R Rossaint

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. pmc Management of bleeding following major trauma: a European guideline
    Donat R Spahn
    Department of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Crit Care 11:R17. 2007
  2. pmc Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials
    Sandro B Rizoli
    Department of Surgery and Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, M4N 3M5 Canada
    Crit Care 10:R178. 2006
  3. pmc Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial
    Yoram Kluger
    Department of Surgery, Rambam Medical Center, POB 9602, Haifa 31096, Israel
    Crit Care 11:R85. 2007
  4. pmc Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding
    Thomas Klitgaard
    Department of Biomodelling, Novo Nordisk A S, Maaloev, Denmark
    Crit Care 10:R104. 2006
  5. ncbi request reprint [Laudation for university professor Dr. med. Konrad Johannes Falke]
    R Rossaint
    Klinik fur Anasthesiologie, Rheinisch Westfälische Technische Hochschule Aachen
    Anaesthesist 53:762-4. 2004
  6. ncbi request reprint Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery
    Rolf Rossaint
    Department of Anesthesiology of the University Hospital, RWTH Aachen, Germany
    Anesthesiology 98:6-13. 2003
  7. ncbi request reprint Nonsurgical treatment of major bleeding
    Rolf Rossaint
    Department of Anesthesiology, Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Anesthesiol Clin 25:35-48, viii. 2007
  8. ncbi request reprint Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial
    S Rex
    Department of Anaesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 52:65-72. 2008
  9. ncbi request reprint External chest compressions using a mechanical feedback device : cross-over simulation study
    M Skorning
    Bereich Notfallmedizin, Klinik fur Anasthesiologie, Universitatsklinikum Aachen, RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Anaesthesist 60:717-22. 2011
  10. ncbi request reprint Coagulation assessment in healthy pigs undergoing single xenon anaesthesia and combinations with isoflurane and sevoflurane
    N A Horn
    Department of Anaesthesiology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelstrasse 30, 52074 Aachen, Germany
    Acta Anaesthesiol Scand 45:634-8. 2001

Detail Information

Publications140 found, 100 shown here

  1. pmc Management of bleeding following major trauma: a European guideline
    Donat R Spahn
    Department of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Crit Care 11:R17. 2007
    ..Evidence-based recommendations can be made with respect to many aspects of the acute management of the bleeding trauma patient, which when implemented may lead to improved patient outcomes...
  2. pmc Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials
    Sandro B Rizoli
    Department of Surgery and Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, M4N 3M5 Canada
    Crit Care 10:R178. 2006
    ....
  3. pmc Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial
    Yoram Kluger
    Department of Surgery, Rambam Medical Center, POB 9602, Haifa 31096, Israel
    Crit Care 11:R85. 2007
    ..We conducted a post hoc sub analysis of patients with TBI and severe blunt polytrauma enrolled into a prospective, international, double-blind, randomized, placebo-controlled study...
  4. pmc Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding
    Thomas Klitgaard
    Department of Biomodelling, Novo Nordisk A S, Maaloev, Denmark
    Crit Care 10:R104. 2006
    ..Recombinant activated factor VII (rFVIIa) has been used as adjunctive therapy in trauma patients with severe bleeding. However, its pharmacokinetics profile remains unknown...
  5. ncbi request reprint [Laudation for university professor Dr. med. Konrad Johannes Falke]
    R Rossaint
    Klinik fur Anasthesiologie, Rheinisch Westfälische Technische Hochschule Aachen
    Anaesthesist 53:762-4. 2004
  6. ncbi request reprint Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery
    Rolf Rossaint
    Department of Anesthesiology of the University Hospital, RWTH Aachen, Germany
    Anesthesiology 98:6-13. 2003
    ..The aim of this clinical multicenter trial was to test the hypothesis of whether recovery after xenon anesthesia is faster compared with an accepted, standardized anesthetic regimen and that it is as effective and safe...
  7. ncbi request reprint Nonsurgical treatment of major bleeding
    Rolf Rossaint
    Department of Anesthesiology, Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Anesthesiol Clin 25:35-48, viii. 2007
    ..If bleeding cannot be stopped by these measures, adjunctive use of fibrinogen or recombinant activated factor VII (rFVIIa) have the potential to correct systemic coagulopathy associated with massive blood loss and its management...
  8. ncbi request reprint Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial
    S Rex
    Department of Anaesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 52:65-72. 2008
    ..We therefore compared the effects of inhaled iloprost vs. intravenous standard therapy in cardiac surgical patients with chronic PHT...
  9. ncbi request reprint External chest compressions using a mechanical feedback device : cross-over simulation study
    M Skorning
    Bereich Notfallmedizin, Klinik fur Anasthesiologie, Universitatsklinikum Aachen, RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Anaesthesist 60:717-22. 2011
    ..The aim of this study was to examine if the use of a mechanical device providing visual feedback and audible assistance during ECC improves performance of healthcare professionals following minimal and simplified instructions...
  10. ncbi request reprint Coagulation assessment in healthy pigs undergoing single xenon anaesthesia and combinations with isoflurane and sevoflurane
    N A Horn
    Department of Anaesthesiology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelstrasse 30, 52074 Aachen, Germany
    Acta Anaesthesiol Scand 45:634-8. 2001
    ..This study was performed to clarify whether xenon or combinations of xenon with isoflurane or sevoflurane modify blood coagulation...
  11. doi request reprint Xenon and isoflurane improved biventricular function during right ventricular ischemia and reperfusion
    M Hein
    Department of Anesthesiology, University Hospital of Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 54:470-8. 2010
    ..Thus, xenon may be a superior treatment for the maintenance of global hemodynamics, especially during right ventricular ischemia, which is generally characterized by a high acute complication rate...
  12. doi request reprint Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model
    C Bleilevens
    Department of Anesthesiology, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Exp Brain Res 224:155-64. 2013
    ..Thus, anesthetic management as well as the grade of ischemia and reperfusion after transient MCAO demonstrated important effects on neurological injury...
  13. doi request reprint Xenon or propofol anaesthesia for patients at cardiovascular risk in non-cardiac surgery
    J H Baumert
    Klinik fur Anaesthesiologie, Universitaetsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Br J Anaesth 100:605-11. 2008
    ....
  14. ncbi request reprint Xenon does not affect human platelet function in vitro
    L W de Rossi
    Department of Anesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Anesth Analg 93:635-40. 2001
    ..These results demonstrate that xenon does not affect the unstimulated or agonist-induced platelet glycoprotein expression, activation of GPIIb/IIIa, or platelet-related hemostasis...
  15. doi request reprint Performance of cardiac output measurement derived from arterial pressure waveform analysis in patients requiring high-dose vasopressor therapy
    S Metzelder
    Department of Anaesthesiology, University Hospital of the RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Br J Anaesth 106:776-84. 2011
    ..We hypothesized that changes in vascular tone induced by high-dose vasopressor therapy affect the accuracy of APCO measurements independently of the FloTrac software version...
  16. ncbi request reprint Duodenal motility is not affected during duodenotomy in pigs
    J Schnoor
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen, Germany
    Acta Vet Hung 54:251-61. 2006
    ..6) seemed to be shortened as compared to pigs of the PEG group. In conclusion, simple laparotomy with duodenotomy did not affect the proximal duodenal motility activity measured by the impedance technique...
  17. doi request reprint aepEX monitor for the measurement of hypnotic depth in patients undergoing balanced xenon anaesthesia
    C Stoppe
    Department of Anaesthesiology, RWTH University Hospital, Pauwelsstr 30, D 52074 Aachen, Germany
    Br J Anaesth 108:80-8. 2012
    ..In the present study, we evaluate the alternative AEP-based auditory-evoked potential index (aepEX) for the measurement of hypnotic depth in patients undergoing general anaesthesia with xenon...
  18. doi request reprint [Stocked medications in emergency physician-based medical services in Germany. Reality and requirements according to guidelines]
    D Rörtgen
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany
    Anaesthesist 60:312-24. 2011
    ..Furthermore, a comparison of the inventory analysis of stored drugs was carried out with the requirements according to guidelines for selected tracer diagnoses...
  19. ncbi request reprint Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury
    R Dembinski
    Department of Anesthesiology, Universitaetsklinikum der RWTH Aachen, Germany
    Anesthesiology 94:461-7. 2001
    ..This study was performed to investigate a possible additive effect of prostacyclin and almitrine on pulmonary ventilation-perfusion (VA/Q) ratio in ALI compared with inhaled prostacyclin or intravenous almitrine alone...
  20. doi request reprint Feasibility and safety of xenon compared with sevoflurane anaesthesia in coronary surgical patients: a randomized controlled pilot study
    C Stoppe
    Department of Anesthesiology, RWTH University Hospital, Pauwelsstr 30, D 52074 Aachen, Germany
    Br J Anaesth 111:406-16. 2013
    ..Thus, the aims of this study were to investigate the feasibility and safety of balanced xenon anaesthesia in patients undergoing cardiac surgery and to gather pilot data for a future randomized multicentre study...
  21. ncbi request reprint Sevoflurane inhibits unstimulated and agonist-induced platelet antigen expression and platelet function in whole blood in vitro
    N A Horn
    Department of Anesthesiology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Anesthesiology 95:1220-5. 2001
    ..Previous studies have reported conflicting results about the effect of sevoflurane on platelet aggregation. To clarify this point, we investigated the effects of sevoflurane on platelet antigen expression and function in vitro...
  22. doi request reprint Xenon alters right ventricular function
    M Hein
    Department of Anesthesiology, University Hospital of Aken, Aachen, Germany
    Acta Anaesthesiol Scand 52:1056-63. 2008
    ..Therefore, we used an animal model to study the effects of xenon as a supplemental anesthetic on right ventricular function, especially right ventricular afterload...
  23. doi request reprint Anti-ischemic effects of inotropic agents in experimental right ventricular infarction
    M Hein
    Department of Anesthesiology, University Hospital of Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 53:941-8. 2009
    ..Therefore, we used a porcine model of RV ischemia and reperfusion (IR) injury to study the influence of milrinone, levosimendan and dobutamine on the extent and degree of myocardial injury...
  24. doi request reprint Establishment of a porcine right ventricular infarction model for cardioprotective actions of xenon and isoflurane
    M Hein
    Department of Anesthesiology, University Hospital of Aken, Aachen, Germany
    Acta Anaesthesiol Scand 52:1194-203. 2008
    ..Therefore, we used a porcine model of RV ischemia and reperfusion (IR) injury to study the influence of isoflurane and xenon on the extent and degree of myocardial injury...
  25. ncbi request reprint Cardiopulmonary effects of iloprost in experimental acute lung injury
    R Dembinski
    Dept of Anaesthesiology, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Eur Respir J 25:81-7. 2005
    ..However, inhaled iloprost improved gas exchange due to a decrease of pulmonary shunt as a long-term effect, possibly as a result of a reduction of lung oedema formation...
  26. ncbi request reprint Effects of the anesthetic gases xenon, halothane, and isoflurane on calcium and potassium currents in human atrial cardiomyocytes
    R Huneke
    Department of Anesthesiology, University Hospital Rheinisch Westfällische Technische Hochschule Aachen, Germany
    Anesthesiology 95:999-1006. 2001
    ..We investigated the effects of halothane, isoflurane, and xenon on calcium and potassium currents in human atrial myocytes to elucidate the cellular and molecular basis of their cardiac actions...
  27. doi request reprint [Dealing with massive bleeding and associated perioperative coagulopathy: recommendations for action of the German Society of Anaesthesiology and Intensive Care Medicine]
    O Grottke
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Anaesthesist 62:213-16, 218-20, 222-4. 2013
    ..This paper introduces a standardized algorithm for the treatment of patients with massive bleeding which was developed in consensus with the German Society of Anaesthesiology and Intensive Care Medicine (DGAI)...
  28. pmc Effects of propofol and fentanyl on duodenal motility activity in pigs
    J Schnoor
    Department of Anesthesiology, University Hospital Aachen, Aachen, Germany
    Can Vet J 46:995-1001. 2005
    ..In contrast, the duration of phase I was prolonged by propofol and propofol-fentanyl. In conclusion, either propofol or propofolfentanyl sedation shortens duodenal feeding patterns, as well as phase II of the migrating motor cycle...
  29. ncbi request reprint Autonomic cardiac control with xenon anaesthesia in patients at cardiovascular risk
    J H Baumert
    Klinik fuer Anaesthesiologie, Universitaetsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Br J Anaesth 98:722-7. 2007
    ..The cardiovascular stability found with xenon anaesthesia may be caused by absence of circulatory depression. Xenon may also act directly on autonomic cardiovascular control...
  30. doi request reprint Myocardial effects of local shock wave therapy in a Langendorff model
    M Becker
    Medical Clinic of Cardiology and Pulmonology, RWTH Aachen University Hospital, Pauwelstrasse 30, 52074 Aachen, Germany
    Ultrasonics 54:131-6. 2014
    ..Applying shock waves to the heart has been reported to stimulate the heart and alter cardiac function. We hypothesized that shock waves could be used to diagnose regional viability...
  31. doi request reprint A laboratory comparison of the performance of the buddy lite™ and enFlow™ fluid warmers
    C S Bruells
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany Department of Surgical Intensive and Intermediate Care, University Hospital of the RWTH Aachen, Aachen, Germany
    Anaesthesia 68:1161-4. 2013
    ..We conclude that both devices provide effective fluid warming at a low flow rate, although the heating capability of the buddy lite is limited at high flow rates...
  32. ncbi request reprint Effects of combined high-dose partial liquid ventilation and almitrine on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury
    A Sommerer
    Klinik fur Anasthesiologie, Universitatsklinikum, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Intensive Care Med 27:574-9. 2001
    ..To determine possible additive effects of combined high-dose partial liquid ventilation (PLV) and almitrine bismesylate (ALM) on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury (ALI)...
  33. doi request reprint Evaluation of bispectral index and auditory evoked potentials for hypnotic depth monitoring during balanced xenon anaesthesia compared with sevoflurane
    A V Fahlenkamp
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Br J Anaesth 105:334-41. 2010
    ..We investigated the performance of the bispectral index (BIS) and the composite A-line autoregressive index (cAAI) while comparing balanced xenon with sevoflurane anaesthesia...
  34. doi request reprint [EzPAP® therapy of postoperative hypoxemia in the recovery room : experiences with the new compact system of end-expiratory positive airway pressure]
    A D Rieg
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Anaesthesist 61:867-74. 2012
    ....
  35. doi request reprint Pumpless arterio-venous extracorporeal lung assist compared with veno-venous extracorporeal membrane oxygenation during experimental lung injury
    R Kopp
    Department of Intensive Care Medicine, University Hospital Aachen, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Br J Anaesth 108:745-53. 2012
    ....
  36. doi request reprint A comparison of waste gas concentrations during xenon or nitrous oxide anaesthesia
    M Coburn
    University Hospital Aachen, RWTH Aachen, Department of Anaesthesiology, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Eur J Anaesthesiol 25:748-51. 2008
    ..The aim of this study was to compare waste gas concentrations during xenon or nitrous oxide anaesthesia...
  37. ncbi request reprint Xenon: recent developments and future perspectives
    M Derwall
    Department of Anesthesiology, University Hospital Aachen, RWTH Aachen, Germany
    Minerva Anestesiol 75:37-45. 2009
    ..Future studies will have to prove whether the high costs of xenon administration might be outweighed by its ability to substantially reduce the sequelae of myocardial and cerebral ischemia...
  38. doi request reprint [Emergency mission documentation in simulated care. Video-based error analysis]
    S Bergrath
    Bereich Notfallmedizin, Lehrstuhl und Klinik für Anästhesiologie, Universitatsklinikum Aachen, Rheinisch Westfälische Technische Hochschule RWTH, Pauwelsstr 30, 52074 Aachen, Deutschland
    Anaesthesist 60:221-9. 2011
    ..The aim of this study was to examine documentation quality in physician staffed emergency medical services (EMS). This study compared simulated on-site care with the associated patient records written by EMS physicians...
  39. doi request reprint [Current developments in xenon research. Importance for anesthesia and intensive care medicine]
    A Brücken
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074 Aachen
    Anaesthesist 59:883-95. 2010
    ..As the high cost of xenon will probably preclude its wider use as a routine anesthetic, data from extensive tests in large numbers of high risk patients is needed to confirm its possible superiority in this setting...
  40. doi request reprint [Ventilation in acute respiratory distress. Lung-protective strategies]
    C S Bruells
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany
    Med Klin Intensivmed Notfmed 107:596-602. 2012
    ..This article reviews the pathophysiology of ARDS and ventilator-induced lung injury and presents current evidence-based strategies for ventilator settings in ARDS...
  41. ncbi request reprint Nitric oxide inhalation in pulmonary hypertension and severe respiratory failure
    M Max
    Klinik fur Anasthesiologie, Medizinische Einrichtungen, Rheinisch Westfalischen Technischen Hochschule Aachen, Germany
    Curr Opin Cardiol 14:432-6. 1999
    ....
  42. ncbi request reprint Magnesium as part of balanced general anaesthesia with propofol, remifentanil and mivacurium: a double-blind, randomized prospective study in 50 patients
    S Schulz-Stubner
    Klinik für Anästhesiologie am Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Eur J Anaesthesiol 18:723-9. 2001
    ....
  43. ncbi request reprint Employment of telemedicine in emergency medicine. Clinical requirement analysis, system development and first test results
    M Czaplik
    Dr Michael Czaplik, University Hospital RWTH Aachen, Department of Anaesthesiology, Pauwelsstr 30, 52074 Aachen, Germany, E mail
    Methods Inf Med 53:99-107. 2014
    ..Telemedicine emerges as a complementary system in EMS that may provide expertise and improve quality of medical treatment on the scene. Hence our aim is to develop and test a specific teleconsultation system...
  44. ncbi request reprint [Teaching non-technical skills for critical incidents: Crisis resource management training for medical students]
    A Kruger
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Rheinisch Westfälische Technische Hochschule RWTH, Pauwelsstr 30, 52074, Aachen, Deutschland
    Anaesthesist 58:582-8. 2009
    ..These skills are not taught during medical education. A crisis resource management (CRM) training was established for 4th to 6th year medical students using a full-scale simulator mannikin (Emergency Care Simulator, ECS, METI)...
  45. ncbi request reprint Hypothermia exerts negative inotropy in human atrial preparations: in vitro-comparison to rabbit myocardium
    A Goetzenich
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    J Cardiovasc Surg (Torino) 50:239-45. 2009
    ..We investigated the effect of mild hypothermia on the contractility and calcium response of atrial and ventricular myocardium...
  46. ncbi request reprint Xenon, a modern anaesthesia gas
    K Hecker
    Department of Anesthesiology, Universitätsklinikum der RWTH Aachen, Aachen, Germany
    Minerva Anestesiol 70:255-60. 2004
    ..In conclusion, the most important positive effects of Xenon are cardiovascular stability, cerebral protection and favourable pharmacokinetics. Negative points are high cost and the limited number of ventilators supplying Xenon...
  47. ncbi request reprint Minimum alveolar concentration (MAC) of xenon in intubated swine
    K E Hecker
    Department of Anaesthesiology, Klinikum der RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Br J Anaesth 92:421-4. 2004
    ..To investigate the anaesthetic as well as the unwanted effects of xenon (Xe) in a swine model, it is useful to know MAC(Xe)...
  48. ncbi request reprint The influence of hypoalbuminemia on maximal flow rates and transmembrane pressure during plasmapheresis--an in vitro study
    J K Unger
    Department of Anaesthesiology, , Germany
    Blood Purif 19:408-16. 2001
    ..CONCLUSION: Maintenance of a physiological AGR in ALF patients might improve the performance of plasmapheresis and--as opposed to raised heparinization--contribute to a safer application...
  49. pmc Effects of a single dose of ketamine on duodenal motility activity in pigs
    J Schnoor
    Department of Anesthesiology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Can Vet J 46:147-52. 2005
    ..05). In conclusion, when gastrointestinal motility has to be investigated, the effects of a single dose of ketamine, even for premedication, should be taken into consideration...
  50. ncbi request reprint Combination of inhaled nitric oxide and intravenous prostacyclin for successful treatment of severe pulmonary hypertension in a patient with acute respiratory distress syndrome
    R Kuhlen
    Department of Anesthesiology, University Hospital Aachen, Germany Ralf
    Intensive Care Med 25:752-4. 1999
    ..To investigate the combination of inhaled nitric oxide (iNO) and intravenously administered prostacyclin (i.v. PGI2) in a patient with severe pulmonary hypertension and acute respiratory distress syndrome (ARDS)...
  51. ncbi request reprint [Ventilator-associated pneumonia]
    R Dembinski
    Abteilung für Operative Intensivmedizin, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Deutschland
    Anaesthesist 57:825-42. 2008
    ..Adequate antimicrobial therapy in due consideration for individual risk factors and local antibiotic resistance is the most important therapeutic measure...
  52. ncbi request reprint Effect of hirudin versus heparin on hemocompatibility of blood contacting biomaterials: an in vitro study
    R Kopp
    Department of Surgical Intensive Care, RWTH Aachen University, Aachen, Germany
    Int J Artif Organs 28:1272-7. 2005
    ..This predestines hirudin as anticoagulant for in vitro studies analyzing hemocompatibility of biomaterials or surface modifications...
  53. ncbi request reprint Modulating the pulmonary circulation: an update
    R Dembinski
    Department of Anesthesiology, University Hospital, RWTH, Aachen, Germany
    Minerva Anestesiol 70:239-43. 2004
    ..Likewise, the combination of different vasodilators merit further investigations to prove efficacy in randomised controlled trials...
  54. ncbi request reprint Breathing pattern and workload during automatic tube compensation, pressure support and T-piece trials in weaning patients
    R Kuhlen
    University of Aachen Medical School, Department of Anesthesiology, Aachen, Germany
    Eur J Anaesthesiol 20:10-6. 2003
    ..The study investigated the effects of automatic tube compensation compared with breathing through a T-piece or pressure support during a trial of spontaneous breathing used for weaning patients from mechanical ventilation of the lungs...
  55. ncbi request reprint Combining partial liquid ventilation and prone position in experimental acute lung injury
    M Max
    Klinik für Anaesthesie, Rheinisch Westfaelische Technische Hochschule Aachen, Germany
    Anesthesiology 91:796-803. 1999
    ..Partial liquid ventilation (PLV) and prone position can improve arterial oxygen tension (PaO2) in acute lung injury (ALI). The authors evaluated additive effects of these techniques in a saline lung lavage model of ALI...
  56. ncbi request reprint Enhancing filtration rates by the use of blood flow around the capillaries of plasmafilters: an in vitro study
    J K Unger
    Department of Anaesthesiology, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Int J Artif Organs 24:821-31. 2001
    ....
  57. ncbi request reprint Changes in pulmonary blood flow during gaseous and partial liquid ventilation in experimental acute lung injury
    M Max
    Klinik für Anaesthesie, Rheinisch Westfaelische Technische Hochschule Aachen, Germany
    Anesthesiology 93:1437-45. 2000
    ....
  58. ncbi request reprint Maximal flow rates and sieving coefficients in different plasmafilters: effects of increased membrane surfaces and effective length under standardized in vitro conditions
    J K Unger
    Department of Anesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Clin Apher 17:190-8. 2002
    ..Thus, enlargement of the membrane surface such as provided by two commercially available and clinically well-established plasmafilters could not be proven to enable higher clearance rates...
  59. pmc Time-dependency of improvements in arterial oxygenation during partial liquid ventilation in experimental acute respiratory distress syndrome
    M Max
    Medizinische Einrichtungen der Rheinisch Westfälischen Technischen Hochschule Aachen, Aachen, Germany
    Crit Care 4:114-9. 2000
    ....
  60. ncbi request reprint Development of a special catheterbag to enable artificial organ evaluation in conscious, unrestrained pigs: technical note
    J K Unger
    Department of Surgery, Charite Campus Virchow, Humboldt University Berlin, Germany
    Int J Artif Organs 23:268-74. 2000
    ..We alleviated the mental distress these animals were exposed to in comparison to former methods based on restraint of the animals...
  61. ncbi request reprint Effect of inhaled nitric oxide in combination with almitrine on ventilation-perfusion distributions in experimental lung injury
    R Dembinski
    Klinik für Anästhesie, Medizinische Einrichtungen der Rheinisch Westfälischen Technischen, Hochschule Aachen, Germany
    Intensive Care Med 26:221-8. 2000
    ..To investigate a possible additive effect of combined nitric oxide (NO) and almitrine bismesylate (ALM) on pulmonary ventilation-perfusion (V(A)/Q) ratio...
  62. ncbi request reprint Effect of PEEP and inhaled nitric oxide on pulmonary gas exchange during gaseous and partial liquid ventilation with small volumes of perfluorocarbon
    M Max
    Klinik für Anästhesie, Medizinische Einrichtungen der RWTH Aachen, Germany
    Acta Anaesthesiol Scand 44:383-90. 2000
    ..The aim of the present study was to compare gas exchange and hemodynamics in experimental ALI during gaseous and partial liquid ventilation at two different levels of PEEP, with and without the inhalation of nitric oxide...
  63. ncbi request reprint [Evidence-based medicine of the acute respiratory distress syndrome]
    R Kopp
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Aachen
    Anaesthesist 52:195-203. 2003
    ..Recommended drug therapy is limited to the administration of stress doses of corticosteroids and a special anti-inflammatory enteral diet...
  64. ncbi request reprint [Respiratory pattern and respiratory strain in automatic tube compensation and inspiratory pressure support]
    R Kuhlen
    Klinik fur Anasthesiologie, RWTH Aachen
    Anaesthesist 48:871-5. 1999
    ..To investigate whether automatic tube compensation (ATC) or conventional pressure support (PS) is suitable to compensate for the work of breathing imposed by the breathing circuit without altering the breathing pattern...
  65. ncbi request reprint Effect of aerosolized prostacyclin and inhaled nitric oxide on experimental hypoxic pulmonary hypertension
    M Max
    Klinik für Anästhesie, Medizinische Einrichtungen der Rheinisch Westfälischen Technischen Hochschule Aachen, Pauwelsstrasse 30, 52 074 Aachen, Germany
    Intensive Care Med 25:1147-54. 1999
    ..To compare the effect of different concentrations of inhaled nitric oxide and doses of nebulized prostacyclin on hypoxia-induced pulmonary hypertension in pigs...
  66. ncbi request reprint Central anticholinergic syndrome in a child undergoing circumcision
    U Schultz
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH, Aachen, Germany
    Acta Anaesthesiol Scand 46:224-6. 2002
    ..This case illustrates the importance of considering central anticholinergic syndrome as a differential diagnosis in children if prolonged sedation after general anesthesia occurs...
  67. ncbi request reprint [Procedure for critical nonsurgical bleeding]
    O Grottke
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen
    Chirurg 78:101-2, 104-9. 2007
    ..Therefore it is crucial to develop a clear strategy for correcting coagulopathy, preventing exsanguination, and minimizing the need for blood transfusion...
  68. ncbi request reprint [Anaesthesiology as a compulsory subject in the new German medical school curriculum. Evaluation of a curricular model at the University Hospital Aachen]
    S K Beckers
    Klinik fur Anasthesiologie, Universitatsklinikum, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstr 30, 52074 Aachen
    Anaesthesist 56:571-80. 2007
    ..Therefore, existing curricular activities had to be changed from facultative courses for a small number of interested students to compulsory activities for all students...
  69. doi request reprint [Lung protective ventilation in ARDS]
    I Biener
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Med Klin Intensivmed Notfmed 108:578-83. 2013
    ..To reduce these reactions an evidence-based concept of lung protective ventilation is essential. ..
  70. doi request reprint Methods for quantitative evaluation of alveolar structure during in vivo microscopy
    M Czaplik
    University Hospital RWTH Aachen, Department of Anaesthesiology, Pauwelsstr 30, 52074 Aachen, Germany
    Respir Physiol Neurobiol 176:123-9. 2011
    ..50 vs. 0.35, p < 0.05; HI: 0.62 vs. 1.83, p < 0.05; CI: 1.56 vs. 1.63, p < 0.001). VAI, HI and CI may help to quantify microscopic images of changes in alveolar structure after experimental ALI...
  71. ncbi request reprint [Venous thromboembolism prophylaxis]
    B Dohmen
    Klinik fur Anasthesiologie, Aachen, Germany
    Anaesthesist 53:657-72; quiz 673. 2004
    ..In patients at intermediate or high risk of venous thromboembolism, additional pharmacological thromboembolism prophylaxis becomes mandatory...
  72. ncbi request reprint Influence of differences in body weight and volume management on experimental results in porcine models
    J Schnoor
    Department of Anesthesiology, University Hospital Aachen, Germany
    Int J Artif Organs 27:924-34. 2004
    ..That is why we studied whether differences in the basic protocol for infusion therapy and different levels of COP according to age or body weight, respectively - impair reproducibility and reliability of experimental results...
  73. ncbi request reprint Can the incidence of accidental dural puncture in laboring women be reduced? A systematic review and meta-analysis
    M Heesen
    Department of Anesthesiology, Klinikum am Bruderwald, Bamberg, Germany
    Minerva Anestesiol 79:1187-97. 2013
    ..Accidental dural puncture (ADP) after epidural analgesia (EDA) for labor pain may cause severe postdural puncture headache (PDPH) and may prolong hospital stay. We aimed to identify techniques that reduce the incidence of ADP...
  74. ncbi request reprint Limitations of arterial pulse pressure variation and left ventricular stroke volume variation in estimating cardiac pre-load during open heart surgery
    S Rex
    Department of Anaesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 51:1258-67. 2007
    ....
  75. doi request reprint [Von Willebrand disease : diagnosis and management]
    C Antony
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Deutschland
    Internist (Berl) 51:1118, 1120-6. 2010
    ..Other forms of treatment can be considered as adjunctive to these...
  76. doi request reprint [Quality assurance in acute pain therapy : Development of software for the acute pain service]
    M Czaplik
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Schmerz 24:358-66. 2010
    ..In the first test period more than 30,000 ward rounds were collected, and a considerably improved documentation quality could be achieved...
  77. ncbi request reprint The effects of sevoflurane and desflurane in vitro on platelet-leukocyte adhesion in whole blood
    N A Horn
    Department of Anaesthesiology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anaesthesia 58:312-9. 2003
    ..The results show that these two volatile anaesthetics have differing effects on the formation of platelet-leukocyte conjugates in vitro. Sevoflurane also enhanced the expression of P-selectin on platelets...
  78. ncbi request reprint Effects of volatile anesthetics on cardiac ion channels
    R Huneke
    Department of Anesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule RWTH, Aachen, Germany
    Acta Anaesthesiol Scand 48:547-61. 2004
    ....
  79. ncbi request reprint Replacement of physiologically autoinhaled nitric oxide in intubated patients
    L Röhrig
    Dept of Anaesthesiology, University Hospital, RWTH Aachen, Aachen, Germany
    Eur Respir J 21:677-81. 2003
    ..In contrast to the test group, it was not replaced after intubation. These findings suggest that in healthy subjects the autoinhalation of nitric oxide does not play an important role in arterial oxygenation during anaesthesia...
  80. doi request reprint [Problems and deficits in the transition from inpatient and outpatient care of cancer patients. A qualitative analysis]
    S Stiel
    Klinik für Palliativmedizin, Universitätsklinikum RWTH Aachen, Pauwelsstr 30, 52074 Aachen
    Schmerz 23:510-7. 2009
    ..The project was initiated by the Public Health Department of the City of Aachen and was carried out with cooperation from all hospitals in the urban areas...
  81. ncbi request reprint Adsorption of xenobiotics to plastic tubing incorporated into dynamic in vitro systems used in pharmacological research--limits and progress
    J K Unger
    Department of Anesthesiology, University Clinic, RWTH Aachen, German
    Biomaterials 22:2031-7. 2001
    ..The silicone-caoutchouc-mixture reached acceptable experimental results with respect to its handling and demonstrated a very low capacity for substrate adsorption...
  82. ncbi request reprint Anesthetic considerations in patients with chronic pulmonary diseases
    D Henzler
    Department of Anesthesiology, University Hospital, RWTH Aachen, Aachen, Germany
    Minerva Anestesiol 70:279-84. 2004
    ..Increasing age and co-morbidities of patients admitted for surgery impose new challenges on the anesthesiologist...
  83. ncbi request reprint [AUTOLINE. Effectiveness of an infusion warmer concept]
    J Schnoor
    Klinik fur Anasthesiologie, Universitatsklinikum, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anaesthesist 54:871-6. 2005
    ....
  84. ncbi request reprint The influence of HES on the filtration properties of capillary membrane plasmaseparation
    C Haltern
    Department of Anaesthesiology, University Hospital, RWTH Aachen, Germany
    Int J Artif Organs 25:798-805. 2002
    ..Further studies have yet to evaluate whether or not the effects described also occur under clinical conditions...
  85. ncbi request reprint The air elimination capabilities of pressure infusion devices and fluid-warmers
    J Schnoor
    Department of Anaesthesiology, University Hospital Aachen, Germany, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Anaesthesia 59:817-21. 2004
    ..In conclusion, air elimination was best performed by the RA system. In terms of the risk of air embolism during pressurised infusions, improvements in air elimination of the investigated devices are still necessary...
  86. ncbi request reprint Procalcitonin serum levels after out-of-hospital cardiac arrest
    Michael Fries
    Department of Anesthesiology, University Hospital of RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Resuscitation 59:105-9. 2003
    ..Based on this observation, studies on larger numbers of patients should prove the predictive value of PCT in those patients...
  87. ncbi request reprint High-frequency oscillatory ventilation in experimental lung injury: effects on gas exchange
    Rolf Dembinski
    Klinik fuer Anaesthesiologie, Universitaetsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Intensive Care Med 28:768-74. 2002
    ....
  88. ncbi request reprint Xenon preserves neutrophil and monocyte function in human whole blood
    Lothar De Rossi
    Department of Anesthesiology, and The Institute Of Transfusion Medicine, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Can J Anaesth 49:942-5. 2002
    ..In the present study, we investigated the effect of xenon on phagocytosis and respiratory burst activity of neutrophils and monocytes in human whole blood...
  89. ncbi request reprint Low-dose multislice spiral computed tomography in acute lung injury: animal experience
    Joachim E Wildberger
    Department of Diagnostic Radiology, University Hospital, University of Technology RWTH, Aachen, Germany
    Invest Radiol 38:9-16. 2003
    ..To compare low-dose multislice spiral CT (MSCT) with a standard protocol for the evaluation of acute lung injury (ALI) in an animal model...
  90. ncbi request reprint Minimum alveolar anesthetic concentration of isoflurane with different xenon concentrations in Swine
    Klaus E Hecker
    Departments of Anesthesiology and Medical Statistics, Klinikum der RWTH Aachen, Germany
    Anesth Analg 96:119-24, table of contents. 2003
    ..75%-1.59%) with 65% Xe. Although this indicates partial antagonism of the two anesthetics, a combination of Xe with isoflurane may prove valuable for patients requiring a fraction of inspired oxygen more than 0.3...
  91. doi request reprint Xenon reduces neurohistopathological damage and improves the early neurological deficit after cardiac arrest in pigs
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:2420-6. 2008
    ..Treatment options to ameliorate brain damage following cardiopulmonary resuscitation from cardiac arrest are limited...
  92. ncbi request reprint Pressure support compared with controlled mechanical ventilation in experimental lung injury
    Rolf Dembinski
    Department of Anesthesiology, Universitaetsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anesth Analg 94:1570-6, table of contents. 2002
    ..005). We conclude that, in this model of ALI, PSV improves gas exchange because of a reduction of .V(A)/.Q inequality. However, improvements in .V(A)/.Q distribution may be more effective with CMV than with PSV...
  93. ncbi request reprint The role of spontaneous breathing during mechanical ventilation
    Ralf Kuhlen
    Klinik fur Anasthesiologie, Universitatsklinikum, RWTH Rheinisch Westfälische Technische Hochschule, Aachen, Germany
    Respir Care 47:296-303; discussion 304-7. 2002
    ..It is the aim of this article to review the effects of preserved spontaneous breathing activity during mechanical ventilation with different ventilatory modalities in acute respiratory failure patients...
  94. ncbi request reprint Ventilation-perfusion distribution related to different inspiratory flow patterns in experimental lung injury
    Rolf Dembinski
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anesth Analg 98:211-9, table of contents. 2004
    ..V(dec) and .V(deco) (P < 0.05). We conclude that contrary to the hypothesis, .V(con)provides a more favorable .V(A)/.Q distribution, and hence better oxygenation, when compared with .V(dec) and .V(deco) in this model of ALI...
  95. ncbi request reprint Temperature-independent Inhibition of L-type calcium currents by halothane and sevoflurane in human atrial cardiomyocytes
    Rocco Hüneke
    University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Anesthesiology 101:409-16. 2004
    ..However, the solubility of anesthetic gases as well as ICa,L are markedly sensitive to the study temperature. Therefore, temperature-dependent effects of halothane and sevoflurane on cardiac ICa,L were analyzed...
  96. ncbi request reprint Ventilation with biphasic positive airway pressure in experimental lung injury. Influence of transpulmonary pressure on gas exchange and haemodynamics
    Dietrich Henzler
    Department of Anaesthesiology, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Intensive Care Med 30:935-43. 2004
    ....
  97. ncbi request reprint Xenon does not prolong neuromuscular block of rocuronium
    Oliver Kunitz
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Anesth Analg 99:1398-401; table of contents. 2004
    ..4 +/- 5.3 min), and clinical recovery (xenon group 18.0 +/- 10.2 and propofol group 17.1 +/- 8.5 min). We conclude that the neuromuscular blocking effects of rocuronium are not different when given during propofol versus xenon anesthesia...
  98. ncbi request reprint Repeated generation of the pulmonary pressure-volume curve may lead to derecruitment in experimental lung injury
    Dietrich Henzler
    Department of Anesthesiology, Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
    Intensive Care Med 31:302-10. 2005
    ..We investigated the effects of repeated construction of an inflation PV curve implemented in a standard ventilator on recruitment or derecruitment in acutely injured lungs...
  99. ncbi request reprint Xenon and isoflurane differentially modulate lipopolysaccharide-induced activation of the nuclear transcription factor KB and production of tumor necrosis factor-alpha and interleukin-6 in monocytes
    Lothar W de Rossi
    Department of Anesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Anesth Analg 98:1007-12, table of contents. 2004
    ..Furthermore, xenon increases, whereas isoflurane inhibits the activation of NF-kappaB, providing a possible molecular mechanism for the different effects on monocyte TNF-alpha and IL-6 production...
  100. ncbi request reprint Is there a need for a recruiting strategy in morbidly obese patients undergoing laparoscopic surgery?
    Dietrich Henzler
    Anesth Analg 98:268; author reply 268-9. 2004
  101. ncbi request reprint S-100 protein and neurohistopathologic changes in a porcine model of acute lung injury
    Michael Fries
    Department of Anesthesiology, University Hospital of Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anesthesiology 102:761-7. 2005
    ....