B Luscher

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi TGFβ1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation: basic functions of C/EBP, SP and SMAD3 transcription factors
    Nadine Hein
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    BMC Mol Biol 12:9. 2011
  2. ncbi ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
    Karla Lh Feijs
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, 52074, Aachen, Germany
    Cell Commun Signal 11:5. 2013
  3. ncbi Cytokines and the skin barrier
    Kai H Hänel
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Int J Mol Sci 14:6720-45. 2013
  4. ncbi Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
    Henning Kleine
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, Aachen, 52074, Germany
    Cell Commun Signal 10:28. 2012
  5. ncbi Phosphorylation during mitosis: how many kinases are out there?
    Bernhard Luscher
    Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
    Cell Cycle 10:3821-2. 2011
  6. ncbi MAD1 and its life as a MYC antagonist: an update
    Bernhard Luscher
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    Eur J Cell Biol 91:506-14. 2012
  7. ncbi Regulation of gene transcription by the oncoprotein MYC
    Bernhard Luscher
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    Gene 494:145-60. 2012
  8. ncbi The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site
    Katrin de Graaf
    Institute of Pharmacology and Toxicology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    BMC Biochem 7:7. 2006
  9. ncbi The world according to MYC. Conference on MYC and the transcriptional control of proliferation and oncogenesis
    Bernhard Luscher
    Institute of Biochemistry, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
    EMBO Rep 8:1110-4. 2007
  10. ncbi Function and regulation of the transcription factors of the Myc/Max/Mad network
    B Luscher
    Abt Biochemie und Molekularbiologie, Institut fur Biochemie, Universitätsklinikum der RWTH, Pauwelstrasse 30, 52057 Aachen, Germany
    Gene 277:1-14. 2001

Collaborators

  • Gerhard Muller-Newen
  • Lars Gunnar Larsson
  • R Bucala
  • J Vervoorts
  • Karla Lh Feijs
  • Henning Kleine
  • Kai H Hänel
  • Elisabeth Kremmer
  • Patricia Verheugd
  • Alexandra H Forst
  • Nicolas Herzog
  • Christian Cornelissen
  • Nadine Hein
  • H Lue
  • Katrin de Graaf
  • S Rottmann
  • Ulrike Linzen
  • Anne Braczynski
  • Jens Malte Baron
  • Terje Johansen
  • Barbara Lippok
  • Juliane Lüscher-Firzlaff
  • Andreas Herrmann
  • Trond Lamark
  • Kan Jiang
  • G Fingerle-Rowson
  • G Fingerle Rowson
  • L Leng
  • J Franz
  • M Thiele
  • S Speckgens
  • E Dahl
  • J Bernhagen
  • Sabine Rottmann
  • Len C Packman
  • Hanna Czajkowska
  • Richard Lilischkis
  • Walter Becker

Detail Information

Publications13

  1. ncbi TGFβ1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation: basic functions of C/EBP, SP and SMAD3 transcription factors
    Nadine Hein
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    BMC Mol Biol 12:9. 2011
    ..Moreover we have recently demonstrated that the MAD1 promoter is controlled by the cytokine granulocyte colony-stimulating factor (G-CSF) through the activation of STAT3, MAP kinases and C/EBP transcription factors...
  2. ncbi ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
    Karla Lh Feijs
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, 52074, Aachen, Germany
    Cell Commun Signal 11:5. 2013
    ..This is partially due to lack of suitable reagents to study mono-ADP-ribosylation, which limits the current understanding of this post-translational modification...
  3. ncbi Cytokines and the skin barrier
    Kai H Hänel
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Int J Mol Sci 14:6720-45. 2013
    ..Here we summarize the current knowledge on cytokines and their functions in healthy skin and their contributions to inflammatory skin diseases...
  4. ncbi Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
    Henning Kleine
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, Aachen, 52074, Germany
    Cell Commun Signal 10:28. 2012
    ..abstract:..
  5. ncbi Phosphorylation during mitosis: how many kinases are out there?
    Bernhard Luscher
    Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
    Cell Cycle 10:3821-2. 2011
  6. ncbi MAD1 and its life as a MYC antagonist: an update
    Bernhard Luscher
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    Eur J Cell Biol 91:506-14. 2012
    ....
  7. ncbi Regulation of gene transcription by the oncoprotein MYC
    Bernhard Luscher
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    Gene 494:145-60. 2012
    ..We note that despite the many molecular details known, we do not have an integrated view of how MYC uses the different tools, neither in a spatial nor in a temporal order...
  8. ncbi The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site
    Katrin de Graaf
    Institute of Pharmacology and Toxicology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    BMC Biochem 7:7. 2006
    ..DYRK1A is a nuclear protein kinase that has been localized to the splicing factor compartment. Here we describe the identification of DYRK1A as a protein kinase that phosphorylates SF3b1 in vitro and in cultivated cells...
  9. ncbi The world according to MYC. Conference on MYC and the transcriptional control of proliferation and oncogenesis
    Bernhard Luscher
    Institute of Biochemistry, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
    EMBO Rep 8:1110-4. 2007
  10. ncbi Function and regulation of the transcription factors of the Myc/Max/Mad network
    B Luscher
    Abt Biochemie und Molekularbiologie, Institut fur Biochemie, Universitätsklinikum der RWTH, Pauwelstrasse 30, 52057 Aachen, Germany
    Gene 277:1-14. 2001
    ..Thus the antagonism of Myc and Mad proteins is explained at the molecular level by the recruitment of opposing chromatin remodeling activities...
  11. ncbi The Mad side of the Max network: antagonizing the function of Myc and more
    S Rottmann
    Abteilung Biochemie und Molekularbiologie, , Klinikum der RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    Curr Top Microbiol Immunol 302:63-122. 2006
    ..In addition, we point out some of the many aspects that have not been clarified and thus leave us with a rather incomplete picture of the functions, both molecular and at the cellular level, of Mad family members...
  12. ncbi Post-translational regulation of the tumor suppressor p27(KIP1)
    J Vervoorts
    Institute of Biochemistry, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52057, Aachen, Germany
    Cell Mol Life Sci 65:3255-64. 2008
    ..Understanding functions and regulation of p27(KIP1) will be important to determine which isoform of p27(KIP1) has anti- or pro-tumorigenic activities. Such knowledge might be of prognostic value and may offer novel therapeutic windows...
  13. ncbi Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
    H Lue
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital RWTH Aachen, Aachen, Germany
    Oncogene 26:5046-59. 2007
    ..Thus, MIF can directly promote cell survival through activation of the PI3K/Akt pathway and this effect is critical for tumor cell survival...