Jurgen Floege

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi Bone marrow transplantation rescues Alport mice
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 21:2721-3. 2006
  2. pmc Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population
    Jurgen Floege
    Div Nephrology, RWTH University of Aachen, Germany
    Nephrol Dial Transplant 26:1948-55. 2011
  3. doi [Glomerulonephritis]
    J Floege
    Klinik für Nieren und Hochdruckkrankheiten, Universitätsklinikum der RWTH Aachen, Germany
    Dtsch Med Wochenschr 138:1515-24; quiz 1525-8. 2013
  4. doi Treatment of IgA nephropathy and Henoch-Schönlein nephritis
    Jurgen Floege
    Division of Nephrology, RWTH University of Aachen, Pauwelstrasse 30, D 52057 Aachen, Germany
    Nat Rev Nephrol 9:320-7. 2013
  5. doi The pathogenesis of IgA nephropathy: what is new and how does it change therapeutic approaches?
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Germany
    Am J Kidney Dis 58:992-1004. 2011
  6. pmc The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait
    Francesco P Schena
    Renal Unit, University of Bari, Italy
    BMC Nephrol 6:14. 2005
  7. doi Current therapy for IgA nephropathy
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany
    J Am Soc Nephrol 22:1785-94. 2011
  8. ncbi Recurrent IgA nephropathy after renal transplantation
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Semin Nephrol 24:287-91. 2004
  9. ncbi When man turns to stone: extraosseous calcification in uremic patients
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Kidney Int 65:2447-62. 2004
  10. doi Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patients
    Jurgen Floege
    Division of Nephrology, RWTH University of Aachen, Aachen, Germany
    Nephrol Dial Transplant 25:1916-23. 2010

Detail Information

Publications113 found, 100 shown here

  1. ncbi Bone marrow transplantation rescues Alport mice
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 21:2721-3. 2006
  2. pmc Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population
    Jurgen Floege
    Div Nephrology, RWTH University of Aachen, Germany
    Nephrol Dial Transplant 26:1948-55. 2011
    ..The existence of such a link in a European haemodialysis population was explored as part of the Analysing Data, Recognising Excellence and Optimising Outcomes (ARO) Chronic Kidney Disease (CKD) Research Initiative...
  3. doi [Glomerulonephritis]
    J Floege
    Klinik für Nieren und Hochdruckkrankheiten, Universitätsklinikum der RWTH Aachen, Germany
    Dtsch Med Wochenschr 138:1515-24; quiz 1525-8. 2013
    ..The most common types of glomerulonephritis in Western Europe comprise IgA-nephropathy, membranous glomerulonephritis and rapidly progressive glomerulonephritis (RPGN). ..
  4. doi Treatment of IgA nephropathy and Henoch-Schönlein nephritis
    Jurgen Floege
    Division of Nephrology, RWTH University of Aachen, Pauwelstrasse 30, D 52057 Aachen, Germany
    Nat Rev Nephrol 9:320-7. 2013
    ..At present, little evidence exists to suggest that any other immunosuppressive therapy beyond corticosteroids is effective in either IgAN or Henoch-Schönlein nephritis...
  5. doi The pathogenesis of IgA nephropathy: what is new and how does it change therapeutic approaches?
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Germany
    Am J Kidney Dis 58:992-1004. 2011
    ....
  6. pmc The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait
    Francesco P Schena
    Renal Unit, University of Bari, Italy
    BMC Nephrol 6:14. 2005
    ..The organization of a multi-centre Biobank for the collection of biological samples and clinical data from IgAN patients and relatives is an important starting point for the identification of the disease susceptibility genes...
  7. doi Current therapy for IgA nephropathy
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany
    J Am Soc Nephrol 22:1785-94. 2011
    ..In other atypical patients with secondary IgAN, treatment should target the underlying primary disease. And fourth is the transplanted patient with recurrent IgAN where the mainstay of treatment is optimized supportive care...
  8. ncbi Recurrent IgA nephropathy after renal transplantation
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Semin Nephrol 24:287-91. 2004
    ..In patients with recurrent IgAN, no specific therapy other than optimal supportive care has been established...
  9. ncbi When man turns to stone: extraosseous calcification in uremic patients
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Kidney Int 65:2447-62. 2004
  10. doi Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patients
    Jurgen Floege
    Division of Nephrology, RWTH University of Aachen, Aachen, Germany
    Nephrol Dial Transplant 25:1916-23. 2010
    ..We report the ADVANCE Study design and baseline subject characteristics...
  11. ncbi [IgA nephropathy: frequent, but rarely diagnosed]
    J Floege
    Abteilung für Nephrologie und Klinische Immunologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany
    Internist (Berl) 44:1131-9. 2003
    ..When end stage renal failure has developed and a renal transplant is performed, about 25% of the patients will experience a clinically relevant recurrence of IgAN with progressive graft dysfunction...
  12. ncbi [Nephrology -- familiar knowledge in the light of new discoveries in molecular and cell biology]
    J Floege
    Medizinische Klinik II, Nephrologie und klinische Immunologie, Rheinisch Westfälische Technische Hochschule Aachen
    Dtsch Med Wochenschr 130:1552-4. 2005
  13. ncbi A new look at platelet-derived growth factor in renal disease
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 19:12-23. 2008
    ..Accordingly, targeted intervention against the various PDGF isoforms offers a promising novel therapeutic approach to renal disease...
  14. ncbi [Nephrology 2005/2006. Recent clinical studies and developments in science]
    Jurgen Floege
    Medizinische Klinik II, Universitätsklinikum der RWTH Aachen, 52057 Aachen
    Dtsch Med Wochenschr 131:1445-8. 2006
  15. doi Immune modulating therapy for IgA nephropathy: rationale and evidence
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, RWTH Aachen, Germany
    Semin Nephrol 28:38-47. 2008
    ....
  16. ncbi Mutant mice provide new insight into the role of (mis-)glycation in IgA nephropathy and other glomerular diseases
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:1518-20. 2007
  17. ncbi The role of PDGF-D in mesangioproliferative glomerulonephritis
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany
    Contrib Nephrol 157:153-8. 2007
    ..In addition, first observations suggest that PDGF-D may also contribute to secondary renal changes that characterize progressive renal failure, i.e. tubulointerstitial fibrosis...
  18. ncbi Recurrent glomerulonephritis following renal transplantation: an update
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Germany
    Nephrol Dial Transplant 18:1260-5. 2003
  19. ncbi Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification
    Ralf Koos
    Department of Cardiology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Thromb Haemost 101:706-13. 2009
    ..In addition, our data suggest that OAC treatment may decrease local expression of MGP, resulting in decreased circulating MGP levels and subsequently increased aortic valve calcifications as an adverse side effect...
  20. doi Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms
    Luigi Villa
    Division of Nephrology, RWTH Aachen University Hospital, Germany
    J Pathol 229:672-84. 2013
    ..We identified down-regulation of platelet-derived growth factor receptors and CCR6 as potential mediators of telmisartan-related renoprotection. CCR6 may also regulate the renal outcome in human mesangioprolfierative glomerulonephritis...
  21. pmc PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis
    Frank Eitner
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 19:281-9. 2008
  22. ncbi Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes
    Uta Kunter
    Division of Nephrology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 18:1754-64. 2007
    ..These data suggest that MSC treatment can be a valuable therapeutic approach only if adipogenic maldifferentiation is prevented...
  23. ncbi Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis
    Ulf Janssen
    Division of Nephrology, Universitie of Aachen, Germany
    Nephron Exp Nephrol 93:e158-67. 2003
    ..Our combined in vivo and in vitro observations suggest that the release of intracellular actin during mesangiolysis is an endogenous pathway by which glomerular capillary damage is augmented...
  24. doi YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo
    Lydia Hanssen
    Division of Nephrology and Clinical Immunology, University Hospital Rheinisch Westfaelische Technische Hochschule Aachen, 52057 Aachen, Germany
    J Immunol 191:2604-13. 2013
    ..In conclusion, our findings identify YB-1 as a major, nonredundant mediator in both systemic and local inflammatory responses. ..
  25. doi Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D
    Claudia R C van Roeyen
    Division of Nephrology, RWTH Aachen University Hospital, Aachen, Germany
    Kidney Int 80:1292-305. 2011
    ..Hence, podocyte-specific growth factor overexpression can induce paracrine mesangial cell proliferation upstream of the filtration flow...
  26. ncbi PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis
    Peter Boor
    Division of Nephrology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 22:1323-31. 2007
    ..Administration of the PDGF-D neutralizing fully human monoclonal antibody CR002 in the acute phase of progressive anti-Thy 1.1 glomerulonephritis reduced glomerular and secondary tubulointerstitial damage...
  27. ncbi Fetuin-A (AHSG) prevents extraosseous calcification induced by uraemia and phosphate challenge in mice
    Ralf Westenfeld
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:1537-46. 2007
    ..Chronic kidney disease (CKD) is associated with vascular and tissue calcification. The extent of vascular calcification has been identified as an independent risk factor of cardiovascular death in patients on haemodialysis...
  28. doi Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts
    Claudia Seikrit
    Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Nephrol Dial Transplant 28:889-900. 2013
    ..Whereas PDGF-CC binds to both the PDGF receptors (PDGFRs)-αα- and -αβ, PDGF-AA binds more selectively to the αα-receptor, suggesting potential differences in the biological activities...
  29. doi Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration
    Bart Smeets
    Division of Nephrology and Immunology, University Hospital of the Aachen University of Technology RWTH, Aachen, Germany
    J Pathol 229:645-59. 2013
    ..Our data indicate rather that these cells represent transiently dedifferentiated tubular cells involved in regeneration...
  30. doi Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury
    Sonja Djudjaj
    Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Pathol 228:286-99. 2012
    ..Thus, specific blockade of this receptor may be suitable as therapeutic option to delay progression of kidney disease...
  31. doi Uraemia disrupts the vascular niche in a 3D co-culture system of human mesenchymal stem cells and endothelial cells
    Rafael Kramann
    Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Nephrol Dial Transplant 27:2693-702. 2012
    ..The uraemic microenvironment predisposes to increased levels of reactive oxygen species, accelerated ageing of endothelial cells (EC) and vascular sclerosis...
  32. doi Extracellular YB-1 blockade in experimental nephritis upregulates Notch-3 receptor expression and signaling
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Nephron Exp Nephrol 118:e100-8. 2011
    ....
  33. doi Analysis of calcifications in patients with coral reef aorta
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital, and Central Facility for Electron Microscopy, RWTH University, Aachen, Germany
    Ann Vasc Surg 24:408-14. 2010
    ..The aim of our study was to investigate calcification inhibitors and the ultrastructure of calcifications in patients with coral reef aorta...
  34. pmc PDGF-C mediates glomerular capillary repair
    Peter Boor
    Division of Nephrology and Immunology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Am J Pathol 177:58-69. 2010
    ..These results identify PDGF-C as a novel, potent pro-angiogenic factor in the kidney that can accelerate capillary healing in experimental glomerulonephritis and thrombotic microangiopathy...
  35. ncbi Complement C5 mediates experimental tubulointerstitial fibrosis
    Peter Boor
    Division of Nephrology, Rheinische Westfälische Technische Hochschule, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 18:1508-15. 2007
    ..Using a combined genetic and pharmacologic approach, C5, in particular C5a, is identified as a novel profibrotic factor in renal disease and as a potential new therapeutic target...
  36. doi Patients with IgA nephropathy exhibit high systemic PDGF-DD levels
    Peter Boor
    RWTH University of Aachen, Germany
    Nephrol Dial Transplant 24:2755-62. 2009
    ..Platelet-derived growth factor (PDGF) is a central mediator of mesangioproliferative glomerulonephritis (GN). In experimental mesangioproliferative GN, PDGF-DD serum levels, unlike PDGF-BB, increased up to 1000-fold...
  37. pmc Fetuin-A protects against atherosclerotic calcification in CKD
    Ralf Westenfeld
    Department of Nephrology, Rheinisch Westfälische Technische Hochschule RWTH Aachen University Hospital, Aachen, Germany
    J Am Soc Nephrol 20:1264-74. 2009
    ..In conclusion, fetuin-A inhibits pathologic calcification in both the soft tissue and vasculature, even in the setting of atherosclerosis...
  38. ncbi The effects of platelet-derived growth factor antagonism in experimental glomerulonephritis are independent of the transforming growth factor-beta system
    Tammo Ostendorf
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 13:658-67. 2002
    ..These observations suggest that the effects of PDGF-B antagonism are independent of TGF-beta in mesangioproliferative glomerulonephritides...
  39. doi Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation
    Claudia R C van Roeyen
    Division of Nephrology, RWTH University Hospital Aachen, Aachen, Germany
    Kidney Int 83:251-63. 2013
    ..Thus, GAS1 is a novel endogenous inhibitor of glomerular mesangial cell proliferation and may be a novel therapeutic target in mesangioproliferative glomerular diseases...
  40. ncbi Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis
    Tammo Ostendorf
    Division of Nephrology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Am Soc Nephrol 17:1054-62. 2006
    ..In conclusion, these data provide evidence for a causal role of PDGF-D in the pathogenesis of renal scarring and point to a new therapeutic approach to progressive mesangioproliferative renal disease...
  41. doi Serological cardiovascular and mortality risk predictors in dialysis patients receiving sevelamer: a prospective study
    Vincent Matthias Brandenburg
    Department of Nephrology, University Hospital of the RWTH Aachen, Pauwelsstase 30, Aachen, Germany
    Nephrol Dial Transplant 25:2672-9. 2010
    ..We assessed how sevelamer hydrochloride influences the evolution of serum fetuin-A and other serological factors predicting cardiovascular outcome and survival in haemodialysis patients...
  42. ncbi R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury
    Maja Milovanceva-Popovska
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int 67:1362-70. 2005
    ..Since podocytes express CDK2 in nephritis and since loss of podocytes contributes to glomerulosclerosis, the rationale of the present study was to test whether CDK2 inhibition is safe in instances of podocyte injury...
  43. doi Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis
    Ina V Martin
    Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Am J Pathol 182:107-17. 2013
    ..PDGF-C antagonism, therefore, may not be effective to treat liver fibrosis...
  44. doi A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects
    Claudia R C van Roeyen
    Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Am J Pathol 180:1979-90. 2012
    ..Manipulation of CCN3 may represent a novel approach to help repair glomerular endothelial damage and mesangioproliferative changes...
  45. pmc Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfalische Technische Hochschule, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 22:387-95. 2011
    ..Lower levels of circulating dp-cMGP may serve as a predictor of mortality in dialysis patients. Whether vitamin K supplementation improves outcomes requires further study...
  46. doi Vascular access calcification predicts mortality in hemodialysis patients
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Aachen, Germany
    Kidney Int 74:1582-7. 2008
    ..Our study suggests that detection of vascular access calcification is a cost-effective method to identify patients at increased mortality risk...
  47. doi Predictors of low circulating endothelial progenitor cell numbers in haemodialysis patients
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Nephrol Dial Transplant 23:2611-8. 2008
    ....
  48. doi Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Kidney Int 75:185-96. 2009
    ..We show that YB-1 is a cell-type specific regulator of CCL5 expression in infiltrating T-cells and monocytes/macrophages and acts as an adaptive controller of inflammation during kidney allograft rejection...
  49. doi Warfarin induces cardiovascular damage in mice
    Thilo Kruger
    From the Department of Nephrology, University Hospital of the Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany T K, S O, N K, P B, G S, V M B, J F Department of Biochemistry, Cardiovascular Research Institute CARIM, University of Maastricht, Maastricht, The Netherlands L J S Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Düsseldorf, Dusseldorf, Germany A M v d S, V V, R W Department of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany P B Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia P B 2nd Department of Medicine, Military Hospital Budapest, Budapest, Hungary B C F Nephrology, Hospital Coburg, Coburg, Germany M K VitaK BV, Maastricht, The Netherlands C V Biointerface Laboratory, Hiroshima University Hospital
    Arterioscler Thromb Vasc Biol 33:2618-24. 2013
    ..Here, we investigated functional cardiovascular characteristics in a mouse model with warfarin-induced media calcification...
  50. doi Y-box binding protein-1 mediates profibrotic effects of calcineurin inhibitors in the kidney
    Lydia Hanssen
    Department of Nephrology and Clinical Immunology, University Hospital Rheinisch Westfälische Technische Hochschule Aachen, Aachen 52057, Germany
    J Immunol 187:298-308. 2011
    ..Our results provide strong evidence for a CNI-dependent induction of YB-1 in MCs that contributes to renal fibrosis via regulation of its own and collagen translation...
  51. ncbi [Early diagnosis of chronic kidney disease. New insights into creatinine and proteinuria]
    Vincent Brandenburg
    Medizinische Klinik II, Nephrologie und klinische Immunologie, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen
    Med Klin (Munich) 101:158-62. 2006
    ..Reduction of proteinuria toward levels < 0.5 g per day would be ideal. By this intervention the risk for both ongoing renal function loss as well as the risk of cardiovascular disease can be markedly reduced...
  52. doi Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis--implications for post-transplantation bone disease
    Ralf Westenfeld
    Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Nephrol Dial Transplant 26:4115-23. 2011
    ..Glucocorticoid-induced osteoporosis on top of pre-existing renal osteodystrophy is considered the major pathogenic factor, while the role of non-glucocorticoid immunosuppressants is less well defined...
  53. doi Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis
    Luigi Villa
    Division of Nephrology, University Hospital RWTH Aachen, Aachen, Germany
    Nephrol Dial Transplant 26:3131-43. 2011
    ..We examined the effect of low-dose telmisartan (LT) and high-dose telmisartan (HT) versus conventional antihypertensive therapy in the rat anti-Thy1.1 model of glomerulonephritis...
  54. ncbi The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis
    Dirk Bokemeyer
    Division of Nephrology, Augusta Hospital, Bochum, Germany
    Nephrol Dial Transplant 22:3431-41. 2007
    ..In vitro, the extracellular signal-regulated kinase (ERK) is an intracellular convergence point of multiple stimuli, which affect the cell cycle. However, the role of ERK in cell cycle regulation in vivo is unknown...
  55. ncbi Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
    ..We aimed to investigate the hypothesis that AHSG deficiency is directly related to uraemic vascular calcification...
  56. ncbi PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 14:1145-53. 2003
    ..We conclude that PDGF-C is constitutively expressed in the human kidney and is upregulated in podocytes and interstitial cells after injury/activation of these cells...
  57. ncbi Ultrasonographic fata morgana
    Vincent M Brandenburg
    Department of Nephrology and Immunology, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Nephrol Dial Transplant 18:845-6. 2003
  58. ncbi Calcification and the usual suspect phosphate: still guilty but there are other guys behind the scenes
    Markus Ketteler
    Division of Nephrology, RWTH University Hospital Aachen, Germany
    Nephrol Dial Transplant 21:33-5. 2006
  59. ncbi Renal side effects of anti-VEGF therapy in man: a new test system
    Tammo Ostendorf
    Division of Nephrology, University Hospital Aachen, Pauwelsstr 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:2778-80. 2007
  60. ncbi Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis
    Masashi Kitahara
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 13:1261-70. 2002
    ..1 glomerulonephritis. These data suggest that selective COX-2 inhibitors should be used with caution among patients with inflammatory endocapillary glomerular disorders...
  61. ncbi Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney
    Frank Eitner
    Division of Nephrology and Immunology, University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 13:910-7. 2002
    ..PDGF-C may therefore be involved in the pathogenesis of renal scarring...
  62. pmc Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells
    Bart Smeets
    Department of Nephrology and Immunology, University Hospital of the Aachen University of Technology, Pauwelsstrasse 30, Aachen, Germany
    J Am Soc Nephrol 20:2604-15. 2009
    ..In conclusion, PECs constitute the majority of cells that compose early extracapillary proliferative lesions in both crescentic glomerulonephritis and collapsing glomerulopathy, suggesting similar pathomechanisms in both diseases...
  63. ncbi Mesangial cell expression of proto-oncogene Ets-1 during progression of mesangioproliferative glomerulonephritis
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital of Aachen, Aachen, Germany
    Kidney Int 66:622-32. 2004
    ..The expression of Ets-1 mRNA and protein was analyzed in healthy rat kidney and in a model for mesangioproliferative disease without and with inhibition of platelet-derived growth factor-B (PDGF-B) activity...
  64. pmc The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
    Cora Schafer
    Interdisciplinary Center for Clinical Research on Biochematerials, University Clinics, Aachen, Germany
    J Clin Invest 112:357-66. 2003
    ..Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases...
  65. ncbi Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis
    Thilo Kruger
    Department of Nephrology and Clinical Immunology, University Clinic of Aachen, Aachen, Germany
    J Am Soc Nephrol 15:613-21. 2004
    ..These results are the first to identify and characterize renal CD11c(+) cells as DC and to demonstrate marked changes in experimental glomerulonephritis...
  66. pmc Subtotal ablation of parietal epithelial cells induces crescent formation
    Eva Maria Sicking
    Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Am Soc Nephrol 23:629-40. 2012
    ..In summary, subtotal ablation of PECs leads the remaining PECs to react with cellular activation and proliferation, which ultimately forms cellular crescents...
  67. doi Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells
    Rafael Kramann
    Department of Nephrology and Clinical Immunology, Medical Faculty RWTH, Aachen University, Aachen, Germany
    Arterioscler Thromb Vasc Biol 31:e45-54. 2011
    ..The current study is based on the hypothesis that mesenchymal stem cells (MSC) constitute critical cells for procalcific extracellular matrix remodeling in patients with chronic kidney disease...
  68. ncbi Inducible nitric oxide synthase-derived nitric oxide promotes glomerular angiogenesis via upregulation of vascular endothelial growth factor receptors
    Tammo Ostendorf
    Division of Nephrology and Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Am Soc Nephrol 15:2307-19. 2004
    ..These data identify iNOS-derived NO production as the first in vivo regulator of the glomerular VEGF system and as an important mechanism promoting glomerular healing...
  69. ncbi Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis
    Uta Kunter
    Division of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 17:2202-12. 2006
    ....
  70. ncbi Therapeutic targets for prevention and regression of progressive fibrosing renal diseases
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Curr Opin Investig Drugs 6:255-61. 2005
    ..This is likely by combining compounds that interfere with a variety of targets simultaneously...
  71. ncbi A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis
    Tammo Ostendorf
    Division Nephrology, University of Aachen, Germany
    J Am Soc Nephrol 14:2237-47. 2003
    ....
  72. doi Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany
    Lab Invest 88:1090-100. 2008
    ....
  73. doi Prognostic impact of renal arterial resistance index upon renal allograft survival: the time point matters
    Rafael Kramann
    Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Nephrol Dial Transplant 27:3958-63. 2012
    ..We performed a retrospective analysis of RI and its power to predict renal allograft failure or death with special emphasis on the time point of RI measurement...
  74. pmc Ultrastructural analysis of vascular calcifications in uremia
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 21:689-96. 2010
    ..Furthermore, considering the core-shell structure of the calcifications, apoptotic bodies or matrix vesicles may serve as a calcification nidus...
  75. ncbi "Missing" inhibitors of calcification: general aspects and implications in renal failure
    Markus Ketteler
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Pediatr Nephrol 20:383-8. 2005
    ....
  76. doi Risk factors for cardiovascular calcifications in non-diabetic Caucasian haemodialysis patients
    Georg Schlieper
    Department of Nephrology, University Hospital Aachen, Aachen, Germany
    Kidney Blood Press Res 32:161-8. 2009
    ..Diabetes mellitus and ethnicity are known factors that affect the extent of cardiovascular calcifications. However, most studies have investigated mixed cohorts with diabetics and/or mixed ethnicity...
  77. pmc Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis
    Bart Smeets
    Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    J Am Soc Nephrol 22:1262-74. 2011
    ..In conclusion, these results demonstrate that PECs contribute to the development and progression of the sclerotic lesions that define FSGS, but this pathogenesis may be relevant to all etiologies of glomerulosclerosis...
  78. ncbi Supportive Versus Immunosuppressive Therapy of Progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol
    Frank Eitner
    Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany
    J Nephrol 21:284-9. 2008
    ..Finally, our trial can serve as a model for various other types of glomerulonephritis, for which such trials are very difficult to perform, given their infrequency...
  79. doi Risk factors for Pneumocystis jiroveci pneumonia (PcP) in renal transplant recipients
    Frank Eitner
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Nephrol Dial Transplant 26:2013-7. 2011
    ..Individual risk factors for susceptibility to PcP are incompletely understood...
  80. ncbi Hypertension superimposed on type II diabetes in Goto Kakizaki rats induces progressive nephropathy
    Ulf Janssen
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int 63:2162-70. 2003
    ..The aim of this study was to investigate the effect of superimposed hypertension on renal function and morphology under conditions of hyper- and normoglycemia...
  81. ncbi In vivo identification of the mitogen-activated protein kinase cascade as a central pathogenic pathway in experimental mesangioproliferative glomerulonephritis
    Dirk Bokemeyer
    Medical Policlinic, Division of Nephrology, University of Bonn, Bonn, Germany
    J Am Soc Nephrol 13:1473-80. 2002
    ..These observations point to ERK as a putative intracellular mediator of the proliferative response in GN and suggest that pharmacologic treatments that interfere with the activation of ERK may be of potential therapeutic interest...
  82. doi Association of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients
    Ralf Koos
    Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RTWH Aachen, RWTH University Aachen, Pauwelsstrasse 30, Aachen 52057, Germany
    Eur Heart J 30:2054-61. 2009
    ..We investigated the relationship between baseline fetuin-A serum levels and the rate of progression of aortic valve calcification (AVC) in non-dialyzed patients with aortic valve disease (AVD)...
  83. doi Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?
    Thilo Krueger
    Division of Nephrology and Clinical Immunology, University Hospital, RWTH University of Aachen, Germany
    Kidney Int 76:18-22. 2009
    ..Additionally, we wish to give an overview of the current literature indicating potential adverse effects of long-term vitamin K antagonists in this population...
  84. doi Renal allograft failure in a hyperparathyroid patient following initiation of a calcimimetic
    Claudia Seikrit
    Division of Nephrology and Immunology, RWTH University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Nat Rev Nephrol 7:237-41. 2011
    ..While on dialysis, he had developed secondary hyperparathyroidism, which persisted after transplantation despite treatment with cinacalcet...
  85. ncbi Vascular calcification in patients with end-stage renal disease
    Jurgen Floege
    Medizinische Klinik II, Klinikum der RWTH, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 19:V59-66. 2004
    ..Yet, it remains unclear whether sevelamer HCl reduces vascular calcification by preventing episodes of hypercalcaemia and/or by reducing low-density lipoprotein (LDL)-cholesterol levels...
  86. ncbi Anticoagulant-free Genius haemodialysis using low molecular weight heparin-coated circuits
    Rolf Dario Frank
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, 52057 Aachen, Germany
    Nephrol Dial Transplant 21:1013-8. 2006
    ..In an alternative approach we evaluated the effects of covalent circuit coating with low molecular weight heparin (LMWH) for intermittent haemodialysis...
  87. doi Sodium thiosulfate in the treatment of calcific uremic arteriolopathy
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Nat Rev Nephrol 5:539-43. 2009
    ..Large clinical trials to evaluate the efficacy and long-term safety of sodium thiosulfate are clearly warranted...
  88. ncbi Novel insights into renal fibrosis
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Aachen, Germany
    Curr Opin Nephrol Hypertens 12:227-32. 2003
    ..Renal fibrosis characterizes a common endpoint of diverse renal diseases which leads to functional impairment ultimately resulting in terminal renal failure...
  89. ncbi Lumbar bone mineral density in very long-term renal transplant recipients: impact of circulating sex hormones
    Vincent M Brandenburg
    Department of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, 52057, Aachen, Germany
    Osteoporos Int 16:1611-20. 2005
    ..The lumbar BMD decreased by -0.6+/-1.9% per year. In postmenopausal long-term renal transplant recipients, low estradiol levels were associated with accelerated bone loss...
  90. ncbi Glomerular remodelling: novel therapeutic approaches derived from the apparently chaotic growth factor network
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Germany
    Nephron 91:582-7. 2002
    ....
  91. doi Littoral cell angioma of the spleen mimicking posttransplantation lymphoma in a 63-year-old renal transplant patient
    Anja Susanne Mühlfeld
    Division of Nephrology and Immunology, University Hospital of the RWTH Aachen, Aachen, Germany
    Am J Kidney Dis 52:e11-4. 2008
    ..More specific tools need to be developed to aid in the differential diagnosis of splenic masses to avoid splenectomy in patients with littoral cell angiomas...
  92. doi A novel bioimpedance technique to monitor fluid volume state during hemodialysis treatment
    Guillermo Medrano
    Philips Chair for Medical Information Technology MedIT, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany
    ASAIO J 56:215-20. 2010
    ..The KK method, especially in combination with proper use of the introduced DeltaRe/UFV (%/L) normalization could possibly offer new options for comfortable online monitoring and the evaluation of fluid volume state during dialysis...
  93. ncbi beta2-microglobulin-derived amyloidosis: an update
    J Floege
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int Suppl 78:S164-71. 2001
    ..Such factors, which have changed over the last years as part of general improvements in dialysis care, may explain why the prevalence of the amyloidosis appears to decrease...
  94. ncbi Role of contact system activation in hemodialyzer-induced thrombogenicity
    R D Frank
    Department of Nephrology and Clinical Immunology, IZKF BIOMAT, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Kidney Int 60:1972-81. 2001
    ..However, the extent of contact activation, its role for intradialytic thrombin generation as well as the influence of different dialyzer membranes have not been well established...
  95. ncbi Inhibition of the renin-angiotensin system ameliorates genetically determined hyperinsulinemia
    J R Ortlepp
    Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Eur J Pharmacol 436:145-50. 2002
    ..6+/-1.5 and 1.8+/-0.4 ng/ml). In conclusion, long-term treatment with an angiotensin-converting enzyme inhibitor or an angiotensin II receptor antagonist can ameliorate obesity and hyperinsulinemia in a genetically determined mouse model...
  96. ncbi Present and future therapy options in IgA-nephropathy
    J Floege
    Department of Nephrology and Immunology, University of Aachen Germany
    J Nephrol 18:354-61. 2005
    ..In this respect a recently described primate model of IgAN offers some hope for the future...
  97. ncbi Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuin
    Markus Ketteler
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
    Blood Purif 20:473-6. 2002
    ....
  98. ncbi [Is there a correlation between C-reactive protein and calcification inhibitors with cardiovascular parameters and risk factors in hemodialysis patients?]
    G Schlieper
    Medizinische Klinik II, Nephrologie und klinische Immunologie, Universitatsklinikum Aachen, Germany
    Dtsch Med Wochenschr 132:1820-4. 2007
    ..Functional and morphological vascular parameters are used to assess cardiovascular risk. The aim of our study was to analyse the relation between pulse wave velocity (PWV) and intima-media-thickness (IMT) with calcification inhibitors...
  99. ncbi Expression of interferon-inducible Mx-proteins in patients with IgA nephropathy or Henoch-Schönlein purpura
    J Floege
    Division of Nephrology, Medical School, Hannover, Germany
    Am J Kidney Dis 33:434-40. 1999
    ..We conclude that, in patients with IgAN/HSP, no evidence of an activation or dysregulation of the type I interferon system can be detected...
  100. ncbi Scintigraphic methods to detect beta2-microglobulin associated amyloidosis (Abeta2-microglobulin amyloidosis)
    J Floege
    Division of Nephrology, Department of Medicine, University of Aachen, Germany
    Nephrol Dial Transplant 16:12-6. 2001
    ....
  101. ncbi Specific antagonism of PDGF prevents renal scarring in experimental glomerulonephritis
    T Ostendorf
    Medizinische Klinik II, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 12:909-18. 2001
    ..These data provide the first evidence for a causal role of PDGF in the pathogenesis of renal scarring and point to a new, highly effective therapeutic approach to progressive, in particular mesangioproliferative, renal disease...