T Gambichler

Summary

Affiliation: Ruhr-University Bochum
Country: Germany

Publications

  1. ncbi request reprint TGFβ/Smad signalling in psoriatic epidermis models exposed to salt water soaks and narrowband ultraviolet B radiation
    T Gambichler
    Department of Dermatology, Venereology, and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany Electronic address
    Cytokine 64:35-8. 2013
  2. ncbi request reprint Treatment regimens, protocols, dosage, and indications for UVA1 phototherapy: facts and controversies
    Thilo Gambichler
    Department of Dermatology, Venereology, and Allergology at Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Clin Dermatol 31:438-54. 2013
  3. doi request reprint Decreased lysyl oxidase-like 2 expression in mid-dermal elastolysis
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 305:359-63. 2013
  4. doi request reprint Clinical characteristics and survival data of melanoma patients with nevus cell aggregates within sentinel lymph nodes
    Thilo Gambichler
    Department of Dermatology, Venereology and Allergology, Skin Cancer Center Ruhr University, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791, Bochum, Germany
    Am J Clin Pathol 139:566-73. 2013
  5. ncbi request reprint Serum 25-hydroxyvitamin D serum levels in a large German cohort of patients with melanoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 168:625-8. 2013
  6. doi request reprint Childhood blastic plasmacytoid dendritic cell neoplasm treated with allogenic stem cell transplantation
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Pediatr Dermatol 30:142-4. 2013
  7. doi request reprint Serum levels of antimicrobial peptides and proteins do not correlate with psoriasis severity and are increased after treatment with fumaric acid esters
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Arch Dermatol Res 304:471-4. 2012
  8. doi request reprint Deep intronic point mutations of the KIT gene in a female patient with cutaneous clear cell sarcoma and her family
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Cancer Genet 205:182-5. 2012
  9. pmc Erythromelalgia and livedo reticularis in a patient with essential thrombocythemia, acquired von Willebrand disease, and elevated anti-phospholipid antibodies
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Ann Dermatol 24:214-7. 2012
  10. ncbi request reprint Differential expression of connective tissue growth factor and extracellular matrix proteins in lichen sclerosus
    T Gambichler
    Department of Dermatology Department of Medicine I, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 26:207-12. 2012

Detail Information

Publications139 found, 100 shown here

  1. ncbi request reprint TGFβ/Smad signalling in psoriatic epidermis models exposed to salt water soaks and narrowband ultraviolet B radiation
    T Gambichler
    Department of Dermatology, Venereology, and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany Electronic address
    Cytokine 64:35-8. 2013
    ..It has been shown that TGFβ1/Smad signalling is altered in a psoriatic model and may play a role in the mode of action of salt water soaks and NB-UVB phototherapy of psoriasis...
  2. ncbi request reprint Treatment regimens, protocols, dosage, and indications for UVA1 phototherapy: facts and controversies
    Thilo Gambichler
    Department of Dermatology, Venereology, and Allergology at Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Clin Dermatol 31:438-54. 2013
    ..We describe and discuss treatment regimens, protocols, dosage, and indications for UVA1 phototherapy. ..
  3. doi request reprint Decreased lysyl oxidase-like 2 expression in mid-dermal elastolysis
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 305:359-63. 2013
    ..More research is warranted in MDE especially with regard to the LOX family, fibulins, fibrillins, and desmosines...
  4. doi request reprint Clinical characteristics and survival data of melanoma patients with nevus cell aggregates within sentinel lymph nodes
    Thilo Gambichler
    Department of Dermatology, Venereology and Allergology, Skin Cancer Center Ruhr University, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791, Bochum, Germany
    Am J Clin Pathol 139:566-73. 2013
    ..This study provides an indirect proof of validity and accuracy of current histopathologic methods for differentiation between nodal nevi and melanoma metastasis...
  5. ncbi request reprint Serum 25-hydroxyvitamin D serum levels in a large German cohort of patients with melanoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 168:625-8. 2013
    ..Observational studies have suggested that 25-hydroxyvitamin D [25(OH)D] is associated with better outcomes in patients with malignant melanoma (MM)...
  6. doi request reprint Childhood blastic plasmacytoid dendritic cell neoplasm treated with allogenic stem cell transplantation
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Pediatr Dermatol 30:142-4. 2013
    ..We report a 15-year-old boy with blastic plasmacytoid dendritic cell neoplasm who was treated with acute myeloid leukemia-based polychemotherapy and subsequent allogenic stem cell transplantation...
  7. doi request reprint Serum levels of antimicrobial peptides and proteins do not correlate with psoriasis severity and are increased after treatment with fumaric acid esters
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Arch Dermatol Res 304:471-4. 2012
    ..Increased serum AMP protein levels in psoriasis resolution are an unexpected observation that needs to be investigated more in detail in future studies...
  8. doi request reprint Deep intronic point mutations of the KIT gene in a female patient with cutaneous clear cell sarcoma and her family
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Cancer Genet 205:182-5. 2012
    ..Future studies investigating KIT intron mutations in a larger cohort of CCS patients are warranted...
  9. pmc Erythromelalgia and livedo reticularis in a patient with essential thrombocythemia, acquired von Willebrand disease, and elevated anti-phospholipid antibodies
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Ann Dermatol 24:214-7. 2012
    ....
  10. ncbi request reprint Differential expression of connective tissue growth factor and extracellular matrix proteins in lichen sclerosus
    T Gambichler
    Department of Dermatology Department of Medicine I, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 26:207-12. 2012
    ..The histopathology of lichen sclerosus (LS) suggests abnormalities in extracellular matrix (ECM) composition...
  11. doi request reprint Impact of ultraviolet radiation on the expression of marker proteins of gap and adhesion junctions in human epidermis
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Photodermatol Photoimmunol Photomed 24:318-21. 2008
    ..We aimed to investigate the impact of ultraviolet B (UVB) as well as UVA1 on the epidermal expression of specific markers of gap and adhesion junctions...
  12. ncbi request reprint A pilot study to optimize laser-assisted hair removal using real-time high-speed infrared imaging
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Photomed Laser Surg 24:651-4. 2006
    ..The aim of this study was to investigate thermal effects on the skin surface during laser-assisted hair removal using real-time high-speed infrared imaging...
  13. ncbi request reprint Versican overexpression in cutaneous malignant melanoma
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Eur J Med Res 13:500-4. 2008
    ..We aimed to investigate the protein expression pattern of decorin and versican in superficial spreading melanoma (SSM) and its precursors...
  14. ncbi request reprint Epidermal thickness assessed by optical coherence tomography and routine histology: preliminary results of method comparison
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    J Eur Acad Dermatol Venereol 20:791-5. 2006
    ..However, there is a lack of systematic studies comparing OCT with histology...
  15. doi request reprint Medium-dose ultraviolet (UV) A1 vs. narrowband UVB phototherapy in atopic eczema: a randomized crossover study
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Br J Dermatol 160:652-8. 2009
    ..Ultraviolet (UV) A1 and narrowband (NB)-UVB have been reported to be effective treatments for atopic eczema (AE)...
  16. ncbi request reprint Cytokine mRNA expression in basal cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, Bochum 44791, Germany
    Arch Dermatol Res 298:139-41. 2006
    ..In accordance with previous studies our data suggest a role for IL-6 and IL-8 in the development and/or progression of BCC, since mRNA expression of both CKs are significantly increased in tumour tissue...
  17. ncbi request reprint Topical tacrolimus neither prevents nor abolishes ultraviolet-induced erythema
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 55:882-5. 2006
    ..05). Our data strongly indicate that topical tacrolimus neither prevents nor abolishes UV-induced erythema in a clinical meaningful degree...
  18. pmc Pattern of mRNA expression of beta-defensins in basal cell carcinoma
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Cancer 6:163. 2006
    ..The present work was aimed on the study of hBD gene expression in basal cell carcinoma (BCC) which is the most common cancer in humans...
  19. ncbi request reprint Management of atopic dermatitis using photo(chemo)therapy
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Arch Dermatol Res 301:197-203. 2009
    ..When photo(chemo)therapy is considered for AD patients, its use is very much dedicated by the cost-effectiveness, availability, and the practicality of attending the clinic several times a week...
  20. ncbi request reprint A randomised controlled trial on photo(chemo)therapy of subacute prurigo
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 31:348-53. 2006
    ..Psoralen ultraviolet A (PUVA) is the standard photo(chemo)therapeutic regimen for patients suffering from subacute prurigo (SP)...
  21. ncbi request reprint Up-regulation of transforming growth factor-beta3 and extracellular matrix proteins in acquired reactive perforating collagenosis
    Thilo Gambichler
    Department of Dermatology, Ruhr University of Bochum, Bochum, Germany
    J Am Acad Dermatol 60:463-9. 2009
    ..Acquired reactive perforating collagenosis (ARPC) is an uncommon itchy dermatosis of unknown etiology...
  22. ncbi request reprint Reference limits for erythema-effective UV doses
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Photochem Photobiol 82:1097-102. 2006
    ..Although the MED data given here are limited to the phototest device used in the present study, the SED results establish comparability between our data and phototest results obtained from laboratories using different UV sources...
  23. ncbi request reprint A comparative pilot study on ultraviolet-induced skin changes assessed by noninvasive imaging techniques in vivo
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Photochem Photobiol 82:1103-7. 2006
    ..However, larger studies are needed to demonstrate the applicability of the findings presented in this pilot study...
  24. ncbi request reprint The European standard for sun-protective clothing: EN 13758
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse, Bochum, Germany
    J Eur Acad Dermatol Venereol 20:125-30. 2006
    ....
  25. ncbi request reprint Correlation between clinical scoring of allergic patch test reactions and optical coherence tomography
    Thilo Gambichler
    Ruhr Universitat Bochum, Department of Dermatology and Allergology, Bochum 44791 Germany
    J Biomed Opt 10:064030. 2005
    ..However, before OCT can be employed as an objective parameter in grading severity of patch test reactions, larger studies are required that correlate clinical patch test readings and OCT findings with histopathology...
  26. ncbi request reprint In vivo data of epidermal thickness evaluated by optical coherence tomography: effects of age, gender, skin type, and anatomic site
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    J Dermatol Sci 44:145-52. 2006
    ..The knowledge of epidermal thickness (ET) is of great significance in many areas of medical and biological research...
  27. ncbi request reprint Changes of antimicrobial peptide mRNA expression in atopic eczema following phototherapy
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, Bochum, Germany
    Br J Dermatol 155:1275-8. 2006
    ..Hence, AMPs may represent important cofactors in the pathogenesis of AE...
  28. ncbi request reprint Increased expression of TGF-beta/Smad proteins in basal cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Eur J Med Res 12:509-14. 2007
    ..There is an increasing evidence that the development of cutaneous epithelial tumours is pathogenetically linked to dysregulations of the transforming growth factor beta (TGF-beta) and its signalling molecules, the Smads...
  29. ncbi request reprint Quantification of ultraviolet protective effects of pityriacitrin in humans
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, Bochum, Germany
    Arch Dermatol Res 299:517-20. 2007
    ..In conclusion, the UV protective effect of PIT is all in all very weak suggesting that PIT is likely only an inferior cofactor in the development of hypopigmentation in pityriasis versicolor alba lesions following sun exposure...
  30. ncbi request reprint Expression of proliferation markers and cell cycle regulators in T cell lymphoproliferative skin disorders
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    J Dermatol Sci 49:125-32. 2008
    ..Abnormal cell proliferation, which results from deregulation of the cell cycle, is fundamental in tumorigenesis...
  31. ncbi request reprint Characterization of benign and malignant melanocytic skin lesions using optical coherence tomography in vivo
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 57:629-37. 2007
    ..Although optical coherence tomography (OCT) is a promising noninvasive imaging technique for the micromorphology of the skin, OCT has not been studied systematically in skin cancer such as malignant melanoma (MM)...
  32. ncbi request reprint Preoperative ultrasonic assessment of thin melanocytic skin lesions using a 100-MHz ultrasound transducer: a comparative study
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Dermatol Surg 33:818-24. 2007
    ..It has been shown that tumor thickness (TT) of melanocytic skin lesions (MSL) of less than 1 mm vertical thickness assessed by 20 MHz are often incorrectly evaluated...
  33. doi request reprint Skin conditions in instrumental musicians: a self-reported survey
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Contact Dermatitis 58:217-22. 2008
    ..Instrumental musicians are a risk group for a variety of skin conditions...
  34. doi request reprint A pilot study of fluorescence diagnosis of basal cell carcinoma using a digital flash light-based imaging system
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Photodermatol Photoimmunol Photomed 24:67-71. 2008
    ..Fluorescence diagnosis (FD) is a promising method for the non-invasive detection of tumor boundaries. We aimed to investigate the clinical utility of a flash light-based fluorescence imaging system...
  35. ncbi request reprint Expression of human beta-defensins in patients with mycosis fungoides
    T Gambichler
    Department of Dermatology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Arch Dermatol Res 299:221-4. 2007
    ..We observed an identical pattern of hBD expression in MD and AD suggesting a common regulatory mechanism that might mainly be driven by T helper 2 lymphocytes...
  36. doi request reprint Gene expression of cytokines in atopic eczema before and after ultraviolet A1 phototherapy
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Br J Dermatol 158:1117-20. 2008
    ..Atopic eczema (AE) is a common pruritic and chronically relapsing inflammatory skin disease in which cytokines seem to represent important factors in the pathogenesis...
  37. ncbi request reprint Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Int Arch Allergy Immunol 147:17-24. 2008
    ..We aimed to investigate mRNA expression levels of various antimicrobial peptides and proteins (AMPs) in AD patients, and compare it with psoriasis vulgaris (PV) patients and healthy subjects...
  38. ncbi request reprint Validation of optical coherence tomography in vivo using cryostat histology
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Phys Med Biol 52:N75-85. 2007
    ..Furthermore, the comparisons with the in vivo OCT profiles demonstrate that cryostat sectioning provides a better preservation of relative and absolute dimensions of skin layers than paraffin embedding...
  39. ncbi request reprint Optical coherence tomography of cutaneous lupus erythematosus correlates with histopathology
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Lupus 16:35-8. 2007
    ..Nevertheless, the current technique does not allow one to visualize definite diagnostic features of cutaneous LE. However, OCT may be a promising method for objective monitoring of LE activity and treatment effects over time in vivo...
  40. ncbi request reprint Acute kidney injury in a patient with melanuria, diffuse melanosis, and metastatic malignant melanoma
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Am J Clin Dermatol 9:267-70. 2008
    ..Diffuse melanosis with melanuria may lead to morphologic and functional kidney changes and warrants careful monitoring of kidney function in affected malignant melanoma patients...
  41. ncbi request reprint In vivo optical coherence tomography of basal cell carcinoma
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    J Dermatol Sci 45:167-73. 2007
    ..Optical coherence tomography (OCT) is a promising non-invasive imaging technique that has not systematically been studied in skin cancer such as basal cell carcinoma (BCC)...
  42. ncbi request reprint Differential expression of decorin in localized scleroderma following ultraviolet-A1 irradiation
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 56:956-9. 2007
    ..After ultraviolet A1 phototherapy, decorin levels of lesional skin were significantly higher than baseline. Decorin may be of significance in the pathogenesis of localized scleroderma...
  43. doi request reprint Tacrolimus ointment neither blocks ultraviolet B nor affects expression of thymine dimers and p53 in human skin
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Dermatol Sci 50:115-22. 2008
    ..There is a lack of data with regard to the interaction between ultraviolet (UV) radiation and topical calcineurin inhibitors...
  44. doi request reprint Expression of minichromosome maintenance proteins in Merkel cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 23:1184-8. 2009
    ..We aimed to assess whether MCM immunohistochemistry can be utilized to examine tumour proliferation in Merkel cell carcinoma (MCC)...
  45. doi request reprint Evaluation of sun awareness with an emphasis on ultraviolet protection by clothing: a survey of adults in Western Germany
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    J Eur Acad Dermatol Venereol 24:155-62. 2010
    ..Little is known about the sun habits of the population in Germany...
  46. doi request reprint Etanercept plus narrowband ultraviolet B phototherapy of psoriasis is more effective than etanercept monotherapy at 6 weeks
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    Br J Dermatol 164:1383-6. 2011
    ..A substantial portion of patients with psoriasis does not achieve a satisfactory response under antitumour necrosis factor (TNF)-α biological therapies...
  47. doi request reprint Mid-dermal elastolysis revisited
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Arch Dermatol Res 302:85-93. 2010
    ..Future therapeutic approaches in MDE patients should focus on agents that are able to block increased elastase activity and induce elastin synthesis...
  48. pmc Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    Eur J Med Res 15:44-6. 2010
    ..Previous reports on lymphocyte subpopulations in systemic sclerosis (SSc) are conflicting. Therefore, we aimed to investigate the lymphocyte subsets in SSc patients who were not on immunosuppressive therapy...
  49. ncbi request reprint Immunohistology of amicrobial pustulosis of the folds
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Clin Exp Dermatol 32:155-8. 2007
    ..However, studies on a larger sample size including controls are needed to substantiate our findings...
  50. doi request reprint Expression of antimicrobial peptides and proteins in etanercept-treated psoriasis patients
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Regul Pept 167:163-6. 2011
    ..We have demonstrated that etanercept-induced improvement of psoriasic lesions is associated with a significant decline of AMP protein expression...
  51. doi request reprint Optical coherence tomography in dermatology: technical and clinical aspects
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Arch Dermatol Res 303:457-73. 2011
    ..The present comprehensive review describes and illustrates technical aspects and clinical applications of OCT methods in dermatology...
  52. doi request reprint Impact of etanercept treatment on ultraviolet B-induced inflammation, cell cycle regulation and DNA damage
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 164:110-5. 2011
    ..Current studies indicate that treatment with tumour necrosis factor (TNF)-α blockers plus ultraviolet (UV) B phototherapy results in higher relative Psoriasis Area and Severity Index reduction as compared with TNF-α monotherapy...
  53. pmc Primary merkel cell carcinoma clinically presenting as deep oedematous mass of the groin
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Eur J Med Res 15:274-6. 2010
    ..MCC showing the aforementioned features may be associated with significant delay of diagnosis and therefore represents an unfavourable prognostic factor...
  54. doi request reprint Expression of extracellular matrix proteins in reticular variant of mid-dermal elastolysis
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 24:1481-4. 2010
    ..Mid-dermal elastolysis (MDE) is a rare disorder of the elastic tissue that is characterized histopathologically by selective loss of elastic fibres in the mid dermis...
  55. ncbi request reprint Significant upregulation of antimicrobial peptides and proteins in lichen sclerosus
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, D 44791 Bochum, Germany
    Br J Dermatol 161:1136-42. 2009
    ..Inflamed and injured epithelia are a particularly rich source of antimicrobial peptides and proteins (AMPs)...
  56. ncbi request reprint Complex extra-intestinal complications of ulcerative colitis in a patient with alpha1-antitrypsin deficiency
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Eur J Med Res 11:135-8. 2006
    ..Testing for alpha1-antitrypsin deficiency in UC patients may detect individuals at higher risk of severe extra-intestinal involvement...
  57. doi request reprint Significantly increased CCL5/RANTES and CCR7 mRNA levels in localized scleroderma
    Thilo Gambichler
    Department of Dermatology, Venereology, and Allergology, Ruhr University Bochum, Germany
    Regul Pept 170:4-6. 2011
    ..Moreover, we have shown for the first time a significant increase of mRNA levels of CCR7 and CCL5/RANTES in LS lesions indicating an important pathogenetic role of chemokines in LS...
  58. ncbi request reprint Acute skin alterations following ultraviolet radiation investigated by optical coherence tomography and histology
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791, Bochum, Germany
    Arch Dermatol Res 297:218-25. 2005
    ..OCT seems to be a useful tool to monitor UV induced effects in vivo...
  59. doi request reprint Immunologically mediated photodermatoses: diagnosis and treatment
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Am J Clin Dermatol 10:169-80. 2009
    ..Overall, IMP form a significant group of skin conditions that can be extremely disabling to the patient and are difficult to diagnose and treat...
  60. ncbi request reprint Comparison of histometric data obtained by optical coherence tomography and routine histology
    Thilo Gambichler
    Ruhr University Bochum, Department of Dermatology, Gudrunstr 56, 44791 Bochum, Germany
    J Biomed Opt 10:44008. 2005
    ..Regarding practicability, precision, and indication spectrum, ET-OCT-V and ET-OCT-M are of different clinical value...
  61. ncbi request reprint Applications of optical coherence tomography in dermatology
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    J Dermatol Sci 40:85-94. 2005
    ....
  62. doi request reprint Immunophenotyping of inflammatory cells in subacute prurigo
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 25:221-6. 2011
    ..Subacute prurigo (SP) is a relatively common disease of papular cutaneous lesions that itch intensely. However, there is a lack of systematic clinical and histological studies on SP...
  63. doi request reprint Minichromosome maintenance proteins are useful adjuncts to differentiate between benign and malignant melanocytic skin lesions
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, Bochum D 44791, Germany
    J Am Acad Dermatol 60:808-13. 2009
    ..Markers identifying premalignant and malignant melanocytic skin lesions are needed...
  64. ncbi request reprint Significant downregulation of transforming growth factor-beta signal transducers in human skin following ultraviolet-A1 irradiation
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Br J Dermatol 156:951-6. 2007
    ....
  65. doi request reprint The impact of salt water soaks on biophysical and molecular parameters in psoriatic epidermis equivalents
    T Gambichler
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Dermatology 223:230-8. 2011
    ..The exact mechanisms of action of balneophototherapy are incompletely understood. We aimed to investigate the effect of salt water soaks on ultraviolet (UV) transmission and the expression of molecular parameters of psoriasis...
  66. doi request reprint Human papillomavirus-associated induction of human beta-defensins in anal intraepithelial neoplasia
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    Br J Dermatol 160:1197-205. 2009
    ..Antimicrobial peptides and proteins (AMPs) are widely distributed effector molecules of the innate immune system with well-known antibacterial activity. However, there is a paucity of information regarding antiviral effects of AMPs...
  67. ncbi request reprint UVA1 and UVB irradiated skin investigated by optical coherence tomography in vivo: a preliminary study
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 30:79-82. 2005
    ..However, further studies are needed to establish its measurement precision and validity, and to investigate in vivo spectral dependence on UV induced skin changes such as skin thickening...
  68. ncbi request reprint Ultraviolet A1-induced downregulation of human beta-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 155:600-7. 2006
    ..Ultraviolet (UV) A1 phototherapy, the most recent advance in the treatment of LS, targets T-cell dermal inflammatory infiltrates via induction of various cytokines and soluble factors besides well-known effects on collagen metabolism...
  69. ncbi request reprint Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Pediatr Dermatol 18:241-5. 2001
    ..Further controlled studies are necessary to investigate whether this combined therapy is superior to UVA1 phototherapy alone...
  70. ncbi request reprint Evaluation of the epidermal refractive index measured by optical coherence tomography
    M Sand
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    Skin Res Technol 12:114-8. 2006
    ..In this pilot study, using OCT in vivo, we aimed to investigate the interday variability of RI measurements and acute changes of RI following the application of a moisturizer...
  71. doi request reprint Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 162:1269-77. 2010
    ..There is a paucity of data published on the progression of high-grade AIN to invasive cancer as well as on clinical and virological characteristics comparing anal margin and anal canal carcinoma...
  72. ncbi request reprint Effects of repeated sunbed exposures on the human skin. In vivo measurements with confocal microscopy
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, Bochum D 44791, Germany
    Photodermatol Photoimmunol Photomed 20:27-32. 2004
    ..Although it is well accepted that sunbed exposure significantly increases melanin pigmentation, its capacity to induce epidermal thickening is discussed controversially...
  73. ncbi request reprint Histomorphologic correlation with routine histology and optical coherence tomography
    F G Bechara
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Skin Res Technol 10:169-73. 2004
    ..We describe a method that makes evaluation and definition of specific morphologic structures of skin tumours via OCT more accurate...
  74. doi request reprint Clonal T-cell populations are frequent in the skin and blood of patients with systemic sclerosis
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 161:785-90. 2009
    ..Pilot studies were suggestive for a role of clonal T cells in the pathogenesis of systemic sclerosis (SSc)...
  75. ncbi request reprint High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 144:1011-6. 2008
    ..The pathogenetic relevance of HHV-8 in cutaneous T-cell lymphoma is controversial. Recently, a highly significant association of HHV-8 in LPP was found, which suggests a role in the pathogenesis of this disease...
  76. doi request reprint Differential expression of microtubule-associated protein 2 in melanocytic skin lesions
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Am J Clin Pathol 131:710-4. 2009
    ..In contrast with the findings of previous studies, our data indicate that MAP-2 is a moderately positive predictor of the progression of SSMs...
  77. ncbi request reprint 1% pimecrolimus, 0.005% calcipotriol, and 0.1% betamethasone in the treatment of intertriginous psoriasis: a double-blind, randomized controlled study
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University of Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 142:1138-43. 2006
    ..Recently, both pimecrolimus and tacrolimus have been investigated for this indication and shown to be safe and effective. So far, to our knowledge, a comparison of one of these drugs with standard regimens for IP has not been performed...
  78. doi request reprint [Acquired reactive perforating collagenosis following herpes zoster as isotopic response?]
    N Scola
    Klinik fur Dermatologie, Venerologie und Allergologie, Ruhr Universitat Bochum, Bochum, Deutschland
    Hautarzt 62:683-7. 2011
    ..We report the sixth case of a herpes zoster-associated reactive perforating collagenosis and discuss the current literature...
  79. ncbi request reprint Mononuclear cells in atopic dermatitis in vivo: immunomodulation of the cutaneous infiltrate by medium-dose UVA1 phototherapy
    F Breuckmann
    Department of Dermatology, Ruhr University Bochum, Germany
    Eur J Med Res 7:315-22. 2002
    ..The purpose of our study was to investigate the extent to which UVA1 irradiation is able to modulate the mononuclear dermal inflammatory infiltrate using different monoclonal antibodies...
  80. ncbi request reprint Standardized tape stripping: a practical and reproducible protocol to uniformly reduce the stratum corneum
    H Dickel
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany
    Skin Pharmacol Physiol 23:259-65. 2010
    ..As a result, our SPT protocol yields a clinically adequate standardization of the SC reduction and the SPT may therefore be recommended for performance in daily clinical routine...
  81. ncbi request reprint In vitro and in vivo determination of the UV protection factor for lightweight cotton and viscose summer fabrics: a preliminary study
    K Hoffmann
    Department of Dermatology, Ruhr University, Bochum, Germany
    J Am Acad Dermatol 43:1009-16. 2000
    ....
  82. ncbi request reprint Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer
    Michael Sand
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Cancer Invest 28:649-53. 2010
    ..In this pilot study, we investigated expression profiles of the two most important enzymes of the miRNA machinery, Drosha and Dicer, in relation to epithelial skin cancer and its premalignant stage...
  83. doi request reprint Preoperative assessment of basal cell carcinoma using conventional fluorescence diagnosis
    Susanne Neus
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, Bochum 44791, Germany
    Arch Dermatol Res 301:289-94. 2009
    ..When compared to clinically based BCC excision, however, FD does not appear to be substantially superior to simple clinical assessment of tumour margins...
  84. doi request reprint Protein expression of carcinoembryonic antigen cell adhesion molecules in benign and malignant melanocytic skin lesions
    Thilo Gambichler
    Dept of Dermatology and Allergology, Ruhr University Bochum, Germany
    Am J Clin Pathol 131:782-7. 2009
    ..Our data support the findings of previous studies indicating that cell adhesion molecules of the CEA family may have a role in the development and progression of cutaneous melanoma and potentially serve as prognostic markers...
  85. ncbi request reprint Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-α and IL-8/CXCL8 mRNA: new insights into the involvement of 'alarmins'
    Heinrich Dickel
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Contact Dermatitis 63:215-22. 2010
    ..It is under discussion whether the cutaneous inflammation induced by tape stripping is a pivotal element in enhancing the allergic contact dermatitis response...
  86. ncbi request reprint Ultraviolet protection by summer textiles. Ultraviolet transmission measurements verified by determination of the minimal erythema dose with solar-simulated radiation
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Br J Dermatol 144:484-9. 2001
    ..Usually, the UPF of a textile is determined by spectrophotometric assessment of the UV transmission (in vitro method)...
  87. pmc Protection against ultraviolet radiation by commercial summer clothing: need for standardised testing and labelling
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    BMC Dermatol 1:6. 2001
    ..The use of clothing as a means of sun protection has been recommended in recent education campaigns. Contrary to popular opinion, however, some fabrics provide insufficient ultraviolet (UV) protection...
  88. pmc Pimecrolimus 1% cream for anogenital lichen sclerosus in childhood
    Stefanie Boms
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    BMC Dermatol 4:14. 2004
    ..Because of the potential side effects of repeated local application of potent glucocorticosteroids, equally-effective, safer therapeutic options are required, especially in the treatment of children...
  89. ncbi request reprint Detection of clonal T cells in the circulation of patients with nephrogenic systemic fibrosis
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 145:1164-9. 2009
    ..Facing the clinical similarities of both diseases, we hypothesized that clonal expansion of T cells could be present in nephrogenic systemic fibrosis as well...
  90. ncbi request reprint Influence of wetness on the ultraviolet protection factor (UPF) of textiles: in vitro and in vivo measurements
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Photodermatol Photoimmunol Photomed 18:29-35. 2002
    ....
  91. ncbi request reprint Decorin is significantly overexpressed in nephrogenic systemic fibrosis
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Am J Clin Pathol 132:139-43. 2009
    ..92). Our results suggest that decorin and TGF-beta1 may have a fundamental role in the pathogenesis of NSF. Conversely, versican seems less likely to be of pathogenetic significance in NSF...
  92. doi request reprint Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 63:490-8. 2010
    ..Early diagnosis and treatment of AIN might prevent development of anal cancer...
  93. ncbi request reprint Fumaric acid esters in necrobiosis lipoidica: results of a prospective noncontrolled study
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 153:802-7. 2005
    ..In recent case reports, fumaric acid esters (FAE) have been reported to be effective in granulomatous skin diseases such as granuloma annulare, cutaneous sarcoidosis and NL...
  94. ncbi request reprint Investigation of basal cell carcinoma [correction of carcionoma] by confocal laser scanning microscopy in vivo
    K Sauermann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Skin Res Technol 8:141-7. 2002
    ..Aim of this study was to investigate basal cell carcinoma (BCC) using in vivo CLSM, and to compare the micromorphologic features of BCC with uninvolved skin...
  95. ncbi request reprint [Bilateral segmental neurofibromatosis simulating epidermal nevus]
    T Gambichler
    Klinik für Dermatologie und Allergologie, Ruhr Universitat Bochum, Gudrunstrasse 56, 44791 Bochum
    Hautarzt 51:862-4. 2000
    ..The unusual morphologic presentation of bilateral segmental neurofibromas in this case points to the wide clinical spectrum of the disease and the significance of histologic examination in systematic nevoid lesions...
  96. ncbi request reprint Defined UV protection by apparel textiles
    K Hoffmann
    Department of Dermatology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol 137:1089-94. 2001
    ..The use of UV blocking fabrics can provide excellent protection against the hazards of sunlight; this is especially true for garments manufactured as UV protective clothing...
  97. ncbi request reprint Mycophenolate sodium for subacute cutaneous lupus erythematosus resistant to standard therapy
    A Kreuter
    Connective Tissue Disease Research Unit, Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 156:1321-7. 2007
    ..Immunosuppressive agents are usually considered a second-line approach in patients with resistant disease...
  98. pmc Histometric data obtained by in vivo confocal laser scanning microscopy in patients with systemic sclerosis
    Kirsten Sauermann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:8. 2002
    ....
  99. ncbi request reprint Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol 141:847-52. 2005
    ..To evaluate the efficacy of pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy in patients with severe localized scleroderma (LS)...
  100. pmc Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:12. 2002
    ..The purpose of our study was to investigate to what extent UVA1 irradiation is able to modulate the status of protease activity by the use of a monoclonal antibody labeling cathepsin G...
  101. doi request reprint Indoor tanning in North Rhine-Westphalia Germany: a self-reported survey
    Maria Dissel
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Photodermatol Photoimmunol Photomed 25:94-100. 2009
    ..We examined the prevalence of indoor tanning in North Rhine-Westphalia and identified correlates of sunbed use...