Research Topics
Species | Christina BackesSummaryAffiliation: Saarland University Country: Germany Publications
| Collaborators
|
Detail Information
Publications
GeneTrail--advanced gene set enrichment analysisChristina Backes
Center for Bioinformatics, Saarland University, Building E1 1, 66041 Saarbrucken, Germany
Nucleic Acids Res 35:W186-92. 2007..GeneTrail is freely accessible at http://genetrail.bioinf.uni-sb.de...- Computation of significance scores of unweighted Gene Set Enrichment AnalysesAndreas Keller
Center for Bioinformatics, Saarland University, Building E1 1, 66804 Saarbrücken, Germany
BMC Bioinformatics 8:290. 2007..To test our algorithm, we applied it not only to simulated data sets, but additionally evaluated expression profiles of squamous cell lung cancer tissue and autologous unaffected tissue... - An integer linear programming approach for finding deregulated subgraphs in regulatory networksChristina Backes
Department of Human Genetics, Saarland University, 66421 Homburg Saar, Germany
Nucleic Acids Res 40:e43. 2012..In summary, our approach opens new avenues for the elucidation of pathogenic mechanisms and for the detection of molecular key players... - Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thalianaMara Schuler
Dept of Biosciences Botany, Campus A2, 4 Saarland University, D 66123 Saarbrucken, Germany
BMC Plant Biol 11:87. 2011..Additionally, GeneTrail offers a feature that allows screening of individually defined biological categories that are relevant for the respective research topic... - Immunogenicity of autoantigensChristina Backes
Center for Bioinformatics, Saarland University, 66041 Saarbrucken, Germany
BMC Genomics 12:340. 2011..To this end, we have carried out the most comprehensive in-silicio study of different groups of autoantigens including large antigen sets identified by our groups combined with publicly available antigen sets... 
Genome wide expression profiling identifies specific deregulated pathways in meningiomaAndreas Keller
Center for Bioinformatics, Saarland University, Building E 1 1, Saarbrücken 66041, Germany
Int J Cancer 124:346-51. 2009..0001). Pathways with increased expression included several metabolic pathways. Extended expression profiling by a novel statistical gene set enrichment identified pathways that have previously not been associated with meningioma...- BNDB - the Biochemical Network DatabaseJan Küntzer
Center for Bioinformatics, Saarland University, 66041 Saarbrucken, Germany
BMC Bioinformatics 8:367. 2007..The standardization and virtual consolidation of the databases is a major challenge resulting in a unified access to a variety of data sources... - GeneTrailExpress: a web-based pipeline for the statistical evaluation of microarray experimentsAndreas Keller
Center for Bioinformatics, Saarland University, Saarbrucken, Germany
BMC Bioinformatics 9:552. 2008..While a variety of tools for normalizing, analysing, or visualizing expression profiles has been developed in the last years, most of these tools offer only functionality for accomplishing certain steps of the evaluation pipeline... - A novel algorithm for detecting differentially regulated paths based on gene set enrichment analysisAndreas Keller
Center for Bioinformatics, Saarland University, Building E 1 1, Saarbrucken, Germany
Bioinformatics 25:2787-94. 2009.... - MicroRNA expression changes after lung cancer resection: a follow-up studyPetra Leidinger
Institute of Human Genetics, Saarland University, Medical School, Homburg, Germany
RNA Biol 9:900-10. 2012..Our data underline the importance of studies that follow the fate of miRNAs over time, both to further our understanding of the biology of miRNA signatures and to establish these signatures as biomarkers... - Is there a general autoantibody signature for cancer?Nicole Ludwig
Department of Human Genetics, Medical School, Saarland University, Building 60, 66421 Homburg Saar, Germany
Eur J Cancer 48:2451-61. 2012..Here we address the question whether cancer specific signatures exist... - miRTrail--a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseasesCedric Laczny
Center for Bioinformatics, Saarland University, Campus E2 1, 66041 Saarbrucken, Germany
BMC Bioinformatics 13:36. 2012..To understand the regulatory processes of miRNAs on genes, integrative computer-aided approaches are essential, especially in the light of complex human diseases as cancer... - GAS41 amplification results in overexpression of a new spindle pole proteinJana Schmitt
Department of Human Genetics, Saarland University, Medical School, Homburg, Germany
Genes Chromosomes Cancer 51:868-80. 2012..We propose that GAS41 amplification may have an effect on the highly altered karyotype of glioblastoma via its role during spindle pole formation... 
Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycinYasser A Elnakady
Department of Pharmaceutical Biotechnology, Saarland University, P O Box 151150, 66041 Saarbrucken, Germany
Chembiochem 8:1261-72. 2007..This study therefore provides evidence that kendomycin mediates its cytotoxic effects, at least in part, through proteasome inhibition...- A dictionary on microRNAs and their putative target pathwaysChristina Backes
Center for Bioinformatics, Saarland University, Germany
Nucleic Acids Res 38:4476-86. 2010..Our target pathways analysis provides a 'miRNA-target pathway' dictionary, which enables researchers to identify target pathways of differentially regulated miRNAs... - Treatment-independent miRNA signature in blood of wilms tumor patientsJana Schmitt
Department of Human Genetics, Saarland University, 66421 Homburg Saar, Germany
BMC Genomics 13:379. 2012..Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001... - Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairmentsMasood Abu-Halima
Department of Human Genetics, Saarland University, Homburg Saar, Germany Department of Obstetrics and Gynecology, IVF and Andrology Laboratory, Saarland University, Homburg Saar, Germany Electronic address
Fertil Steril 99:1249-1255.e16. 2013..To determine whether microRNAs are differentially expressed in men with normal versus impaired spermatogenesis, and to find a biomarker for accurate diagnosis of male infertility... - Integrative analysis of cancer-related data using CAPPierre Dönnes
Center for Bioinformatics, Saarland University, Saarbrucken, Germany
FASEB J 18:1465-7. 2004..CAP is freely available at the following web site: http://www.bioinf.uni-sb.de/CAP/... - Toward the blood-borne miRNome of human diseasesAndreas Keller
Biomarker Discovery Center, Heidelberg, Germany
Nat Methods 8:841-3. 2011..We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs... - Genome-wide gene amplification during differentiation of neural progenitor cells in vitroUlrike Fischer
Department of Human Genetics, Saarland University, Homburg Saar, Germany
PLoS ONE 7:e37422. 2012..Gene amplifications in normal human cells as physiological process has not been reported yet and may bear resemblance to developmental gene amplifications in amphibians and insects... - Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targetsNicole Comtesse
Department of Human Genetics, Medical School, University of Saarland, Building 60, 66421 Homburg Saar, Germany
Proc Natl Acad Sci U S A 102:9601-6. 2005..The frequent antibody response against specific antigens offers new diagnostic and therapeutic targets for meningioma. We developed a statistical learning method to differentiate sera of meningioma patients from sera of healthy donors... - New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencingAndreas Keller
Department of Human Genetics, Saarland University, 66421 Homburg, Saar, Germany
Nat Commun 3:698. 2012..Sequences corresponding to ~60% of the genome of Borrelia burgdorferi are indicative of the earliest human case of infection with the pathogen for Lyme borreliosis... - GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequencesChristina Backes
Department of Human Genetics Building 60 Medical School, University of Saarland, 66421 Homburg/Saar, Germany
Nucleic Acids Res 33:W208-13. 2005..We tested GraBCas on already known substrates and showed its usefulness for protein sequence analysis. GraBCas is available at http://wwwalt.med-rz.uniklinik-saarland.de/med_fak/humangenetik/software/index.html...