C Fahlke

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi Molecular mechanisms of ion conduction in ClC-type chloride channels: lessons from disease-causing mutations
    C Fahlke
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Kidney Int 57:780-6. 2000
  2. ncbi Ion permeation and selectivity in ClC-type chloride channels
    C Fahlke
    Institute of Physiology, RWTH Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Am J Physiol Renal Physiol 280:F748-57. 2001
  3. ncbi Molecular basis for decreased muscle chloride conductance in the myotonic goat
    C L Beck
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Proc Natl Acad Sci U S A 93:11248-52. 1996
  4. ncbi Mechanism of ion permeation in skeletal muscle chloride channels
    C Fahlke
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    J Gen Physiol 110:551-64. 1997
  5. ncbi Pore stoichiometry of a voltage-gated chloride channel
    C Fahlke
    Department of Medicine Nephrology, and The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6600, USA
    Nature 394:687-90. 1998
  6. ncbi A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog
    T H Rhodes
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    FEBS Lett 456:54-8. 1999
  7. ncbi Residues lining the inner pore vestibule of human muscle chloride channels
    C Fahlke
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:1759-65. 2001
  8. ncbi A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel
    C Fahlke
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 94:2729-34. 1997

Collaborators

  • C H Vite
  • T H Rhodes
  • A L George
  • C L Beck
  • D F Patterson
  • U Giger

Detail Information

Publications8

  1. ncbi Molecular mechanisms of ion conduction in ClC-type chloride channels: lessons from disease-causing mutations
    C Fahlke
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Kidney Int 57:780-6. 2000
    ..This review describes recent experiments using a combination of cellular electrophysiology, molecular genetics, and recombinant DNA technology to study the molecular basis of ion permeation and selection in ClC-type chloride channels...
  2. ncbi Ion permeation and selectivity in ClC-type chloride channels
    C Fahlke
    Institute of Physiology, RWTH Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Am J Physiol Renal Physiol 280:F748-57. 2001
    ..These novel tools have provided new insights into basic mechanisms underlying the function of these biologically important channels...
  3. ncbi Molecular basis for decreased muscle chloride conductance in the myotonic goat
    C L Beck
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Proc Natl Acad Sci U S A 93:11248-52. 1996
    ..These results provide a molecular basis for the decreased chloride conductance in myotonic muscle...
  4. ncbi Mechanism of ion permeation in skeletal muscle chloride channels
    C Fahlke
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    J Gen Physiol 110:551-64. 1997
    ..These results have implications for understanding mechanisms of ion selectivity in hClC-1, and for defining the intimate relationship between gating and permeation in ClC channels...
  5. ncbi Pore stoichiometry of a voltage-gated chloride channel
    C Fahlke
    Department of Medicine Nephrology, and The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6600, USA
    Nature 394:687-90. 1998
    ..We conclude that human CIC-1 has a single functional pore...
  6. ncbi A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog
    T H Rhodes
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    FEBS Lett 456:54-8. 1999
    ..Genetic and electrophysiological characterization of the myotonic dog provides a new and potentially valuable animal model of an inherited skeletal muscle disease that has advantages over existing models of myotonia congenita...
  7. ncbi Residues lining the inner pore vestibule of human muscle chloride channels
    C Fahlke
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:1759-65. 2001
    ....
  8. ncbi A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel
    C Fahlke
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 94:2729-34. 1997
    ..Both binding sites are preserved in the mutant but have decreased affinities for iodide. These findings suggest that Gly 230 is critical for normal ion conductance in hClC-1 and that this residue resides within the channel pore...