Karsten Junge

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi [Primary angiosarcoma of the lung]
    K Junge
    Klinik fur Chirurgie, RWTH Aachen
    Chirurg 72:969-72. 2001
  2. ncbi Modification of collagen formation using supplemented mesh materials
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 10:492-7. 2006
  3. ncbi Risk factors related to recurrence in inguinal hernia repair: a retrospective analysis
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Hernia 10:309-15. 2006
  4. ncbi Influence of mesh materials on collagen deposition in a rat model
    K Junge
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    J Invest Surg 15:319-28. 2002
  5. ncbi Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 9:212-7. 2005
  6. ncbi Breaking strength and tissue elasticity after Shouldice repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, Germany
    Hernia 7:17-20. 2003
  7. ncbi Titanium coating of a polypropylene mesh for hernia repair: effect on biocompatibilty
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Hernia 9:115-9. 2005
  8. ncbi Gentamicin supplementation of polyvinylidenfluoride mesh materials for infection prophylaxis
    Karsten Junge
    Department of Surgery, German Centre of Excellence for Biomaterial and Implant Pathology, Technical University of Aachen, Aachen, Germany
    Biomaterials 26:787-93. 2005
  9. ncbi Persistent extracellular matrix remodelling at the interface to polymers used for hernia repair
    K Junge
    Department of Surgery, German Centre of Excellence for Biomaterial and Implant Pathology, Technical University of Aachen, Aachen, Germany
    Eur Surg Res 35:497-504. 2003
  10. ncbi Mesh reconstruction preventing sacral herniation
    K Junge
    Department of Surgery, RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Hernia 7:224-6. 2003

Detail Information

Publications84

  1. ncbi [Primary angiosarcoma of the lung]
    K Junge
    Klinik fur Chirurgie, RWTH Aachen
    Chirurg 72:969-72. 2001
    ..Angiosarcomas are uncommon neoplasias, normally located in the skin, liver or heart. Primary angiosarcoma of the lung is rare...
  2. ncbi Modification of collagen formation using supplemented mesh materials
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 10:492-7. 2006
    ..Therefore the development of bioactive mesh materials to achieve a local modification of the scar formation to improve patients outcome is advisable...
  3. ncbi Risk factors related to recurrence in inguinal hernia repair: a retrospective analysis
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Hernia 10:309-15. 2006
    ..Patients at risk should preoperatively be identified in order to improve treatment by, for example, the application of mesh techniques...
  4. ncbi Influence of mesh materials on collagen deposition in a rat model
    K Junge
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    J Invest Surg 15:319-28. 2002
    ..The quality of the ECM deposition as determined by collagen type I/III ratio is impaired in general, whereas the quantity of ECM deposition is markedly influenced by the kind of mesh material...
  5. ncbi Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 9:212-7. 2005
    ..This study was designed to evaluate the influence of this additional supplementation on the biocompatibility in a rodent animal model...
  6. ncbi Breaking strength and tissue elasticity after Shouldice repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, Germany
    Hernia 7:17-20. 2003
    ..Therefore, an early postoperative return to normal activity can be recommended...
  7. ncbi Titanium coating of a polypropylene mesh for hernia repair: effect on biocompatibilty
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Hernia 9:115-9. 2005
    ..No significant improvement of biocompatibility was found when analyzing the effect of titanium coating compared to the pure polypropylene mesh structure...
  8. ncbi Gentamicin supplementation of polyvinylidenfluoride mesh materials for infection prophylaxis
    Karsten Junge
    Department of Surgery, German Centre of Excellence for Biomaterial and Implant Pathology, Technical University of Aachen, Aachen, Germany
    Biomaterials 26:787-93. 2005
    ..The presented data confirm that an antibiotic surface modification of PVDF mesh samples is feasible. By analyzing cytotoxicity in vitro as well as biocompatibility in vivo no side effects were observed...
  9. ncbi Persistent extracellular matrix remodelling at the interface to polymers used for hernia repair
    K Junge
    Department of Surgery, German Centre of Excellence for Biomaterial and Implant Pathology, Technical University of Aachen, Aachen, Germany
    Eur Surg Res 35:497-504. 2003
    ..951, p = 0.049), there was no relation to the expression of collagenases (MMP-1/MMP-13) with regard to the amount of inflammatory and connective tissue formation despite partly significant differences between implanted polymers...
  10. ncbi Mesh reconstruction preventing sacral herniation
    K Junge
    Department of Surgery, RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Hernia 7:224-6. 2003
    ..The cystic tumor was resected and a mesh repair performed to prevent sacral herniation. The current literature is summarized; etiology and management recommendations of this rare complication are discussed...
  11. ncbi Improved collagen type I/III ratio at the interface of gentamicin-supplemented polyvinylidenfluoride mesh materials
    Karsten Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 392:465-71. 2007
    ..Therefore, the development of bioactive mesh materials to achieve a local modification of the scar formation to improve patients outcome is advisable...
  12. ncbi Caecal-diverticulitis: a rare differential diagnosis for right-sided lower abdominal pain
    K Junge
    Department of Surgery, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Colorectal Dis 5:241-5. 2003
    ..The objective of this report is to outline our experience with diverticulitis of the caecum, which is a rare condition that is particularly difficult to diagnose correctly pre-operatively...
  13. ncbi Impact of proinflammatory cytokine knockout on mesh integration
    Karsten Junge
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    J Invest Surg 22:256-62. 2009
    ..However, a desirable reduced amount of inflammatory tissue formation as well as an increased collagen type I/III ratio due to cytokine knockout could not be observed...
  14. ncbi Influence of mesh materials on the integrity of the vas deferens following Lichtenstein hernioplasty: an experimental model
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Hernia 12:621-6. 2008
    ..The aim of this study was to evaluate the effect of different mesh structures on integrity of the vas deferens...
  15. ncbi Adhesion formation of a polyvinylidenfluoride/polypropylene mesh for intra-abdominal placement in a rodent animal model
    Karsten Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Surg Endosc 23:327-33. 2009
    ....
  16. ncbi Decreased collagen type I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses
    Karsten Junge
    Department of Surgery, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 389:17-22. 2004
    ..Whereas alloplastic prostheses are nowadays routinely used, the quantity and quality of collagen formation after repair in humans has not been analysed in a large cohort...
  17. ncbi Zinc deficiency impairs wound healing of colon anastomosis in rats
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074 Aachen, Germany
    Int J Colorectal Dis 25:251-7. 2010
    ..Anastomotic leakage is a relevant surgical complication. The aim of the study was to investigate the influence of a controlled preoperative zinc deficiency on the extracellular matrix composition of colon anastomosis...
  18. ncbi Gentamicin supplemented polyvinylidenfluoride mesh materials enhance tissue integration due to a transcriptionally reduced MMP-2 protein expression
    Marcel Binnebösel
    Department of General, Visceral and Transplantation Surgery, RWTH Aachen University Hospital, Aachen, Germany
    BMC Surg 12:1. 2012
    ....
  19. ncbi Impact of gentamicin-supplemented polyvinylidenfluoride mesh materials on MMP-2 expression and tissue integration in a transgenic mice model
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    Langenbecks Arch Surg 395:413-20. 2010
    ....
  20. ncbi Morphology, quality, and composition in mature human peritoneal adhesions
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 393:59-66. 2008
    ..Adhesions are supposed to consist of avascular scar tissue. The aim of the present study was to analyze whether mature postsurgical adhesions even after years still reveal a dynamic remodeling process...
  21. ncbi Mesh biocompatibility: effects of cellular inflammation and tissue remodelling
    Karsten Junge
    Department of General, Visceral and Transplantation Surgery, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Langenbecks Arch Surg 397:255-70. 2012
    ....
  22. ncbi Intraperitoneally applied gentamicin increases collagen content and mechanical stability of colon anastomosis in rats
    Marcel Binnebösel
    Department of Surgery, Aachen University Hospital, Pauwelsstr 30, 52074 Aachen, Germany
    Int J Colorectal Dis 24:433-40. 2009
    ....
  23. ncbi Damage to the spermatic cord by the Lichtenstein and TAPP procedures in a pig model
    Karsten Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrase 30, 52074, Aachen, Germany
    Surg Endosc 25:146-52. 2011
    ..Obstructive azoospermia induced by mesh implantation is a rare but serious complication. Whether different operative techniques or mesh materials used have an effect on the integrity of the testicle and spermatic cord remains unclear...
  24. ncbi Functional and morphologic properties of a modified mesh for inguinal hernia repair
    Karsten Junge
    Department of Surgery, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    World J Surg 26:1472-80. 2002
    ..The present study thus confirms the benefits of material-reduced mesh modifications. The new low-weight mesh (Vypro II) could be advantageous in inguinal hernia repair...
  25. ncbi Biomechanical analyses of overlap and mesh dislocation in an incisional hernia model in vitro
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Aachen, Germany
    Surgery 142:365-71. 2007
    ..The aim of the current study was to evaluate the dependence of mesh dislocation on defect size, facial overlap, mesh-position, and orientation of the mesh in cases of anisotropic stretchability...
  26. ncbi Changes of the extracellular matrix as a risk factor for anastomotic leakage after large bowel surgery
    Michael Stumpf
    Department of Surgery, University Hospital, Medical Faculty of the Rhenish Westphalian Technical University Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Surgery 137:229-34. 2005
    ..This prospective study was initiated to test the hypothesis that preexisting disorders in the extracellular matrix (ECM) may be a factor influencing the onset of anastomotic wound healing complications...
  27. ncbi Effect of zinc pretreatment on pulmonary endothelial cells in vitro and pulmonary function in a porcine model of endotoxemia
    Carsten Johannes Krones
    Department of Surgery, The Technical University of Aachen, Aachen, Germany
    J Surg Res 123:251-6. 2005
    ..As protective effects of zinc are described in vitro as well as in vivo, this study investigates its impact on septic porcine pulmonary endothelial monolayers as well as on the pulmonary function of endotoxemic pigs...
  28. ncbi Deleterious effect of zinc in a pig model of acute endotoxemia
    Carsten Krones
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    J Invest Surg 17:249-56. 2004
    ..The same potentials characterizing zinc as a promising tool of prophylactic therapy in sepsis seem to ban its use during the acute phase...
  29. ncbi Reduced expression of collagen type I and increased expression of matrix metalloproteinases 1 in patients with Crohn's disease
    Michael Stumpf
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    J Invest Surg 18:33-8. 2005
    ..Further studies have to be done to elucidate these interesting aspect of the pathogenesis in Crohn's disease...
  30. ncbi Suture-free small bowel anastomoses using collagen fleece covered with fibrin glue in pigs
    Michael Stumpf
    Department of Surgery, Medical Faculty of Rheinisch Westfalischen, Technical University, Aachen, Germany
    J Invest Surg 22:138-47. 2009
    ..This study was initiated to test a hypothesis that a reduction of suture material leading to suture-free glued intestinal anastomoses is feasible and enables an improved wound healing...
  31. ncbi Biocompatibility of PLGA/sP(EO-stat-PO)-coated mesh surfaces under constant shearing stress
    Gabriele Böhm
    Department of Surgery, University Hospital, Technical University of Aachen, Aachen, Germany
    Eur Surg Res 47:118-29. 2011
    ..Biocompatibility is tested in an animal model...
  32. ncbi Review of wound healing with reference to an unrepairable abdominal hernia
    Karsten Junge
    Department of Surgery, RWTH Aachen, Germany
    Eur J Surg 168:67-73. 2002
    ..This stimulated us to review the biochemistry of wound repair. We studied the composition of his collagen and tried to find out whether it was intrinsically faulty or whether its fault had been caused by the medication he was taken...
  33. ncbi Collagen in colon disease
    Michael Stumpf
    Department of Surgery, Medical Faculty, University Hospital, Rhenish Westphalian Technical University RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 10:498-501. 2006
    ..This concept could explain the well known situation where an anastomotic breakdown is observed, despite the absence of other known risk factors and after a technically correct anastomosis...
  34. ncbi Delayed wound healing in sacrococcygeal pilonidal sinus coincides with an altered collagen composition
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    World J Surg 33:130-6; discussion 137. 2009
    ..This study was initiated to test whether disorders in the extracellular matrix (ECM) may be detected in patients with pilonidal sinus and delayed wound healing or recurrent disease, respectively...
  35. ncbi Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    Langenbecks Arch Surg 396:133-7. 2011
    ..The aim of our pilot study was to evaluate the influence of small intestinal serosal defect closure on peritoneal wound healing, leakage rate, and adhesion formation in a rabbit model...
  36. ncbi Biocompatibility of prosthetic meshes in abdominal surgery
    Marcel Binnebösel
    Department of Surgery, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Semin Immunopathol 33:235-43. 2011
    ..The most important properties of meshes were found to be the type of filament, tensile strength, and experimental data, which indicate that particularly the mesh's porosity is of outstanding importance...
  37. ncbi Impact of polymer pore size on the interface scar formation in a rat model
    U Klinge
    Department of Surgery, Institute of Pathology, The Technical University of Aachen, Pauwelsstrasse 30, Aachen, D-52057, Germany
    J Surg Res 103:208-14. 2002
    ..With regard to the quite similar polymer surface the pore size appears to be of major importance in tissue reaction and for the biocompatibility of mesh structures...
  38. ncbi [Incisional hernia - how do I do it? Standard surgical approach]
    J Conze
    Klinik und Poliklinik für Chirurgie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen
    Chirurg 81:192-200. 2010
    ....
  39. ncbi Regulation of MMP-2 gene transcription in dermal wounds
    Petra Lynen Jansen
    Interdisciplinary Centre for Clinical Research BIOMAT, University Hospital, RWTH Aachen, Aachen, Germany
    J Invest Dermatol 127:1762-7. 2007
    ..The findings define a crucial role for the enhancer element RE-1 in injury-induced MMP-2 transcription of the skin...
  40. ncbi Biomechanical analyses of mesh fixation in TAPP and TEP hernia repair
    R Schwab
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Surg Endosc 22:731-8. 2008
    ....
  41. ncbi Risk factors for early recurrence after inguinal hernia repair
    Petra Lynen Jansen
    Department of Surgery, University Hospital, RWTH Aachen, Germany
    BMC Surg 9:18. 2009
    ..This study evaluates if age and family history can be identified as risk factors for early recurrence after primary hernia repair...
  42. ncbi Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    World J Surg 32:296-304. 2008
    ..Besides various individual factors, notably the inflammatory response to peritoneal defects affects adhesion formation. The aim of this study was to investigate whether there is inflammatory activity even in persistent adhesions...
  43. ncbi Postoperative peridural analgesia increases the strength of colonic contractions without impairing anastomotic healing in rats
    Marc Jansen
    Department of Surgery, Rhenish Westfalian Technical University, Pauwelsstrasse 30, 52057 Aachen, Germany
    Int J Colorectal Dis 18:50-4. 2003
    ..There are conflicting opinions on the effect of early peristalsis on healing of colonic anastomoses...
  44. ncbi Impact of mesh positioning on foreign body reaction and collagenous ingrowth in a rabbit model of open incisional hernia repair
    M Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Aachen, Germany
    Hernia 14:71-7. 2010
    ..Different mesh techniques are used in 75-80% of hernia repair. The aim of this study was to evaluate the dependence of mesh positioning and the type of mesh implanted on foreign body reaction and collagenous ingrowth...
  45. ncbi Effect of tension induced by Shouldice repair on postoperative course and long-term outcome
    Karsten Junge
    Department of Surgery, Technical University of Aachen, Germany
    Eur J Surg 168:329-33. 2002
    ..To record intraoperative tension during Shouldice hernioplasty and correlate it with postoperative course and long-term outcome...
  46. ncbi Chronological evaluation of inflammatory mediators during peritoneal adhesion formation using a rat model
    Marcel Binnebösel
    Department of General, Visceral and Transplantation Surgery, RWTH Aachen University Hospital, Pauwelsstrasse 30, Aachen, Germany
    Langenbecks Arch Surg 396:371-8. 2011
    ..The inflammatory response to peritoneal injury is considered to be of particular importance in adhesion formation. The aim of this study was to investigate the dynamics of inflammatory mediators in peritoneal adhesions...
  47. ncbi Incisional abdominal hernia: the open mesh repair
    V Schumpelick
    Department of Surgery, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 389:1-5. 2004
    ..Mesh techniques are the methods of choice for the repair of incisional hernias since these are due to the formation of unstable scar tissue...
  48. ncbi Improved abdominal wall wound healing by helium pneumoperitoneum
    R Rosch
    Department of Surgery, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Surg Endosc 20:1892-6. 2006
    ..CONCLUSION: The results suggest that helium pneumoperitoneum may ameliorate wound healing within the abdominal wall and could therefore represent a beneficial gas for endoscopic hernia repair...
  49. ncbi Influence of laparotomy closure technique on collagen synthesis in the incisional region
    J J Höer
    Surgical University Hospital, Rhenish Westfalian Technical University Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 6:93-8. 2002
    ..To investigate whether these differences in biomechanical properties influence collagen synthesis in the incisional region, an animal experiment on laparotomy closure was performed...
  50. ncbi Do drainage liquid characteristics serve as predictors for seroma formation after incisional hernia repair?
    C D Klink
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    Hernia 14:175-9. 2010
    ..Furthermore, the characteristics of drainage liquid were compared to the characteristics of seroma liquid...
  51. ncbi Influence of implantation interval on the long-term biocompatibility of surgical mesh
    B Klosterhalfen
    Institute of Pathology, German Centre of Excellence for Biomaterial and Implant Pathology, Interdisciplinary Centre of Clinical Science BIOMAT, Rhenish Westfalian Technical High School Aachen, Aachen, Germany
    Br J Surg 89:1043-8. 2002
    ..The aim was to study the long-term tissue response to polypropylene mesh...
  52. ncbi [Surgical treatment and prophylaxis of parastomal hernias]
    R Rosch
    Chirurgische Klinik und Poliklinik, Universitätsklinik der RWTH Aachen, Aachen
    Zentralbl Chir 133:464-7. 2008
    ..Also, the prophylactic use of meshes is able to reduce the incidence of parastomal hernias. With regard to short- and long-term complications, their general recommendation must be proven in further studies...
  53. ncbi [Risk factors for anastomotic leakage after colorectal surgery]
    M Stumpf
    Chirurgische Universitatsklinik, RWTH Aachen, Aachen
    Zentralbl Chir 134:242-8. 2009
    ..This study was initiated to investigate those clinical risk factors which may influence the onset of anastomotic wound-healing complications...
  54. ncbi PVDF as a new polymer for the construction of surgical meshes
    U Klinge
    Department of Surgery, Technical University of Aachen, Germany
    Biomaterials 23:3487-93. 2002
    ..Analyzing the results confirmed that construction of hernia meshes made of PVDF could be an advantageous alternative to the commonly used materials due to an improved biostability. lowered bending stiffness and a minimum tissue response...
  55. ncbi Biomaterial-dependent MMP-2 expression in fibroblasts from patients with recurrent incisional hernias
    R Rosch
    Department of Surgery, University Hospital Aachen, Aachen, Germany
    Hernia 10:125-30. 2006
    ....
  56. ncbi Functional and morphological evaluation of a low-weight, monofilament polypropylene mesh for hernia repair
    U Klinge
    Surgical Department of the University Clinic of the Rhenish Westfalian Technical University Aachen, Germany
    J Biomed Mater Res 63:129-36. 2002
    ..In conclusion, these data confirm the improved biocompatibility of material-reduced mesh implants...
  57. ncbi Inguinal tensile strength and pain level after Shouldice repair
    C Peiper
    Surgical University Clinic, Rhenish Westfalian Technical University Aachen, Germany
    Hernia 5:129-34. 2001
    ..Tension of the abdominal wall in the inguinal region induced by Shouldice repair of an inguinal hernia is said to be responsible for elevated postoperative pain levels...
  58. ncbi Analysis of c-myc, PAI-1 and uPAR in patients with incisional hernias
    R Rosch
    Department of Surgery, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Hernia 12:285-8. 2008
    ..The aim of the present study was to further characterise the scarring process in such patients...
  59. ncbi Laparoscopy and collagen metabolism
    R Rosch
    Department of Surgery of the RWTH Aachen, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 10:507-10. 2006
    ..As the endoscopic technique has, nowadays, become routinely applied for diverse abdominal diseases worldwide, we present a review of literature facing its impact on collagen biology...
  60. ncbi Influence of pneumoperitoneum on small bowel anastomoses: a histological analysis in the rat model
    R Rosch
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    J Invest Surg 18:63-9. 2005
    ..Our results suggest that within a certain range of pressures and time, laparoscopic assisted surgery using CO2 pneumoperitoneum can be performed safely. Helium gas offers no advantages over CO2...
  61. ncbi Intraabdominal adhesion formation of polypropylene mesh. Influence of coverage of omentum and polyglactin
    J Conze
    Department of Surgery, Rhenish Westphalian Technical University, Aachen, Germany
    Surg Endosc 19:798-803. 2005
    ..To investigate the adhesive potential induced by the biomaterial, an animal model was performed. In addition, the influence of coverage by omentum or a polyglactin barrier was investigated...
  62. ncbi Analysis of collagen-interacting proteins in patients with incisional hernias
    R Rosch
    Department of Surgery, University Hospital, RWTH, Pauwelsstrasse 30, 52074, Aachen, Germany
    Langenbecks Arch Surg 387:427-32. 2003
    ..We investigated known collagen-interacting proteins to further characterize connective tissue in these patients...
  63. ncbi Mesh implants in hernia repair. Inflammatory cell response in a rat model
    R Rosch
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Eur Surg Res 35:161-6. 2003
    ..To approach biocompatibility of surgical meshes we therefore examined the infiltrate of these cells as well as the proliferation rate in response to different clinically applied materials...
  64. ncbi Peritoneal release of TNFalpha and IL-6 after elective colorectal surgery and anastomotic leakage
    P Bertram
    Department of Surgery, Rhenish Westphalian Technical University, Aachen, Germany
    J Invest Surg 16:65-9. 2003
    ..21). After elective colorectal surgery, neither postoperative abdominal drainage fluid TNFalpha nor IL-6 monitoring is helpful to decide on the need for revision in patients with anastomotic leakage...
  65. ncbi Impact of pressure and gas type on anastomotic wound healing in rats
    Raphael Rosch
    Department of Surgery, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 389:261-6. 2004
    ..We therefore investigated the effects of pressure and gas type on anastomosis healing in a rat model...
  66. ncbi A case of bilateral inguinal hernia recurrence in infancy: investigations on collagen metabolism
    R Rosch
    Department of Surgery, University Hospital Aachen, Germany
    Hernia 8:160-3. 2004
    ..Due to previous observations of an altered collagen metabolism in hernia patients, a severe connective-tissue pathology in the infant was hypothesised...
  67. ncbi Vypro II mesh in hernia repair: impact of polyglactin on long-term incorporation in rats
    R Rosch
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Eur Surg Res 35:445-50. 2003
    ..As it has been suggested that polyglactin induces fibroplastic reactions and wound complications, this study was designed to evaluate the long-term tissue reaction to polyglactin in the Vypro II mesh...
  68. ncbi Incisional intercostal hernia after a nephrectomy
    R Rosch
    Department of Surgery, University Hospital, Aachen, Germany
    Hernia 10:97-9. 2006
    ..As with other incisional hernias, the hernia repair using mesh implantation in the retromuscular region is technically feasible and represents the treatment of choice...
  69. ncbi Fibrin sealant for mesh fixation in Lichtenstein repair: biomechanical analysis of different techniques
    R Schwab
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    Hernia 11:139-45. 2007
    ..There are currently no biomechanical data available for evaluation of the quality of adhesion achieved with fibrin sealant during Lichtenstein hernia repair...
  70. ncbi Individual inflammatory response of human blood monocytes to mesh biomaterials
    A Schachtrupp
    Department of Surgery, Rhenish Westphalian Technical University, Aachen, Germany
    Br J Surg 90:114-20. 2003
    ..As monocytes take a key position in the inflammatory foreign body reaction, their specific release of cytokines was investigated in vitro after incubation with alloplastic materials...
  71. ncbi Do multifilament alloplastic meshes increase the infection rate? Analysis of the polymeric surface, the bacteria adherence, and the in vivo consequences in a rat model
    U Klinge
    Department of Surgery Technical University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Biomed Mater Res 63:765-71. 2002
    ..In vivo, the adherence of bacteria to the implant material depends on the surface area, which favors the use of monofilament materials...
  72. ncbi Gas-related impact of pneumoperitoneum on systemic wound healing
    R Rosch
    Department of Surgery, University Hospital Aachen, Aachen, Germany
    Langenbecks Arch Surg 393:75-80. 2008
    ..The aim of the present study was to investigate the gas-dependent effects of pneumoperitoneum on wound healing distant from the abdomen...
  73. ncbi Different matrix micro-environments in colon cancer and diverticular disease
    U Klinge
    Department of Surgery of the RWTH Aachen, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany
    Int J Colorectal Dis 22:515-20. 2007
    ..An altered matrix composition as potential underlying pathology for the development of colorectal cancer was hypothesized...
  74. ncbi A porcine model of the abdominal compartment syndrome
    Christian Toens
    Department of Surgery, Rhenish-Westphalian Technical University, Aachen, Germany
    Shock 18:316-21. 2002
    ..Because function or integrity of additional organ systems was impaired, an IAP of 30 mmHg has to be considered a predisposition for the multi-organ dysfunction syndrome in this porcine model...
  75. ncbi The lateral incisional hernia: anatomical considerations for a standardized retromuscular sublay repair
    M Stumpf
    Chirurgische Universitatsklinik, der RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Hernia 13:293-7. 2009
    ..The aim of the study was to elucidate this field of hernia surgery and give some guidelines for retromuscular sublay mesh repair outside the midline...
  76. ncbi Evaluation of tissue components in the peripheral nervous system using Sirius red staining and immunohistochemistry: a comparative study (human, pig, rat)
    D Kaemmer
    Department of Surgery, RWTH Aachen University Hospital, Aachen, Germany
    J Neurosci Methods 190:112-6. 2010
    ..However, in particular studies of collagen accumulation in nerves, species dependant differences have to be considered...
  77. ncbi Extended distal pancreatectomy with en bloc resection of the celiac axis for locally advanced pancreatic cancer: a case report and review of the literature
    Patrick H Alizai
    Department of General, Visceral and Transplantat Surgery, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Case Report Med 2012:543167. 2012
    ..A preoperative embolization of the celiac axis may avoid ischemia-related complications of the stomach or the liver...
  78. ncbi [Leiomyosarcoma of the hernial sac in inguinal hernia]
    C J Krones
    , Pauwelsstrasse 30, 52074 Aachen
    Chirurg 73:283-6. 2002
    ..The exact evaluation of the surroundings should follow. There is no other standardized therapy besides operation. A case of leiomyosarcoma in inguinal hernia will present the entity of neoplastic disease in hernial sac...
  79. ncbi The rare epidemiologic coincidence of diverticular disease and advanced colonic neoplasia
    C J Krones
    Surgical Department, Medical College, Rhenish Westfalian Technical University, Aachen Pauwelsstr 30, 52074 Aachen, Germany
    Int J Colorectal Dis 21:18-24. 2006
    ..Because directly comparing data are rare, this retrospective study evaluates the coincidence of neoplastic lesions and diverticular disease...
  80. ncbi The Gist of literature on pediatric GIST: review of clinical presentation
    D A Kaemmer
    Medical Faculty, Department of Surgery, Rheinish Westphalian Technical University, Aachen, Germany
    J Pediatr Hematol Oncol 31:108-12. 2009
    ..To provide a review of existing literature on pediatric GIST with focus on clinical presentation...
  81. ncbi Hernia fibroblasts lack beta-estradiol-induced alterations of collagen gene expression
    Petra Lynen Jansen
    Interdisciplinary Center for Clinical Research BIOMAT, University Hospital Aachen, Germany
    BMC Cell Biol 7:36. 2006
    ..We compared primary fibroblast cultures from male/female subjects without/without incisional hernia disease...
  82. ncbi Is there a risk of infertility after inguinal mesh repair? Experimental studies in the pig and the rabbit
    Christian Peiper
    Surgical Clinic, Evangelisches Krankenhaus, Pferdebachstr 27, 58455, Witten, Germany
    Hernia 10:7-12. 2006
    ..This may have an influence also on spermatogenesis. Due to this a strict indication for implantation of a prosthetic mesh during inguinal hernia repair is recommended...
  83. ncbi The influence of inguinal mesh repair on the spermatic cord: a pilot study in the rabbit
    Christian Peiper
    Surgical Clinic, Evangelisches Krankenhaus, Witten, Germany
    J Invest Surg 18:273-8. 2005
    ..This may have an influence also on spermatogenesis. Therefore, we recommend strict indications for implantation of a prosthetic mesh during inguinal hernia repair...
  84. ncbi The lightweight and large porous mesh concept for hernia repair
    Bernd Klosterhalfen
    The Institute of Pathology, Hospital of Düren, Roonstrasse 30, D 52351 Düren, Germany
    Expert Rev Med Devices 2:103-17. 2005
    ....