Hans Georg Joost

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi [Insulin resistance and metabolic syndrome]
    H G Joost
    Institut für Pharmakologie und Toxikologie Medizinische Fakultät, RWTH Aachen, FRG
    Z Kardiol 89:377-82. 2000
  2. ncbi The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)
    H G Joost
    Institute of Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, Germany
    Mol Membr Biol 18:247-56. 2001
  3. ncbi Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators
    Hans Georg Joost
    Institut fuer Pharmakologie und Toxikologie, Medizinische Fakultaet der RWTH Aachen, 52057 Aachen, Germany
    Am J Physiol Endocrinol Metab 282:E974-6. 2002
  4. ncbi Cellular models for the analysis of signaling by protein kinase B and the forkhead transcription factor FKHR (Foxo1a)
    Hans Martin Orth
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, D 52057 Aachen, Germany
    Regul Pept 121:19-24. 2004
  5. ncbi Concentration-dependent stimulatory and inhibitory effect of troglitazone on insulin-induced fatty acid synthase expression and protein kinase B activity in 3T3-L1 adipocytes
    Andreas Barthel
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, 52057 Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 365:290-5. 2002
  6. ncbi Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase
    Andreas Barthel
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, D 52057 Aachen, Germany
    Endocrinology 143:3183-6. 2002
  7. ncbi Construction and characterization of a conditionally active construct of the insulin-regulated forkhead transcription factor FKHR
    Andreas Barthel
    Institute of Pharmacology and Toxicology, Technical University of Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Exp Clin Endocrinol Diabetes 110:304-9. 2002
  8. ncbi Unusual function of the activation loop in the protein kinase DYRK1A
    Stephan Wiechmann
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, Germany
    Biochem Biophys Res Commun 302:403-8. 2003
  9. ncbi Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
    Paul Hekerman
    Institute of Pharmacology and Toxicology, Medical Faculty of the Aachen University, Germany
    FEBS J 272:109-19. 2005
  10. ncbi Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population
    Georgia J Pass
    Institute for Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, Wendlingweg 2, D 52072 Aachen, Germany
    J Pharmacol Exp Ther 302:442-50. 2002

Collaborators

Detail Information

Publications25

  1. ncbi [Insulin resistance and metabolic syndrome]
    H G Joost
    Institut für Pharmakologie und Toxikologie Medizinische Fakultät, RWTH Aachen, FRG
    Z Kardiol 89:377-82. 2000
    ..Because prevalence and course of the diabetes markedly depend on the extent of obesity and insulin resistance, these symptoms of the metabolic syndrome represent crucial targets for preventive and therapeutic strategies...
  2. ncbi The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)
    H G Joost
    Institute of Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, Germany
    Mol Membr Biol 18:247-56. 2001
    ....
  3. ncbi Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators
    Hans Georg Joost
    Institut fuer Pharmakologie und Toxikologie, Medizinische Fakultaet der RWTH Aachen, 52057 Aachen, Germany
    Am J Physiol Endocrinol Metab 282:E974-6. 2002
    ..Therefore, this letter provides a summary of the family members and suggests a systematic nomenclature for SLC2A and GLUT symbols...
  4. ncbi Cellular models for the analysis of signaling by protein kinase B and the forkhead transcription factor FKHR (Foxo1a)
    Hans Martin Orth
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, D 52057 Aachen, Germany
    Regul Pept 121:19-24. 2004
    ..Therefore, these cell systems might serve as useful tools for the development of anti-diabetic drugs...
  5. ncbi Concentration-dependent stimulatory and inhibitory effect of troglitazone on insulin-induced fatty acid synthase expression and protein kinase B activity in 3T3-L1 adipocytes
    Andreas Barthel
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, 52057 Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 365:290-5. 2002
    ..The therapeutic, stimulatory effect is produced by low concentrations of troglitazone (250 nM), and is presumably mediated by enhanced activation of PKB...
  6. ncbi Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase
    Andreas Barthel
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, D 52057 Aachen, Germany
    Endocrinology 143:3183-6. 2002
    ..Our data suggest that AICAR and glucose starvation inhibit G6Pase expression by a reduction of the cellular level of FKHR, presumably mediated by specific degradation of the protein...
  7. ncbi Construction and characterization of a conditionally active construct of the insulin-regulated forkhead transcription factor FKHR
    Andreas Barthel
    Institute of Pharmacology and Toxicology, Technical University of Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Exp Clin Endocrinol Diabetes 110:304-9. 2002
    ..forkhead in rhabdomyosarcoma; G6Pase, glucose-6-phosphatase; PKB, protein kinase B; PI 3-kinase, phosphatidyl-inositol 3-kinase; IRU, insulin-responsive unit; Tx, 4-hydroxytamoxifen, ER, estrogen receptor; HBD, hormone binding domain..
  8. ncbi Unusual function of the activation loop in the protein kinase DYRK1A
    Stephan Wiechmann
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, Germany
    Biochem Biophys Res Commun 302:403-8. 2003
    ..These data show that the contribution of Gln-323 and Tyr-321 to the full catalytic activity of DYRK1A is a specific functional characteristic of the DYRK family...
  9. ncbi Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
    Paul Hekerman
    Institute of Pharmacology and Toxicology, Medical Faculty of the Aachen University, Germany
    FEBS J 272:109-19. 2005
    ..Activation and inhibition of AMPK appears to require additional components of the signalling pathways that are not present in beta cells...
  10. ncbi Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population
    Georgia J Pass
    Institute for Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, Wendlingweg 2, D 52072 Aachen, Germany
    J Pharmacol Exp Ther 302:442-50. 2002
    ....
  11. ncbi The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa
    Annette Schurmann
    Institut of Pharmacology and Toxicology, Medical Faculty, Tecnical University of Aachen, Germany
    Cell Tissue Res 307:237-42. 2002
    ..This specific expression and localization of GLUT8 suggests that the transport facilitator plays a major role in the fuel supply of mature spermatozoa, and that it is a potential target for inhibition of sperm cell function...
  12. doi Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo
    Susanne Neschen
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Physiol Genomics 33:333-40. 2008
    ..UCP1-mediated uncoupling of oxidative phosphorylation in skeletal muscle was paralleled by AMPK activation and thereby stimulated insulin-mediated glucose uptake in skeletal muscle...
  13. ncbi Nutrition-/diet-induced changes in gene expression in white adipose tissue
    Hadi Al-Hasani
    German Institute for Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Best Pract Res Clin Endocrinol Metab 19:589-603. 2005
    ..This chapter will summarize recent studies of PUFA- and obesity-induced changes in gene expression in white adipose tissue...
  14. ncbi Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue
    Andrea Scheepers
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Mol Membr Biol 22:339-51. 2005
    ..Our data indicate that different promoters and splicing of the human SLC2A11 gene generate three GLUT11 isoforms which are expressed in a tissue specific manner but do not appear to differ in their functional characteristics...
  15. pmc The central melanocortin system directly controls peripheral lipid metabolism
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3475-88. 2007
    ..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity...
  16. pmc Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity
    Christina Osswald
    Institute of Anatomy and Cell Biology, Bavarian Julius Maximilians University, Koellikerstrasse 6, 97070 Wurzburg, Germany
    Mol Cell Biol 25:78-87. 2005
    ..At this age, serum leptin was increased, whereas food intake was the same as for wild-type mice. The data suggest that the removal of RS1 leads to leptin-independent up-regulation of food intake, which causes obesity...
  17. ncbi Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism
    Marcin Kortylewski
    Institut fur Biochemie, RWTH Aachen, 52057 Aachen, Germany
    J Biol Chem 278:5242-9. 2003
    ..Our results indicate that FKHR can modulate the IL-6-induced transcriptional activity by acting as a coactivator of STAT3...
  18. doi A meta-analysis of QTL for diabetes-related traits in rodents
    Christian Schmidt
    Department of Pharmacology, German Institute for Human Nutrition Potsdam Rehbrücke, Nuthetal, Germany
    Physiol Genomics 34:42-53. 2008
    ..An interactive physical map of the QTL is available online at http://www.diabesitygenes.org...
  19. pmc Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties
    Susanne Leder
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat der RWTH Aachen, Wendlingweg 2, Germany
    Biochem J 372:881-8. 2003
    ....
  20. ncbi The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function
    Andrea Scheepers
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    JPEN J Parenter Enteral Nutr 28:364-71. 2004
    ..In addition, a malfunction of glucose transporter expression or regulation (GLUT4) appears to contribute to the insulin resistance syndrome...
  21. ncbi Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice
    Hella S Jürgens
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Physiol Genomics 25:234-41. 2006
    ..Because NZO mice differ strikingly from the ob/ob strain in their resistance to cold stress, we suggest that the molecular defects causing hyperphagia in NZO mice are located distal from leptin and its receptor...
  22. ncbi Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity
    Jana Buchmann
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Endocrinology 148:1561-73. 2007
    ..01). Our data indicate a previously unrecognized role of ABCG1 in the regulation of energy balance and triglyceride storage...
  23. ncbi Consuming fructose-sweetened beverages increases body adiposity in mice
    Hella Jürgens
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Obes Res 13:1146-56. 2005
    ....
  24. ncbi Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
    Gregor Bahrenberg
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät der Rheinisch Westfälische Technische Hochschule Aachen, Aachen D 52057, Germany
    Mol Endocrinol 16:859-72. 2002
    ..These findings show that LEPRa/LEPRb heterodimers cannot activate STAT3 and identify sequence elements within the LEPR that are critical for the activation of JAK2 and STAT3...
  25. ncbi Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex
    Ulrike Schmidt
    German Institute of Human Nutrition, Potsdam, Nuthetal, Germany
    J Cell Sci 119:2321-31. 2006
    ....