Jurgen Floege

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi The pathogenesis of IgA nephropathy: what is new and how does it change therapeutic approaches?
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Germany
    Am J Kidney Dis 58:992-1004. 2011
  2. ncbi The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait
    Francesco P Schena
    Renal Unit, University of Bari, Italy
    BMC Nephrol 6:14. 2005
  3. ncbi When man turns to stone: extraosseous calcification in uremic patients
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Kidney Int 65:2447-62. 2004
  4. ncbi [IgA nephropathy: frequent, but rarely diagnosed]
    J Floege
    Abteilung für Nephrologie und Klinische Immunologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany
    Internist (Berl) 44:1131-9. 2003
  5. ncbi [Nephrology 2005/2006. Recent clinical studies and developments in science]
    Jurgen Floege
    Medizinische Klinik II, Universitätsklinikum der RWTH Aachen, 52057 Aachen
    Dtsch Med Wochenschr 131:1445-8. 2006
  6. ncbi Immune modulating therapy for IgA nephropathy: rationale and evidence
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, RWTH Aachen, Germany
    Semin Nephrol 28:38-47. 2008
  7. ncbi A new look at platelet-derived growth factor in renal disease
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 19:12-23. 2008
  8. ncbi Recurrent IgA nephropathy after renal transplantation
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Semin Nephrol 24:287-91. 2004
  9. ncbi The role of PDGF-D in mesangioproliferative glomerulonephritis
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany
    Contrib Nephrol 157:153-8. 2007
  10. ncbi [Nephrology -- familiar knowledge in the light of new discoveries in molecular and cell biology]
    J Floege
    Medizinische Klinik II, Nephrologie und klinische Immunologie,
    Dtsch Med Wochenschr 130:1552-4. 2005

Detail Information

Publications94

  1. ncbi The pathogenesis of IgA nephropathy: what is new and how does it change therapeutic approaches?
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Germany
    Am J Kidney Dis 58:992-1004. 2011
    ....
  2. ncbi The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait
    Francesco P Schena
    Renal Unit, University of Bari, Italy
    BMC Nephrol 6:14. 2005
    ..The organization of a multi-centre Biobank for the collection of biological samples and clinical data from IgAN patients and relatives is an important starting point for the identification of the disease susceptibility genes...
  3. ncbi When man turns to stone: extraosseous calcification in uremic patients
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Kidney Int 65:2447-62. 2004
  4. ncbi [IgA nephropathy: frequent, but rarely diagnosed]
    J Floege
    Abteilung für Nephrologie und Klinische Immunologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany
    Internist (Berl) 44:1131-9. 2003
    ..When end stage renal failure has developed and a renal transplant is performed, about 25% of the patients will experience a clinically relevant recurrence of IgAN with progressive graft dysfunction...
  5. ncbi [Nephrology 2005/2006. Recent clinical studies and developments in science]
    Jurgen Floege
    Medizinische Klinik II, Universitätsklinikum der RWTH Aachen, 52057 Aachen
    Dtsch Med Wochenschr 131:1445-8. 2006
  6. ncbi Immune modulating therapy for IgA nephropathy: rationale and evidence
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, RWTH Aachen, Germany
    Semin Nephrol 28:38-47. 2008
    ....
  7. ncbi A new look at platelet-derived growth factor in renal disease
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 19:12-23. 2008
    ..Accordingly, targeted intervention against the various PDGF isoforms offers a promising novel therapeutic approach to renal disease...
  8. ncbi Recurrent IgA nephropathy after renal transplantation
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Semin Nephrol 24:287-91. 2004
    ..In patients with recurrent IgAN, no specific therapy other than optimal supportive care has been established...
  9. ncbi The role of PDGF-D in mesangioproliferative glomerulonephritis
    Jurgen Floege
    Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany
    Contrib Nephrol 157:153-8. 2007
    ..In addition, first observations suggest that PDGF-D may also contribute to secondary renal changes that characterize progressive renal failure, i.e. tubulointerstitial fibrosis...
  10. ncbi [Nephrology -- familiar knowledge in the light of new discoveries in molecular and cell biology]
    J Floege
    Medizinische Klinik II, Nephrologie und klinische Immunologie,
    Dtsch Med Wochenschr 130:1552-4. 2005
  11. ncbi Mutant mice provide new insight into the role of (mis-)glycation in IgA nephropathy and other glomerular diseases
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:1518-20. 2007
  12. ncbi Bone marrow transplantation rescues Alport mice
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 21:2721-3. 2006
  13. ncbi Recurrent glomerulonephritis following renal transplantation: an update
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Germany
    Nephrol Dial Transplant 18:1260-5. 2003
  14. ncbi Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patients
    Jurgen Floege
    Division of Nephrology, RWTH University of Aachen, Aachen, Germany
    Nephrol Dial Transplant 25:1916-23. 2010
    ..We report the ADVANCE Study design and baseline subject characteristics...
  15. ncbi Current therapy for IgA nephropathy
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany
    J Am Soc Nephrol 22:1785-94. 2011
    ..In other atypical patients with secondary IgAN, treatment should target the underlying primary disease. And fourth is the transplanted patient with recurrent IgAN where the mainstay of treatment is optimized supportive care...
  16. ncbi Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population
    Jurgen Floege
    Div Nephrology, RWTH University of Aachen, Germany
    Nephrol Dial Transplant 26:1948-55. 2011
    ..The existence of such a link in a European haemodialysis population was explored as part of the Analysing Data, Recognising Excellence and Optimising Outcomes (ARO) Chronic Kidney Disease (CKD) Research Initiative...
  17. ncbi Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification
    Ralf Koos
    Department of Cardiology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Thromb Haemost 101:706-13. 2009
    ..In addition, our data suggest that OAC treatment may decrease local expression of MGP, resulting in decreased circulating MGP levels and subsequently increased aortic valve calcifications as an adverse side effect...
  18. ncbi Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes
    Uta Kunter
    Division of Nephrology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 18:1754-64. 2007
    ..These data suggest that MSC treatment can be a valuable therapeutic approach only if adipogenic maldifferentiation is prevented...
  19. ncbi Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D
    Claudia R C van Roeyen
    Division of Nephrology, RWTH Aachen University Hospital, Aachen, Germany
    Kidney Int 80:1292-305. 2011
    ..Hence, podocyte-specific growth factor overexpression can induce paracrine mesangial cell proliferation upstream of the filtration flow...
  20. ncbi Fetuin-A (AHSG) prevents extraosseous calcification induced by uraemia and phosphate challenge in mice
    Ralf Westenfeld
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:1537-46. 2007
    ..Chronic kidney disease (CKD) is associated with vascular and tissue calcification. The extent of vascular calcification has been identified as an independent risk factor of cardiovascular death in patients on haemodialysis...
  21. ncbi PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis
    Peter Boor
    Division of Nephrology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 22:1323-31. 2007
    ..Administration of the PDGF-D neutralizing fully human monoclonal antibody CR002 in the acute phase of progressive anti-Thy 1.1 glomerulonephritis reduced glomerular and secondary tubulointerstitial damage...
  22. ncbi Uraemia disrupts the vascular niche in a 3D co-culture system of human mesenchymal stem cells and endothelial cells
    Rafael Kramann
    Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Nephrol Dial Transplant 27:2693-702. 2012
    ..The uraemic microenvironment predisposes to increased levels of reactive oxygen species, accelerated ageing of endothelial cells (EC) and vascular sclerosis...
  23. ncbi Extracellular YB-1 blockade in experimental nephritis upregulates Notch-3 receptor expression and signaling
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Nephron Exp Nephrol 118:e100-8. 2011
    ....
  24. ncbi Complement C5 mediates experimental tubulointerstitial fibrosis
    Peter Boor
    Division of Nephrology, Rheinische Westfälische Technische Hochschule, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 18:1508-15. 2007
    ..Using a combined genetic and pharmacologic approach, C5, in particular C5a, is identified as a novel profibrotic factor in renal disease and as a potential new therapeutic target...
  25. ncbi Fetuin-A protects against atherosclerotic calcification in CKD
    Ralf Westenfeld
    Department of Nephrology, Rheinisch Westfälische Technische Hochschule RWTH Aachen University Hospital, Aachen, Germany
    J Am Soc Nephrol 20:1264-74. 2009
    ..In conclusion, fetuin-A inhibits pathologic calcification in both the soft tissue and vasculature, even in the setting of atherosclerosis...
  26. ncbi PDGF-C mediates glomerular capillary repair
    Peter Boor
    Division of Nephrology and Immunology, University Hospital Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Am J Pathol 177:58-69. 2010
    ..These results identify PDGF-C as a novel, potent pro-angiogenic factor in the kidney that can accelerate capillary healing in experimental glomerulonephritis and thrombotic microangiopathy...
  27. ncbi Analysis of calcifications in patients with coral reef aorta
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital, and Central Facility for Electron Microscopy, RWTH University, Aachen, Germany
    Ann Vasc Surg 24:408-14. 2010
    ..The aim of our study was to investigate calcification inhibitors and the ultrastructure of calcifications in patients with coral reef aorta...
  28. ncbi Patients with IgA nephropathy exhibit high systemic PDGF-DD levels
    Peter Boor
    RWTH University of Aachen, Germany
    Nephrol Dial Transplant 24:2755-62. 2009
    ..Platelet-derived growth factor (PDGF) is a central mediator of mesangioproliferative glomerulonephritis (GN). In experimental mesangioproliferative GN, PDGF-DD serum levels, unlike PDGF-BB, increased up to 1000-fold...
  29. ncbi Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury
    Sonja Djudjaj
    Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany Department of Nephrology and Immunology, RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Pathol 228:286-99. 2012
    ..Thus, specific blockade of this receptor may be suitable as therapeutic option to delay progression of kidney disease. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd...
  30. ncbi Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis
    Tammo Ostendorf
    Division of Nephrology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Am Soc Nephrol 17:1054-62. 2006
    ..In conclusion, these data provide evidence for a causal role of PDGF-D in the pathogenesis of renal scarring and point to a new therapeutic approach to progressive mesangioproliferative renal disease...
  31. ncbi Serological cardiovascular and mortality risk predictors in dialysis patients receiving sevelamer: a prospective study
    Vincent Matthias Brandenburg
    Department of Nephrology, University Hospital of the RWTH Aachen, Pauwelsstase 30, Aachen, Germany
    Nephrol Dial Transplant 25:2672-9. 2010
    ..We assessed how sevelamer hydrochloride influences the evolution of serum fetuin-A and other serological factors predicting cardiovascular outcome and survival in haemodialysis patients...
  32. ncbi A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects
    Claudia R C van Roeyen
    Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Am J Pathol 180:1979-90. 2012
    ..Manipulation of CCN3 may represent a novel approach to help repair glomerular endothelial damage and mesangioproliferative changes...
  33. ncbi Vascular access calcification predicts mortality in hemodialysis patients
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Aachen, Germany
    Kidney Int 74:1582-7. 2008
    ..Our study suggests that detection of vascular access calcification is a cost-effective method to identify patients at increased mortality risk...
  34. ncbi Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Kidney Int 75:185-96. 2009
    ..We show that YB-1 is a cell-type specific regulator of CCL5 expression in infiltrating T-cells and monocytes/macrophages and acts as an adaptive controller of inflammation during kidney allograft rejection...
  35. ncbi Predictors of low circulating endothelial progenitor cell numbers in haemodialysis patients
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Nephrol Dial Transplant 23:2611-8. 2008
    ....
  36. ncbi Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfalische Technische Hochschule, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 22:387-95. 2011
    ..Lower levels of circulating dp-cMGP may serve as a predictor of mortality in dialysis patients. Whether vitamin K supplementation improves outcomes requires further study...
  37. ncbi The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis
    Dirk Bokemeyer
    Division of Nephrology, Augusta Hospital, Bochum, Germany
    Nephrol Dial Transplant 22:3431-41. 2007
    ..In vitro, the extracellular signal-regulated kinase (ERK) is an intracellular convergence point of multiple stimuli, which affect the cell cycle. However, the role of ERK in cell cycle regulation in vivo is unknown...
  38. ncbi Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
    ..We aimed to investigate the hypothesis that AHSG deficiency is directly related to uraemic vascular calcification...
  39. ncbi PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 14:1145-53. 2003
    ..We conclude that PDGF-C is constitutively expressed in the human kidney and is upregulated in podocytes and interstitial cells after injury/activation of these cells...
  40. ncbi Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney
    Frank Eitner
    Division of Nephrology and Immunology, University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 13:910-7. 2002
    ..PDGF-C may therefore be involved in the pathogenesis of renal scarring...
  41. ncbi Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis
    Luigi Villa
    Division of Nephrology, University Hospital RWTH Aachen, Aachen, Germany
    Nephrol Dial Transplant 26:3131-43. 2011
    ..We examined the effect of low-dose telmisartan (LT) and high-dose telmisartan (HT) versus conventional antihypertensive therapy in the rat anti-Thy1.1 model of glomerulonephritis...
  42. ncbi Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis--implications for post-transplantation bone disease
    Ralf Westenfeld
    Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Nephrol Dial Transplant 26:4115-23. 2011
    ..Glucocorticoid-induced osteoporosis on top of pre-existing renal osteodystrophy is considered the major pathogenic factor, while the role of non-glucocorticoid immunosuppressants is less well defined...
  43. ncbi Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells
    Bart Smeets
    Department of Nephrology and Immunology, University Hospital of the Aachen University of Technology, Pauwelsstrasse 30, Aachen, Germany
    J Am Soc Nephrol 20:2604-15. 2009
    ..In conclusion, PECs constitute the majority of cells that compose early extracapillary proliferative lesions in both crescentic glomerulonephritis and collapsing glomerulopathy, suggesting similar pathomechanisms in both diseases...
  44. ncbi The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
    Cora Schafer
    Interdisciplinary Center for Clinical Research on Biochematerials, University Clinics, Aachen, Germany
    J Clin Invest 112:357-66. 2003
    ..Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases...
  45. ncbi Mesangial cell expression of proto-oncogene Ets-1 during progression of mesangioproliferative glomerulonephritis
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital of Aachen, Aachen, Germany
    Kidney Int 66:622-32. 2004
    ..The expression of Ets-1 mRNA and protein was analyzed in healthy rat kidney and in a model for mesangioproliferative disease without and with inhibition of platelet-derived growth factor-B (PDGF-B) activity...
  46. ncbi Y-box binding protein-1 mediates profibrotic effects of calcineurin inhibitors in the kidney
    Lydia Hanssen
    Department of Nephrology and Clinical Immunology, University Hospital Rheinisch Westfälische Technische Hochschule Aachen, Aachen 52057, Germany
    J Immunol 187:298-308. 2011
    ..Our results provide strong evidence for a CNI-dependent induction of YB-1 in MCs that contributes to renal fibrosis via regulation of its own and collagen translation...
  47. ncbi Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis
    Thilo Kruger
    Department of Nephrology and Clinical Immunology, University Clinic of Aachen, Aachen, Germany
    J Am Soc Nephrol 15:613-21. 2004
    ..These results are the first to identify and characterize renal CD11c(+) cells as DC and to demonstrate marked changes in experimental glomerulonephritis...
  48. ncbi Subtotal ablation of parietal epithelial cells induces crescent formation
    Eva Maria Sicking
    Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Am Soc Nephrol 23:629-40. 2012
    ..In summary, subtotal ablation of PECs leads the remaining PECs to react with cellular activation and proliferation, which ultimately forms cellular crescents...
  49. ncbi Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis
    Uta Kunter
    Division of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    J Am Soc Nephrol 17:2202-12. 2006
    ....
  50. ncbi Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells
    Rafael Kramann
    Department of Nephrology and Clinical Immunology, Medical Faculty RWTH, Aachen University, Aachen, Germany
    Arterioscler Thromb Vasc Biol 31:e45-54. 2011
    ..The current study is based on the hypothesis that mesenchymal stem cells (MSC) constitute critical cells for procalcific extracellular matrix remodeling in patients with chronic kidney disease...
  51. ncbi A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis
    Tammo Ostendorf
    Division Nephrology, University of Aachen, Germany
    J Am Soc Nephrol 14:2237-47. 2003
    ....
  52. ncbi Inducible nitric oxide synthase-derived nitric oxide promotes glomerular angiogenesis via upregulation of vascular endothelial growth factor receptors
    Tammo Ostendorf
    Division of Nephrology and Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Am Soc Nephrol 15:2307-19. 2004
    ..These data identify iNOS-derived NO production as the first in vivo regulator of the glomerular VEGF system and as an important mechanism promoting glomerular healing...
  53. ncbi Therapeutic targets for prevention and regression of progressive fibrosing renal diseases
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Curr Opin Investig Drugs 6:255-61. 2005
    ..This is likely by combining compounds that interfere with a variety of targets simultaneously...
  54. ncbi Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany
    Lab Invest 88:1090-100. 2008
    ....
  55. ncbi Risk factors for cardiovascular calcifications in non-diabetic Caucasian haemodialysis patients
    Georg Schlieper
    Department of Nephrology, University Hospital Aachen, Aachen, Germany
    Kidney Blood Press Res 32:161-8. 2009
    ..Diabetes mellitus and ethnicity are known factors that affect the extent of cardiovascular calcifications. However, most studies have investigated mixed cohorts with diabetics and/or mixed ethnicity...
  56. ncbi Ultrastructural analysis of vascular calcifications in uremia
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 21:689-96. 2010
    ..Furthermore, considering the core-shell structure of the calcifications, apoptotic bodies or matrix vesicles may serve as a calcification nidus...
  57. ncbi "Missing" inhibitors of calcification: general aspects and implications in renal failure
    Markus Ketteler
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Pediatr Nephrol 20:383-8. 2005
    ....
  58. ncbi Supportive Versus Immunosuppressive Therapy of Progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol
    Frank Eitner
    Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany
    J Nephrol 21:284-9. 2008
    ..Finally, our trial can serve as a model for various other types of glomerulonephritis, for which such trials are very difficult to perform, given their infrequency...
  59. ncbi Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis
    Bart Smeets
    Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    J Am Soc Nephrol 22:1262-74. 2011
    ..In conclusion, these results demonstrate that PECs contribute to the development and progression of the sclerotic lesions that define FSGS, but this pathogenesis may be relevant to all etiologies of glomerulosclerosis...
  60. ncbi Association of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients
    Ralf Koos
    Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RTWH Aachen, RWTH University Aachen, Pauwelsstrasse 30, Aachen 52057, Germany
    Eur Heart J 30:2054-61. 2009
    ..We investigated the relationship between baseline fetuin-A serum levels and the rate of progression of aortic valve calcification (AVC) in non-dialyzed patients with aortic valve disease (AVD)...
  61. ncbi Hypertension superimposed on type II diabetes in Goto Kakizaki rats induces progressive nephropathy
    Ulf Janssen
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int 63:2162-70. 2003
    ..The aim of this study was to investigate the effect of superimposed hypertension on renal function and morphology under conditions of hyper- and normoglycemia...
  62. ncbi Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?
    Thilo Krueger
    Division of Nephrology and Clinical Immunology, University Hospital, RWTH University of Aachen, Germany
    Kidney Int 76:18-22. 2009
    ..Additionally, we wish to give an overview of the current literature indicating potential adverse effects of long-term vitamin K antagonists in this population...
  63. ncbi In vivo identification of the mitogen-activated protein kinase cascade as a central pathogenic pathway in experimental mesangioproliferative glomerulonephritis
    Dirk Bokemeyer
    Medical Policlinic, Division of Nephrology, University of Bonn, Bonn, Germany
    J Am Soc Nephrol 13:1473-80. 2002
    ..These observations point to ERK as a putative intracellular mediator of the proliferative response in GN and suggest that pharmacologic treatments that interfere with the activation of ERK may be of potential therapeutic interest...
  64. ncbi Risk factors for Pneumocystis jiroveci pneumonia (PcP) in renal transplant recipients
    Frank Eitner
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Nephrol Dial Transplant 26:2013-7. 2011
    ..Individual risk factors for susceptibility to PcP are incompletely understood...
  65. ncbi Vascular calcification in patients with end-stage renal disease
    Jurgen Floege
    Medizinische Klinik II, Klinikum der RWTH, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Nephrol Dial Transplant 19:V59-66. 2004
    ..Yet, it remains unclear whether sevelamer HCl reduces vascular calcification by preventing episodes of hypercalcaemia and/or by reducing low-density lipoprotein (LDL)-cholesterol levels...
  66. ncbi Anticoagulant-free Genius haemodialysis using low molecular weight heparin-coated circuits
    Rolf Dario Frank
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, 52057 Aachen, Germany
    Nephrol Dial Transplant 21:1013-8. 2006
    ..In an alternative approach we evaluated the effects of covalent circuit coating with low molecular weight heparin (LMWH) for intermittent haemodialysis...
  67. ncbi Novel insights into renal fibrosis
    Frank Eitner
    Division of Nephrology and Immunology, Aachen University, Aachen, Germany
    Curr Opin Nephrol Hypertens 12:227-32. 2003
    ..Renal fibrosis characterizes a common endpoint of diverse renal diseases which leads to functional impairment ultimately resulting in terminal renal failure...
  68. ncbi Renal allograft failure in a hyperparathyroid patient following initiation of a calcimimetic
    Claudia Seikrit
    Division of Nephrology and Immunology, RWTH University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Nat Rev Nephrol 7:237-41. 2011
    ..While on dialysis, he had developed secondary hyperparathyroidism, which persisted after transplantation despite treatment with cinacalcet...
  69. ncbi Sodium thiosulfate in the treatment of calcific uremic arteriolopathy
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
    Nat Rev Nephrol 5:539-43. 2009
    ..Large clinical trials to evaluate the efficacy and long-term safety of sodium thiosulfate are clearly warranted...
  70. ncbi Lumbar bone mineral density in very long-term renal transplant recipients: impact of circulating sex hormones
    Vincent M Brandenburg
    Department of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, 52057, Aachen, Germany
    Osteoporos Int 16:1611-20. 2005
    ..The lumbar BMD decreased by -0.6+/-1.9% per year. In postmenopausal long-term renal transplant recipients, low estradiol levels were associated with accelerated bone loss...
  71. ncbi Littoral cell angioma of the spleen mimicking posttransplantation lymphoma in a 63-year-old renal transplant patient
    Anja Susanne Mühlfeld
    Division of Nephrology and Immunology, University Hospital of the RWTH Aachen, Aachen, Germany
    Am J Kidney Dis 52:e11-4. 2008
    ..More specific tools need to be developed to aid in the differential diagnosis of splenic masses to avoid splenectomy in patients with littoral cell angiomas...
  72. ncbi Glomerular remodelling: novel therapeutic approaches derived from the apparently chaotic growth factor network
    Jurgen Floege
    Division of Nephrology and Immunology, University of Aachen, Germany
    Nephron 91:582-7. 2002
    ....
  73. ncbi A novel bioimpedance technique to monitor fluid volume state during hemodialysis treatment
    Guillermo Medrano
    Philips Chair for Medical Information Technology MedIT, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany
    ASAIO J 56:215-20. 2010
    ..The KK method, especially in combination with proper use of the introduced DeltaRe/UFV (%/L) normalization could possibly offer new options for comfortable online monitoring and the evaluation of fluid volume state during dialysis...
  74. ncbi Present and future therapy options in IgA-nephropathy
    J Floege
    Department of Nephrology and Immunology, University of Aachen Germany
    J Nephrol 18:354-61. 2005
    ..In this respect a recently described primate model of IgAN offers some hope for the future...
  75. ncbi beta2-microglobulin-derived amyloidosis: an update
    J Floege
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int Suppl 78:S164-71. 2001
    ..Such factors, which have changed over the last years as part of general improvements in dialysis care, may explain why the prevalence of the amyloidosis appears to decrease...
  76. ncbi Role of contact system activation in hemodialyzer-induced thrombogenicity
    R D Frank
    Department of Nephrology and Clinical Immunology, IZKF BIOMAT, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Kidney Int 60:1972-81. 2001
    ..However, the extent of contact activation, its role for intradialytic thrombin generation as well as the influence of different dialyzer membranes have not been well established...
  77. ncbi Inhibition of the renin-angiotensin system ameliorates genetically determined hyperinsulinemia
    J R Ortlepp
    Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Eur J Pharmacol 436:145-50. 2002
    ..6+/-1.5 and 1.8+/-0.4 ng/ml). In conclusion, long-term treatment with an angiotensin-converting enzyme inhibitor or an angiotensin II receptor antagonist can ameliorate obesity and hyperinsulinemia in a genetically determined mouse model...
  78. ncbi Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuin
    Markus Ketteler
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
    Blood Purif 20:473-6. 2002
    ....
  79. ncbi Expression of interferon-inducible Mx-proteins in patients with IgA nephropathy or Henoch-Schönlein purpura
    J Floege
    Division of Nephrology, Medical School, Hannover, Germany
    Am J Kidney Dis 33:434-40. 1999
    ..We conclude that, in patients with IgAN/HSP, no evidence of an activation or dysregulation of the type I interferon system can be detected...
  80. ncbi [Is there a correlation between C-reactive protein and calcification inhibitors with cardiovascular parameters and risk factors in hemodialysis patients?]
    G Schlieper
    Medizinische Klinik II, Nephrologie und klinische Immunologie, Universitatsklinikum Aachen, Germany
    Dtsch Med Wochenschr 132:1820-4. 2007
    ..Functional and morphological vascular parameters are used to assess cardiovascular risk. The aim of our study was to analyse the relation between pulse wave velocity (PWV) and intima-media-thickness (IMT) with calcification inhibitors...
  81. ncbi Imaging techniques in the diagnosis of dialysis-related amyloidosis
    M Ketteler
    Division of Nephrology, University Hospital of Aachen Technical University, Aachen, Germany
    Semin Dial 14:90-3. 2001
    ..In conclusion, scintigraphy for A beta(2)M with (111)In-labeled rh beta(2)M provides a homogeneous and safe recombinant protein source and represents a suitable detection method of beta(2)M amyloid deposits in dialysis patients...
  82. ncbi Specific antagonism of PDGF prevents renal scarring in experimental glomerulonephritis
    T Ostendorf
    Medizinische Klinik II, University of Aachen, Aachen, Germany
    J Am Soc Nephrol 12:909-18. 2001
    ..These data provide the first evidence for a causal role of PDGF in the pathogenesis of renal scarring and point to a new, highly effective therapeutic approach to progressive, in particular mesangioproliferative, renal disease...
  83. ncbi Scintigraphic methods to detect beta2-microglobulin associated amyloidosis (Abeta2-microglobulin amyloidosis)
    J Floege
    Division of Nephrology, Department of Medicine, University of Aachen, Germany
    Nephrol Dial Transplant 16:12-6. 2001
    ....
  84. ncbi PDGF-B gene single-nucleotide polymorphisms are not predictive for disease onset or progression of IgA nephropathy
    B Bicanski
    Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Germany
    Clin Nephrol 67:65-72. 2007
    ....
  85. ncbi Clinical research for patient empowerment--a qualitative approach on the improvement of heart health promotion in chronic illness
    Christian Meyer
    Division of Cardiology, Pulmonology and Vascular Medicine, Europian Master in Health Promotion, University of Aachen, Medical Clinic I, Aachen, Germany
    Med Sci Monit 14:CR358-65. 2008
    ..The aim of the present study was to investigate whether theory-based empowerment, using motivational interviewing, can be facilitated within clinical research in patients with severe chronic diseases...
  86. ncbi Pro-fibrogenic potential of PDGF-D in liver fibrosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, and Division of Nephrology, RWTH University Hospital Aachen, D 52074 Aachen, Germany
    J Hepatol 46:1064-74. 2007
    ..We analyzed the expression of platelet-derived growth factor D (PDGF-D) in an experimental bile duct-ligated (BDL) rat model and assessed its biological function in cultured hepatic stellate cells (HSC) and myofibroblasts (MFB)...
  87. ncbi [Therapy and prophylaxis of renal failure]
    V M Brandenburg
    Medizinische Klinik II, Nephrologie und klinische Immunologie,
    Internist (Berl) 44:819-24, 826-30. 2003
    ..Supportive therapy thus represents a highly complex and interdisciplinary treatment, which should prompt an early inclusion of a nephrologist into the therapeutic strategy...
  88. ncbi [Daily problems involving contact with terminally ill patients with renal failure]
    M J Moeller
    Medizinische Klinik II, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen
    Internist (Berl) 48:795-803. 2007
    ..These patients often present with infections in which case the degree of immunosuppression may need to be reduced. Vaccinations as well as an increased risk for malignancies require special attention in these patients...
  89. ncbi Recruitment of podocytes from glomerular parietal epithelial cells
    Daniel Appel
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule University of Aachen, Aachen, Germany
    J Am Soc Nephrol 20:333-43. 2009
    ..In conclusion, we demonstrate for the first time recruitment of podocytes from PECs in juvenile mice. Unraveling the mechanisms of PEC recruitment onto the glomerular tuft may lead to novel therapeutic approaches to renal injury...
  90. ncbi No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients
    Friederike Malycha
    Department of Human Genetics, Division of Nephrology and Immunology, Aachen, Germany
    Nephrol Dial Transplant 24:321-4. 2009
    ..Mosaic mutations of cosmc have been shown to result in autoimmune disease. We hypothesized that cosmc mutations might contribute to the altered IgA1 galactosylation in IgAN patients...
  91. ncbi Factor Xa-activated whole blood clotting time (Xa-ACT) for bedside monitoring of dalteparin anticoagulation during haemodialysis
    Rolf Dario Frank
    Department of Nephrology and Clinical Immunlogy, University Hospital Aachen, D 52057 Aachen, Germany
    Nephrol Dial Transplant 19:1552-8. 2004
    ..The available laboratory tests for monitoring LMWH anticoagulation are time-consuming and expensive, and the suitability of the conventional activated clotting time (ACT) is controversial. A simple and cheap bedside test would be useful...
  92. ncbi Case series of idiopathic membranous nephropathy with long-term beneficial effects of ACTH peptide 1-24
    T Rauen
    Department of Nephrology and Clinical Immunology, RWTH University Hospital, Aachen
    Clin Nephrol 71:637-42. 2009
    ..The objective of the present case series was to evaluate long-term ACTH effects on proteinuria and renal function...
  93. ncbi Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients
    A S Mühlfeld
    Division of Nephrology and Immunology, University of Aachen, Aachen, Germany
    Am J Transplant 7:1865-8. 2007
    ..All patients awaiting renal transplantation should be screened for a history of thrombosis and, if appropriate, tested for SPS. Affected patients should receive dose-adjusted acetylsalicylic acid...
  94. ncbi Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells
    C R C van Roeyen
    Division of Nephrology, RWTH Aachen University, Aachen, Germany
    Kidney Int 69:1393-402. 2006
    ..Rare apparently differential gene regulation did not result in different protein expression, suggesting that in HMCs both PDGFs exert their biological activity almost exclusively via the PDGF beta-receptor...