Hans F Merk

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. doi request reprint [Modern light protection from the view of occupational dermatology]
    H F Merk
    Univ Hautklinik, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Deutschland
    Hautarzt 63:796-800. 2012
  2. ncbi request reprint Topical diclofenac in the treatment of actinic keratoses
    Hans F Merk
    Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen, Aachen, Germany
    Int J Dermatol 46:12-8. 2007
  3. ncbi request reprint [Photodermatoses]
    H F Merk
    Universitäts Hautklinik, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen
    Hautarzt 57:1058. 2006
  4. ncbi request reprint [The effect of low molecular weight substances on the human skin. Molecular mechanisms and their consequences]
    H F Merk
    Universitäts Hautklinik, Klinik für Dermatologie and Allergologie, RWTH Aachen
    Hautarzt 55:1125-9. 2004
  5. ncbi request reprint Concepts in molecular dermatotoxicology
    Hans F Merk
    Department of Dermatology and Allergology, RWTH Aachen, Aachen, Germany
    Exp Dermatol 15:692-704. 2006
  6. ncbi request reprint Allergy, skin and environment
    H F Merk
    Univ Hautklinik der RWTH Aachen, Germany
    Zentralbl Hyg Umweltmed 202:85-100. 1999
  7. ncbi request reprint [Pharmacotherapy of allergic diseases]
    Hans F Merk
    Universitäts Hautklinik, RWTH Aachen
    Z Arztl Fortbild Qualitatssich 97:453-60. 2003
  8. ncbi request reprint [Allergic occupational dermatoses. Role of in vitro studies in diagnosis and prevention]
    H F Merk
    Universitäts Hautklinik, RWTH Aachen, Aachen
    Hautarzt 55:31-3. 2004
  9. ncbi request reprint Diagnosis of drug hypersensitivity: lymphocyte transformation test and cytokines
    Hans F Merk
    Univ Klinik für Dermatologie und Allergologie, RWTH Aachen, Germany
    Toxicology 209:217-20. 2005
  10. ncbi request reprint [Pharmacogenetics: Important aspects for dermatology]
    H F Merk
    Universität Hautklinik, Klinik für Dermatologie and Allergologie der RWTH Aachen
    Hautarzt 56:44-7. 2005

Detail Information

Publications93

  1. doi request reprint [Modern light protection from the view of occupational dermatology]
    H F Merk
    Univ Hautklinik, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Deutschland
    Hautarzt 63:796-800. 2012
    ..The recent changes in the recognition of UV-induced skin cancers as occupational diseases increases the need for preventive strategies which are supported by appropriate clinical studies...
  2. ncbi request reprint Topical diclofenac in the treatment of actinic keratoses
    Hans F Merk
    Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen, Aachen, Germany
    Int J Dermatol 46:12-8. 2007
  3. ncbi request reprint [Photodermatoses]
    H F Merk
    Universitäts Hautklinik, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen
    Hautarzt 57:1058. 2006
  4. ncbi request reprint [The effect of low molecular weight substances on the human skin. Molecular mechanisms and their consequences]
    H F Merk
    Universitäts Hautklinik, Klinik für Dermatologie and Allergologie, RWTH Aachen
    Hautarzt 55:1125-9. 2004
    ..An improved understanding of the metabolism of low molecular weight compounds can lead to new therapeutic strategies. One example is the introduction of photodynamic therapy with topical applied porphyrin precursors...
  5. ncbi request reprint Concepts in molecular dermatotoxicology
    Hans F Merk
    Department of Dermatology and Allergology, RWTH Aachen, Aachen, Germany
    Exp Dermatol 15:692-704. 2006
    ..From this knowledge, novel concepts for skin protection have been developed. Here, we provide a brief overview of some of the most exciting and intriguing concepts in molecular dermatotoxicology...
  6. ncbi request reprint Allergy, skin and environment
    H F Merk
    Univ Hautklinik der RWTH Aachen, Germany
    Zentralbl Hyg Umweltmed 202:85-100. 1999
    ..At these diseases, their diagnose and therapy and especially the promising progress in research with regard to these diseases which has been obtained during the last years will be focussed in this review...
  7. ncbi request reprint [Pharmacotherapy of allergic diseases]
    Hans F Merk
    Universitäts Hautklinik, RWTH Aachen
    Z Arztl Fortbild Qualitatssich 97:453-60. 2003
    ..New technologies such as the chip technology or proteonomics allow for the selection of compounds suitable for further clinical development...
  8. ncbi request reprint [Allergic occupational dermatoses. Role of in vitro studies in diagnosis and prevention]
    H F Merk
    Universitäts Hautklinik, RWTH Aachen, Aachen
    Hautarzt 55:31-3. 2004
    ....
  9. ncbi request reprint Diagnosis of drug hypersensitivity: lymphocyte transformation test and cytokines
    Hans F Merk
    Univ Klinik für Dermatologie und Allergologie, RWTH Aachen, Germany
    Toxicology 209:217-20. 2005
    ....
  10. ncbi request reprint [Pharmacogenetics: Important aspects for dermatology]
    H F Merk
    Universität Hautklinik, Klinik für Dermatologie and Allergologie der RWTH Aachen
    Hautarzt 56:44-7. 2005
    ....
  11. ncbi request reprint Skin: major target organ of allergic reactions to small molecular weight compounds
    Hans F Merk
    Department of Dermatology and Allergology, Univ Hospital, RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Toxicol Appl Pharmacol 224:313-7. 2007
    ..Evidence supporting the role of metabolism in the development of drug allergy and allergic contact dermatitis is demonstrated in the example of sulphonamides and fragrances...
  12. ncbi request reprint Standard treatment: the role of antihistamines
    H F Merk
    Department of Dermatology and Allergology, University Hospital, RWTH Aachen, Germany
    J Investig Dermatol Symp Proc 6:153-6. 2001
    ..This development has brought antihistamines very close to the ideal antihistamines that are desired by clinicians to treat most types of urticaria in patients who have to take these drugs for a long time...
  13. doi request reprint [Pharmacogenetics]
    H F Merk
    Universitäts Hautklinik Klinik für Dermatologie and Allergologie, RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Hautarzt 61:650-3. 2010
    ..Another potentially important area is assessing risk factors to prevent allergic reactions to antibiotics, especially with regard to the effective treatment of MRSA...
  14. ncbi request reprint The skin: target organ in immunotoxicology of small-molecular-weight compounds
    H F Merk
    Department of Dermatology and Allergology, University Hospital, RWTH Aachen, Germany
    Skin Pharmacol Appl Skin Physiol 14:419-30. 2001
    ..Examples include well-designed patch tests, assays involving antigen-presenting cells such as dendritic cells, but also T lymphocytes, basophiles or keratinocytes...
  15. ncbi request reprint [Angioedema]
    H F Merk
    Universitäts Hautklinik, RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Hautarzt 58:1041-5. 2007
    ..Icatibant is a bradykinin-receptor-2 antagonist and blocks bradykinin-induced angioedema in HANE. How applicable this will be to ACE-inhibitor angioedema remains to be seen...
  16. ncbi request reprint [Anaphylaxis]
    H F Merk
    Universitäts Hautklinik, RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Hautarzt 58:1023-4. 2007
  17. ncbi request reprint Drug skin metabolites and allergic drug reactions
    Hans F Merk
    Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, Aachen D 52074, Germany
    Curr Opin Allergy Clin Immunol 9:311-5. 2009
    ..Presentation of recent studies about xenobiotica metabolism of the skin and its impact on drug-allergic reactions...
  18. ncbi request reprint Downregulation of STRA6 expression in epidermal keratinocytes leads to hyperproliferation-associated differentiation in both in vitro and in vivo skin models
    Claudia Skazik
    Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany
    J Invest Dermatol 134:1579-88. 2014
    ..By its influence on hyperproliferation-associated differentiation, STRA6 could also have a role in skin regeneration and could be a target for pharmacological approaches to improve wound healing. ..
  19. doi request reprint Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts
    Tonio Wiederholt
    Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany
    Exp Dermatol 18:969-78. 2009
    ..In conclusion, these studies provided new insight in the molecular mechanisms linked to the stimulatory effect of pantothenate and panthenol on the proliferation of dermal fibroblasts...
  20. ncbi request reprint Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models
    Ruth Heise
    Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, Aachen, Germany
    J Invest Dermatol 126:2473-80. 2006
    ..In light of our prior studies documenting the functional activity of RA metabolites, expression of CYP26 in the sebaceous gland epithelium supports the suggestion that altered RA metabolism may be involved in the pathogenesis of acne...
  21. ncbi request reprint Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis
    Mark M Neis
    Department of Dermatology and Allergology, University Hospital RWTH Aachen, Germany
    J Allergy Clin Immunol 118:930-7. 2006
    ..IL-31 is produced by activated T lymphocytes, preferentially by TH2 cells. Transgenic mice overexpressing IL-31 have a phenotype resembling allergic dermatitis in human subjects...
  22. doi request reprint Evaluation of the sensitizing potential of antibiotics in vitro using the human cell lines THP-1 and MUTZ-LC and primary monocyte-derived dendritic cells
    Katrin Sebastian
    Department of Dermatology and Allergology, RWTH Aachen University Hospital, D 52074 Aachen, Germany
    Toxicol Appl Pharmacol 262:283-92. 2012
    ....
  23. ncbi request reprint Expression and function of macrophage migration inhibitory factor in the pathogenesis of UV-induced cutaneous nonmelanoma skin cancer
    Ruth Heise
    Department of Dermatology and Allergology, RWTH Aachen University, Aachen, Germany
    Photochem Photobiol 88:1157-64. 2012
    ..These findings indicate that MIF may be an important factor in the pathogenesis of NMSC tumorigenesis and progression in an inflammatory environment...
  24. doi request reprint Reactivity of in vitro activated human T lymphocytes to p-phenylenediamine and related substances
    Claudia Skazik
    Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen, Germany
    Contact Dermatitis 59:203-11. 2008
    ..Patch tests to p-phenylenediamine (PPD) and related substances often show concurrent reactions that can be attributed to separate sensitization or cross-reactivity...
  25. ncbi request reprint Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro
    Jens M Baron
    Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany
    J Invest Dermatol 125:143-53. 2005
    ....
  26. doi request reprint Active transport of contact allergens in human monocyte-derived dendritic cells is mediated by multidrug resistance related proteins
    Claudia Skazik
    Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Pauwelsstrase 30, D 52074 Aachen, Germany
    Arch Biochem Biophys 508:212-6. 2011
    ..These results strongly support the functional role of MRPs in the active efflux of contact allergens also in antigen-presenting cells like moDCs, a novel mechanism which could possibly play a role in the pathogenesis of contact allergy...
  27. doi request reprint Cutaneous metabolic activation of carvoxime, a self-activating, skin-sensitizing prohapten
    Hagen Ott
    Department of Dermatology and Allergology and Interdisciplinary Centre for Clinical Research IZKF, BIOMAT, RWTH Aachen University, D 52074 Aachen, Germany
    Chem Res Toxicol 22:399-405. 2009
    ....
  28. doi request reprint Microarray-based detection of specific IgE against recombinant ω-5-gliadin in suspected wheat-dependent exercise-induced anaphylaxis
    Richard Brans
    Department of Dermatology and Allergology, University Hospital Aachen, Germany
    Eur J Dermatol 22:358-62. 2012
    ..In contrast, the improved version of the microarray seems to be as adequate as FEIA in the detection of sIgE against ω-5-gliadin. However, further large-scale studies are warranted to confirm these results...
  29. doi request reprint Differential expression of influx and efflux transport proteins in human antigen presenting cells
    Claudia Skazik
    Department of Dermatology, University Hospital RWTH Aachen, Aachen, Germany
    Exp Dermatol 17:739-47. 2008
    ....
  30. doi request reprint Effects of photodynamic therapy evaluated in a novel three-dimensional squamous cell carcinoma organ construct of the skin
    Daniela Hoeller Obrigkeit
    Department of Dermatology and Allergology, University Clinic of the RWTH, Aachen, Germany
    Photochem Photobiol 85:272-8. 2009
    ..This in vitro model consistently reproduces the tumor development and dynamics of growing SCCs in vivo and provides a useful approach for screening new treatment modalities for this form of cutaneous cancer...
  31. ncbi request reprint Characterization of T cell responses to fragrances
    S Sieben
    Department of Dermatology, University Hospital, Aachen, Germany
    Toxicol Appl Pharmacol 172:172-8. 2001
    ..In addition, our results suggest that CYPs can be involved in the formation of the nominative antigen...
  32. pmc Allelic loss underlies type 2 segmental Hailey-Hailey disease, providing molecular confirmation of a novel genetic concept
    Pamela Poblete-Gutiérrez
    Department of Dermatology and Allergology, University Clinic of the Rheinisch Westfäkusche Technische Hochschule Aachen, Aachen, Germany
    J Clin Invest 114:1467-74. 2004
    ....
  33. doi request reprint Allergen microarrays: a novel tool for high-resolution IgE profiling in adults with atopic dermatitis
    Hagen Ott
    Department of Dermatology and Allergology, University Hospital Aachen, D 52074 Aachen, Germany
    Eur J Dermatol 20:54-61. 2010
    ..However, further large-scale studies in unselected patient populations are needed before the introduction of allergen microarrays into daily clinical practice...
  34. ncbi request reprint Anaphylaxis induced by glucocorticoids
    Stephan M Erdmann
    Department of Dermatology and Allergology, University Hospital of RWTH Aachen, Aachen, Germany
    J Am Board Fam Pract 18:143-6. 2005
    ..Clinicians should be aware that allergic reactions to glucocorticoids can occur and that worsening of symptoms does not always mean treatment failure...
  35. doi request reprint [Wheat-dependent, exercise-induced anaphylaxis]
    R Brans
    Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Hautarzt 60:956-60. 2009
    ....
  36. doi request reprint Value of component based diagnostics in IgE-mediated hymenoptera sting reactions
    Mark M Neis
    Department of Dermatology and Allergology, University Hospital RWTH Aachen, Aachen, Germany
    Cutan Ocul Toxicol 31:117-23. 2012
    ....
  37. ncbi request reprint MnSOD polymorphisms in sensitized patients with delayed-type hypersensitivity reactions to the chemical allergen para-phenylene diamine: a case-control study
    Richard Brans
    Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Toxicology 212:148-54. 2005
    ..5; 95% CI, 0.7-2.34). These data suggest that the C (Ala) allele of MnSOD modifies contact dermatitis risk among older females, but is not an independent susceptibility factor for contact sensitization to PPD...
  38. doi request reprint P-Glycoprotein (ABCB1) expression in human skin is mainly restricted to dermal components
    Claudia Skazik
    Department of Dermatology and Allergology, University Hospital RWTH Aachen, Aachen, Germany Department of Dermatology, University of Bonn, Bonn, Germany Department of Dermatology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Exp Dermatol 20:450-2. 2011
    ..It may also prevent the uptake of xenobiotics into the skin by functioning as a barrier located in the dermal vasculature...
  39. ncbi request reprint Interleukin-6-type cytokines upregulate expression of multidrug resistance-associated proteins in NHEK and dermal fibroblasts
    Alexandra Dreuw
    Department of Biochemistry, University Hospital, Aachen, Germany
    J Invest Dermatol 124:28-37. 2005
    ..Several inflammatory skin diseases show an enhanced expression of IL-6-type cytokines. Correspondingly, upregulation of MRP expression was found in lesional skin taken from patients with psoriasis and lichen planus...
  40. ncbi request reprint In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: drug-specific proliferation associated with interleukin-5 secretion
    B Sachs
    Department of Dermatology and Allergology, University Hospitals, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Br J Dermatol 144:316-20. 2001
    ..We report a woman who developed a generalized exanthem 1 day after receiving chlorazepate and four other drugs related to anaesthesia for surgery of the larynx. Patch tests pointed to chlorazepate as the culprit drug for the skin rash...
  41. ncbi request reprint Drug metabolism in the skin
    J M Baron
    Department of Dermatology, University Hospital, RWTH Aachen, Aachen, Germany
    Curr Opin Allergy Clin Immunol 1:287-91. 2001
    ....
  42. doi request reprint Expression and induction of cytochrome p450 isoenzymes in human skin equivalents
    M M Neis
    Department of Dermatology, University Hospital of the RWTH University, Aachen, Germany
    Skin Pharmacol Physiol 23:29-39. 2010
    ..The proof of the expression and inducibility of CYP enzymes in organotypic skin models suggests that skin equivalents are a valuable tool that can emulate CYP-dependent metabolism of drugs and other xenobiotics in human skin...
  43. ncbi request reprint Preferential usage of TCR-Vbeta17 by peripheral and cutaneous T cells in nickel-induced contact dermatitis
    L Büdinger
    Department of Dermatology, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    J Immunol 167:6038-44. 2001
    ..These in vitro and in vivo findings strongly suggest that T cells with a restricted TCR-Vbeta repertoire, i.e., Vbeta17, predominate in NiSO(4)-induced contact dermatitis and may be crucial in the effector phase of Ni hypersensitivity...
  44. ncbi request reprint Identification of N-acetyltransferase 2 genotypes by continuous monitoring of fluorogenic hybridization probes
    B Blomeke
    Department of Dermatology, University Hospital, Pauwelsstrasse 30, RWTH Aachen, 52074, Germany
    Anal Biochem 275:93-7. 1999
    ..This new facile approach allows for the easy detection of NAT2 polymorphisms in hundreds of samples in only a day...
  45. ncbi request reprint Histamine receptors on lymphocytes: distribution and functional significance
    B Sachs
    Department of Dermatology and Allergology, University Hospitals, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Skin Pharmacol Appl Skin Physiol 13:313-23. 2000
    ..In this review, the authors discuss the current knowledge on distribution and functional significance of histamine H1 and histamine H2 receptors on human lymphocytes...
  46. doi request reprint [Immunologic control parameters during specific immunotherapy]
    H Ott
    Klinik für Dermatologie und Allergologie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Deutschland
    Hautarzt 59:551-6. 2008
    ..In the future, a combination of different diagnostic methods defining sequential immunological modifications could lead to the identification of an in vitro profile characteristic of a successful SIT...
  47. ncbi request reprint Expression and function of cytochrome p450-dependent enzymes in human skin cells
    J M Baron
    Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Pauwelsstrabe 30, D 52074 Aachen, Germany
    Curr Med Chem 15:2258-64. 2008
    ..Therefore knowledge of skin-specific CYP expression and function is a prerequisite for pharmacological studies of the skin...
  48. ncbi request reprint Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes
    J M Baron
    Department of Dermatology, Hospital, RWTH Aachen, Germany
    J Invest Dermatol 116:541-8. 2001
    ....
  49. doi request reprint Tacrolimus modulates dendritic cell activation in the sensitization phase of allergic contact dermatitis
    H Ott
    Department of Dermatology and Allergology, RWTH Aachen University Hospital, Aachen, Germany
    Skin Pharmacol Physiol 23:53-9. 2010
    ..Knowledge of the effect of topically applied calcineurin antagonists such as tacrolimus on the sensitization phase of allergic contact dermatitis is currently limited...
  50. ncbi request reprint [Anaphylaxis in childhood and adolescence]
    H Ott
    Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Hautarzt 58:1032-40. 2007
    ..Affected patients, their relatives and other caregivers should receive extensive training in order to guarantee an adequate emergency management of anaphylactic children...
  51. ncbi request reprint In vitro analysis of birch-pollen-associated food allergy by use of recombinant allergens in the basophil activation test
    S M Erdmann
    Department of Dermatology and Allergology, University Hospital of Aachen, Aachen, Germany
    Int Arch Allergy Immunol 136:230-8. 2005
    ..In birch-pollen-associated food allergy to celery, carrot and apple, Bet v 1, Api g 1, Dau c 1 and Mal d 1 are major allergens. Recombinant allergens have not yet been used in the CD63-based basophil activation test (BAT)...
  52. ncbi request reprint [In vitro allergy testing]
    H Ott
    Klinik für Dermatologie und Allergologie, Universitäts Hautklinik, Aachen
    Hautarzt 57:502, 504-8. 2006
    ..New options are provided by allergen microarray technology, which makes it possible to determine not only the specific antigenic protein but also to analyze different epitopes...
  53. ncbi request reprint [Array technology in skin pharmacology and allergology]
    J M Baron
    Hautklinik, Universitätsklinikum der RWTH Aachen
    Hautarzt 54:315-20. 2003
    ....
  54. ncbi request reprint Microarrays of recombinant Hevea brasiliensis proteins: a novel tool for the component-resolved diagnosis of natural rubber latex allergy
    H Ott
    Department of Dermatology and Allergology, University Hospital Aachen, Aachen, Germany
    J Investig Allergol Clin Immunol 20:129-38. 2010
    ..Component-resolved diagnosis using microarray technology has recently been introduced in clinical allergology, but its applicability in patients with natural rubber latex (NRL) allergy has not been investigated...
  55. ncbi request reprint Determination of interleukin-5 secretion from drug-specific activated ex vivo peripheral blood mononuclear cells as a test system for the in vitro detection of drug sensitization
    B Sachs
    Department of Dermatology and Allergology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Clin Exp Allergy 32:736-44. 2002
    ..Accumulation of eosinophils following IL-5 secretion from drug-specific stimulated T cells is a characteristic histological feature of drug-induced skin eruptions...
  56. pmc Characterization of SLCO5A1/OATP5A1, a Solute Carrier Transport Protein with Non-Classical Function
    Katrin Sebastian
    Department of Dermatology and Allergology, University Hospital RWTH Aachen, Aachen, Germany
    PLoS ONE 8:e83257. 2013
    ..In conclusion, we provide evidence that OATP5A1 might be a non-classical OATP family member which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. ..
  57. ncbi request reprint Pilot study: optical coherence tomography as a non-invasive diagnostic perspective for real time visualisation of onychomycosis
    Faris Abuzahra
    Department of Dermatology and Allergology, University Clinic, RWTH Aachen University, Aachen, Germany
    Mycoses 53:334-9. 2010
    ..Furthermore, OCT offers the opportunity to screen several areas of the same nail plate and to detect fungal elements during local or systemic therapy...
  58. ncbi request reprint The basophil activation test in wasp venom allergy: sensitivity, specificity and monitoring specific immunotherapy
    S M Erdmann
    Department of Dermatology and Allergology, University Hospital of Aachen, Aachen, Germany
    Allergy 59:1102-9. 2004
    ..Furthermore, to date, no in vitro test exists to monitor successful specific immunotherapy (SIT) with wasp venom. Therefore, the potentially harmful sting challenge is still recommended...
  59. doi request reprint High-resolution transcriptional profiling of chemical-stimulated dendritic cells identifies immunogenic contact allergens, but not prohaptens
    H Ott
    Department of Dermatology and Allergology, RWTH Aachen University Hospital, Aachen, Germany hagen ott post rwth aachen de
    Skin Pharmacol Physiol 23:213-24. 2010
    ....
  60. doi request reprint [Sensitisation to p-Phenylenediamine. Effects of metabolism and individual susceptibility]
    R Brans
    Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen
    Hautarzt 60:26-31. 2009
    ..g. TNF-alpha) or metabolizing enzymes (e.g. N-acetyltransferase) may have influence on these mechanisms and the individual susceptibility for sensitization...
  61. ncbi request reprint An improved and rapid method to construct skin equivalents from human hair follicles and fibroblasts
    D Hoeller
    Department of Dermatology and Allergology, University Clinic of the RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen, Germany
    Exp Dermatol 10:264-71. 2001
    ..Using autologous cell sources and cell culture media enriched with serum from the respective cell donor, it will be possible to use these SEs for autologous transplantation, thereby reducing the risk of transplant rejection...
  62. ncbi request reprint The molecular basis of porphyria cutanea tarda in Chile: identification and functional characterization of mutations in the uroporphyrinogen decarboxylase gene
    Pamela Poblete-Gutiérrez
    Department of Dermatology and Allergology, University Clinic of the RWTH Aachen, Aachen, Germany
    Exp Dermatol 13:372-9. 2004
    ..The data further emphasize the molecular heterogeneity in type II PCT and demonstrate the advantages of molecular genetic techniques as a diagnostic tool and in the detection of clinically asymptomatic mutation carriers...
  63. doi request reprint Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes
    Christine Götz
    Leibniz Institut für Umweltmedizinische Forschung IUF, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Exp Dermatol 21:364-9. 2012
    ..We conclude from our studies that 3D epidermal models, like the EPI-200 employed here, are superior over monolayer cultures in mimicking human skin xenobiotic metabolism and thus better suited for dermatotoxicity testing...
  64. doi request reprint Clinical usefulness of microarray-based IgE detection in children with suspected food allergy
    H Ott
    Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 63:1521-8. 2008
    ..The aim of this study was to evaluate the utility of microarray-based IgE detection in the diagnostic workup of food allergy and to compare this new diagnostic tool with established methods of allergen-specific IgE detection...
  65. ncbi request reprint Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity
    C N Renn
    Department of Dermatology and Allergology, University Hospitals, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Br J Dermatol 147:1166-70. 2002
    ..Teenagers and young adults frequently develop maculopapular exanthema following amoxicillin intake within infectious mononucleosis. The underlying pathomechanisms are still largely unknown...
  66. ncbi request reprint CD63 expression on basophils as a tool for the diagnosis of pollen-associated food allergy: sensitivity and specificity
    S M Erdmann
    Department of Dermatology and Allergology and Institute of Biometry, University Hospital of RWTH Aachen, Aachen, Germany
    Clin Exp Allergy 33:607-14. 2003
    ..Basophil activation is associated with the expression of CD63. Because allergens can induce basophil activation by cross-linking specific IgE, increased CD63 expression has been proposed as a novel in vitro test for immediate type allergy...
  67. ncbi request reprint Combined in vivo and in vitro approach for the characterization of penicillin-specific polyclonal lymphocyte reactivity: tolerance tests with safe penicillins instead of challenge with culprit drugs
    B Sachs
    Department of Dermatology and Allergology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Br J Dermatol 151:809-16. 2004
    ..Amino-penicillins are a major cause of delayed-type reactions to penicillins...
  68. ncbi request reprint Comparison of patch test results with a standard series among white and black racial groups
    H Dickel
    , Aachen, Germany
    Am J Contact Dermat 12:77-82. 2001
    ....
  69. ncbi request reprint Unilateral facial telangiectases suggest type 1 segmental manifestation of Osler-Rendu-Weber syndrome in an 11-year-old boy
    Pamela Poblete-Gutiérrez
    Department of Dermatology and Allergology, University Clinic of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Eur J Dermatol 13:537-9. 2003
    ..In this case, we propose a probable segmental type 1 manifestation of the autosomal dominantly inherited Osler-Weber-Rendu syndrome...
  70. doi request reprint Prospective randomized study on the efficacy of blue light in the treatment of psoriasis vulgaris
    Antonia Weinstabl
    Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Pauwelstrasse 30, Aachen, Germany
    Dermatology 223:251-9. 2011
    ..Blue light has no known toxic effects on human skin, but reduces the proliferative capacity of keratinocytes in vitro. We therefore investigated the efficacy of blue light in the treatment of psoriasis vulgaris (PV)...
  71. ncbi request reprint Radical resection of giant congenital melanocytic nevus and reconstruction with meek-graft covered integra dermal template
    Jurgen Kopp
    Department of Plastic and Reconstructive Surgery, Hand Surgery, Burn Center, Aachen, Germany
    Dermatol Surg 29:653-7. 2003
    ..Giant congenital melanocytic nevi represent a surgical challenge, particularly in cases in which the size of the nevus exceeds certain extend and malignant transformations have to be considered...
  72. ncbi request reprint Allergic contact dermatitis from phenylephrine in eyedrops
    Stephan Michael Erdmann
    Department of Dermatology and Allergology, University Hospitals of RWTH Aachen, Aachen, Germany
    Am J Contact Dermat 13:37-8. 2002
    ..Although phenylephrine is an epinephrine analog delayed type hypersensitivity to phenylephrine did not result in cross reactivity with chemically related epinephrine and ephedrine...
  73. doi request reprint [Basophil activation test as in vitro assay for cisplatin allergy]
    A Viardot-Helmer
    Hautklinik, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Deutschland
    Hautarzt 59:883-4. 2008
    ..We were asked to verify an adverse reaction to contrast media. Using the basophil activation test, we demonstrated a hypersensitivity reaction to cisplatin with distinct induction of CD63-expression on basophilic granulocytes...
  74. ncbi request reprint Barber's hair sinus in a female hairdresser: uncommon manifestation of an occupational dermatosis
    C M Schröder
    Department of Dermatology and Allergology, University Clinic of the RWTH, Aachen, Germany
    J Eur Acad Dermatol Venereol 20:209-11. 2006
    ..Whereas, to date, the disease has almost exclusively been reported to occur on the hands of male hairdressers, we herein present the first case of a female hairdresser who developed a barber's hair sinus on one of her feet...
  75. doi request reprint [Delayed hypersensitivity to East Indian rosewood]
    A Viardot-Helmer
    Klinik für Allergologie und Dermatologie, Universitatsklinikum Aachen, Pauwelsstrabe 30, 52074, Aachen, Deutschland
    Hautarzt 59:465-6. 2008
  76. ncbi request reprint Xenobiotics in vitro: the influence of L-cystine, pantothenat, and miliacin on metabolic and proliferative capacity of keratinocytes
    D Hoeller Obrigkeit
    Department of Dermatology and Allergology, University Clinic RWTH, Aachen, Germany
    Cutan Ocul Toxicol 25:13-22. 2006
    ..g., Priorin). Furthermore, this work emphasizes the suitability of keratinocyte monolayers for pharmacological testings...
  77. doi request reprint [Aspects of occupational skin diseases in hair dressers]
    R Brans
    Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Hautarzt 60:973-8. 2009
    ..It is of great importance to fulfill and extent these requirements to further minimize the risk of occupational skin disease in this profession...
  78. ncbi request reprint [Meeting of the Department of Dermatology, University of Aachen]
    H Ott
    Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen
    Hautarzt 57:1111-26. 2006
  79. doi request reprint [Contact sensitization to azole antimycotics]
    R Brans
    Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Deutschland
    Hautarzt 60:372-5. 2009
    ..Patch testing revealed positive reactions to clotrimazole, croconazole, oxiconazole and tioconazole. Cross-sensitivity was possible, but multiple sensitizations could not be excluded...
  80. ncbi request reprint A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites
    Moa Andresen Bergström
    Dermatochemistry and Skin Allergy, Department of Chemistry, Goteborg University, Goteborg, Sweden
    J Invest Dermatol 127:1145-53. 2007
    ....
  81. ncbi request reprint Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones
    Sonja Sieben
    Department of Dermatology, University Hospital RWTH Aachen, Germany
    J Allergy Clin Immunol 109:1005-11. 2002
    ..Allergic contact dermatitis to paraphenylenediamine (PPD) is a frequent cause of morbidity and occupational disability...
  82. ncbi request reprint Lymphocyte transformation test as a diagnostic test in allergic contact dermatitis
    Hans F Merk
    Contact Dermatitis 53:246. 2005
  83. ncbi request reprint Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions
    Esther A Coors
    Department of Dermatology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Ann Allergy Asthma Immunol 95:593-9. 2005
    ..Whereas its relevance as a contact allergen has declined during the past decades, it is of current relevance as a "hidden" inductor of anaphylactoid reactions...
  84. doi request reprint Elicitation response characteristics to mono- and to N,N'-diacetyl-para-phenylenediamine
    Brunhilde Blomeke
    Department of Ecotoxicology and Toxicology, University of Trier, Am Wissenschaftspark 25 27, 54296, Trier, Germany
    Contact Dermatitis 58:355-8. 2008
    ..Beside auto-oxidation to Bandrowski's base, PPD is enzymatically acetylated to monoacetyl-PPD (MAPPD) and to N,N'-diacetyl-PPD (DAPPD) in skin and keratinocytes...
  85. doi request reprint Allergological approach to drug hypersensitivity reactions
    Bernhard Przybilla
    Klinik und Poliklinik fur Dermatologie und Allergologie, Ludwig Maximilians Universität Frauenlobstr 9 1180337 Munich, Germany
    J Dtsch Dermatol Ges 6:240-3. 2008
  86. ncbi request reprint Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Invest Dermatol 128:67-78. 2008
    ..Gene expression profiling might complement the diagnostic spectrum in dermatology and may provide new pathogenetic insights...
  87. ncbi request reprint Onychomycosis in a diabetic patient due to Trichophyton gallinae
    Pamela Poblete-Gutiérrez
    Mycoses 49:254-7. 2006
    ..Herein, clinical, diagnostic, and epidemiological aspects of this zoophilic dermatophyte are briefly reviewed...
  88. ncbi request reprint Xenobiotic metabolism in human skin and 3D human skin reconstructs: a review
    Sue Gibbs
    Safety and Environmental Assurance Centre, Unilever, Colworth Park, Sharnbrook, Bedfordshire, UK
    Curr Drug Metab 8:758-72. 2007
    ..In order to be able to use 3D skin models in this context, we need to understand their metabolic competency in relation to xenobiotic biotransformation and whether functional activity is representative of that seen in human skin...
  89. ncbi request reprint The "strip" patch test: results of a multicentre study towards a standardization
    Heinrich Dickel
    Department of Dermatology, Environmental Medicine, and Health Theory, University of Osnabruck, Sedanstr 115, 49090 Osnabrück, Germany
    Arch Dermatol Res 296:212-9. 2004
    ..Penetration of the substances is enhanced by repeated applications of adhesive tape prior to their application to the skin. However, no guidelines exist for standardized performance of the SPT...
  90. ncbi request reprint Multiple patch-test reactions: a pilot evaluation of a combination approach to visualize patterns of multiple sensitivity in patch-test databases and a proposal for a multiple sensitivity index
    Heinrich Dickel
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrueck, Osnabrueck, Germany
    Am J Contact Dermat 14:148-53. 2003
    ..Studies addressing this topic have primarily concerned the occurrence of pairs of allergens, and some reports hypothesize a predisposing factor that influences the individual sensitivity of patients to multiple reactions...
  91. ncbi request reprint Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: association with survival
    Motoko Tanaka-Nozaki
    Department of Surgery I, Nippon Medical School, Tokyo, Japan
    Oncol Rep 10:1425-9. 2003
    ..These findings suggest that TS mRNA was induced by 5-FU treatment, and the overall induction level varied between individuals. Therefore, the estimation of TS mRNA induction may be useful to predict the efficacy of 5-FU treatment...
  92. doi request reprint Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    Int J Cancer 123:2605-15. 2008
    ..Collectively, our findings support the concept that IFN-associated host responses play an important role in tumor immunosurveillance in the skin...
  93. ncbi request reprint Fluoroquinolone-associated anaphylaxis in spontaneous adverse drug reaction reports in Germany: differences in reporting rates between individual fluoroquinolones and occurrence after first-ever use
    Bernhardt Sachs
    Division of Pharmacovigilance, Federal Institute for Drugs and Medical Devices BfArM, Bonn, Germany
    Drug Saf 29:1087-100. 2006
    ..According to pathophysiology, anaphylaxis may be immune mediated (anaphylactic) or not (anaphylactoid). The latter may occur after first-ever intake since no sensitisation phase is necessary...