B Huppertz

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi request reprint Immunohistochemistry of matrix metalloproteinases (MMP), their substrates, and their inhibitors (TIMP) during trophoblast invasion in the human placenta
    B Huppertz
    Department of Anatomy, RWTH Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Cell Tissue Res 291:133-48. 1998
  2. ncbi request reprint Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta
    B Huppertz
    Institut für Anatomie der RWTH Aachen, Germany
    Histochem Cell Biol 110:495-508. 1998
  3. ncbi request reprint The apoptosis cascade--morphological and immunohistochemical methods for its visualization
    B Huppertz
    Department of Anatomy, University of Technology, Aachen, Germany
    Anat Embryol (Berl) 200:1-18. 1999
  4. ncbi request reprint Extracellular matrix components of the placental extravillous trophoblast: immunocytochemistry and ultrastructural distribution
    B Huppertz
    Department of Anatomy, RWTH Aachen, Germany
    Histochem Cell Biol 106:291-301. 1996
  5. ncbi request reprint Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women
    F Reister
    Department of Obstetrics and Gynecology, University of Technology, Aachen, Germany
    Lab Invest 81:1143-52. 2001
  6. ncbi request reprint Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation
    B Huppertz
    Department of Anatomy, University Hospital RWTH Aachen, Germany
    Placenta 24:181-90. 2003
  7. ncbi request reprint Human trophoblast contains an intracellular protein reactive with an antibody against CD133--a novel marker for trophoblast
    A J Pötgens
    Department of Anatomy, University Hospital Aachen, Aachen, Germany
    Placenta 22:639-45. 2001
  8. ncbi request reprint Pre-eclampsia and maternal anaemia display reduced apoptosis and opposite invasive phenotypes of extravillous trophoblast
    M Kadyrov
    Department of Anatomy, University Hospital, Aachen, Germany
    Placenta 24:540-8. 2003
  9. ncbi request reprint Cytokeratin antibodies as differential markers of trophoblast and fetomaternal syncytial plaques in the sheep placentome
    M Kadyrov
    Department of Anatomy II, University Hospital, RWTH Aachen, Aachen, Germany
    Placenta 28:1107-9. 2007
  10. ncbi request reprint Syncytial fusion of human trophoblast depends on caspase 8
    S Black
    Department of Anatomy, University Hospital Aachen, Germany
    Cell Death Differ 11:90-8. 2004

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Immunohistochemistry of matrix metalloproteinases (MMP), their substrates, and their inhibitors (TIMP) during trophoblast invasion in the human placenta
    B Huppertz
    Department of Anatomy, RWTH Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Cell Tissue Res 291:133-48. 1998
    ..Within the extracellular matrix, immunolocalization of matrix metalloproteinases as well as their inhibitors showed a specific relation to certain extracellular matrix molecules...
  2. ncbi request reprint Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta
    B Huppertz
    Institut für Anatomie der RWTH Aachen, Germany
    Histochem Cell Biol 110:495-508. 1998
    ..Completion of the apoptotic cascade takes place in and around syncytial sprouts, providing further evidence that these are the sites of trophoblast shedding into the maternal circulation...
  3. ncbi request reprint The apoptosis cascade--morphological and immunohistochemical methods for its visualization
    B Huppertz
    Department of Anatomy, University of Technology, Aachen, Germany
    Anat Embryol (Berl) 200:1-18. 1999
    ..We offer technical advice at each stage based upon our experience of studying differentiation and apoptosis in human placental trophoblast...
  4. ncbi request reprint Extracellular matrix components of the placental extravillous trophoblast: immunocytochemistry and ultrastructural distribution
    B Huppertz
    Department of Anatomy, RWTH Aachen, Germany
    Histochem Cell Biol 106:291-301. 1996
    ..Glycosylation with "i" in this matrix may be involved in immunological masking, thus preventing rejection of placenta and fetus...
  5. ncbi request reprint Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women
    F Reister
    Department of Obstetrics and Gynecology, University of Technology, Aachen, Germany
    Lab Invest 81:1143-52. 2001
    ..The mechanisms by which macrophages are activated and recruited to the placental bed are presently unknown but are likely central to the pathogenesis of preeclampsia...
  6. ncbi request reprint Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation
    B Huppertz
    Department of Anatomy, University Hospital RWTH Aachen, Germany
    Placenta 24:181-90. 2003
    ..Since uteroplacental ischaemia is a significant risk factor for pre-eclampsia, these findings may explain the link between reduced uteroplacental blood flow and the systemic clinical manifestations of this disease...
  7. ncbi request reprint Human trophoblast contains an intracellular protein reactive with an antibody against CD133--a novel marker for trophoblast
    A J Pötgens
    Department of Anatomy, University Hospital Aachen, Aachen, Germany
    Placenta 22:639-45. 2001
    ..The exact nature of this protein is not yet understood. However, AC133-2 is applicable as a positive marker for the characterization of all subtypes of trophoblast and for trophoblast cell lines...
  8. ncbi request reprint Pre-eclampsia and maternal anaemia display reduced apoptosis and opposite invasive phenotypes of extravillous trophoblast
    M Kadyrov
    Department of Anatomy, University Hospital, Aachen, Germany
    Placenta 24:540-8. 2003
    ..Increased invasive depth could be explained by hypoxia-stimulated mitosis and decreased apoptosis of extravillous trophoblast. Reduced trophoblast invasion in pre-eclampsia cannot be explained by higher rates of apoptosis...
  9. ncbi request reprint Cytokeratin antibodies as differential markers of trophoblast and fetomaternal syncytial plaques in the sheep placentome
    M Kadyrov
    Department of Anatomy II, University Hospital, RWTH Aachen, Aachen, Germany
    Placenta 28:1107-9. 2007
    ..This antibody proved to be a useful tool for easy histological orientation in the sheep placenta. In combination with other antibodies in double immunohistochemistry it facilitates exact localization of antigens...
  10. ncbi request reprint Syncytial fusion of human trophoblast depends on caspase 8
    S Black
    Department of Anatomy, University Hospital Aachen, Germany
    Cell Death Differ 11:90-8. 2004
    ..We conclude that expression and activity of caspase 8 is a prerequisite for differentiation and syncytial fusion of cytotrophoblast cells...
  11. ncbi request reprint Apoptosis and syncytial fusion in human placental trophoblast and skeletal muscle
    B Huppertz
    Department of Anatomy, University Hospital, Aachen, Germany
    Int Rev Cytol 205:215-53. 2001
    ..Data obtained in skeletal muscles support this assumption and reveal a considerable degree of homology in genesis, maintenance and turnover of both tissues...
  12. ncbi request reprint Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro
    B Huppertz
    Department of Anatomy, University of Technology, Aachen, Germany
    Lab Invest 79:1687-702. 1999
    ..Our data confirm that the apoptosis cascade in villous trophoblast is regulated in parallel with trophoblast differentiation, syncytial fusion, and trophoblast turnover...
  13. ncbi request reprint Aberrations of early trophoblast differentiation predispose to pregnancy failure: lessons from the anti-phospholipid syndrome
    P Bose
    Department of Anatomy II, University Hospital RWTH Aachen, Wendlingweg 2, Aachen 52057, Germany
    Placenta 27:869-75. 2006
    ..The aim of this study was to compare the nuclear CT:ST ratio in normal and pathological pregnancy and thus establish the relationship between cytotrophoblast and syncytiotrophoblast nuclear number during early gestation...
  14. ncbi request reprint Expression of a cytokeratin 18 neo-epitope is a specific marker for trophoblast apoptosis in human placenta
    M Kadyrov
    Department of Anatomy, University of Technology, Wendlingweg 2, D 52057 Aachen, Germany
    Placenta 22:44-8. 2001
    ..The data suggest that M30 is superior to the TUNEL reaction as a marker for the detection of trophoblast apoptosis since it is easier to handle, more specific for apoptosis and less prone to artifacts...
  15. ncbi request reprint Extravillous trophoblast apoptosis--a workshop report
    B Huppertz
    Department of Anatomy II, University Hospital RWTH Aachen, Wendlingweg 2, 52057 Aachen, Germany
    Placenta 26:S46-8. 2005
    ..On the other hand, apoptosis of intramural/endovascular trophoblast seems to be highly relevant for a correct transformation of spiral arteries...
  16. ncbi request reprint Extravillous trophoblast: proliferation and invasion during pregnancy
    B Huppertz
    Department of Anatomy, University Hospital RWTH Aachen, Germany
    Pathologica 95:231-2. 2003
  17. ncbi request reprint Low-dose-rate ionizing irradiation for inhibition of secondary cataract formation
    A M Joussen
    Department of Ophthalmology, University of Technology RWTH Aachen, Aachen, Germany
    Int J Radiat Oncol Biol Phys 49:817-25. 2001
    ..However, diffusion into the anterior chamber may lead to damage of corneal endothelial cells. This study evaluated the inhibition of lens epithelial cell proliferation with a capsular bag ring, labeled with a beta-emitting radioisotope...
  18. ncbi request reprint Placental angiogenesis, maternal and fetal vessels--a workshop report
    B Huppertz
    Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University of Graz, Austria
    Placenta 28:S94-6. 2007
  19. ncbi request reprint Spatial and temporal distribution of Tie-1 and Tie-2 during very early development of the human placenta
    U A Kayisli
    Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
    Placenta 27:648-59. 2006
    ..Due to their spatial distribution we speculate on an additional role in regulation of villous and extravillous trophoblastic behavior...
  20. ncbi request reprint Bi-potential behaviour of cytotrophoblasts in first trimester chorionic villi
    D Baczyk
    Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Canada
    Placenta 27:367-74. 2006
    ..We suggest bipotential trophoblast progenitor cells persist during first trimester human placental development...
  21. ncbi request reprint Pathogenesis of intrauterine growth restriction (IUGR)-conclusions derived from a European Union Biomed 2 Concerted Action project 'Importance of Oxygen Supply in Intrauterine Growth Restricted Pregnancies'-a workshop report
    C P Sibley
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester, UK
    Placenta 23:S75-9. 2002
  22. ncbi request reprint Regulation of functional steroid receptors and ligand-induced responses in telomerase-immortalized human endometrial epithelial cells
    S Hombach-Klonisch
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada
    J Mol Endocrinol 34:517-34. 2005
    ..Thus, hTERT-EECs may be regarded as a novel in vitro model to investigate the role of human EECs in steroid hormone-dependent normal physiology and pathologies, including implantation failure, endometriosis and endometrial cancer...
  23. ncbi request reprint A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells
    A K Gupta
    Laboratory for Prenatal Medicine, University Women s Hospital Department of Research, University of Basel, CH 4031 Basel, Switzerland
    Placenta 26:59-66. 2005
    ....
  24. ncbi request reprint Pre-eclampsia as a 'three stage problem'--a workshop report
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Philipp Rosenthalstr 55, 04103, Leipzig, Germany
    Placenta 25:585-7. 2004
  25. ncbi request reprint Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis
    R Demir
    Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya 07070, Turkey
    Placenta 25:560-72. 2004
    ..The sequential expression of growth factors in different cell types may point to the fact that placental vasculogenesis and angiogenesis are clearly distinct events...
  26. ncbi request reprint Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta
    D Baczyk
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Canada
    Placenta 25:553-9. 2004
    ..They also highlight the fact that villous cytotrophoblast cells are extremely heterogeneous with respect to GCM1 expression, a factor that should be considered when using isolated cytotrophoblast cells for culture studies...
  27. ncbi request reprint The 'reference trap' revisited: examples of the dangers in using ratios to describe fetoplacental angiogenesis and trophoblast turnover
    T M Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, UK
    Placenta 24:1-7. 2003
    ..Sometimes (e.g. when relying on biopsy samples), the size of the reference cannot be determined. In such cases, ratio data must be interpreted with due caution...
  28. ncbi request reprint Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast
    A E P Heazell
    University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 29:175-86. 2008
    ..The potential role of the p53-pathway in the control of cell turnover in villous trophoblast and the regulation of p53 by altered O(2) tension merits further investigation...