were observed in the control group. In conclusion, renal denervation reduced blood pressure and heart rate during exercise, improved mean workload, and increased exercise time without impairing chronotropic competence. ..
  16. ncbi request reprint Rapid effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition on coronary endothelial function
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 93:e98-103. 2003
    ..Statin treatment improves endothelium-dependent coronary vasomotion within 24 hours in the absence of significant cholesterol reduction. The full text of this article is available online at http://www.circresaha.org...
  17. ncbi request reprint Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment
    Christoph Maack
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 108:1567-74. 2003
    ..Isoprenylation of rac1 can be inhibited by statin therapy. Thus, we examined ROS and rac1 in human failing myocardium and tested their regulation by statins in vivo...
  18. ncbi request reprint Role of Rac1 GTPase activation in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 50:359-67. 2007
    ..We aimed to study the role of Rac1 GTPase in atrial fibrillation (AF)...
  19. ncbi request reprint Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circulation 105:2083-91. 2002
    ..It has not been completely clarified whether selective estrogen receptor modulators (SERMs) such as raloxifene exert vasoprotective effects similar to those of estrogens...
  20. ncbi request reprint Identification of a novel redox-sensitive gene, Id3, which mediates angiotensin II-induced cell growth
    Cornelius Mueller
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg, Germany
    Circulation 105:2423-8. 2002
    ..Angiotensin II (Ang II) is one of the most potent inducers of oxidative stress in the vasculature. The molecular events involved in Ang II-induced proliferation of vascular smooth muscle cells (VSMCs) are only partially understood...
  21. ncbi request reprint Cellular antioxidant effects of atorvastatin in vitro and in vivo
    Sven Wassmann
    Medizinische Klinik und Poliklinik Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:300-5. 2002
    ..These effects of atorvastatin may contribute to the vasoprotective effects of statins...
  22. doi request reprint Improvement of endothelial function of the corpus cavernosum in apolipoprotein E knockout mice treated with irbesartan
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Pharmacol Exp Ther 327:692-8. 2008
    ..This result emphasizes the beneficial effect of inhibition of the renin-angiotensin system even in terms of erectile function...
  23. ncbi request reprint Effects of diuretic treatment on cardiac and circulating RAS in chronic heart failure post-myocardial infarction in rats
    Ute Seeland
    Innere Medizin III, Kardiologie und Angiologie, Med Klinik und Poliklinik der Universität des Saarlandes, 66421 Homburg Saar, Germany
    Eur J Heart Fail 5:241-6. 2003
    ..Heart failure is often treated with ACE inhibitors and diuretics although diuretic treatment could activate the renin-angiotensin system (RAS)...
  24. pmc Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Straße D 66421, Homburg Saar, Germany
    Eur Heart J 34:2839-49. 2013
    ..The aim of this study was to characterize myocardial function and ventricular-arterial coupling in a mouse model of diabetes and to analyse the effect of selective heart rate (HR) reduction by If-inhibition in this HFPEF-model...
  25. ncbi request reprint Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg, Germany
    Brain Res 942:23-30. 2002
    ..The effects are independent of changes in cholesterol levels and are equivalent or even superior to the protective effects by simvastatin and atorvastatin in this animal model...
  26. ncbi request reprint Effects of sildenafil (viagra) on human myocardial contractility, in vitro arrhythmias, and tension of internal mammaria arteries and saphenous veins
    Bodo Cremers
    Medizinische Klinik und Poliklinik, Innere Medizin III, Chirurgische Klinik und Poliklinik, Abteilung Thorax und Herz, Homburg, Germany
    J Cardiovasc Pharmacol 41:734-43. 2003
    ..4 +/- 10.1%, n = 4, P < 0.02) as well as in veins (73.5 +/- 6.3%, n = 6, P < 0.02). Sildenafil exerts potent vasodilatory actions but has no direct influence on human myocardial contractility or proarrhythmic effects in vitro...
  27. doi request reprint Ramipril and telmisartan exhibit differential effects in cardiac pressure overload-induced hypertrophy without an additional benefit of the combination of both drugs
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Cardiovasc Pharmacol Ther 18:87-93. 2013
    ..We aimed to characterize different cellular effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin 1 (AT1) receptor blockers (ARBs) as mono- or combination therapy in cardiac pressure overload. Methods and..
  28. doi request reprint Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Hypertension 61:225-31. 2013
    ..Modulation of the autonomic nervous system by RDN might provide rate control and reduce susceptibility to AF. Whether RDN may provide rate control in a larger number of patients with AF deserves further clinical studies...
  29. doi request reprint Long-term follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter
    Bruno Scheller
    Klinik fur Innere Medizin, III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    JACC Cardiovasc Interv 5:323-30. 2012
    ..This study presents long-term clinical follow-up, including binary restenosis rate and major adverse cardiovascular events, of the PACCOCATH-ISR (Treatment of In-Stent Restenosis by Paclitaxel Coated PTCA Balloons) I and II trial...
  30. doi request reprint Paclitaxel and sirolimus differentially affect growth and motility of endothelial progenitor cells and coronary artery smooth muscle cells
    Yvonne P Clever
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 7:K32-42. 2011
    ..This study investigates the time-dependent influence on growth and motility of paclitaxel and sirolimus alone and combined with the coating additive iopromide on EPC and hCASMC...
  31. ncbi request reprint [Update cardiology 2001/2002-part II. From unstable coronary syndrome to terminal heart failure]
    Roland Fries
    Medizinische Klinik und Poliklinik, Innere Medizin III Kardiologie Angiologie, Universitatskliniken des Saarlandes, Hamburg Saar
    Med Klin (Munich) 98:326-34. 2003
    ....
  32. doi request reprint ACE inhibition promotes upregulation of endothelial progenitor cells and neoangiogenesis in cardiac pressure overload
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 83:106-14. 2009
    ..We hypothesized that ACE inhibitors may exert beneficial effects during pressure-induced myocardial hypertrophy by regulating progenitor cell function...
  33. doi request reprint Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Circulation 120:2438-47. 2009
    ..This study examines the effects of exercising on vascular telomere biology and endothelial apoptosis in mice and the effects of long-term endurance training on telomere biology in humans...
  34. pmc Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE-/- mice
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 40, 66421 Homburg Saar, Germany
    Cardiovasc Res 90:484-92. 2011
    ..However, their effects on blood monocytes, endothelial function, atherogenesis, and sterol tissue concentrations are poorly understood...
  35. doi request reprint Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Atherosclerosis 216:23-34. 2011
    ..PPAR-γ agonists may mediate vascular effects in addition to insulin sensitizing. We therefore examined whether pioglitazone regulates vascular telomere biology...
  36. doi request reprint Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Homburg Saar D 66421, Germany
    Cardiovasc Res 87:485-93. 2010
    ..The small GTPase Rac1 seems to play a role in the pathogenesis of atrial fibrillation (AF). The aim of the present study was to characterize the effects of Rac1 overexpression on atrial electrophysiology...
  37. doi request reprint Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Hypertension 62:767-74. 2013
    ..However, the generation of atrial oxidative stress was not modulated. ..
  38. ncbi request reprint Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  39. ncbi request reprint Physical activity is inversely associated with microalbuminuria in hypertensive patients at high cardiovascular risk: data from I-SEARCH
    Janine Pöss
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Eur J Prev Cardiol 19:1066-73. 2012
    ..Physical activity improves endothelial function. This analysis aims to explore the impact of regular physical exercise on the prevalence and the degree of MAU in hypertensive individuals at high cardiovascular risk...
  40. doi request reprint Two year follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter
    Bruno Scheller
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Clin Res Cardiol 97:773-81. 2008
    ..We are presenting an extension of a previously published trial on the efficacy and safety of a paclitaxel-coated balloon in coronary ISR in a larger patient population and after a complete follow-up of 2 years...
  41. doi request reprint Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:172-8. 2012
    ..Renal denervation displays antiarrhythmic effects by reducing NTP-induced AERP shortening and inhibits postapneic BP rises associated with obstructive events...
  42. ncbi request reprint Drug-eluting balloon: very short-term exposure and overlapping
    Bodo Cremers
    University of Saarland, Homburg Saar, Department of Internal Medicine III, Germany
    Thromb Haemost 101:201-6. 2009
    ..DEB were found to effectively reduce neointimal proliferation regardless of inflation time and dose within the tested range. No adverse reactions were seen as dose was increased to more than three times the clinically tested dose...
  43. ncbi request reprint Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Chem Phys Lipids 164:451-6. 2011
    ..The aim of the present study was to evaluate markers of cholesterol metabolism and determine their relationship with CVD in patients without diabetes mellitus who were not receiving statin treatment...
  44. ncbi request reprint Response and non-response to renal denervation: who is the ideal candidate?
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 9:R54-7. 2013
    ..In order to ensure treatment success further criteria have to be fulfilled, such as exclusion of secondary hypertension and optimised medical therapy...
  45. doi request reprint Expanding the indication spectrum: renal denervation in diabetes
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 9:R117-21. 2013
    ..This review highlights the background of approaching the renal sympathetic nerves as a potential new therapeutic option to improve glycaemic control in patients with resistant hypertension...
  46. doi request reprint Therapeutic potential of renal sympathetic denervation in patients with chronic heart failure
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    EuroIntervention 9:R122-6. 2013
    ....
  47. ncbi request reprint Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation
    Kerstin Strehlow
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, 66421 Homburg Saar, Germany
    Circulation 107:3059-65. 2003
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to positively influence endothelialization, vascular repair, and angiogenesis...
  48. ncbi request reprint Modulation of antioxidant enzyme expression and function by estrogen
    Kerstin Strehlow
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circ Res 93:170-7. 2003
    ..Estrogen acts antioxidative at least to some extent via stimulation of MnSOD and ecSOD expression and activity, which may contribute to its vasoprotective effects...
  49. doi request reprint Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 60:419-24. 2012
    ....
  50. ncbi request reprint Contrast media as carriers for local drug delivery. Successful inhibition of neointimal proliferation in the porcine coronary stent model
    Bruno Scheller
    Internal Medicine III, University of Saarland, D 66421 Homburg Saar, Germany
    Eur Heart J 24:1462-7. 2003
    ..The aim of this study was to test a novel taxane-contrast agent formulation for this new approach in the setting of coronary stenting...
  51. doi request reprint The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in mice
    Janine Pöss
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstr, 66421, Homburg, Saar, Germany
    Basic Res Cardiol 105:725-35. 2010
    ..Aliskiren increased number and function of PAC in mice and prevented atherosclerotic lesion formation. The effects were observed independent of blood pressure lowering...
  52. doi request reprint Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Mol Cell Cardiol 50:678-85. 2011
    ..In cardiac fibroblasts, Rac1 GTPase mediates upregulation of fibronectin via LOX and CTGF. Inhibition of this signaling pathway may therefore represent a target for the prevention of fibrotic atrial remodeling...
  53. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance
    Christian Werner
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Diabetes 56:2609-15. 2007
    ..The effect represents a potential regenerative mechanism in atherosclerosis and is observed in normoglycemic individuals with stable coronary artery disease...
  54. ncbi request reprint Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Circulation 117:2377-87. 2008
    ..We hypothesized that selective heart rate reduction may influence endothelial function and atherogenesis and tested the effects of the I(f) current inhibitor ivabradine in apolipoprotein E-deficient mice...
  55. doi request reprint Alterations in cholesterol homeostasis are associated with coronary heart disease in patients with aortic stenosis
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Coron Artery Dis 20:376-82. 2009
    ..Therefore, the aim of this study was to investigate differences in cholesterol metabolism in relation to vascular diseases in this subset of patients...
  56. ncbi request reprint Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    Ulrich Laufs
    Klinik fur Innere Medizin III, niversitätsklinikum des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 25:809-14. 2005
    ..The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase...
  57. ncbi request reprint Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH
    Michael Bohm
    Klinik für Innere Medizin III Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Homburg Saar, Germany
    J Hypertens 26:18-25. 2008
    ..In patients in sinus rhythm (n = 18 900) the relationship between increased heart rate and the prevalence of MAU was analysed...
  58. ncbi request reprint AT1 receptor antagonism improves endothelial dysfunction in postmenopausal women
    Kerstin Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Maturitas 53:176-83. 2006
    ..AT1 receptor antagonism improves vascular function in postmenopausal women without HRT. Thus, AT1 receptor blockade may resemble an efficient approach for the prevention of vascular dysfunction in estrogen-deficient women...
  59. doi request reprint Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, 66424, Homburg Saar, Germany
    Clin Res Cardiol 102:11-22. 2013
    ..A cut-off value of ≥75 bpm was chosen by the EMEA for approval for the use of ivabradine in chronic heart failure...
  60. doi request reprint Aldosterone promotes atrial fibrillation
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, D 66421 Homburg Saar, Germany
    Eur Heart J 33:2098-108. 2012
    ..However, it is unclear whether this is the consequence of altered haemodynamics or a direct aldosterone effect. It was the aim of the study to demonstrate load-independent effects of aldosterone on atrial structure and electrophysiology...
  61. doi request reprint Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Kirrbergerstraße, Homburg Saar, Germany
    Eur J Heart Fail 14:404-13. 2012
    ..Cognitive function and psychological co-morbidities are associated with hospitalization, disability, and mortality...
  62. doi request reprint Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    J Pharmacol Exp Ther 325:818-23. 2008
    ..These effects may be related to a reduction of ROS production, which is independent of heart rate reduction, because metoprolol did not increase endothelial function...
  63. ncbi request reprint Short- and long-term effects of a novel paclitaxel coated stent in the porcine coronary model
    Bruno Scheller
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 97:118-23. 2008
    ..The aim of the present animal studies was to evaluate the novel paclitaxel coated Coroflex. Please stent in the porcine coronary model...
  64. ncbi request reprint Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 94:534-41. 2004
    ..This interaction of the proinflammatory cytokine IL-6 with the renin-angiotensin system may represent an important pathogenetic mechanism in the atherosclerotic process...
  65. doi request reprint Cardiorespiratory response to exercise after renal sympathetic denervation in patients with resistant hypertension
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 58:1176-82. 2011
    ..This study sought to investigate the effects of interventional renal sympathetic denervation (RD) on cardiorespiratory response to exercise...
  66. doi request reprint Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarland, Homburg Saar, Germany
    J Am Coll Cardiol 55:469-80. 2010
    ..We studied the signal transduction of atrial structural remodeling that contributes to the pathogenesis of atrial fibrillation (AF)...
  67. doi request reprint Heart rate reduction in cardiovascular disease and therapy
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg Saar, Germany
    Clin Res Cardiol 100:11-9. 2011
    ..Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy...
  68. doi request reprint Hot topics in cardiology: data from IABP-SHOCK II, TRILOGY-ACS, WOEST, ALTIDUDE, FAME II and more
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421 Homburg Saar, Germany
    Clin Res Cardiol 101:861-74. 2012
    ..in Clin Res Cardiol 100:955-971, 2011; Schirmer et al. in Clin Res Cardiol 98:691-699, 2009)...
  69. ncbi request reprint Microalbuminuria independently correlates to cardiovascular comorbidity burden in patients with hypertension
    Felix Mahfoud
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 101:761-6. 2012
    ..Microalbuminuria (MAU) is a marker for endothelial dysfunction and a predictor of cardiovascular events. Cardiovascular risk and mortality are mainly influenced by associated morbidities and risk factors...
  70. ncbi request reprint Cardiomyocytes of noncardiac origin in myocardial biopsies of human transplanted hearts
    Patrick Muller
    Departments of Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 106:31-5. 2002
    ....
  71. doi request reprint Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis
    Andrey Kazakov
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Cardiovasc Res 93:397-405. 2012
    ..We hypothesized that eNOS of the bone marrow (BM) affects cardiac remodelling during myocardial hypertrophy via the regulation of BM-derived vascular progenitor cells...
  72. doi request reprint Update on myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Strasse 1, Homburg Saar, Germany
    J Am Coll Cardiol 59:779-92. 2012
    ..Further investigations by controlled, randomized studies are needed to definitively determine their role in the treatment of myocarditis...
  73. doi request reprint Heart failure with normal left ventricular ejection fraction: what is the evidence?
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Trends Cardiovasc Med 18:280-92. 2008
    ..In contrast to heart failure with reduced ejection fraction, large-scale randomized controlled drug trials for HFNEF are scarce and could not demonstrate mortality reduction so far...
  74. doi request reprint Role of integrin-linked kinase for functional capacity of endothelial progenitor cells in patients with stable coronary artery disease
    Christian Werner
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 377:331-6. 2008
    ..Functionally, ILK is necessary and sufficient for SDF-1-triggered migration and adhesion in EPCs. These data extend current knowledge about the role of ILK in EPC biology and implicate ILK as a therapeutic target in CAD...
  75. doi request reprint RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection
    Christian Werner
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Res Cardiol 97:418-31. 2008
    ....
  76. ncbi request reprint Telmisartan inhibits beta2-integrin MAC-1 expression in human T-lymphocytes
    Andreas Link
    Klinik fur Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hypertens 24:1891-8. 2006
    ..Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are well known, the underlying mechanisms are poorly understood...
  77. ncbi request reprint Rapid immunomodulation by rosuvastatin in patients with acute coronary syndrome
    Andreas Link
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421Homburg Saar, Germany
    Eur Heart J 27:2945-55. 2006
    ..It is unclear how rapidly the beneficial effects of statins occur in patients with ACS and whether these drug properties are related to lipid lowering...
  78. ncbi request reprint Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy
    Florian Custodis
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 71:342-51. 2006
    ..NADPH oxidase is a major source of ROS production. The small GTPase Rac1 mediates the activation of NADPH oxidase; however, the mechanism of Rac1 activation is incompletely understood...
  79. ncbi request reprint Biventricular versus conventional right ventricular stimulation for patients with standard pacing indication and left ventricular dysfunction: the Homburg Biventricular Pacing Evaluation (HOBIPACE)
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 47:1927-37. 2006
    ....
  80. ncbi request reprint Images in cardiovascular medicine. Cardiac imaging in isolated noncompaction of ventricular myocardium
    Magnus Baumhakel
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circulation 106:e16-7. 2002
  81. doi request reprint Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, Homburg Saar, Germany
    Eur Heart J 33:1223-31. 2012
    ..Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth...
  82. doi request reprint Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy
    Stephanie I Bettink
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 397:208-13. 2010
    ..We conclude that in both SDF-1- and angiotensin II-triggered signaling, ILK is a central mediator of rac1-induced oxidative stress and myocardial hypertrophy...
  83. doi request reprint Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study
    Felix Mahfoud
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 123:1940-6. 2011
    ..We investigated the effect of catheter-based renal sympathetic denervation on glucose metabolism and blood pressure control in patients with resistant hypertension...
  84. ncbi request reprint Relationship between cholesterol synthesis and intestinal absorption is associated with cardiovascular risk
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 40, D 66421 Homburg Saar, Germany
    Atherosclerosis 210:362-5. 2010
    ..Therefore, prospective clinical trials are needed to evaluate whether subjects with altered cholesterol homeostasis may benefit from treatment strategies that reduce cholesterol absorption in addition to statin treatment...
  85. doi request reprint Beneficial association of β-blocker therapy on recovery from severe acute heart failure treatment: data from the Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support trial
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Crit Care Med 39:940-4. 2011
    ..The aim is to determine whether β-blocker use at study entry and/or at discharge has an impact on 31- and 180-day survival...
  86. doi request reprint Virus serology in patients with suspected myocarditis: utility or futility?
    Felix Mahfoud
    Klinik fur Innere Medizin III, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse 1, Homburg Saar, Germany
    Eur Heart J 32:897-903. 2011
    ..We determined prospectively the diagnostic value of virus serology in comparison with endomyocardial biopsy (EMB) including viral genome detection and immunohistochemistry in patients with clinically suspected myocarditis...
  87. ncbi request reprint The cardiac effects of prolonged vitamin B12 and folate deficiency in rats
    Omid Taban-Shomal
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, 66421 Homburg Saar, Germany
    Cardiovasc Toxicol 9:95-102. 2009
    ..05), and tissue HCY (Co vs VitDef: 0.13 +/- 0.07 vs 0.07 +/- 0.04 micromol/g protein, P < 0.05) were lower in VitDef animals. Folate and vitamin B12 deficiency do not affect cardiac function and morphology...
  88. doi request reprint Atrial fibrillation and heart rate independently correlate to microalbuminuria in hypertensive patients
    Michael Bohm
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitat des Saarlandes, Kirrberger Strasse, 66424 Homburg Saar, Germany
    Eur Heart J 30:1364-71. 2009
    ..To investigate the relationship between microalbuminuria (MAU) and atrial fibrillation (AF) and to further evaluate whether the heart rate dependency of MAU in patients without AF is maintained in patients with a history of AF...
  89. doi request reprint Prognostic electrocardiographic parameters in patients with suspected myocarditis
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstraße, 66421 Homburg Saar, Germany
    Eur J Heart Fail 13:398-405. 2011
    ..The objective of this study was to investigate the prognostic value of electrocardiographic (ECG) parameters for outcome in patients acutely admitted with myocarditis without previous heart failure who underwent endomyocardial biopsy...
  90. ncbi request reprint Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction
    Bruno Scheller
    Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 42:634-41. 2003
    ..The Southwest German Interventional Study in Acute Myocardial Infarction (SIAM III) investigated potentially beneficial effects of immediate stenting after thrombolysis as opposed to a more conservative treatment regimen...
  91. ncbi request reprint Predictors of outcome in patients with suspected myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Circulation 118:639-48. 2008
    ..The objective of this study was to identify the prognostic indicators in patients with suspected myocarditis who underwent endomyocardial biopsy...
  92. ncbi request reprint Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg, Germany
    Eur J Cardiovasc Prev Rehabil 12:407-14. 2005
    ..Exercise is a central component of the primary prevention of vascular diseases. The effect of physical activity on circulating EPC in healthy individuals is not known...
  93. ncbi request reprint HMG-CoA reductase inhibitors in chronic heart failure: potential mechanisms of benefit and risk
    Ulrich Laufs
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Drugs 66:145-54. 2006
    ....
  94. ncbi request reprint Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Am J Cardiol 93:84-8. 2004
    ..Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation...
  95. ncbi request reprint [From risk factors to symptomatic coronary artery disease. Update cardiology 2001/2002--part I]
    Roland Fries
    Medizinische Klinik und Poliklinik, Innere Medizin III, Kardiologie Angiologie, Universitatskliniken des Saarlandes, Hamburg Saar
    Med Klin (Munich) 98:218-25. 2003
    ....
  96. doi request reprint Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, 66424 Homburg Saar, Germany
    Stroke 42:1742-9. 2011
    ..Vascular effects of mental stress are only partially understood. Therefore, we studied effects of chronic stress and heart rate (HR) on endothelial function and cerebral ischemia...
  97. ncbi request reprint Carvedilol but not metoprolol reduces beta-adrenergic responsiveness after complete elimination from plasma in vivo
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 109:3182-90. 2004
    ..Here, we determined the significance of this phenomenon on human beta-ARs in vitro and in vivo...
  98. ncbi request reprint Endogenous activation of mitochondrial KATP channels protects human failing myocardium from hydroxyl radical-induced stunning
    Christoph Maack
    Medizinische Klinik und Poliklinik, Innere Medizin III Kardiologie Angiologie, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circ Res 105:811-7. 2009
    ..Furthermore, although ATP-dependent K+ channels (K(ATP) channels) are implicated in myocardial protection during ischemia/reperfusion ("ischemic preconditioning"), their role in heart failure has hardly been elucidated...
  99. pmc Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock
    Andreas Link
    Klinik fur Innere Medizin III, Universitat des Saarlandes, 66421 Homburg Saar, Germany
    Crit Care 12:R159. 2008
    ....
  100. ncbi request reprint Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor
    Christoph Maack
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 108:348-53. 2003
    ....
  101. ncbi request reprint Addition of paclitaxel to contrast media prevents restenosis after coronary stent implantation
    Bruno Scheller
    Internal Medicine III Cardiology Angiology, University of Saarland, Homburg Saar, Germany
    J Am Coll Cardiol 42:1415-20. 2003
    ..The present study was designed to test the efficacy of paclitaxel added to the contrast agent iopromide in the prevention of restenosis...