A Kreuter

Summary

Affiliation: Ruhr-University Bochum
Country: Germany

Publications

  1. pmc A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis
    Lara Bossini-Castillo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avenida del Conocimiento s n, Granada, 18100, Spain
    Arthritis Res Ther 14:R85. 2012
  2. pmc Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avda, del Conocimiento s n, 18010, Granada, SpainArmilla Granada, Spain
    Arthritis Res Ther 14:R154. 2012
  3. doi request reprint Association of autoimmune diseases with lichen sclerosus in 532 male and female patients
    Alexander Kreuter
    Connective Tissue Disease Research Unit of the Department of Dermatology, Venereology, and Allergology at Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Acta Derm Venereol 93:238-41. 2013
  4. doi request reprint Coexistence of lichen sclerosus and morphea: a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center
    Alexander Kreuter
    Connective Tissue Disease Research Unit of Department of Dermatology, Venereology, and Allergology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 67:1157-62. 2012
  5. doi request reprint Localized scleroderma
    Alexander Kreuter
    Department of Dermatology, Venerology and Allergology, Ruhr University Bochum, Bochum, Germany
    Dermatol Ther 25:135-47. 2012
  6. doi request reprint [Scleromyxedema. A chronic progressive systemic disease]
    A Kreuter
    Klinik fur Dermatologie, Venerologie und Allergologie, Ruhr Universität Bochum im St Josef Hospital, Gudrunstr 56, 44791, Bochum, Deutschland
    Z Rheumatol 71:504-14. 2012
  7. pmc Immunohistochemical investigations and introduction of new therapeutic strategies in scleromyxoedema: case report
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 4:12. 2004
  8. pmc UVA/UVA1 phototherapy and PUVA photochemotherapy in connective tissue diseases and related disorders: a research based review
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    BMC Dermatol 4:11. 2004
  9. pmc Fibromatosis of the hand associated with EMO syndrome: a case report
    Carolin Appelhans
    Dept, of Dermatology, Ruhr University Bochum, Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Dermatol 4:17. 2004
  10. pmc Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:12. 2002

Collaborators

Detail Information

Publications139 found, 100 shown here

  1. pmc A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis
    Lara Bossini-Castillo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avenida del Conocimiento s n, Granada, 18100, Spain
    Arthritis Res Ther 14:R85. 2012
    ..The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population...
  2. pmc Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avda, del Conocimiento s n, 18010, Granada, SpainArmilla Granada, Spain
    Arthritis Res Ther 14:R154. 2012
    ..The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc)...
  3. doi request reprint Association of autoimmune diseases with lichen sclerosus in 532 male and female patients
    Alexander Kreuter
    Connective Tissue Disease Research Unit of the Department of Dermatology, Venereology, and Allergology at Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Acta Derm Venereol 93:238-41. 2013
    ..7, 95% CI 1.1-6.5; p=0.023), and elevated autoantibodies (OR 4.1, 95% CI 1.9-9.3; p<0.0001) as compared to male patients. This observation is suggestive for a different pathogenetic background in male and female patients...
  4. doi request reprint Coexistence of lichen sclerosus and morphea: a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center
    Alexander Kreuter
    Connective Tissue Disease Research Unit of Department of Dermatology, Venereology, and Allergology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 67:1157-62. 2012
    ..Recently, a prospective multicenter study demonstrated a surprisingly high percentage of genital LiS in patients with morphea...
  5. doi request reprint Localized scleroderma
    Alexander Kreuter
    Department of Dermatology, Venerology and Allergology, Ruhr University Bochum, Bochum, Germany
    Dermatol Ther 25:135-47. 2012
    ....
  6. doi request reprint [Scleromyxedema. A chronic progressive systemic disease]
    A Kreuter
    Klinik fur Dermatologie, Venerologie und Allergologie, Ruhr Universität Bochum im St Josef Hospital, Gudrunstr 56, 44791, Bochum, Deutschland
    Z Rheumatol 71:504-14. 2012
    ..Scleromyxedema is a rare connective tissue disease that may affect numerous internal organs in addition to the skin. The disease is almost exclusively associated with monoclonal gammopathy...
  7. pmc Immunohistochemical investigations and introduction of new therapeutic strategies in scleromyxoedema: case report
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 4:12. 2004
    ..Even though different casuistic treatment modalities have been described, to date, curing still seems to be impossible...
  8. pmc UVA/UVA1 phototherapy and PUVA photochemotherapy in connective tissue diseases and related disorders: a research based review
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    BMC Dermatol 4:11. 2004
    ..Nevertheless, controlled studies investigating the efficacy of UVA irradiation in connective tissue diseases and related disorders are rare...
  9. pmc Fibromatosis of the hand associated with EMO syndrome: a case report
    Carolin Appelhans
    Dept, of Dermatology, Ruhr University Bochum, Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Dermatol 4:17. 2004
    ..EMO syndrome, defined as a triad including exophthalmus, pretibial myxedema and osteoarthropathia, is a rare condition in patients suffering from hyperthyreosis...
  10. pmc Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:12. 2002
    ..The purpose of our study was to investigate to what extent UVA1 irradiation is able to modulate the status of protease activity by the use of a monoclonal antibody labeling cathepsin G...
  11. pmc Pimecrolimus 1% cream for anogenital lichen sclerosus in childhood
    Stefanie Boms
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    BMC Dermatol 4:14. 2004
    ..Because of the potential side effects of repeated local application of potent glucocorticosteroids, equally-effective, safer therapeutic options are required, especially in the treatment of children...
  12. doi request reprint Human papillomavirus-associated induction of human beta-defensins in anal intraepithelial neoplasia
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    Br J Dermatol 160:1197-205. 2009
    ..Antimicrobial peptides and proteins (AMPs) are widely distributed effector molecules of the innate immune system with well-known antibacterial activity. However, there is a paucity of information regarding antiviral effects of AMPs...
  13. doi request reprint Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 162:1269-77. 2010
    ..There is a paucity of data published on the progression of high-grade AIN to invasive cancer as well as on clinical and virological characteristics comparing anal margin and anal canal carcinoma...
  14. ncbi request reprint Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol 141:847-52. 2005
    ..To evaluate the efficacy of pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy in patients with severe localized scleroderma (LS)...
  15. doi request reprint Human papillomavirus-associated diseases in HIV-infected men who have sex with men
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Curr Opin Infect Dis 22:109-14. 2009
    ..Moreover, data are provided on penile and oral HPV-associated diseases, for which only limited information is available in the literature...
  16. ncbi request reprint Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 52:603-8. 2005
    ..HIV infection is strongly associated with a higher prevalence of genital HPV infection, a higher incidence of AIN, and, consecutively, an increased risk for anal cancer...
  17. doi request reprint Lupus erythematosus tumidus: response to antimalarial treatment in 36 patients with emphasis on smoking
    Alexander Kreuter
    Connective Tissue Disease Research Unit, Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol 145:244-8. 2009
    ..To determine the efficacy of antimalarial drug use in patients with lupus erythematosus tumidus...
  18. ncbi request reprint Ultraviolet A1 phototherapy decreases inhibitory SMAD7 gene expression in localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 298:265-72. 2006
    ..UVA1 phototherapy demonstrated the alteration of SMAD7 gene expression in LS, as SMAD7 mRNA levels normalized after UVA1. The pathogenetic relevance of SMAD7 levels with respect to clinical improvement needs further investigation...
  19. doi request reprint [Anal intraepithelial neoplasia and anal carcinoma: an increasing problem in HIV patients]
    A Kreuter
    Klinik für Dermatologie und Allergologie, Ruhr Universitat Bochum, Bochum, Deutschland
    Hautarzt 61:21-6. 2010
    ..Basic diagnostic workup includes clinical inspection of the perianal area, digital rectal examination, and anal cytology...
  20. doi request reprint Clonal T-cell populations are frequent in the skin and blood of patients with systemic sclerosis
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 161:785-90. 2009
    ..Pilot studies were suggestive for a role of clonal T cells in the pathogenesis of systemic sclerosis (SSc)...
  21. ncbi request reprint Ultraviolet A1-induced downregulation of human beta-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 155:600-7. 2006
    ..Ultraviolet (UV) A1 phototherapy, the most recent advance in the treatment of LS, targets T-cell dermal inflammatory infiltrates via induction of various cytokines and soluble factors besides well-known effects on collagen metabolism...
  22. ncbi request reprint 1% pimecrolimus, 0.005% calcipotriol, and 0.1% betamethasone in the treatment of intertriginous psoriasis: a double-blind, randomized controlled study
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University of Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 142:1138-43. 2006
    ..Recently, both pimecrolimus and tacrolimus have been investigated for this indication and shown to be safe and effective. So far, to our knowledge, a comparison of one of these drugs with standard regimens for IP has not been performed...
  23. doi request reprint Anal intraepithelial neoplasia in HIV infection
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Germany
    J Dtsch Dermatol Ges 6:925-34. 2008
    ..The impact of HPV vaccination on AIN development will also need to be assessed. Long-term follow-up of these patients is essential to gain more insight into the natural history of anogenital HPV infection in HIV-positive MSM...
  24. doi request reprint [AWMF Guideline no. 013/066. Diagnosis and therapy of circumscribed scleroderma]
    Alexander Kreuter
    Dermatologische Klinik der Ruhr Universität Bochum
    J Dtsch Dermatol Ges 7:S1-14. 2009
    ....
  25. ncbi request reprint A randomized controlled study of low-dose UVA1, medium-dose UVA1, and narrowband UVB phototherapy in the treatment of localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 54:440-7. 2006
    ..To date, a randomized comparison study to evaluate the efficacy and safety of different, commonly used phototherapeutic modalities in LS is still outstanding...
  26. doi request reprint Diversity of human papillomavirus types in periungual squamous cell carcinoma
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 161:1262-9. 2009
    ..There is accumulating evidence that infections with certain high-risk alpha-human papillomaviruses (HPVs) are involved in the pathogenesis of digital squamous cell carcinomas (SCCs) and their precursor lesions (SCCs in situ)...
  27. doi request reprint Detection of clonal T cells in the circulation of patients with nephrogenic systemic fibrosis
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 145:1164-9. 2009
    ..Conclusion As in systemic sclerosis, clonally expanded T-cell populations could play a critical role in the pathogenesis of nephrogenic systemic fibrosis, probably as an in vivo-activated inflammatory response to gadolinium exposure...
  28. doi request reprint Pulsed high-dose corticosteroids combined with low-dose methotrexate treatment in patients with refractory generalized extragenital lichen sclerosus
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 145:1303-8. 2009
    ..This combination therapy should be considered in generalized disease, especially disease that is refractory to conventional treatment...
  29. ncbi request reprint [Anal carcinoma and anal intraepithelial neoplasia in HIV-infections]
    Alexander Kreuter
    Dermatologische Klinik der Ruhr Universität, Bochum, Germany
    J Dtsch Dermatol Ges 4:611-2. 2006
  30. doi request reprint Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 63:490-8. 2010
    ..Early diagnosis and treatment of AIN might prevent development of anal cancer...
  31. doi request reprint Clinical features and efficacy of antimalarial treatment for reticular erythematous mucinosis: a case series of 11 patients
    Alexander Kreuter
    Connective Tissue Disease Research Unit, Department of Dermatology, Venereology, and Allergology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol 147:710-5. 2011
    ..Although antimalarial treatment is generally considered the most effective approach, only a few case reports exist on its use in REM syndrome...
  32. doi request reprint Expression of antimicrobial peptides in different subtypes of cutaneous lupus erythematosus
    Alexander Kreuter
    Department of Dermatology, Venereology, and Allergology, Ruhr University, Bochum, Germany
    J Am Acad Dermatol 65:125-33. 2011
    ..Skin infections rarely occur in patients with cutaneous lupus erythematosus (CLE), and AMP expression in CLE has not been previously evaluated...
  33. ncbi request reprint Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Pediatr Dermatol 18:241-5. 2001
    ..Further controlled studies are necessary to investigate whether this combined therapy is superior to UVA1 phototherapy alone...
  34. ncbi request reprint p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 157:523-30. 2007
    ..In a pilot study, imiquimod, a topical immune response modifier, has been reported to be beneficial in the treatment of AIN...
  35. ncbi request reprint Low-dose ultraviolet A1 phototherapy for extragenital lichen sclerosus: results of a preliminary study
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    J Am Acad Dermatol 46:251-5. 2002
    ....
  36. pmc Treatment of disseminated granuloma annulare with fumaric acid esters
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    BMC Dermatol 2:5. 2002
    ..We report a patient with recalcitrant DGA who was treated with fumaric acid esters (FAE)...
  37. ncbi request reprint Irregularly shaped leucoplakic lesion of the anus. Diagnosis: anal intraepithelial neoplasia (AIN)
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Germany
    Clin Exp Dermatol 32:621-3. 2007
  38. doi request reprint A human papillomavirus-associated disease with disseminated warts, depressed cell-mediated immunity, primary lymphedema, and anogenital dysplasia: WILD syndrome
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 144:366-72. 2008
    ..Although skin cancer frequently develops in the sun-exposed cutaneous lesions of patients with EV, the anogenital area is usually not affected by squamous cell carcinomas related to mucosal HPV types...
  39. ncbi request reprint Mycophenolate sodium for subacute cutaneous lupus erythematosus resistant to standard therapy
    A Kreuter
    Connective Tissue Disease Research Unit, Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 156:1321-7. 2007
    ..Immunosuppressive agents are usually considered a second-line approach in patients with resistant disease...
  40. doi request reprint Painful unusual ulcers of the ankle
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Germany
    Clin Exp Dermatol 33:377-9. 2008
  41. ncbi request reprint Giant condyloma acuminatum of buschke and löwenstein
    Alexander Kreuter
    Ruhr University Bochum, Bochum, Germany
    N Engl J Med 365:1624. 2011
    ..Clinical examination of the gluteal cleft revealed a locally destructive, cauliflower-like, verrucous mass measuring 15 cm in diameter. There was no associated regional lymphadenopathy...
  42. doi request reprint High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 144:1011-6. 2008
    ..The pathogenetic relevance of HHV-8 in cutaneous T-cell lymphoma is controversial. Recently, a highly significant association of HHV-8 in LPP was found, which suggests a role in the pathogenesis of this disease...
  43. ncbi request reprint Pulsed intravenous immunoglobulin therapy in livedoid vasculitis: an open trial evaluating 9 consecutive patients
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University, Bochum, Germany
    J Am Acad Dermatol 51:574-9. 2004
    ..However, no continuing benefit has been reported in any of these modalities. Recently, encouraging case reports about the successful use of intravenous immunoglobulin (IVIg) in LV have been published...
  44. doi request reprint Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men
    Alexander Kreuter
    1Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Invest Dermatol 128:2078-83. 2008
    ..However, new AIN lesions associated with previously undetected HPV types frequently occur in untreated areas...
  45. ncbi request reprint Optical coherence tomography of cutaneous lupus erythematosus correlates with histopathology
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Lupus 16:35-8. 2007
    ..Nevertheless, the current technique does not allow one to visualize definite diagnostic features of cutaneous LE. However, OCT may be a promising method for objective monitoring of LE activity and treatment effects over time in vivo...
  46. ncbi request reprint Increased expression of TGF-beta/Smad proteins in basal cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Eur J Med Res 12:509-14. 2007
    ..There is an increasing evidence that the development of cutaneous epithelial tumours is pathogenetically linked to dysregulations of the transforming growth factor beta (TGF-beta) and its signalling molecules, the Smads...
  47. ncbi request reprint Expression of human beta-defensins in patients with mycosis fungoides
    T Gambichler
    Department of Dermatology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Arch Dermatol Res 299:221-4. 2007
    ..We observed an identical pattern of hBD expression in MD and AD suggesting a common regulatory mechanism that might mainly be driven by T helper 2 lymphocytes...
  48. ncbi request reprint Opposing effects of UVA1 phototherapy on the expression of bcl-2 and p53 in atopic dermatitis
    F Breuckmann
    Department of Dermatology, Ruhr-University, Bochum, Germany
    Arch Dermatol Res 293:178-83. 2001
    ..In summary, medium-dose UVA1 irradiation led to a marked modulation of the expression of p53 and bcl-2, and this plays a key role in regulating UVA1-induced apoptosis...
  49. doi request reprint The expression of antimicrobial peptides is significantly altered in cutaneous squamous cell carcinoma and precursor lesions
    N Scola
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 167:591-7. 2012
    ..Antimicrobial peptides and proteins are not only effectors of the immune system but are also attributed important roles in tumour progression or tumour suppression in several malignancies such as oral squamous cell carcinoma (SCC)...
  50. doi request reprint Expression of antimicrobial peptides and proteins in etanercept-treated psoriasis patients
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Regul Pept 167:163-6. 2011
    ..We have demonstrated that etanercept-induced improvement of psoriasic lesions is associated with a significant decline of AMP protein expression...
  51. doi request reprint Etanercept plus narrowband ultraviolet B phototherapy of psoriasis is more effective than etanercept monotherapy at 6 weeks
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    Br J Dermatol 164:1383-6. 2011
    ..A substantial portion of patients with psoriasis does not achieve a satisfactory response under antitumour necrosis factor (TNF)-α biological therapies...
  52. doi request reprint Impact of etanercept treatment on ultraviolet B-induced inflammation, cell cycle regulation and DNA damage
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 164:110-5. 2011
    ..Current studies indicate that treatment with tumour necrosis factor (TNF)-α blockers plus ultraviolet (UV) B phototherapy results in higher relative Psoriasis Area and Severity Index reduction as compared with TNF-α monotherapy...
  53. doi request reprint Medium-dose ultraviolet (UV) A1 vs. narrowband UVB phototherapy in atopic eczema: a randomized crossover study
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Br J Dermatol 160:652-8. 2009
    ..Ultraviolet (UV) A1 and narrowband (NB)-UVB have been reported to be effective treatments for atopic eczema (AE)...
  54. ncbi request reprint Changes of antimicrobial peptide mRNA expression in atopic eczema following phototherapy
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, Bochum, Germany
    Br J Dermatol 155:1275-8. 2006
    ..Hence, AMPs may represent important cofactors in the pathogenesis of AE...
  55. ncbi request reprint Epidermal thickness assessed by optical coherence tomography and routine histology: preliminary results of method comparison
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    J Eur Acad Dermatol Venereol 20:791-5. 2006
    ..However, there is a lack of systematic studies comparing OCT with histology...
  56. ncbi request reprint UVA1 and UVB irradiated skin investigated by optical coherence tomography in vivo: a preliminary study
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 30:79-82. 2005
    ..However, further studies are needed to establish its measurement precision and validity, and to investigate in vivo spectral dependence on UV induced skin changes such as skin thickening...
  57. ncbi request reprint A randomised controlled trial on photo(chemo)therapy of subacute prurigo
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 31:348-53. 2006
    ..Psoralen ultraviolet A (PUVA) is the standard photo(chemo)therapeutic regimen for patients suffering from subacute prurigo (SP)...
  58. ncbi request reprint Treatment of condylomata acuminata with pegylated interferon alfa-2b in HIV-infected patients
    N H Brockmeyer
    Department of Dermatology, Ruhr University Bochum, Germany
    Eur J Med Res 11:27-32. 2006
    ..STUDY GOALS: This open trial was initiated to determine the safety and efficacy of a new formulation of interferon, pegylated interferon-alpha2b (PEG-IFN, PegIntron in the treatment of recalcitrant CA in patients with HIV infection. -..
  59. doi request reprint Differential expression of connective tissue growth factor and extracellular matrix proteins in lichen sclerosus
    T Gambichler
    Department of Dermatology Department of Medicine I, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 26:207-12. 2012
    ..The histopathology of lichen sclerosus (LS) suggests abnormalities in extracellular matrix (ECM) composition...
  60. doi request reprint Immunophenotyping of inflammatory cells in subacute prurigo
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 25:221-6. 2011
    ..Subacute prurigo (SP) is a relatively common disease of papular cutaneous lesions that itch intensely. However, there is a lack of systematic clinical and histological studies on SP...
  61. ncbi request reprint Significant downregulation of transforming growth factor-beta signal transducers in human skin following ultraviolet-A1 irradiation
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Br J Dermatol 156:951-6. 2007
    ....
  62. doi request reprint A randomized, half-side comparative study of aminolaevulinate photodynamic therapy vs. CO(2) laser ablation in immunocompetent patients with multiple actinic keratoses
    N Scola
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 167:1366-73. 2012
    ..Photodynamic therapy (PDT) and laser ablation (LA) are frequently used treatment options for multiple actinic keratoses (AK), yet they have not been compared head to head...
  63. doi request reprint Prevalence of human polyomaviruses in common and rare types of non-Merkel cell carcinoma skin cancer
    N Scola
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Br J Dermatol 167:1315-20. 2012
    ..Little is known about the association of human polyomaviruses (HPyVs) other than Merkel cell polyomavirus (MCPyV) with nonmelanoma skin cancer...
  64. doi request reprint [Acquired reactive perforating collagenosis following herpes zoster as isotopic response?]
    N Scola
    Klinik fur Dermatologie, Venerologie und Allergologie, Ruhr Universitat Bochum, Bochum, Deutschland
    Hautarzt 62:683-7. 2011
    ..We report the sixth case of a herpes zoster-associated reactive perforating collagenosis and discuss the current literature...
  65. pmc Bilateral linear scleroderma "en coup de sabre" associated with facial atrophy and neurological complications
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791, Bochum, Germany
    BMC Dermatol 1:9. 2001
    ..The disease may be associated with facial hemiatrophy. Various ophthalmological and neurological abnormalities have been observed in patients with LSCS. We describe an unusual case of LSC...
  66. pmc Pattern of mRNA expression of beta-defensins in basal cell carcinoma
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Cancer 6:163. 2006
    ..The present work was aimed on the study of hBD gene expression in basal cell carcinoma (BCC) which is the most common cancer in humans...
  67. ncbi request reprint Efficacy of ultraviolet A1 phototherapy on the expression of bcl-2 in atopic dermatitis and cutaneous T-cell lymphoma in vivo: a comparison study
    F Breuckmann
    Department of Dermatology, Clinical and Experimental Photodermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Photodermatol Photoimmunol Photomed 18:217-22. 2002
    ..Furthermore, we investigated whether medium-dose ultraviolet A1 (UVA1) phototherapy is able to modulate the expression of bcl-2 within the dermal inflammatory infiltrate...
  68. pmc Kaposi sarcoma in a HIV uninfected man who has sex with men
    Anja Potthoff
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Eur J Med Res 15:79-80. 2010
    ..KS in HIV-negative MSM has only been reported sporadically. It was shown that KS in these patients clinically resembles classic KS but occurs at a younger age, is limited to the skin, and is associated with a good prognosis...
  69. doi request reprint Gene expression of cytokines in atopic eczema before and after ultraviolet A1 phototherapy
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Br J Dermatol 158:1117-20. 2008
    ..Atopic eczema (AE) is a common pruritic and chronically relapsing inflammatory skin disease in which cytokines seem to represent important factors in the pathogenesis...
  70. doi request reprint Significant upregulation of antimicrobial peptides and proteins in lichen sclerosus
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, D 44791 Bochum, Germany
    Br J Dermatol 161:1136-42. 2009
    ..Inflamed and injured epithelia are a particularly rich source of antimicrobial peptides and proteins (AMPs)...
  71. ncbi request reprint Mononuclear cells in atopic dermatitis in vivo: immunomodulation of the cutaneous infiltrate by medium-dose UVA1 phototherapy
    F Breuckmann
    Department of Dermatology, Ruhr University Bochum, Germany
    Eur J Med Res 7:315-22. 2002
    ..The purpose of our study was to investigate the extent to which UVA1 irradiation is able to modulate the mononuclear dermal inflammatory infiltrate using different monoclonal antibodies...
  72. ncbi request reprint Immunohistochemical investigation of mid-dermal elastolysis
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 29:192-5. 2004
    ..Our data may indicate inflammatory processes and an altered balance between MMPs and TIMPs in MDE. Furthermore CD34+ dendritic fibroblasts and/or histiocytes are possibly involved in the pathogenesis of MDE...
  73. ncbi request reprint Nephrogenic fibrosing dermopathy
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 29:258-60. 2004
    ..Because the pathogenesis of NFD may not entirely be attributable to haemodialysis, the role of circulating factors in the development of cutaneous manifestations requires further investigation...
  74. ncbi request reprint Low-dose ultraviolet-A1 phototherapy for lichen sclerosus et atrophicus
    A Kreuter
    Department of Dermatology, Ruhr-University Bochum, Germany
    Clin Exp Dermatol 26:30-2. 2001
    ..Long-wave UVA irradiation has been shown to induce intensively collagenase activity in human dermal fibroblasts. We suggest that UVA1 irradiation could be an effective treatment in patients suffering from extragenital LSA...
  75. doi request reprint Expression of minichromosome maintenance proteins in Merkel cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 23:1184-8. 2009
    ..We aimed to assess whether MCM immunohistochemistry can be utilized to examine tumour proliferation in Merkel cell carcinoma (MCC)...
  76. ncbi request reprint Fumaric acid esters in necrobiosis lipoidica: results of a prospective noncontrolled study
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 153:802-7. 2005
    ..In recent case reports, fumaric acid esters (FAE) have been reported to be effective in granulomatous skin diseases such as granuloma annulare, cutaneous sarcoidosis and NL...
  77. ncbi request reprint Reference limits for erythema-effective UV doses
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Photochem Photobiol 82:1097-102. 2006
    ..Although the MED data given here are limited to the phototest device used in the present study, the SED results establish comparability between our data and phototest results obtained from laboratories using different UV sources...
  78. pmc Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    Eur J Med Res 15:44-6. 2010
    ..Previous reports on lymphocyte subpopulations in systemic sclerosis (SSc) are conflicting. Therefore, we aimed to investigate the lymphocyte subsets in SSc patients who were not on immunosuppressive therapy...
  79. pmc Primary merkel cell carcinoma clinically presenting as deep oedematous mass of the groin
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Eur J Med Res 15:274-6. 2010
    ..MCC showing the aforementioned features may be associated with significant delay of diagnosis and therefore represents an unfavourable prognostic factor...
  80. ncbi request reprint Expression of proliferation markers and cell cycle regulators in T cell lymphoproliferative skin disorders
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    J Dermatol Sci 49:125-32. 2008
    ..Abnormal cell proliferation, which results from deregulation of the cell cycle, is fundamental in tumorigenesis...
  81. ncbi request reprint Immunohistology of amicrobial pustulosis of the folds
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Clin Exp Dermatol 32:155-8. 2007
    ..However, studies on a larger sample size including controls are needed to substantiate our findings...
  82. ncbi request reprint Cytokine mRNA expression in basal cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, Bochum 44791, Germany
    Arch Dermatol Res 298:139-41. 2006
    ..In accordance with previous studies our data suggest a role for IL-6 and IL-8 in the development and/or progression of BCC, since mRNA expression of both CKs are significantly increased in tumour tissue...
  83. doi request reprint Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Invest Dermatol 128:2316-24. 2008
    ..In view of the PIN prevalence found in our study, all HIV+MSM should be screened for PIN in addition to AIN screening...
  84. doi request reprint Tacrolimus ointment neither blocks ultraviolet B nor affects expression of thymine dimers and p53 in human skin
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Dermatol Sci 50:115-22. 2008
    ..There is a lack of data with regard to the interaction between ultraviolet (UV) radiation and topical calcineurin inhibitors...
  85. ncbi request reprint Impact of amphotericin B on the cytochrome P450 system in HIV-infected patients
    Norbert H Brockmeyer
    Department of Dermatology, Ruhr University Bochum, Gudrunstr, Germany
    Eur J Med Res 9:51-4. 2004
    ..To investigate whether cytochrome P450-dependent enzymes are influenced by amphotericin B (Am-B) during the treatment of Candida oesophagitis in HIV-infected patients...
  86. ncbi request reprint Unilateral generalized morphea is a rare variant of localized scleroderma
    C Appelhans
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Eur J Med Res 11:152-6. 2006
    ..Treatment with combined low-dose methotrexate and pulsed high-dose corticosteroid therapy might represent a promising treatment option for UGM...
  87. doi request reprint Cytokine mRNA levels in human fat tissue after injection lipolysis with phosphatidylcholine and deoxycholate
    Falk G Bechara
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol Res 300:455-9. 2008
    ..Injection lipolysis induces acute panniculitis within the treated fat tissue, associated with changes of the cytokine profile. However, their pathogenetic relevance with respect to clinical dissolving of fat needs further investigation...
  88. doi request reprint Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Int Arch Allergy Immunol 147:17-24. 2008
    ..We aimed to investigate mRNA expression levels of various antimicrobial peptides and proteins (AMPs) in AD patients, and compare it with psoriasis vulgaris (PV) patients and healthy subjects...
  89. ncbi request reprint Pimecrolimus 1% cream for cutaneous lupus erythematosus
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    J Am Acad Dermatol 51:407-10. 2004
    ..001). This was an open and uncontrolled study on a limited number of cases. We suggest that pimecrolimus 1% cream could be an efficacious and safe treatment option for cutaneous lupus erythematosus...
  90. ncbi request reprint Low-dose UVA1 phototherapy in systemic sclerosis: effects on acrosclerosis
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 50:740-7. 2004
    ..Increased collagen synthesis, vascular damage, and T-lymphocytic infiltration contribute to the development of systemic sclerosis. Preliminary studies revealed the effectiveness of low-dose UVA1 phototherapy in acrosclerosis...
  91. doi request reprint Development of spinocellular carcinoma in a long-lasting and therapy resistant venous ulcer - two case studies
    Stefanie Reich-Schupke
    Dermatology Clinic, Ruhr University of Bochum, St Josef Hospital, Germany
    J Dtsch Dermatol Ges 6:569-72. 2008
    ..While squamous cell carcinoma can primarily cause a leg ulcer, the malignant transformation of a primary venous leg ulcer to squamous cell carcinoma is rarer...
  92. ncbi request reprint Liposomal pegylated doxorubicin versus low-dose recombinant interferon Alfa-2a in the treatment of advanced classic Kaposi's sarcoma; retrospective analysis of three German centers
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Cancer Invest 23:653-9. 2005
    ..Several studies reported the effectiveness of pegylated liposomal doxorubicin (PLD) and low-dose recombinant interferon alfa-2a (IFNalpha) in the treatment of AIDS-associated KS...
  93. doi request reprint Differential expression of microtubule-associated protein 2 in melanocytic skin lesions
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Am J Clin Pathol 131:710-4. 2009
    ..In contrast with the findings of previous studies, our data indicate that MAP-2 is a moderately positive predictor of the progression of SSMs...
  94. doi request reprint Minichromosome maintenance proteins are useful adjuncts to differentiate between benign and malignant melanocytic skin lesions
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, Bochum D 44791, Germany
    J Am Acad Dermatol 60:808-13. 2009
    ..Markers identifying premalignant and malignant melanocytic skin lesions are needed...
  95. doi request reprint Protein expression of carcinoembryonic antigen cell adhesion molecules in benign and malignant melanocytic skin lesions
    Thilo Gambichler
    Dept of Dermatology and Allergology, Ruhr University Bochum, Germany
    Am J Clin Pathol 131:782-7. 2009
    ..Our data support the findings of previous studies indicating that cell adhesion molecules of the CEA family may have a role in the development and progression of cutaneous melanoma and potentially serve as prognostic markers...
  96. ncbi request reprint Modulation of endothelial dysfunction and apoptosis: UVA1-mediated skin improvement in systemic sclerosis
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 296:235-9. 2004
    ..Our results suggest that UVA1 irradiation exerts its positive effects by a modulation of endothelial regulation/transformation beside the proposed induction of T cell apoptosis and collagenases...
  97. ncbi request reprint UVA1-induced decrease in dermal neuron-specific enolase (NSE) in acrosclerosis
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 296:182-4. 2004
    ..Even though the origin and the functional mechanisms remain obscure, NSE might be relevant directly within sclerotic skin lesions and may possibly be used as a diagnostic marker at least in SSc-associated acrosclerotic skin...
  98. ncbi request reprint Topical tacrolimus neither prevents nor abolishes ultraviolet-induced erythema
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 55:882-5. 2006
    ..05). Our data strongly indicate that topical tacrolimus neither prevents nor abolishes UV-induced erythema in a clinical meaningful degree...
  99. ncbi request reprint Generalized fungal infection in a patient with AIDS appearing as skin papules
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, D 44791 Bochum, Germany
    Eur J Med Res 8:435-7. 2003
    ..We report a HIV-positive man from Cameroon presenting with generalized cutaneous papules and nodes, oral candidiasis, and soor esophagitis, who was successfully treated with fluconazole monotherapy...
  100. doi request reprint Decorin is significantly overexpressed in nephrogenic systemic fibrosis
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Am J Clin Pathol 132:139-43. 2009
    ..92). Our results suggest that decorin and TGF-beta1 may have a fundamental role in the pathogenesis of NSF. Conversely, versican seems less likely to be of pathogenetic significance in NSF...
  101. ncbi request reprint Acute skin alterations following ultraviolet radiation investigated by optical coherence tomography and histology
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791, Bochum, Germany
    Arch Dermatol Res 297:218-25. 2005
    ..OCT seems to be a useful tool to monitor UV induced effects in vivo...