Rüdiger Blindt

Summary

Affiliation: RWTH Aachen
Country: Germany

Publications

  1. ncbi request reprint Abciximab inhibits the migration and invasion potential of human coronary artery smooth muscle cells
    R Blindt
    Medical Clinic I and Interdisciplinary Center of Clinical Research BIOMAT, University of Aachen Hospital, Pauwelsstr 30, Aachen, 52074, Germany
    J Mol Cell Cardiol 32:2195-206. 2000
  2. ncbi request reprint Downregulation of N-cadherin in the neointima stimulates migration of smooth muscle cells by RhoA deactivation
    Rüdiger Blindt
    Medical Clinic I, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Cardiovasc Res 62:212-22. 2004
  3. ncbi request reprint A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells
    Rüdiger Blindt
    Department of Cardiology, University Hospital Aachen, Aachen, Germany
    J Am Coll Cardiol 47:1786-95. 2006
  4. ncbi request reprint Expression patterns of integrins on quiescent and invasive smooth muscle cells and impact on cell locomotion
    Rüdiger Blindt
    Medical Clinic I, University Hospital RWTH Aachen, D 52074, Aachen, Germany
    J Mol Cell Cardiol 34:1633-44. 2002
  5. ncbi request reprint Decrease of vascular smooth muscle cell locomotion by abciximab, but not tirofiban: a possible role of different affinity to alpha v beta 3 integrins
    Rüdiger Blindt
    University Hospital, Aachen, Medical Clinic I, Regensburg, Germany
    Coron Artery Dis 13:357-64. 2002
  6. ncbi request reprint Activation of IP and EP(3) receptors alters cAMP-dependent cell migration
    Rüdiger Blindt
    Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Eur J Pharmacol 444:31-7. 2002
  7. ncbi request reprint Characterization of differential gene expression in quiescent and invasive human arterial smooth muscle cells
    Rüdiger Blindt
    Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
    J Vasc Res 39:340-52. 2002
  8. ncbi request reprint Upregulation of the cytoskeletal-associated protein Moesin in the neointima of coronary arteries after balloon angioplasty: a new marker of smooth muscle cell migration?
    Rüdiger Blindt
    Medical Clinic I, University Hospital, RWTH Aachen, Aachen, Germany
    Cardiovasc Res 54:630-9. 2002
  9. ncbi request reprint The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis
    Rüdiger Blindt
    Department of Cardiology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Thromb Haemost 98:1329-34. 2007
  10. ncbi request reprint Intravascular ultrasonic comparative analysis of degree of intimal hyperplasia produced by four different stents in the coronary arteries
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 94:1548-50. 2004

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Abciximab inhibits the migration and invasion potential of human coronary artery smooth muscle cells
    R Blindt
    Medical Clinic I and Interdisciplinary Center of Clinical Research BIOMAT, University of Aachen Hospital, Pauwelsstr 30, Aachen, 52074, Germany
    J Mol Cell Cardiol 32:2195-206. 2000
    ..The results of this study indicate that the alpha v beta 3 antagonist abciximab is a potent inhibitor of hcSMC migration and invasion which could explain the observed lower reintervention rate after PTCA and stent implantation...
  2. ncbi request reprint Downregulation of N-cadherin in the neointima stimulates migration of smooth muscle cells by RhoA deactivation
    Rüdiger Blindt
    Medical Clinic I, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Cardiovasc Res 62:212-22. 2004
    ..The aim of the study was to analyze whether cadherin- and Rho-family GTPases-mediated dynamic rearrangement of cell-cell adhesion play an important role during human arterial smooth muscle cell (haSMC) migration...
  3. ncbi request reprint A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells
    Rüdiger Blindt
    Department of Cardiology, University Hospital Aachen, Aachen, Germany
    J Am Coll Cardiol 47:1786-95. 2006
    ..Novel stents loaded with an integrin-binding cyclic Arg-Gly-Asp peptide (cRGD) were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting endothelial progenitor cells (EPCs)...
  4. ncbi request reprint Expression patterns of integrins on quiescent and invasive smooth muscle cells and impact on cell locomotion
    Rüdiger Blindt
    Medical Clinic I, University Hospital RWTH Aachen, D 52074, Aachen, Germany
    J Mol Cell Cardiol 34:1633-44. 2002
    ....
  5. ncbi request reprint Decrease of vascular smooth muscle cell locomotion by abciximab, but not tirofiban: a possible role of different affinity to alpha v beta 3 integrins
    Rüdiger Blindt
    University Hospital, Aachen, Medical Clinic I, Regensburg, Germany
    Coron Artery Dis 13:357-64. 2002
    ..Therefore, the objective of this study was to compare the effectiveness of abciximab and tirofiban to affect VSMC migration and invasion...
  6. ncbi request reprint Activation of IP and EP(3) receptors alters cAMP-dependent cell migration
    Rüdiger Blindt
    Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Eur J Pharmacol 444:31-7. 2002
    ..767. It is concluded that the prostacyclin mimetic iloprost inhibits vascular cell migration, which probably depends on a G(s)-mediated increase of intracellular cAMP. EP(3) receptors conversely stimulate CHO migration...
  7. ncbi request reprint Characterization of differential gene expression in quiescent and invasive human arterial smooth muscle cells
    Rüdiger Blindt
    Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
    J Vasc Res 39:340-52. 2002
    ..In conclusion, several relevant potential candidate genes for the quiescent and the invasive SMC phenotype were identified and genes already known to be differentially regulated by previous analysis were confirmed...
  8. ncbi request reprint Upregulation of the cytoskeletal-associated protein Moesin in the neointima of coronary arteries after balloon angioplasty: a new marker of smooth muscle cell migration?
    Rüdiger Blindt
    Medical Clinic I, University Hospital, RWTH Aachen, Aachen, Germany
    Cardiovasc Res 54:630-9. 2002
    ..The increased migrative and invasive potential of cells transfected with Moesin confirmed the functional role of Moesin in cell migration. This indicates an important role of Moesin during restenosis development...
  9. ncbi request reprint The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis
    Rüdiger Blindt
    Department of Cardiology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Thromb Haemost 98:1329-34. 2007
    ..Patients with a VASP-PRI >48% seem to have a significantly increased risk...
  10. ncbi request reprint Intravascular ultrasonic comparative analysis of degree of intimal hyperplasia produced by four different stents in the coronary arteries
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 94:1548-50. 2004
    ..048 and p <0.001), respectively, whereas mean intimal hyperplasia thickness treated with dexamethasone-eluting stents was similar to those lesions treated with bare metal stents...
  11. ncbi request reprint Sirolimus- and paclitaxel-eluting stents in comparison with balloon angioplasty for treatment of in-stent restenosis
    Ekaterina Iofina
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 64:28-34. 2005
    ..The combination of improved acute gain and reduced late loss results in a significantly improved angiographic follow-up result in comparison with PTCA...
  12. ncbi request reprint Long-term assessment of a novel biodegradable paclitaxel-eluting coronary polylactide stent
    Felix Vogt
    Medical Clinic I, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Eur Heart J 25:1330-40. 2004
    ..Paclitaxel was shown to inhibit vascular smooth muscle cell proliferation and migration...
  13. ncbi request reprint Association of C-reactive protein and myocardial perfusion in patients with ST-elevation acute myocardial infarction
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Atherosclerosis 186:177-83. 2006
    ..The combination of clinical data, myocardial reperfusion levels after primary angioplasty for AMI and admission CRP increases the predictive value for subsequent survival...
  14. ncbi request reprint Polymer-based paclitaxel-eluting stents are superior to nonpolymer-based paclitaxel-eluting stents in the treatment of de novo coronary lesions
    Ekaterina Iofina
    The Medical Clinic I, University Aachen, Aachen, Germany
    Am J Cardiol 98:1022-7. 2006
    ..032). In conclusion, polymer-based PESs result in superior angiographic and IVUS follow-up findings compared with nonpolymer-based PESs...
  15. doi request reprint Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis
    Felix Vogt
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    J Am Coll Cardiol 52:302-11. 2008
    ..The aim of this study was to elucidate the role of angio-associated migratory cell protein (AAMP) for the migration of vascular smooth muscle cells (SMCs) and for the development of neointimal hyperplasia after vascular injury...
  16. doi request reprint Effect of statin therapy before Q-wave myocardial infarction on myocardial perfusion
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH, Aachen, Germany
    Am J Cardiol 101:139-43. 2008
    ..In conclusion, statin pretreatment in patients with AMI was associated with decreased systemic inflammation and better perfusion after primary angioplasty of the infarct-related artery...
  17. ncbi request reprint Evaluation of a high-dose dexamethasone-eluting stent
    Rainer Hoffmann
    Medical Clinic I, University Hospital Aachen, Germany
    Am J Cardiol 94:193-5. 2004
    ..96 +/- 0.63 mm due to an average intimal hyperplasia area obstruction of 32 +/- 21%, indicating that high-dose dexamethasone-loaded stents do not significantly reduce neointimal proliferation...
  18. doi request reprint Follow-up results after interventional treatment of infarct-related saphenous vein graft occlusion
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, 52057 Aachen, Germany
    Coron Artery Dis 21:61-4. 2010
    ..Few data are available on intermediate and long-term results after revascularization of acute saphenous vein graft occlusion...
  19. ncbi request reprint Impact of metabolic syndrome on clinical and angiographic outcome after sirolimus-eluting stent implantation
    Ekaterina Stellbrink
    Medical Clinic I, University Clinic Aachen, Aachen, Germany
    Coron Artery Dis 18:601-6. 2007
    ..Patients with metabolic syndrome (MetS) are at increased risk of cardiovascular events. The impact of MetS on clinical events and restenosis after drug-eluting stent placement is not well defined...
  20. doi request reprint The risk of definitive stent thrombosis is increased after "off-label" stent implantation irrespective of drug-eluting stent or bare-metal stent use
    Rainer Hoffmann
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Clin Res Cardiol 98:549-54. 2009
    ..This study evaluated predictors of stent thrombosis in clinical practice after the use of drug-eluting as well as bare-metal stents (BMS), including adherence to the FDA indications for DES...
  21. ncbi request reprint Three-year follow-up after intracoronary beta-radiation therapy for in-stent restenosis
    Ekaterina Iofina
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 67:600-6. 2006
    ..Whether the beneficial effect from radiation is sustained during long-term follow-up remains a concern. This study sought to evaluate the effectiveness of IRT using a beta-emitter during a 3-year follow-up period...
  22. doi request reprint Development and characterization of a coronary polylactic acid stent prototype generated by selective laser melting
    Christian Flege
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    J Mater Sci Mater Med 24:241-55. 2013
    ..SLM is advocated for the development of biodegradable coronary PLLA and PCL stents, potentially optimized for future bifurcation applications...
  23. ncbi request reprint Reduced numbers of circulating endothelial progenitor cells in patients with coronary artery disease associated with long-term statin treatment
    Mihail Hristov
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, University Hospital Aachen, Aachen, Germany
    Atherosclerosis 192:413-20. 2007
    ..Thus, the statin dose during chronic and continuous treatment independently predicts reduced numbers of circulating as well as isolated EPCs in patients with CAD...
  24. ncbi request reprint Impact of the metabolic syndrome on angiographic and clinical events after coronary intervention using bare-metal or sirolimus-eluting stents
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 100:1347-52. 2007
    ..In contrast, DM is associated with significantly increased event rates...
  25. ncbi request reprint Treatment of In-Stent restenosis using a stent with non-polymer-based paclitaxel elution
    Rainer Hoffmann
    Medical Clinic I, University Aachen, Aachen, Germany
    Am J Cardiol 93:760-2. 2004
    ..At 6-month follow-up, in-stent late loss was 0.44 +/- 0.54 mm and the restenosis rate was 20%, indicating effective treatment for reduction of recurrent restenosis...
  26. ncbi request reprint Efficient transfection method for primary cells
    Astrid Hamm
    Institute of Pathology, RWTH, Aachen, Germany
    Tissue Eng 8:235-45. 2002
    ..In summary, this method presents an effective and fast mean for transfection of primary and stem cells demonstrated by four cell types which are only transfected with low efficiency by other methods...
  27. doi request reprint Introduction of a high-throughput double-stent animal model for the evaluation of biodegradable vascular stents
    Mauricio Borinski
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    J Biomed Mater Res B Appl Biomater 100:2023-8. 2012
    ....
  28. doi request reprint German stereotaxis-guided percutaneous coronary intervention study group: first multicenter real world experience
    Korff Krause
    Department of Cardiology, Asklepios Klinik, St Georg St, Hamburg, Germany
    Clin Res Cardiol 98:541-7. 2009
    ..The Niobe Stereotaxis system consists of two 0.8 Tesla magnets and a navigation software allowing to move specially designed coronary wires...
  29. ncbi request reprint Evaluation of aortocoronary bypass stents with cardiac MDCT compared with conventional catheter angiography
    Georg Mühlenbruch
    Department of Diagnostic Radiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    AJR Am J Roentgenol 188:361-9. 2007
    ..The objective of our study was to determine the accuracy of 16-MDCT for evaluation of stent patency and in-stent stenosis in venous coronary bypass grafts...
  30. ncbi request reprint Coronary artery stents in multislice computed tomography: in vitro artifact evaluation
    Andreas H Mahnken
    Department of Diagnostic Radiology, University of Technology, Aachen, Germany
    Invest Radiol 39:27-33. 2004
    ..The aim of this study was to systematically compare the ability to assess the coronary artery lumen in the presence of coronary artery stents in multislice spiral CT (MSCT)...
  31. ncbi request reprint Usefulness of myocardial blush grade early and late after primary coronary angioplasty for acute myocardial infarction in predicting left ventricular function
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
    Am J Cardiol 92:1015-9. 2003
    ..044, p = 0.033). In conclusion, tissue reperfusion after angioplasty for AMI is characterized by frequent improvement over time, as indicated by repeated MBG analysis. Patients with recovery of perfusion have better, final LV function...