T Gambichler

Summary

Affiliation: Ruhr-University Bochum
Country: Germany

Publications

  1. pmc Successful treatment of recalcitrant cutaneous sarcoidosis with fumaric acid esters
    Ute Nowack
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    BMC Dermatol 2:15. 2002
  2. pmc Histometric data obtained by in vivo confocal laser scanning microscopy in patients with systemic sclerosis
    Kirsten Sauermann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:8. 2002
  3. pmc Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:12. 2002
  4. pmc Treatment of disseminated granuloma annulare with fumaric acid esters
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    BMC Dermatol 2:5. 2002
  5. pmc Serum folate levels after UVA exposure: a two-group parallel randomised controlled trial
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 1:8. 2001
  6. pmc Bilateral linear scleroderma "en coup de sabre" associated with facial atrophy and neurological complications
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791, Bochum, Germany
    BMC Dermatol 1:9. 2001
  7. pmc Impact of UVA exposure on psychological parameters and circulating serotonin and melatonin
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    BMC Dermatol 2:6. 2002
  8. ncbi request reprint Influence of wetness on the ultraviolet protection factor (UPF) of textiles: in vitro and in vivo measurements
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Photodermatol Photoimmunol Photomed 18:29-35. 2002
  9. ncbi request reprint Uncommon vascular naevi associated with focal acantholytic dyskeratosis
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Clin Exp Dermatol 27:195-8. 2002
  10. ncbi request reprint Ultraviolet protection factor of fabrics: comparison of laboratory and field-based measurements
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, D 44791 Bochum, Germany
    Photodermatol Photoimmunol Photomed 18:135-40. 2002

Detail Information

Publications151 found, 100 shown here

  1. pmc Successful treatment of recalcitrant cutaneous sarcoidosis with fumaric acid esters
    Ute Nowack
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    BMC Dermatol 2:15. 2002
    ..Systemic treatment for cutaneous sarcoidosis can be used for large disfiguring lesions, generalized involvement, or recalcitrant lesions that did not respond to topical therapy...
  2. pmc Histometric data obtained by in vivo confocal laser scanning microscopy in patients with systemic sclerosis
    Kirsten Sauermann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:8. 2002
    ....
  3. pmc Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:12. 2002
    ..The purpose of our study was to investigate to what extent UVA1 irradiation is able to modulate the status of protease activity by the use of a monoclonal antibody labeling cathepsin G...
  4. pmc Treatment of disseminated granuloma annulare with fumaric acid esters
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    BMC Dermatol 2:5. 2002
    ..We report a patient with recalcitrant DGA who was treated with fumaric acid esters (FAE)...
  5. pmc Serum folate levels after UVA exposure: a two-group parallel randomised controlled trial
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 1:8. 2001
    ..To investigate the influence of UVA radiation on serum folate levels in vivo, we conducted a two-group randomised controlled trial on healthy subjects...
  6. pmc Bilateral linear scleroderma "en coup de sabre" associated with facial atrophy and neurological complications
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791, Bochum, Germany
    BMC Dermatol 1:9. 2001
    ..The disease may be associated with facial hemiatrophy. Various ophthalmological and neurological abnormalities have been observed in patients with LSCS. We describe an unusual case of LSC...
  7. pmc Impact of UVA exposure on psychological parameters and circulating serotonin and melatonin
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    BMC Dermatol 2:6. 2002
    ..People tend to feel better after exposure to ultraviolet (UV) radiation. This study was performed to investigate the impact of UVA exposure on psychological and neuroendocrine parameters...
  8. ncbi request reprint Influence of wetness on the ultraviolet protection factor (UPF) of textiles: in vitro and in vivo measurements
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Photodermatol Photoimmunol Photomed 18:29-35. 2002
    ....
  9. ncbi request reprint Uncommon vascular naevi associated with focal acantholytic dyskeratosis
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Clin Exp Dermatol 27:195-8. 2002
    ....
  10. ncbi request reprint Ultraviolet protection factor of fabrics: comparison of laboratory and field-based measurements
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, D 44791 Bochum, Germany
    Photodermatol Photoimmunol Photomed 18:135-40. 2002
    ..To compare UPF values obtained by spectrophotometry, determination of the minimal erythema dose (MED), and biological dosimetry, we conducted laboratory and field-based measurements on various fabric materials...
  11. ncbi request reprint Plasma levels of opioid peptides after sunbed exposures
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstasse 56, D 4479 Bochum, Germany
    Br J Dermatol 147:1207-11. 2002
    ..Circulating opioid peptides have been suggested as being important in this effect...
  12. pmc Protection against ultraviolet radiation by commercial summer clothing: need for standardised testing and labelling
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    BMC Dermatol 1:6. 2001
    ..The use of clothing as a means of sun protection has been recommended in recent education campaigns. Contrary to popular opinion, however, some fabrics provide insufficient ultraviolet (UV) protection...
  13. ncbi request reprint [Bilateral segmental neurofibromatosis simulating epidermal nevus]
    T Gambichler
    Klinik für Dermatologie und Allergologie, Ruhr Universitat Bochum, Gudrunstrasse 56, 44791 Bochum
    Hautarzt 51:862-4. 2000
    ..The unusual morphologic presentation of bilateral segmental neurofibromas in this case points to the wide clinical spectrum of the disease and the significance of histologic examination in systematic nevoid lesions...
  14. ncbi request reprint Treatment of Birt-Hogg-Dubé syndrome with erbium:YAG laser
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    J Am Acad Dermatol 43:856-8. 2000
    ..Although the lesions could be successfully ablated up to the papillary dermis without scar formation, a relapse was observed after 6 months. Thus deeper laser ablations may possibly prevent relapses from dermal residual lesions...
  15. ncbi request reprint Deep shave excision of macular melanocytic nevi with the razor blade biopsy technique
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Bochum, Germany
    Dermatol Surg 26:662-6. 2000
    ..Usually superficial shave excision is performed with a common scalpel blade for the removal of papular nevi. However, there is little known about deep shave excision of macular melanocytic nevi with the razor blade technique...
  16. ncbi request reprint Clearance of ichthyosis linearis circumflexa with balneophototherapy
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    J Eur Acad Dermatol Venereol 14:397-9. 2000
    ..As only short periods of remission may be expected, intermittent balneophototherapy would be probably necessary to control the disease...
  17. ncbi request reprint Generalized essential telangiectasia successfully treated with high-energy, long-pulse, frequency-doubled Nd:YAG laser
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Dermatol Surg 27:355-7. 2001
    ..Generalized essential telangiectasia is a rare cutaneous disorder with limited therapeutic options...
  18. ncbi request reprint Balneophototherapy of psoriasis: highly concentrated salt water versus tap water--a randomized, one-blind, right/left comparative study
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Rödermark, Germany
    Photodermatol Photoimmunol Photomed 17:22-5. 2001
    ....
  19. ncbi request reprint Ultraviolet protection by summer textiles. Ultraviolet transmission measurements verified by determination of the minimal erythema dose with solar-simulated radiation
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Br J Dermatol 144:484-9. 2001
    ..Usually, the UPF of a textile is determined by spectrophotometric assessment of the UV transmission (in vitro method)...
  20. doi request reprint Human papillomavirus-associated induction of human beta-defensins in anal intraepithelial neoplasia
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    Br J Dermatol 160:1197-205. 2009
    ..Antimicrobial peptides and proteins (AMPs) are widely distributed effector molecules of the innate immune system with well-known antibacterial activity. However, there is a paucity of information regarding antiviral effects of AMPs...
  21. ncbi request reprint Optical coherence tomography of cutaneous lupus erythematosus correlates with histopathology
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Lupus 16:35-8. 2007
    ..Nevertheless, the current technique does not allow one to visualize definite diagnostic features of cutaneous LE. However, OCT may be a promising method for objective monitoring of LE activity and treatment effects over time in vivo...
  22. ncbi request reprint Increased expression of TGF-beta/Smad proteins in basal cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Eur J Med Res 12:509-14. 2007
    ..There is an increasing evidence that the development of cutaneous epithelial tumours is pathogenetically linked to dysregulations of the transforming growth factor beta (TGF-beta) and its signalling molecules, the Smads...
  23. doi request reprint Expression of antimicrobial peptides and proteins in etanercept-treated psoriasis patients
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Regul Pept 167:163-6. 2011
    ..We have demonstrated that etanercept-induced improvement of psoriasic lesions is associated with a significant decline of AMP protein expression...
  24. ncbi request reprint Ultraviolet A1-induced downregulation of human beta-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 155:600-7. 2006
    ..Ultraviolet (UV) A1 phototherapy, the most recent advance in the treatment of LS, targets T-cell dermal inflammatory infiltrates via induction of various cytokines and soluble factors besides well-known effects on collagen metabolism...
  25. doi request reprint Etanercept plus narrowband ultraviolet B phototherapy of psoriasis is more effective than etanercept monotherapy at 6 weeks
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    Br J Dermatol 164:1383-6. 2011
    ..A substantial portion of patients with psoriasis does not achieve a satisfactory response under antitumour necrosis factor (TNF)-α biological therapies...
  26. ncbi request reprint Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Pediatr Dermatol 18:241-5. 2001
    ..Further controlled studies are necessary to investigate whether this combined therapy is superior to UVA1 phototherapy alone...
  27. doi request reprint Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 162:1269-77. 2010
    ..There is a paucity of data published on the progression of high-grade AIN to invasive cancer as well as on clinical and virological characteristics comparing anal margin and anal canal carcinoma...
  28. doi request reprint The expression of antimicrobial peptides is significantly altered in cutaneous squamous cell carcinoma and precursor lesions
    N Scola
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 167:591-7. 2012
    ..Antimicrobial peptides and proteins are not only effectors of the immune system but are also attributed important roles in tumour progression or tumour suppression in several malignancies such as oral squamous cell carcinoma (SCC)...
  29. doi request reprint Serum levels of antimicrobial peptides and proteins do not correlate with psoriasis severity and are increased after treatment with fumaric acid esters
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Arch Dermatol Res 304:471-4. 2012
    ..Increased serum AMP protein levels in psoriasis resolution are an unexpected observation that needs to be investigated more in detail in future studies...
  30. ncbi request reprint UVA1 and UVB irradiated skin investigated by optical coherence tomography in vivo: a preliminary study
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 30:79-82. 2005
    ..However, further studies are needed to establish its measurement precision and validity, and to investigate in vivo spectral dependence on UV induced skin changes such as skin thickening...
  31. ncbi request reprint Epidermal thickness assessed by optical coherence tomography and routine histology: preliminary results of method comparison
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    J Eur Acad Dermatol Venereol 20:791-5. 2006
    ..However, there is a lack of systematic studies comparing OCT with histology...
  32. doi request reprint Differential expression of connective tissue growth factor and extracellular matrix proteins in lichen sclerosus
    T Gambichler
    Department of Dermatology Department of Medicine I, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 26:207-12. 2012
    ..The histopathology of lichen sclerosus (LS) suggests abnormalities in extracellular matrix (ECM) composition...
  33. ncbi request reprint Changes of antimicrobial peptide mRNA expression in atopic eczema following phototherapy
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, Bochum, Germany
    Br J Dermatol 155:1275-8. 2006
    ..Hence, AMPs may represent important cofactors in the pathogenesis of AE...
  34. ncbi request reprint Histomorphologic correlation with routine histology and optical coherence tomography
    F G Bechara
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Skin Res Technol 10:169-73. 2004
    ..We describe a method that makes evaluation and definition of specific morphologic structures of skin tumours via OCT more accurate...
  35. doi request reprint Immunophenotyping of inflammatory cells in subacute prurigo
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 25:221-6. 2011
    ..Subacute prurigo (SP) is a relatively common disease of papular cutaneous lesions that itch intensely. However, there is a lack of systematic clinical and histological studies on SP...
  36. ncbi request reprint Expression of human beta-defensins in patients with mycosis fungoides
    T Gambichler
    Department of Dermatology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Arch Dermatol Res 299:221-4. 2007
    ..We observed an identical pattern of hBD expression in MD and AD suggesting a common regulatory mechanism that might mainly be driven by T helper 2 lymphocytes...
  37. doi request reprint Medium-dose ultraviolet (UV) A1 vs. narrowband UVB phototherapy in atopic eczema: a randomized crossover study
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Br J Dermatol 160:652-8. 2009
    ..Ultraviolet (UV) A1 and narrowband (NB)-UVB have been reported to be effective treatments for atopic eczema (AE)...
  38. ncbi request reprint Repeatability of in vitro measurements of the ultraviolet protection factor (UPF) by spectrophotometry with automatic sampling
    K Hoffmann
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Skin Res Technol 7:223-6. 2001
    ..We report here spectrophotometric measurements of textiles using a newly developed autosampler. Measurement precision was evaluated under repeatable conditions...
  39. doi request reprint Impact of etanercept treatment on ultraviolet B-induced inflammation, cell cycle regulation and DNA damage
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 164:110-5. 2011
    ..Current studies indicate that treatment with tumour necrosis factor (TNF)-α blockers plus ultraviolet (UV) B phototherapy results in higher relative Psoriasis Area and Severity Index reduction as compared with TNF-α monotherapy...
  40. doi request reprint A randomized, half-side comparative study of aminolaevulinate photodynamic therapy vs. CO(2) laser ablation in immunocompetent patients with multiple actinic keratoses
    N Scola
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 167:1366-73. 2012
    ..Photodynamic therapy (PDT) and laser ablation (LA) are frequently used treatment options for multiple actinic keratoses (AK), yet they have not been compared head to head...
  41. doi request reprint Expression of microRNAs in basal cell carcinoma
    M Sand
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, 44791 Bochum, Germany
    Br J Dermatol 167:847-55. 2012
    ..Perturbations in the expression profiles of microRNAs (miRNAs) have been reported for a variety of different cancers. Differentially expressed miRNAs have not been systematically evaluated in basal cell carcinoma (BCC) of the skin...
  42. doi request reprint The impact of salt water soaks on biophysical and molecular parameters in psoriatic epidermis equivalents
    T Gambichler
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Dermatology 223:230-8. 2011
    ..The exact mechanisms of action of balneophototherapy are incompletely understood. We aimed to investigate the effect of salt water soaks on ultraviolet (UV) transmission and the expression of molecular parameters of psoriasis...
  43. doi request reprint [Acquired reactive perforating collagenosis following herpes zoster as isotopic response?]
    N Scola
    Klinik fur Dermatologie, Venerologie und Allergologie, Ruhr Universitat Bochum, Bochum, Deutschland
    Hautarzt 62:683-7. 2011
    ..We report the sixth case of a herpes zoster-associated reactive perforating collagenosis and discuss the current literature...
  44. doi request reprint Gene expression of cytokines in atopic eczema before and after ultraviolet A1 phototherapy
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Br J Dermatol 158:1117-20. 2008
    ..Atopic eczema (AE) is a common pruritic and chronically relapsing inflammatory skin disease in which cytokines seem to represent important factors in the pathogenesis...
  45. ncbi request reprint Significant downregulation of transforming growth factor-beta signal transducers in human skin following ultraviolet-A1 irradiation
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Br J Dermatol 156:951-6. 2007
    ....
  46. ncbi request reprint A randomised controlled trial on photo(chemo)therapy of subacute prurigo
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 31:348-53. 2006
    ..Psoralen ultraviolet A (PUVA) is the standard photo(chemo)therapeutic regimen for patients suffering from subacute prurigo (SP)...
  47. doi request reprint Clonal T-cell populations are frequent in the skin and blood of patients with systemic sclerosis
    A Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 161:785-90. 2009
    ..Pilot studies were suggestive for a role of clonal T cells in the pathogenesis of systemic sclerosis (SSc)...
  48. ncbi request reprint Validation of optical coherence tomography in vivo using cryostat histology
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Phys Med Biol 52:N75-85. 2007
    ..Furthermore, the comparisons with the in vivo OCT profiles demonstrate that cryostat sectioning provides a better preservation of relative and absolute dimensions of skin layers than paraffin embedding...
  49. doi request reprint Expression of minichromosome maintenance proteins in Merkel cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 23:1184-8. 2009
    ..We aimed to assess whether MCM immunohistochemistry can be utilized to examine tumour proliferation in Merkel cell carcinoma (MCC)...
  50. doi request reprint Diversity of human papillomavirus types in periungual squamous cell carcinoma
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 161:1262-9. 2009
    ..There is accumulating evidence that infections with certain high-risk alpha-human papillomaviruses (HPVs) are involved in the pathogenesis of digital squamous cell carcinomas (SCCs) and their precursor lesions (SCCs in situ)...
  51. ncbi request reprint Defined UV protection by apparel textiles
    K Hoffmann
    Department of Dermatology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol 137:1089-94. 2001
    ..The use of UV blocking fabrics can provide excellent protection against the hazards of sunlight; this is especially true for garments manufactured as UV protective clothing...
  52. ncbi request reprint Effects of repeated sunbed exposures on the human skin. In vivo measurements with confocal microscopy
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, Bochum D 44791, Germany
    Photodermatol Photoimmunol Photomed 20:27-32. 2004
    ..Although it is well accepted that sunbed exposure significantly increases melanin pigmentation, its capacity to induce epidermal thickening is discussed controversially...
  53. ncbi request reprint Quantification of ultraviolet protective effects of pityriacitrin in humans
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, Bochum, Germany
    Arch Dermatol Res 299:517-20. 2007
    ..In conclusion, the UV protective effect of PIT is all in all very weak suggesting that PIT is likely only an inferior cofactor in the development of hypopigmentation in pityriasis versicolor alba lesions following sun exposure...
  54. ncbi request reprint In vitro and in vivo determination of the UV protection factor for lightweight cotton and viscose summer fabrics: a preliminary study
    K Hoffmann
    Department of Dermatology, Ruhr University, Bochum, Germany
    J Am Acad Dermatol 43:1009-16. 2000
    ....
  55. ncbi request reprint Change in ultraviolet (UV) transmission following the application of vaseline to non-irradiated and UVB-exposed split skin
    K Hoffmann
    Department of Dermatology, Clinical and Experimental Photodermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 143:532-8. 2000
    ..Topical preparations such as emollients used in combination with phototherapy can interfere with such treatment...
  56. ncbi request reprint Mechanisms of apoptosis: UVA1-induced immediate and UVB-induced delayed apoptosis in human T cells in vitro
    F Breuckmann
    Department of Dermatology, Ruhr University Bochum, Germany
    J Eur Acad Dermatol Venereol 17:418-29. 2003
    ..The purpose of our study was to determine the regulating pathway, time course and dose dependence of UVA1- vs. UVB-induced cell death in human T lymphocytes...
  57. ncbi request reprint Mycophenolate sodium for subacute cutaneous lupus erythematosus resistant to standard therapy
    A Kreuter
    Connective Tissue Disease Research Unit, Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Br J Dermatol 156:1321-7. 2007
    ..Immunosuppressive agents are usually considered a second-line approach in patients with resistant disease...
  58. pmc Primary merkel cell carcinoma clinically presenting as deep oedematous mass of the groin
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Eur J Med Res 15:274-6. 2010
    ..MCC showing the aforementioned features may be associated with significant delay of diagnosis and therefore represents an unfavourable prognostic factor...
  59. ncbi request reprint Expression of proliferation markers and cell cycle regulators in T cell lymphoproliferative skin disorders
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    J Dermatol Sci 49:125-32. 2008
    ..Abnormal cell proliferation, which results from deregulation of the cell cycle, is fundamental in tumorigenesis...
  60. doi request reprint Altered gene expression in squamous cell carcinoma arising from congenital unilateral linear porokeratosis
    N Scola
    Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Germany
    Clin Exp Dermatol 37:781-5. 2012
    ..Speculatively, p16(INK4a) and psoriasin could be involved in the pathogenesis of CULP. Moreover, psoriasin may play a role in the malignant transformation of CULP to SCC...
  61. ncbi request reprint The European standard for sun-protective clothing: EN 13758
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse, Bochum, Germany
    J Eur Acad Dermatol Venereol 20:125-30. 2006
    ....
  62. ncbi request reprint Immunohistochemical investigation of mid-dermal elastolysis
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 29:192-5. 2004
    ..Our data may indicate inflammatory processes and an altered balance between MMPs and TIMPs in MDE. Furthermore CD34+ dendritic fibroblasts and/or histiocytes are possibly involved in the pathogenesis of MDE...
  63. ncbi request reprint Investigation of basal cell carcinoma [correction of carcionoma] by confocal laser scanning microscopy in vivo
    K Sauermann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Skin Res Technol 8:141-7. 2002
    ..Aim of this study was to investigate basal cell carcinoma (BCC) using in vivo CLSM, and to compare the micromorphologic features of BCC with uninvolved skin...
  64. ncbi request reprint Cytokine mRNA expression in basal cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, Bochum 44791, Germany
    Arch Dermatol Res 298:139-41. 2006
    ..In accordance with previous studies our data suggest a role for IL-6 and IL-8 in the development and/or progression of BCC, since mRNA expression of both CKs are significantly increased in tumour tissue...
  65. pmc Pattern of mRNA expression of beta-defensins in basal cell carcinoma
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Cancer 6:163. 2006
    ..The present work was aimed on the study of hBD gene expression in basal cell carcinoma (BCC) which is the most common cancer in humans...
  66. doi request reprint Expression of extracellular matrix proteins in reticular variant of mid-dermal elastolysis
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 24:1481-4. 2010
    ..Mid-dermal elastolysis (MDE) is a rare disorder of the elastic tissue that is characterized histopathologically by selective loss of elastic fibres in the mid dermis...
  67. doi request reprint Evaluation of sun awareness with an emphasis on ultraviolet protection by clothing: a survey of adults in Western Germany
    T Gambichler
    Department of Dermatology, Ruhr University of Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    J Eur Acad Dermatol Venereol 24:155-62. 2010
    ..Little is known about the sun habits of the population in Germany...
  68. doi request reprint Significant upregulation of antimicrobial peptides and proteins in lichen sclerosus
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, D 44791 Bochum, Germany
    Br J Dermatol 161:1136-42. 2009
    ..Inflamed and injured epithelia are a particularly rich source of antimicrobial peptides and proteins (AMPs)...
  69. ncbi request reprint Reference limits for erythema-effective UV doses
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Photochem Photobiol 82:1097-102. 2006
    ..Although the MED data given here are limited to the phototest device used in the present study, the SED results establish comparability between our data and phototest results obtained from laboratories using different UV sources...
  70. ncbi request reprint p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 157:523-30. 2007
    ..In a pilot study, imiquimod, a topical immune response modifier, has been reported to be beneficial in the treatment of AIN...
  71. ncbi request reprint Fumaric acid esters in necrobiosis lipoidica: results of a prospective noncontrolled study
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 153:802-7. 2005
    ..In recent case reports, fumaric acid esters (FAE) have been reported to be effective in granulomatous skin diseases such as granuloma annulare, cutaneous sarcoidosis and NL...
  72. ncbi request reprint Nephrogenic fibrosing dermopathy
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 29:258-60. 2004
    ..Because the pathogenesis of NFD may not entirely be attributable to haemodialysis, the role of circulating factors in the development of cutaneous manifestations requires further investigation...
  73. doi request reprint Non-invasive imaging of mid-dermal elastolysis
    N Scola
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 36:155-60. 2011
    ..Our preliminary findings indicate that noninvasive skin imaging methods such as OCT and HFUS might be suitable techniques for the evaluation and monitoring of elastolytic skin disorders such as MDE...
  74. ncbi request reprint UV transmission measurements of small skin specimens with special quartz cuvettes
    K Hoffmann
    Department of Dermatology, Ruhr University, Bochum, Germany
    Dermatology 201:307-11. 2000
    ..The penetration of different wavelengths of UV radiation through human skin is of major importance, especially for the determination of photoprotective properties of sunscreens and UV-protective clothes...
  75. ncbi request reprint Mononuclear cells in atopic dermatitis in vivo: immunomodulation of the cutaneous infiltrate by medium-dose UVA1 phototherapy
    F Breuckmann
    Department of Dermatology, Ruhr University Bochum, Germany
    Eur J Med Res 7:315-22. 2002
    ..The purpose of our study was to investigate the extent to which UVA1 irradiation is able to modulate the mononuclear dermal inflammatory infiltrate using different monoclonal antibodies...
  76. pmc Pimecrolimus 1% cream for anogenital lichen sclerosus in childhood
    Stefanie Boms
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    BMC Dermatol 4:14. 2004
    ..Because of the potential side effects of repeated local application of potent glucocorticosteroids, equally-effective, safer therapeutic options are required, especially in the treatment of children...
  77. doi request reprint Tacrolimus ointment neither blocks ultraviolet B nor affects expression of thymine dimers and p53 in human skin
    Thilo Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Dermatol Sci 50:115-22. 2008
    ..There is a lack of data with regard to the interaction between ultraviolet (UV) radiation and topical calcineurin inhibitors...
  78. doi request reprint Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Invest Dermatol 128:2316-24. 2008
    ..In view of the PIN prevalence found in our study, all HIV+MSM should be screened for PIN in addition to AIN screening...
  79. ncbi request reprint Impact of amphotericin B on the cytochrome P450 system in HIV-infected patients
    Norbert H Brockmeyer
    Department of Dermatology, Ruhr University Bochum, Gudrunstr, Germany
    Eur J Med Res 9:51-4. 2004
    ..To investigate whether cytochrome P450-dependent enzymes are influenced by amphotericin B (Am-B) during the treatment of Candida oesophagitis in HIV-infected patients...
  80. ncbi request reprint Diagnostic and neural analysis of skin cancer (DANAOS). A multicentre study for collection and computer-aided analysis of data from pigmented skin lesions using digital dermoscopy
    K Hoffmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 149:801-9. 2003
    ..A prototype for the computer-aided diagnosis of PSLs using artificial neural networks (NNs) has recently been developed: diagnostic and neural analysis of skin cancer (DANAOS)...
  81. ncbi request reprint Ultraviolet A1 phototherapy decreases inhibitory SMAD7 gene expression in localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 298:265-72. 2006
    ..UVA1 phototherapy demonstrated the alteration of SMAD7 gene expression in LS, as SMAD7 mRNA levels normalized after UVA1. The pathogenetic relevance of SMAD7 levels with respect to clinical improvement needs further investigation...
  82. doi request reprint Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 63:490-8. 2010
    ..Early diagnosis and treatment of AIN might prevent development of anal cancer...
  83. doi request reprint Pulsed high-dose corticosteroids combined with low-dose methotrexate treatment in patients with refractory generalized extragenital lichen sclerosus
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 145:1303-8. 2009
    ..This combination therapy should be considered in generalized disease, especially disease that is refractory to conventional treatment...
  84. ncbi request reprint Erbium:YAG laser-assisted preparation of a combined dermal/full thickness sandwich skin graft
    Falk G Bechara
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Dermatol Surg 32:353-8. 2006
    ..Skin grafting is a common procedure to close defects after tumor resection. However, delicate areas such as the heel or the sole of the foot can be closed with a specially designed graft as described in this article...
  85. doi request reprint Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men
    Alexander Kreuter
    1Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Invest Dermatol 128:2078-83. 2008
    ..However, new AIN lesions associated with previously undetected HPV types frequently occur in untreated areas...
  86. doi request reprint Detection of clonal T cells in the circulation of patients with nephrogenic systemic fibrosis
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 145:1164-9. 2009
    ..Conclusion As in systemic sclerosis, clonally expanded T-cell populations could play a critical role in the pathogenesis of nephrogenic systemic fibrosis, probably as an in vivo-activated inflammatory response to gadolinium exposure...
  87. ncbi request reprint Changes in venous refilling time from childhood to adulthood in subjects with apparently normal veins
    Markus Stucker
    Department of Dermatology and Allergology, St Josef Hospital, Ruhr University Bochum, Germany
    J Vasc Surg 41:296-302. 2005
    ..original) pupils of 11 secondary schools in the city of Bochum, Germany at four different periods (BO I 1982-1983, 10 to 12 years; BO II 1986-1987, 14 to 16 years; BO III 1991, 18 to 20 years; and BO IV 2001-2002, 29 to 31 years), 1990..
  88. ncbi request reprint A randomized controlled study of low-dose UVA1, medium-dose UVA1, and narrowband UVB phototherapy in the treatment of localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    J Am Acad Dermatol 54:440-7. 2006
    ..To date, a randomized comparison study to evaluate the efficacy and safety of different, commonly used phototherapeutic modalities in LS is still outstanding...
  89. doi request reprint Cytokine mRNA levels in human fat tissue after injection lipolysis with phosphatidylcholine and deoxycholate
    Falk G Bechara
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol Res 300:455-9. 2008
    ..Injection lipolysis induces acute panniculitis within the treated fat tissue, associated with changes of the cytokine profile. However, their pathogenetic relevance with respect to clinical dissolving of fat needs further investigation...
  90. doi request reprint [AWMF Guideline no. 013/066. Diagnosis and therapy of circumscribed scleroderma]
    Alexander Kreuter
    Dermatologische Klinik der Ruhr Universität Bochum
    J Dtsch Dermatol Ges 7:S1-14. 2009
    ....
  91. ncbi request reprint Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol 141:847-52. 2005
    ..To evaluate the efficacy of pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy in patients with severe localized scleroderma (LS)...
  92. doi request reprint Hyaluronic acid new formulation: experience in HIV-associated facial lipoatrophy
    Falk G Bechara
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Dermatology 217:244-9. 2008
    ..Facial lipoatrophy (FLA) is a stigmatizing complication of antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection...
  93. doi request reprint High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides
    Alexander Kreuter
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 144:1011-6. 2008
    ..The pathogenetic relevance of HHV-8 in cutaneous T-cell lymphoma is controversial. Recently, a highly significant association of HHV-8 in LPP was found, which suggests a role in the pathogenesis of this disease...
  94. doi request reprint Lupus erythematosus tumidus: response to antimalarial treatment in 36 patients with emphasis on smoking
    Alexander Kreuter
    Connective Tissue Disease Research Unit, Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol 145:244-8. 2009
    ..To determine the efficacy of antimalarial drug use in patients with lupus erythematosus tumidus...
  95. doi request reprint Merkel cell polyomavirus infection in HIV-positive men
    Ulrike Wieland
    Institute of Virology, National Reference Center for Papillomaviruses and Polyomaviruses, University of Cologne, Cologne, Germany
    Arch Dermatol 147:401-6. 2011
    ..To evaluate Merkel cell polyomavirus (MCPyV) DNA prevalence and load among men with human immunodeficiency virus (HIV) (hereafter referred to as HIV-positive men) and among healthy male control subjects...
  96. ncbi request reprint Assessment of quality of life in patients with primary axillary hyperhidrosis before and after suction-curettage
    Falk G Bechara
    Departments of Dermatology, Ruhr University Bochum, Germany
    J Am Acad Dermatol 57:207-12. 2007
    ..However, changes of quality of life after minimally invasive surgical procedures such as suction-curettage (SC) have not been investigated so far...
  97. ncbi request reprint Comparison of methods: determination of UV protection of clothing
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Germany
    Recent Results Cancer Res 160:55-61. 2002
    ..Taken together, the in vitro method is the most practicable and inexpensive method for routine measurements of UPF, but dosimetry seems to be a highly useful method for determining the UPF in real exposure situations...
  98. ncbi request reprint 1% pimecrolimus, 0.005% calcipotriol, and 0.1% betamethasone in the treatment of intertriginous psoriasis: a double-blind, randomized controlled study
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University of Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Arch Dermatol 142:1138-43. 2006
    ..Recently, both pimecrolimus and tacrolimus have been investigated for this indication and shown to be safe and effective. So far, to our knowledge, a comparison of one of these drugs with standard regimens for IP has not been performed...
  99. ncbi request reprint Low-dose ultraviolet A1 phototherapy for extragenital lichen sclerosus: results of a preliminary study
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    J Am Acad Dermatol 46:251-5. 2002
    ....
  100. ncbi request reprint Pulsed intravenous immunoglobulin therapy in livedoid vasculitis: an open trial evaluating 9 consecutive patients
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University, Bochum, Germany
    J Am Acad Dermatol 51:574-9. 2004
    ..However, no continuing benefit has been reported in any of these modalities. Recently, encouraging case reports about the successful use of intravenous immunoglobulin (IVIg) in LV have been published...
  101. doi request reprint MicroRNAs and the skin: tiny players in the body's largest organ
    Michael Sand
    Department of Dermatology, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    J Dermatol Sci 53:169-75. 2009
    ..Disruption of miRNA metabolism is also involved in wound healing and inflammatory skin conditions. Here, we review the role of miRNAs in cutaneous biology...