U Klinge

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi request reprint Abnormal collagen I to III distribution in the skin of patients with incisional hernia
    U Klinge
    Department of Surgery, Technical University of Aachen, Germany
    Eur Surg Res 32:43-8. 2000
  2. ncbi request reprint Influence of polyglactin-coating on functional and morphological parameters of polypropylene-mesh modifications for abdominal wall repair
    U Klinge
    The Department of Surgery, IZKF BIOMAT, The Technical University of Aachen, Germany
    Biomaterials 20:613-23. 1999
  3. ncbi request reprint Expression of the extracellular matrix proteins collagen I, collagen III and fibronectin and matrix metalloproteinase-1 and -13 in the skin of patients with inguinal hernia
    U Klinge
    Department of Surgery, Technical University of Aachen, Germany
    Eur Surg Res 31:480-90. 1999
  4. ncbi request reprint Synthesis of type I and III collagen, expression of fibronectin and matrix metalloproteinases-1 and -13 in hernial sac of patients with inguinal hernia
    U Klinge
    The Department of Surgery, The Technical University of Aachen, Germany
    Int J Surg Investig 1:219-27. 1999
  5. doi request reprint Treatment algorithm for postoperative upper gastrointestinal fistulas and leaks using combined vicryl plug and fibrin glue
    G Bohm
    Department of Surgery, University Hospital Aachen, Aachen, Germany
    Endoscopy 42:599-602. 2010
  6. doi request reprint Comet-tail-like inflammatory infiltrate to polymer filaments develops in tension-free conditions
    C D Klink
    Department of Surgery, RWTH Aachen, Aachen, Germany
    Eur Surg Res 46:73-81. 2011
  7. ncbi request reprint Biomechanical analyses of mesh fixation in TAPP and TEP hernia repair
    R Schwab
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Surg Endosc 22:731-8. 2008
  8. ncbi request reprint Biomaterial-dependent MMP-2 expression in fibroblasts from patients with recurrent incisional hernias
    R Rosch
    Department of Surgery, University Hospital Aachen, Aachen, Germany
    Hernia 10:125-30. 2006
  9. ncbi request reprint Influence of suture material and suture technique on collagen fibril diameters in midline laparotomies
    J Hoer
    Department of Surgery, University Hospital RWTH Aachen, Germany
    Eur Surg Res 32:359-67. 2000
  10. ncbi request reprint Persistent extracellular matrix remodelling at the interface to polymers used for hernia repair
    K Junge
    Department of Surgery, German Centre of Excellence for Biomaterial and Implant Pathology, Technical University of Aachen, Aachen, Germany
    Eur Surg Res 35:497-504. 2003

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Abnormal collagen I to III distribution in the skin of patients with incisional hernia
    U Klinge
    Department of Surgery, Technical University of Aachen, Germany
    Eur Surg Res 32:43-8. 2000
    ..Furthermore, it might explain the high recurrence rates of hernia repair by simple closure, as a repetition of the primarily failing technique, and the improvement by the additional use of alloplastic material...
  2. ncbi request reprint Influence of polyglactin-coating on functional and morphological parameters of polypropylene-mesh modifications for abdominal wall repair
    U Klinge
    The Department of Surgery, IZKF BIOMAT, The Technical University of Aachen, Germany
    Biomaterials 20:613-23. 1999
    ..Whereas the addition of polyglactin filaments appears to be favourable, the coating of polypropylene with polyglactin seems to hinder the incorporation of the mesh...
  3. ncbi request reprint Expression of the extracellular matrix proteins collagen I, collagen III and fibronectin and matrix metalloproteinase-1 and -13 in the skin of patients with inguinal hernia
    U Klinge
    Department of Surgery, Technical University of Aachen, Germany
    Eur Surg Res 31:480-90. 1999
    ....
  4. ncbi request reprint Synthesis of type I and III collagen, expression of fibronectin and matrix metalloproteinases-1 and -13 in hernial sac of patients with inguinal hernia
    U Klinge
    The Department of Surgery, The Technical University of Aachen, Germany
    Int J Surg Investig 1:219-27. 1999
    ..The absence of changes of the expression of collagenases (MMP-1, MMP-13) and the constant levels of fibronectin underline the central role of collagen synthesis for the development of indirect or direct hernias...
  5. doi request reprint Treatment algorithm for postoperative upper gastrointestinal fistulas and leaks using combined vicryl plug and fibrin glue
    G Bohm
    Department of Surgery, University Hospital Aachen, Aachen, Germany
    Endoscopy 42:599-602. 2010
    ....
  6. doi request reprint Comet-tail-like inflammatory infiltrate to polymer filaments develops in tension-free conditions
    C D Klink
    Department of Surgery, RWTH Aachen, Aachen, Germany
    Eur Surg Res 46:73-81. 2011
    ..These complications are accompanied by an intense inflammatory infiltrate around the polymer fibres. To characterize this effect, the response to polypropylene fibres in the absence of tension was examined...
  7. ncbi request reprint Biomechanical analyses of mesh fixation in TAPP and TEP hernia repair
    R Schwab
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Surg Endosc 22:731-8. 2008
    ....
  8. ncbi request reprint Biomaterial-dependent MMP-2 expression in fibroblasts from patients with recurrent incisional hernias
    R Rosch
    Department of Surgery, University Hospital Aachen, Aachen, Germany
    Hernia 10:125-30. 2006
    ....
  9. ncbi request reprint Influence of suture material and suture technique on collagen fibril diameters in midline laparotomies
    J Hoer
    Department of Surgery, University Hospital RWTH Aachen, Germany
    Eur Surg Res 32:359-67. 2000
    ..Although laparotomy closure is associated with a cumulative 15% failure rate, the effect of different suture techniques and materials on the ultrastructural composition of the healing incision has not been investigated...
  10. ncbi request reprint Persistent extracellular matrix remodelling at the interface to polymers used for hernia repair
    K Junge
    Department of Surgery, German Centre of Excellence for Biomaterial and Implant Pathology, Technical University of Aachen, Aachen, Germany
    Eur Surg Res 35:497-504. 2003
    ..951, p = 0.049), there was no relation to the expression of collagenases (MMP-1/MMP-13) with regard to the amount of inflammatory and connective tissue formation despite partly significant differences between implanted polymers...
  11. ncbi request reprint Gas-related impact of pneumoperitoneum on systemic wound healing
    R Rosch
    Department of Surgery, University Hospital Aachen, Aachen, Germany
    Langenbecks Arch Surg 393:75-80. 2008
    ..The aim of the present study was to investigate the gas-dependent effects of pneumoperitoneum on wound healing distant from the abdomen...
  12. ncbi request reprint Polypropylene in the intra-abdominal position: influence of pore size and surface area
    J Conze
    Department of Surgery, Rhenish Westphalian Technical University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 8:365-72. 2004
    ..The following study was designed to investigate the adhesive potential of different polypropylene meshes when placed in direct contact with intestine...
  13. ncbi request reprint Titanium coating of a polypropylene mesh for hernia repair: effect on biocompatibilty
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Hernia 9:115-9. 2005
    ..No significant improvement of biocompatibility was found when analyzing the effect of titanium coating compared to the pure polypropylene mesh structure...
  14. ncbi request reprint Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 9:212-7. 2005
    ..This study was designed to evaluate the influence of this additional supplementation on the biocompatibility in a rodent animal model...
  15. doi request reprint Large-pore PDS mesh compared to small-pore PG mesh
    J Otto
    Department of Surgery, University Clinic RWTH Aachen, Pauwelsstrasse, Aachen, Germany
    J Invest Surg 23:190-6. 2010
    ..Therefore, a new mesh was constructed of absorbable polydioxanon monofilaments (PDS) with increased porosity and longer degradation time...
  16. ncbi request reprint Collagen I/III and matrix metalloproteinases (MMP) 1 and 13 in the fascia of patients with incisional hernias
    U Klinge
    Department of Surgery, Technical University of Aachen, Germany
    J Invest Surg 14:47-54. 2001
    ..Furthermore, these results might explain the poor results of a mesh-free hernia repair, which again builds up scar tissue of inadequate collagen composition and strength...
  17. doi request reprint Serum analyses for protein, albumin and IL-1-RA serve as reliable predictors for seroma formation after incisional hernia repair
    C D Klink
    Department of Surgery, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Hernia 15:69-73. 2011
    ..The aim of this study was to identify potential parameters as predictors for seroma formation after incisional hernia mesh repair...
  18. ncbi request reprint Modification of collagen formation using supplemented mesh materials
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 10:492-7. 2006
    ..Therefore the development of bioactive mesh materials to achieve a local modification of the scar formation to improve patients outcome is advisable...
  19. ncbi request reprint Mesh implants in hernia repair. Inflammatory cell response in a rat model
    R Rosch
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Eur Surg Res 35:161-6. 2003
    ..To approach biocompatibility of surgical meshes we therefore examined the infiltrate of these cells as well as the proliferation rate in response to different clinically applied materials...
  20. doi request reprint In vitro and in vivo characteristics of gentamicin-supplemented polyvinylidenfluoride mesh materials
    C D Klink
    Department of Surgery, RWTH Aachen, Germany
    J Biomed Mater Res A 100:1195-202. 2012
    ..A significantly decreased foreign body granuloma formation compared to the pure PVDF mesh group was found. In vitro analysis showed efficient antibiotic effects of the Gentamicin supplementation compared to the pure PVDF mesh...
  21. doi request reprint Do drainage liquid characteristics serve as predictors for seroma formation after incisional hernia repair?
    C D Klink
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    Hernia 14:175-9. 2010
    ..Furthermore, the characteristics of drainage liquid were compared to the characteristics of seroma liquid...
  22. doi request reprint Influence of mesh materials on the integrity of the vas deferens following Lichtenstein hernioplasty: an experimental model
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Hernia 12:621-6. 2008
    ..The aim of this study was to evaluate the effect of different mesh structures on integrity of the vas deferens...
  23. ncbi request reprint Vypro II mesh in hernia repair: impact of polyglactin on long-term incorporation in rats
    R Rosch
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Eur Surg Res 35:445-50. 2003
    ..As it has been suggested that polyglactin induces fibroplastic reactions and wound complications, this study was designed to evaluate the long-term tissue reaction to polyglactin in the Vypro II mesh...
  24. ncbi request reprint Intraabdominal adhesion formation of polypropylene mesh. Influence of coverage of omentum and polyglactin
    J Conze
    Department of Surgery, Rhenish Westphalian Technical University, Aachen, Germany
    Surg Endosc 19:798-803. 2005
    ..To investigate the adhesive potential induced by the biomaterial, an animal model was performed. In addition, the influence of coverage by omentum or a polyglactin barrier was investigated...
  25. ncbi request reprint Analysis of c-myc, PAI-1 and uPAR in patients with incisional hernias
    R Rosch
    Department of Surgery, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Hernia 12:285-8. 2008
    ..The aim of the present study was to further characterise the scarring process in such patients...
  26. ncbi request reprint Fibrin sealant for mesh fixation in Lichtenstein repair: biomechanical analysis of different techniques
    R Schwab
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    Hernia 11:139-45. 2007
    ..There are currently no biomechanical data available for evaluation of the quality of adhesion achieved with fibrin sealant during Lichtenstein hernia repair...
  27. ncbi request reprint Incisional abdominal hernia: the open mesh repair
    V Schumpelick
    Department of Surgery, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 389:1-5. 2004
    ..Mesh techniques are the methods of choice for the repair of incisional hernias since these are due to the formation of unstable scar tissue...
  28. ncbi request reprint Influence of mesh materials on collagen deposition in a rat model
    K Junge
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    J Invest Surg 15:319-28. 2002
    ..The quality of the ECM deposition as determined by collagen type I/III ratio is impaired in general, whereas the quantity of ECM deposition is markedly influenced by the kind of mesh material...
  29. ncbi request reprint Improved abdominal wall wound healing by helium pneumoperitoneum
    R Rosch
    Department of Surgery, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Surg Endosc 20:1892-6. 2006
    ..Questions remain regarding the risk of port-site hernias and hernia recurrence. The current study investigated the gas-dependent effects of pneumoperitoneum on laparotomy wound healing...
  30. doi request reprint Comparison of long-term biocompability of PVDF and PP meshes
    C D Klink
    Department of Surgery, RWTH Aachen, Germany
    J Invest Surg 24:292-9. 2011
    ..Mesh repair in hernia surgery has become an integral component. Although meshes made of PVDF are already in clinical use, so far no data of long-term biocompability are available...
  31. ncbi request reprint PVDF as a new polymer for the construction of surgical meshes
    U Klinge
    Department of Surgery, Technical University of Aachen, Germany
    Biomaterials 23:3487-93. 2002
    ..Analyzing the results confirmed that construction of hernia meshes made of PVDF could be an advantageous alternative to the commonly used materials due to an improved biostability. lowered bending stiffness and a minimum tissue response...
  32. ncbi request reprint Individual inflammatory response of human blood monocytes to mesh biomaterials
    A Schachtrupp
    Department of Surgery, Rhenish Westphalian Technical University, Aachen, Germany
    Br J Surg 90:114-20. 2003
    ..As monocytes take a key position in the inflammatory foreign body reaction, their specific release of cytokines was investigated in vitro after incubation with alloplastic materials...
  33. ncbi request reprint A case of bilateral inguinal hernia recurrence in infancy: investigations on collagen metabolism
    R Rosch
    Department of Surgery, University Hospital Aachen, Germany
    Hernia 8:160-3. 2004
    ..Due to previous observations of an altered collagen metabolism in hernia patients, a severe connective-tissue pathology in the infant was hypothesised...
  34. ncbi request reprint Prosthetic implants for hernia repair
    V Schumpelick
    Department of Surgery, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Br J Surg 90:1457-8. 2003
  35. ncbi request reprint Evaluation of tissue components in the peripheral nervous system using Sirius red staining and immunohistochemistry: a comparative study (human, pig, rat)
    D Kaemmer
    Department of Surgery, RWTH Aachen University Hospital, Aachen, Germany
    J Neurosci Methods 190:112-6. 2010
    ..However, in particular studies of collagen accumulation in nerves, species dependant differences have to be considered...
  36. ncbi request reprint Temporary closure of the abdominal wall (laparostomy)
    A Schachtrupp
    Department of Surgery, Rhenish Westphalian Technical University, Pauwelsstr 30, 52074 Aachen, Germany
    Hernia 6:155-62. 2002
    ..Nevertheless, in the complex situation requiring a temporary abdominal wall closure, use of absorbable mesh material is common and represents the state of the art...
  37. ncbi request reprint Breaking strength and tissue elasticity after Shouldice repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, Germany
    Hernia 7:17-20. 2003
    ..Therefore, an early postoperative return to normal activity can be recommended...
  38. ncbi request reprint Functional impairment and complaints following incisional hernia repair with different polypropylene meshes
    G Welty
    Department of Surgery, Technical University of Aachen, Germany
    Hernia 5:142-7. 2001
    ..Three-dimensional stereographic examinations were well in accordance with our clinical findings. Our data support the hypothesis that the use of low-weight large-pore meshes is advantageous for abdominal wall function...
  39. ncbi request reprint Validation of IC-VIEW fluorescence videography in a rabbit model of mesenteric ischaemia and reperfusion
    C Toens
    Department of Surgery, Marienhospital, Dusseldorf, Germany
    Int J Colorectal Dis 21:332-8. 2006
    ..The aim of this study was to investigate the scientific value of this technique in mesenteric ischaemia in a rabbit model of controlled mesenteric ischaemia and reperfusion...
  40. ncbi request reprint Are collagens the culprits in the development of incisional and inguinal hernia disease?
    U Klinge
    Department of Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 10:472-7. 2006
    ..An overview of the literature is provided, and the consequences for surgical practice are discussed...
  41. ncbi request reprint The biology of hernia formation
    P Lynen Jansen
    Department of Surgery, University Hospital of Aachen, Aachen, Germany
    Surgery 136:1-4. 2004
  42. ncbi request reprint Incisional intercostal hernia after a nephrectomy
    R Rosch
    Department of Surgery, University Hospital, Aachen, Germany
    Hernia 10:97-9. 2006
    ..As with other incisional hernias, the hernia repair using mesh implantation in the retromuscular region is technically feasible and represents the treatment of choice...
  43. ncbi request reprint Analysis of collagen-interacting proteins in patients with incisional hernias
    R Rosch
    Department of Surgery, University Hospital, RWTH, Pauwelsstrasse 30, 52074, Aachen, Germany
    Langenbecks Arch Surg 387:427-32. 2003
    ..We investigated known collagen-interacting proteins to further characterize connective tissue in these patients...
  44. ncbi request reprint The surgical trauma of abdominal wall incision. A comparison of laparoscopic vs open surgery with three-dimensional stereography
    M Stumpf
    Department of Surgery, University Hospital, Rheinisch Westphälische Technische Hochschule RWTH, Pauwelsstrasse 30, 52057 Aachen, Germany
    Surg Endosc 15:1147-9. 2001
    ..The new technique of three-dimensional stereography makes it possible to describe and calculate the mobility of the abdominal wall and the nature of the underlying disturbances...
  45. ncbi request reprint Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease
    M Stumpf
    Department of Surgery, Medical College, Rhenish Westphalian Technical University, Aachen, Germany
    Int J Colorectal Dis 16:271-5. 2001
    ..Further studies must focus on the complex interactions of several extracellular matrix components...
  46. ncbi request reprint The Pfannenstiel or so called "bikini cut": still effective more than 100 years after first description
    K Kisielinski
    Department of Surgery, University Hospital, Rhenish Westphalian Technical University, Pauwelsstr 30, 52074, Aachen, Germany
    Hernia 8:177-81. 2004
    ..Complications of nerve damage, however, should be recognised, especially when extending the incision too far laterally...
  47. ncbi request reprint Results after endoscopic treatment of postoperative upper gastrointestinal fistulas and leaks using combined Vicryl plug and fibrin glue
    S Truong
    Department of Surgery, University Hospital Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Surg Endosc 18:1105-8. 2004
    ..Depending on the clinical presentation, the treatment options include surgery, conservative treatment with or without external drainage or endoscopic treatment...
  48. ncbi request reprint Functional assessment and tissue response of short- and long-term absorbable surgical meshes
    U Klinge
    The Department of Surgery, The Technical University of Aachen, Germany
    Biomaterials 22:1415-24. 2001
    ..The implantation of the long-term absorbable LTS-mesh seems to be favourable with respect to its long-term mechanical stability and the decreased connective tissue formation...
  49. ncbi request reprint Risk factors related to recurrence in inguinal hernia repair: a retrospective analysis
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Hernia 10:309-15. 2006
    ..Patients at risk should preoperatively be identified in order to improve treatment by, for example, the application of mesh techniques...
  50. doi request reprint The Gist of literature on pediatric GIST: review of clinical presentation
    D A Kaemmer
    Medical Faculty, Department of Surgery, Rheinish Westphalian Technical University, Aachen, Germany
    J Pediatr Hematol Oncol 31:108-12. 2009
    ..To provide a review of existing literature on pediatric GIST with focus on clinical presentation...
  51. ncbi request reprint Impact of polymer pore size on the interface scar formation in a rat model
    U Klinge
    Department of Surgery, Institute of Pathology, The Technical University of Aachen, Pauwelsstrasse 30, Aachen, D 52057, Germany
    J Surg Res 103:208-14. 2002
    ..In comparison to the physiological scar process following a simple abdominal wall incision, the chronic inflammation at the interface to the polymers lead to specific morphological alterations...
  52. ncbi request reprint Intra-abdominal pressure: a reliable criterion for laparostomy closure?
    A Schachtrupp
    Department of Surgery, Rhenish Westphalian Technical University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 6:102-7. 2002
    ..Extended incisional hernia is inevitable when fascial closure is missed (up to 90% of cases). Intra-abdominal pressure (IAP) has not yet been evaluated as a criterion for the feasibility of fascial closure...
  53. ncbi request reprint Different matrix micro-environments in colon cancer and diverticular disease
    U Klinge
    Department of Surgery of the RWTH Aachen, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany
    Int J Colorectal Dis 22:515-20. 2007
    ..An altered matrix composition as potential underlying pathology for the development of colorectal cancer was hypothesized...
  54. ncbi request reprint [Management of recurrent inguinal hernia after previous mesh repair: a challenge]
    R Schwab
    Chirurgische Klinik und Poliklinik der RWTH Aachen
    Chirurg 77:523-30. 2006
    ..This applies to at least 10% of recurrences. Needed is a therapeutic algorithm for the surgical management of recurrent hernias after previous mesh repair...
  55. ncbi request reprint Experimental comparison of monofile light and heavy polypropylene meshes: less weight does not mean less biological response
    U Klinge
    World J Surg 31:867-8; author reply 869-70. 2007
  56. ncbi request reprint Laparoscopy and collagen metabolism
    R Rosch
    Department of Surgery of the RWTH Aachen, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 10:507-10. 2006
    ..As the endoscopic technique has, nowadays, become routinely applied for diverse abdominal diseases worldwide, we present a review of literature facing its impact on collagen biology...
  57. ncbi request reprint [Incisional hernia]
    J Conze
    Chirurgische Klinik und Poliklinik der RWTH Aachen
    Chirurg 76:897-909; quiz 910. 2005
    ..Preparation must take into account the special anatomic features of the abdominal wall, especially in the area of the Linea alba and Linea semilunaris...
  58. ncbi request reprint [Comment by request of the editorial staff]
    V Schumpelick
    Chirurgische Universitatsklinik und Poliklinik, RWTH, Aachen, Pauwelsstrasse 30, 52074 Aachen
    Chirurg 73:838. 2002
  59. ncbi request reprint Do multifilament alloplastic meshes increase the infection rate? Analysis of the polymeric surface, the bacteria adherence, and the in vivo consequences in a rat model
    U Klinge
    Department of Surgery Technical University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Biomed Mater Res 63:765-71. 2002
    ..In vivo, the adherence of bacteria to the implant material depends on the surface area, which favors the use of monofilament materials...
  60. ncbi request reprint [Update on incisional hernia. Parastomal hernia]
    R Kasperk
    Chirurgische Klinik und Poliklinik Universitätsklinikum der RWTH Aachen, Germany
    Chirurg 73:895-8. 2002
    ..Only with the last technique of abdominal wall reinforcement it is possible to achieve a recurrence rate of under 20%. The best type of mesh and the optimal implantation technique are still under discussion...
  61. ncbi request reprint [Retromuscular mesh repair for ventral incision hernia in Germany]
    V Schumpelick
    Chirurgische Klinik und Poliklinik, Universitätsklinikum der RWTH Aachen, Germany
    Chirurg 73:888-94. 2002
    ..Open mesh repair, particularly with modern low-weight polypropylene meshes applied by the retromuscular underlay technique, offers excellent results in the treatment of incision hernias, even in long-term follow-up studies...
  62. ncbi request reprint [Prevention of incisional hernia]
    J Hoer
    Chirurgische Klinik und Poliklinik, Universitätsklinikum der RWTH Aachen, Germany
    Chirurg 73:881-7. 2002
    ....
  63. ncbi request reprint Influence of laparotomy closure technique on collagen synthesis in the incisional region
    J J Höer
    Surgical University Hospital, Rhenish Westfalian Technical University Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 6:93-8. 2002
    ..To investigate whether these differences in biomechanical properties influence collagen synthesis in the incisional region, an animal experiment on laparotomy closure was performed...
  64. ncbi request reprint Influence of implantation interval on the long-term biocompatibility of surgical mesh
    B Klosterhalfen
    Institute of Pathology, German Centre of Excellence for Biomaterial and Implant Pathology, Interdisciplinary Centre of Clinical Science BIOMAT, Rhenish Westfalian Technical High School Aachen, Aachen, Germany
    Br J Surg 89:1043-8. 2002
    ..The aim was to study the long-term tissue response to polypropylene mesh...
  65. ncbi request reprint [Meshes in inguinal hernia repair]
    Ch Peiper
    Chirurgische Universitatsklinik und Poliklinik, RWTH Aachen
    Zentralbl Chir 127:573-7. 2002
    ..This includes the hernia classification, the number of previous operations and the possibility of a defect in collagen metabolism. The unknown long-term risks for the patient may be taken only in strong indications...
  66. ncbi request reprint [Factors influencing the development of incisional hernia. A retrospective study of 2,983 laparotomy patients over a period of 10 years]
    J Hoer
    Chirurgische Universitätsklinik der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen
    Chirurg 73:474-80. 2002
    ..Incisional hernia formation is one of the most frequent complications in visceral surgery requiring reoperation. Risk factors for incisional hernia formation and preventive strategies are not clearly defined...
  67. ncbi request reprint Functional and morphological evaluation of a low-weight, monofilament polypropylene mesh for hernia repair
    U Klinge
    Surgical Department of the University Clinic of the Rhenish Westfalian Technical University Aachen, Germany
    J Biomed Mater Res 63:129-36. 2002
    ..In conclusion, these data confirm the improved biocompatibility of material-reduced mesh implants...
  68. ncbi request reprint Causes of recurrences after Lichtenstein tension-free hernioplasty
    U Klinge
    Hernia 7:100-1; author reply 102-3. 2003
  69. ncbi request reprint [Surgical options in chronic pancreatitis]
    C J Krones
    Chirurgische Universitäts und Poliklinik der Rheinisch Westfälischen Technischen Hochschule Aachen
    Dtsch Med Wochenschr 128:1599-601. 2003
  70. ncbi request reprint The rare epidemiologic coincidence of diverticular disease and advanced colonic neoplasia
    C J Krones
    Surgical Department, Medical College, Rhenish Westfalian Technical University, Aachen Pauwelsstr 30, 52074 Aachen, Germany
    Int J Colorectal Dis 21:18-24. 2006
    ..Because directly comparing data are rare, this retrospective study evaluates the coincidence of neoplastic lesions and diverticular disease...
  71. ncbi request reprint [Minimally-invasive surgery for inguinal hernia--contra]
    U Klinge
    Chirurgische Klinik der Rheinisch Westfälischen Technischen Hochschule Aachen
    Dtsch Med Wochenschr 130:535. 2005
  72. ncbi request reprint [Anastomotic leakage in the gastrointestinal tract-repair and prognosis]
    M Stumpf
    Chirurgische Klinik, Universitätsklinikum der RWTH Aachen
    Chirurg 75:1056-62. 2004
    ..Preliminary results indicate the presence of a risk population with collagen metabolism disturbances that have a major effect on wound healing after gastrointestinal anastomosis...
  73. ncbi request reprint Technical consideration for subxiphoidal incisional hernia repair
    J Conze
    Surgical Department and Institute for Anatomy, Rhenish Westphalian Technical University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 9:84-7. 2005
    ..This is complicated when cartilaginous or osseous structures border the fascial defect, most notably at the xiphoid after sternotomy or in large proximal incisional hernias...
  74. ncbi request reprint Pitfalls in retromuscular mesh repair for incisional hernia: the importance of the "fatty triangle"
    J Conze
    Surgical Department, Rhenish Westphalian Technical University, Pauwelsstrasse 30, 52074, Aachen, Germany
    Hernia 8:255-9. 2004
    ..Knowledge of the anatomy and preparation of the "fatty triangle" enables a mesh positioning according to the principles of retromuscular mesh repair...
  75. ncbi request reprint [Fascial healing and wound failure]
    V Fackeldey
    Chirurgische Universitäts und Poliklinik, RWTH Aachen
    Chirurg 75:477-83. 2004
    ..New aspects of pharmacotherapy and better understanding of collagen synthesis and dynamics of closure tension might improve the clinical situation in the future...
  76. ncbi request reprint Surgical mesh as a scaffold for tissue regeneration in the esophagus
    Petra Lynen Jansen
    Interdisciplinary Center for Clinical Research IZKF BIOMAT, Rhenish Westfalian Technical University, Aachen, Germany
    Eur Surg Res 36:104-11. 2004
    ..This study was aimed to reconstitute the esophageal wall and to investigate the functional and histological consequences of a new, non-absorbable polyvinylidene fluoride (PVDF) mesh and an absorbable polyglactin 910 (Vicryl((R))) mesh...
  77. ncbi request reprint Inguinal hernia on the internet: a critical comparison of Germany and the UK
    C J Krones
    Chirurgische Universitätsklinik und Poliklinik der Rheinisch Westfälischen Technischen Hochschule, Pauwelsstr 30, 52057, Aachen, Deutschland
    Hernia 8:47-52. 2004
    ..Patients need competent guides to process surgical information from the Internet. The establishment of specialised institutions to control surgical Web sites according to quality, content, and legality on the European level is urgent...
  78. ncbi request reprint [Information on the Internet for patients and general practitioners--critical analysis using the example of inguinal hernia]
    C J Krones
    Chirurgische Universitatsklinik und Poliklinik, Rheinisch Westfalische Technische Hochschule, Aachen
    Chirurg 74:762-7. 2003
    ..The Internet offers an increasing amount of medical information, but its value for surgical patients is doubtful...
  79. ncbi request reprint Herniosis: a biological approach
    U Klinge
    Hernia 8:300-1. 2004
  80. doi request reprint Mesh for hernia repair
    U Klinge
    Rhenish Westphalian Technical University Aachen and University Hospital Aachen, Pauwelsstrasse, D 52074 Aachen, Germany
    Br J Surg 95:539-40. 2008