B Luscher

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. pmc TGFβ1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation: basic functions of C/EBP, SP and SMAD3 transcription factors
    Nadine Hein
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    BMC Mol Biol 12:9. 2011
  2. pmc Regulation of sirtuin function by posttranslational modifications
    Franziska Flick
    Medical School, Institute of Biochemistry and Molecular Biology, RWTH Aachen University Aachen, Germany
    Front Pharmacol 3:29. 2012
  3. pmc Regulation of the MAD1 promoter by G-CSF
    Kan Jiang
    Institut fur Biochemie, Universitatsklinikum, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
    Nucleic Acids Res 36:1517-31. 2008
  4. pmc The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
    Ruwin Pandithage
    Abteilung Biochemie und Molekularbiologie, Institut fur Biochemie, Universitatsklinikum, Rheinisch Westfälische Technische Hochschule Aachen University, 52057 Aachen, Germany
    J Cell Biol 180:915-29. 2008
  5. pmc ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
    Karla Lh Feijs
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, 52074, Aachen, Germany
    Cell Commun Signal 11:5. 2013
  6. pmc Cytokines and the skin barrier
    Kai H Hänel
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Int J Mol Sci 14:6720-45. 2013
  7. pmc Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
    Henning Kleine
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, Aachen, 52074, Germany
    Cell Commun Signal 10:28. 2012
  8. ncbi request reprint Phosphorylation during mitosis: how many kinases are out there?
    Bernhard Luscher
    Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
    Cell Cycle 10:3821-2. 2011
  9. doi request reprint MAD1 and its life as a MYC antagonist: an update
    Bernhard Luscher
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    Eur J Cell Biol 91:506-14. 2012
  10. doi request reprint Regulation of gene transcription by the oncoprotein MYC
    Bernhard Luscher
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    Gene 494:145-60. 2012

Collaborators

  • Bernd Knöll
  • Nadine Hein
  • Terje Johansen
  • Lars Gunnar Larsson
  • R Bucala
  • J Vervoorts
  • Gerhard Muller-Newen
  • Karla Lh Feijs
  • Henning Kleine
  • Elisabeth Kremmer
  • Juliane Lüscher-Firzlaff
  • Kai H Hänel
  • Alexandra H Forst
  • Patricia Verheugd
  • Nicolas Herzog
  • Franziska Flick
  • Ruwin Pandithage
  • Kan Jiang
  • H Lue
  • Richard Lilischkis
  • Katrin de Graaf
  • S Rottmann
  • Christian Cornelissen
  • Ulrike Linzen
  • Anne Braczynski
  • Jens Malte Baron
  • Andreas Herrmann
  • Barbara Lippok
  • Trond Lamark
  • Britta Jedamzik
  • Kolja Eckert
  • Alexandra Wolf
  • Edwin Lasonder
  • Kai Harting
  • G Fingerle-Rowson
  • S Speckgens
  • E Dahl
  • L Leng
  • J Bernhagen
  • M Thiele
  • J Franz
  • Walter Becker
  • Hanna Czajkowska
  • Sabine Rottmann
  • Len C Packman

Detail Information

Publications16

  1. pmc TGFβ1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation: basic functions of C/EBP, SP and SMAD3 transcription factors
    Nadine Hein
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    BMC Mol Biol 12:9. 2011
    ..Moreover we have recently demonstrated that the MAD1 promoter is controlled by the cytokine granulocyte colony-stimulating factor (G-CSF) through the activation of STAT3, MAP kinases and C/EBP transcription factors...
  2. pmc Regulation of sirtuin function by posttranslational modifications
    Franziska Flick
    Medical School, Institute of Biochemistry and Molecular Biology, RWTH Aachen University Aachen, Germany
    Front Pharmacol 3:29. 2012
    ..Together these findings point to key regulatory roles of the N- and C-terminal extensions in controlling sirtuin functions, thus connecting these regulators to different signaling pathways...
  3. pmc Regulation of the MAD1 promoter by G-CSF
    Kan Jiang
    Institut fur Biochemie, Universitatsklinikum, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
    Nucleic Acids Res 36:1517-31. 2008
    ..Our findings provide the base for the characterization of additional signal transduction pathways that control the expression of MAD1...
  4. pmc The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
    Ruwin Pandithage
    Abteilung Biochemie und Molekularbiologie, Institut fur Biochemie, Universitatsklinikum, Rheinisch Westfälische Technische Hochschule Aachen University, 52057 Aachen, Germany
    J Cell Biol 180:915-29. 2008
    ..Collectively, our findings identify a posttranslational mechanism that controls SIRT2 function, and they provide evidence for a novel regulatory circuitry involving Cdks, SIRT2, and microtubules...
  5. pmc ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
    Karla Lh Feijs
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, 52074, Aachen, Germany
    Cell Commun Signal 11:5. 2013
    ..This is partially due to lack of suitable reagents to study mono-ADP-ribosylation, which limits the current understanding of this post-translational modification...
  6. pmc Cytokines and the skin barrier
    Kai H Hänel
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Int J Mol Sci 14:6720-45. 2013
    ..Here we summarize the current knowledge on cytokines and their functions in healthy skin and their contributions to inflammatory skin diseases...
  7. pmc Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
    Henning Kleine
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, Aachen, 52074, Germany
    Cell Commun Signal 10:28. 2012
    ..abstract:..
  8. ncbi request reprint Phosphorylation during mitosis: how many kinases are out there?
    Bernhard Luscher
    Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
    Cell Cycle 10:3821-2. 2011
  9. doi request reprint MAD1 and its life as a MYC antagonist: an update
    Bernhard Luscher
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    Eur J Cell Biol 91:506-14. 2012
    ....
  10. doi request reprint Regulation of gene transcription by the oncoprotein MYC
    Bernhard Luscher
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany
    Gene 494:145-60. 2012
    ..We note that despite the many molecular details known, we do not have an integrated view of how MYC uses the different tools, neither in a spatial nor in a temporal order...
  11. pmc The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site
    Katrin de Graaf
    Institute of Pharmacology and Toxicology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    BMC Biochem 7:7. 2006
    ..DYRK1A is a nuclear protein kinase that has been localized to the splicing factor compartment. Here we describe the identification of DYRK1A as a protein kinase that phosphorylates SF3b1 in vitro and in cultivated cells...
  12. pmc The world according to MYC. Conference on MYC and the transcriptional control of proliferation and oncogenesis
    Bernhard Luscher
    Institute of Biochemistry, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
    EMBO Rep 8:1110-4. 2007
  13. ncbi request reprint Function and regulation of the transcription factors of the Myc/Max/Mad network
    B Luscher
    Abt Biochemie und Molekularbiologie, Institut fur Biochemie, Universitätsklinikum der RWTH, Pauwelstrasse 30, 52057 Aachen, Germany
    Gene 277:1-14. 2001
    ..Thus the antagonism of Myc and Mad proteins is explained at the molecular level by the recruitment of opposing chromatin remodeling activities...
  14. ncbi request reprint The Mad side of the Max network: antagonizing the function of Myc and more
    S Rottmann
    Abteilung Biochemie und Molekularbiologie, Institut fur Biochemie, Klinikum der RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    Curr Top Microbiol Immunol 302:63-122. 2006
    ..In addition, we point out some of the many aspects that have not been clarified and thus leave us with a rather incomplete picture of the functions, both molecular and at the cellular level, of Mad family members...
  15. doi request reprint Post-translational regulation of the tumor suppressor p27(KIP1)
    J Vervoorts
    Institute of Biochemistry, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52057, Aachen, Germany
    Cell Mol Life Sci 65:3255-64. 2008
    ..Understanding functions and regulation of p27(KIP1) will be important to determine which isoform of p27(KIP1) has anti- or pro-tumorigenic activities. Such knowledge might be of prognostic value and may offer novel therapeutic windows...
  16. ncbi request reprint Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
    H Lue
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital RWTH Aachen, Aachen, Germany
    Oncogene 26:5046-59. 2007
    ..Thus, MIF can directly promote cell survival through activation of the PI3K/Akt pathway and this effect is critical for tumor cell survival...