Genomes and Genes


Sebastian Rumpf


Country: Germany


  1. Krämer R, Rode S, Rumpf S. Rab11 is required for neurite pruning and developmental membrane protein degradation in Drosophila sensory neurons. Dev Biol. 2019;: pubmed publisher
    ..Loss of Rab11 also leads to defects in larval dendrite elaboration, and Neuroglian and Ppk26 localization is already altered at this stage. Our data highlight the importance of membrane protein recycling during development. ..
  2. Rumpf S, Wolterhoff N, Herzmann S. Functions of Microtubule Disassembly during Neurite Pruning. Trends Cell Biol. 2019;29:291-297 pubmed publisher
    ..Based on these data, we propose a general model for spatial pruning regulation by microtubules and discuss how microtubule-associated proteins such as Tau could contribute to these regulatory aspects. ..
  3. Rode S, Ohm H, Anhäuser L, Wagner M, Rosing M, Deng X, et al. Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila. Cell Rep. 2018;24:2287-2299.e4 pubmed publisher
    ..We propose that an eIF3-eIF4A-dependent alternative initiation pathway bypasses 4E-BP to ensure adequate translation of ecdysone-induced genes. ..
  4. Herzmann S, Götzelmann I, Reekers L, Rumpf S. Spatial regulation of microtubule disruption during dendrite pruning in Drosophila. Development. 2018;145: pubmed publisher
    ..Local microtubule organization may therefore contribute spatial information for severing sites during dendrite pruning. ..
  5. Herzmann S, Krumkamp R, Rode S, Kintrup C, Rumpf S. PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila. EMBO J. 2017;36:1981-1991 pubmed publisher
    ..Our results shed light on the signaling cascades and epistatic relationships involved in neurite destabilization during dendrite pruning. ..