Research Topics
Species | Rüdiger BlindtSummaryAffiliation: RWTH Aachen Country: Germany Publications
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Detail Information
Publications
Abciximab inhibits the migration and invasion potential of human coronary artery smooth muscle cellsR Blindt
Medical Clinic I and Interdisciplinary Center of Clinical Research BIOMAT, University of Aachen Hospital, Pauwelsstr 30, Aachen, 52074, Germany
J Mol Cell Cardiol 32:2195-206. 2000..The results of this study indicate that the alpha v beta 3 antagonist abciximab is a potent inhibitor of hcSMC migration and invasion which could explain the observed lower reintervention rate after PTCA and stent implantation...- The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosisRüdiger Blindt
Department of Cardiology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
Thromb Haemost 98:1329-34. 2007..In conclusion, determination of VASP phosphorylation is superior to conventional platelet aggregometry and angiographic parameters for assessing the risk of ST. Patients with a VASP-PRI >48% seem to have a significantly increased risk... - A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cellsRüdiger Blindt
Department of Cardiology, University Hospital Aachen, Aachen, Germany
J Am Coll Cardiol 47:1786-95. 2006..Novel stents loaded with an integrin-binding cyclic Arg-Gly-Asp peptide (cRGD) were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting endothelial progenitor cells (EPCs)... - Downregulation of N-cadherin in the neointima stimulates migration of smooth muscle cells by RhoA deactivationRüdiger Blindt
Medical Clinic I, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
Cardiovasc Res 62:212-22. 2004..The aim of the study was to analyze whether cadherin- and Rho-family GTPases-mediated dynamic rearrangement of cell-cell adhesion play an important role during human arterial smooth muscle cell (haSMC) migration... - Expression patterns of integrins on quiescent and invasive smooth muscle cells and impact on cell locomotionRüdiger Blindt
Medical Clinic I, University Hospital RWTH Aachen, D 52074, Aachen, Germany
J Mol Cell Cardiol 34:1633-44. 2002.... - Decrease of vascular smooth muscle cell locomotion by abciximab, but not tirofiban: a possible role of different affinity to alpha v beta 3 integrinsRüdiger Blindt
University Hospital, Aachen, Medical Clinic I, Regensburg, Germany
Coron Artery Dis 13:357-64. 2002..Therefore, the objective of this study was to compare the effectiveness of abciximab and tirofiban to affect VSMC migration and invasion... - Upregulation of the cytoskeletal-associated protein Moesin in the neointima of coronary arteries after balloon angioplasty: a new marker of smooth muscle cell migration?Rüdiger Blindt
Medical Clinic I, University Hospital, RWTH Aachen, Aachen, Germany
Cardiovasc Res 54:630-9. 2002..The increased migrative and invasive potential of cells transfected with Moesin confirmed the functional role of Moesin in cell migration. This indicates an important role of Moesin during restenosis development... - Characterization of differential gene expression in quiescent and invasive human arterial smooth muscle cellsRüdiger Blindt
Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
J Vasc Res 39:340-52. 2002..In conclusion, several relevant potential candidate genes for the quiescent and the invasive SMC phenotype were identified and genes already known to be differentially regulated by previous analysis were confirmed... - Activation of IP and EP(3) receptors alters cAMP-dependent cell migrationRüdiger Blindt
Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
Eur J Pharmacol 444:31-7. 2002..767. It is concluded that the prostacyclin mimetic iloprost inhibits vascular cell migration, which probably depends on a G(s)-mediated increase of intracellular cAMP. EP(3) receptors conversely stimulate CHO migration... - Intravascular ultrasonic comparative analysis of degree of intimal hyperplasia produced by four different stents in the coronary arteriesRainer Hoffmann
Medical Clinic I, University RWTH Aachen, Aachen, Germany
Am J Cardiol 94:1548-50. 2004..048 and p <0.001), respectively, whereas mean intimal hyperplasia thickness treated with dexamethasone-eluting stents was similar to those lesions treated with bare metal stents... - Association of C-reactive protein and myocardial perfusion in patients with ST-elevation acute myocardial infarctionRainer Hoffmann
Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
Atherosclerosis 186:177-83. 2006..The combination of clinical data, myocardial reperfusion levels after primary angioplasty for AMI and admission CRP increases the predictive value for subsequent survival... 
Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosisFelix Vogt
Department of Cardiology, RWTH Aachen University, Aachen, Germany
J Am Coll Cardiol 52:302-11. 2008..The aim of this study was to elucidate the role of angio-associated migratory cell protein (AAMP) for the migration of vascular smooth muscle cells (SMCs) and for the development of neointimal hyperplasia after vascular injury...- Effect of statin therapy before Q-wave myocardial infarction on myocardial perfusionRainer Hoffmann
Medical Clinic I, University Hospital RWTH, Aachen, Germany
Am J Cardiol 101:139-43. 2008..In conclusion, statin pretreatment in patients with AMI was associated with decreased systemic inflammation and better perfusion after primary angioplasty of the infarct-related artery... - Evaluation of a high-dose dexamethasone-eluting stentRainer Hoffmann
Medical Clinic I, University Hospital Aachen, Germany
Am J Cardiol 94:193-5. 2004..96 +/- 0.63 mm due to an average intimal hyperplasia area obstruction of 32 +/- 21%, indicating that high-dose dexamethasone-loaded stents do not significantly reduce neointimal proliferation... - Follow-up results after interventional treatment of infarct-related saphenous vein graft occlusionRainer Hoffmann
Medical Clinic I, University RWTH Aachen, 52057 Aachen, Germany
Coron Artery Dis 21:61-4. 2010..Few data are available on intermediate and long-term results after revascularization of acute saphenous vein graft occlusion... - Impact of metabolic syndrome on clinical and angiographic outcome after sirolimus-eluting stent implantationEkaterina Stellbrink
Medical Clinic I, University Clinic Aachen, Aachen, Germany
Coron Artery Dis 18:601-6. 2007..Patients with metabolic syndrome (MetS) are at increased risk of cardiovascular events. The impact of MetS on clinical events and restenosis after drug-eluting stent placement is not well defined... - The risk of definitive stent thrombosis is increased after "off-label" stent implantation irrespective of drug-eluting stent or bare-metal stent useRainer Hoffmann
Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
Clin Res Cardiol 98:549-54. 2009..This study evaluated predictors of stent thrombosis in clinical practice after the use of drug-eluting as well as bare-metal stents (BMS), including adherence to the FDA indications for DES... - Impact of the metabolic syndrome on angiographic and clinical events after coronary intervention using bare-metal or sirolimus-eluting stentsRainer Hoffmann
Medical Clinic I, University RWTH Aachen, Aachen, Germany
Am J Cardiol 100:1347-52. 2007..In contrast, DM is associated with significantly increased event rates... - Reduced numbers of circulating endothelial progenitor cells in patients with coronary artery disease associated with long-term statin treatmentMihail Hristov
Institute for Molecular Cardiovascular Research, RWTH Aachen University, University Hospital Aachen, Aachen, Germany
Atherosclerosis 192:413-20. 2007..Thus, the statin dose during chronic and continuous treatment independently predicts reduced numbers of circulating as well as isolated EPCs in patients with CAD... - Treatment of In-Stent restenosis using a stent with non-polymer-based paclitaxel elutionRainer Hoffmann
Medical Clinic I, University Aachen, Aachen, Germany
Am J Cardiol 93:760-2. 2004..At 6-month follow-up, in-stent late loss was 0.44 +/- 0.54 mm and the restenosis rate was 20%, indicating effective treatment for reduction of recurrent restenosis... - Introduction of a high-throughput double-stent animal model for the evaluation of biodegradable vascular stentsMauricio Borinski
Department of Cardiology, RWTH Aachen University, Aachen, Germany
J Biomed Mater Res B Appl Biomater 100:2023-8. 2012.... - German stereotaxis-guided percutaneous coronary intervention study group: first multicenter real world experienceKorff Krause
Department of Cardiology, Asklepios Klinik, St Georg St, Hamburg, Germany
Clin Res Cardiol 98:541-7. 2009..The Niobe Stereotaxis system consists of two 0.8 Tesla magnets and a navigation software allowing to move specially designed coronary wires... - Evaluation of aortocoronary bypass stents with cardiac MDCT compared with conventional catheter angiographyGeorg Mühlenbruch
Department of Diagnostic Radiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
AJR Am J Roentgenol 188:361-9. 2007..The objective of our study was to determine the accuracy of 16-MDCT for evaluation of stent patency and in-stent stenosis in venous coronary bypass grafts... - Coronary artery stents in multislice computed tomography: in vitro artifact evaluationAndreas H Mahnken
Department of Diagnostic Radiology, University of Technology, Aachen, Germany
Invest Radiol 39:27-33. 2004..The aim of this study was to systematically compare the ability to assess the coronary artery lumen in the presence of coronary artery stents in multislice spiral CT (MSCT)... - Development and characterization of a coronary polylactic acid stent prototype generated by selective laser meltingChristian Flege
Department of Cardiology, RWTH Aachen University, Aachen, Germany
J Mater Sci Mater Med 24:241-55. 2013..SLM is advocated for the development of biodegradable coronary PLLA and PCL stents, potentially optimized for future bifurcation applications... - Usefulness of myocardial blush grade early and late after primary coronary angioplasty for acute myocardial infarction in predicting left ventricular functionRainer Hoffmann
Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
Am J Cardiol 92:1015-9. 2003..044, p = 0.033). In conclusion, tissue reperfusion after angioplasty for AMI is characterized by frequent improvement over time, as indicated by repeated MBG analysis. Patients with recovery of perfusion have better, final LV function...