Markus G Rudolph

Summary

Country: Germany

Publications

  1. ncbi request reprint A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects
    Markus G Rudolph
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 172:2994-3002. 2004
  2. ncbi request reprint Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gammadelta T-cell ligand T10
    Markus G Rudolph
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Crystallogr D Biol Crystallogr 60:656-64. 2004
  3. pmc Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions
    John G Luz
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:1175-86. 2002
  4. ncbi request reprint Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B
    Markus G Rudolph
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 324:975-90. 2002
  5. ncbi request reprint Structural and thermodynamic correlates of T cell signaling
    Markus G Rudolph
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Annu Rev Biophys Biomol Struct 31:121-49. 2002
  6. ncbi request reprint Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta
    Markus G Rudolph
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Crystallogr D Biol Crystallogr 59:290-8. 2003
  7. ncbi request reprint The specificity of TCR/pMHC interaction
    Markus G Rudolph
    The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 14:52-65. 2002
  8. ncbi request reprint Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme
    Achim Dickmanns
    Abteilung Molekulare Strukturbiologie, Institut fur Mikrobiologie und Genetik, Georg August Universitat, Justus von Liebig Weg 9, D 37077 Gottingen, Germany
    J Biol Chem 280:15180-7. 2005
  9. ncbi request reprint Purification, crystallization and preliminary X-ray analysis of the GTP-binding protein Rab9 implicated in endosome-to-TGN vesicle trafficking
    Julia G Wittmann
    Molecular Structural Biology, University of Gottingen, Justus von Liebig Weg 11, Goettingen D 37077, Germany
    Acta Crystallogr D Biol Crystallogr 60:580-2. 2004
  10. ncbi request reprint Pseudo-merohedral twinning in monoclinic crystals of human orotidine-5'-monophosphate decarboxylase
    Julia G Wittmann
    Department of Molecular Structural Biology, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Acta Crystallogr D Biol Crystallogr 63:744-9. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects
    Markus G Rudolph
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 172:2994-3002. 2004
    ....
  2. ncbi request reprint Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gammadelta T-cell ligand T10
    Markus G Rudolph
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Crystallogr D Biol Crystallogr 60:656-64. 2004
    ..46. Native Patterson analyses pointed to the presence of pseudo-translation among the four molecules present in the asymmetric unit. Data analysis, structure determination and model refinement are discussed...
  3. pmc Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions
    John G Luz
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:1175-86. 2002
    ..Thus, the allogeneic mutation causes the same peptide to be presented differently, temporally and spatially, by the allogeneic and syngeneic MHCs...
  4. ncbi request reprint Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B
    Markus G Rudolph
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 324:975-90. 2002
    ..This loop change contributes to profound changes in the shape of the A-pocket in the peptide-binding groove and may explain the function of RT1-A1(c) as an inhibitory natural killer cell ligand...
  5. ncbi request reprint Structural and thermodynamic correlates of T cell signaling
    Markus G Rudolph
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Annu Rev Biophys Biomol Struct 31:121-49. 2002
    ....
  6. ncbi request reprint Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta
    Markus G Rudolph
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Crystallogr D Biol Crystallogr 59:290-8. 2003
    ..35) and SeMet (alpha approximately 0.40) forms. Structure determination and refinement are discussed with emphasis on the possible reasons for successful phasing using untreated twinned MAD data...
  7. ncbi request reprint The specificity of TCR/pMHC interaction
    Markus G Rudolph
    The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 14:52-65. 2002
    ..Alloreactive-complex structures determined or modelled so far indicate increased interactions of the TCR beta-chain with the pMHC compared with their syngeneic counterparts...
  8. ncbi request reprint Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme
    Achim Dickmanns
    Abteilung Molekulare Strukturbiologie, Institut fur Mikrobiologie und Genetik, Georg August Universitat, Justus von Liebig Weg 9, D 37077 Gottingen, Germany
    J Biol Chem 280:15180-7. 2005
    ..The putative peptide binding site is buried between the monomers, indicating a biological significance of the dimer. The structure suggests the capability of pFGE to form a heterodimer with FGE...
  9. ncbi request reprint Purification, crystallization and preliminary X-ray analysis of the GTP-binding protein Rab9 implicated in endosome-to-TGN vesicle trafficking
    Julia G Wittmann
    Molecular Structural Biology, University of Gottingen, Justus von Liebig Weg 11, Goettingen D 37077, Germany
    Acta Crystallogr D Biol Crystallogr 60:580-2. 2004
    ..The crystallization of Rab9, a key regulatory component in the recycling of mannose-6-phosphate receptors from endosomes to the trans-Golgi network, is described here...
  10. ncbi request reprint Pseudo-merohedral twinning in monoclinic crystals of human orotidine-5'-monophosphate decarboxylase
    Julia G Wittmann
    Department of Molecular Structural Biology, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Acta Crystallogr D Biol Crystallogr 63:744-9. 2007
    ..44. Data analysis, the origin of the twinning and structure determination are discussed...
  11. ncbi request reprint Probing the oxygen-binding site of the human formylglycine-generating enzyme using halide ions
    Dirk Roeser
    Department of Molecular Structural Biology, University of Gottingen, D 37077 Gottingen, Germany
    Acta Crystallogr D Biol Crystallogr 63:621-7. 2007
    ..Unexpectedly, data collected at a wavelength of 1.54 A from the iodide-containing crystal and data collected at a wavelength of 0.8 A from a bromide-containing crystal were sufficient for SIRAS phasing...
  12. ncbi request reprint Crystal structure and nucleotide binding of the Thermus thermophilus RNA helicase Hera N-terminal domain
    Markus G Rudolph
    Department of Molecular Structural Biology, University of Gottingen, D 37077 Gottingen, Germany
    J Mol Biol 361:731-43. 2006
    ..It is possible that this mode of dimerization represents the prototypic architecture in RNA helicases of thermophilic origin...
  13. ncbi request reprint How TCRs bind MHCs, peptides, and coreceptors
    Markus G Rudolph
    Department of Molecular Structural Biology, University of Gottingen, 37077 Gottingen, Germany
    Annu Rev Immunol 24:419-66. 2006
    ..Notwithstanding, the impressive array of self, foreign (microbial), and autoimmune TCR complexes have uncovered the diverse ways in which antigens can be specifically recognized by TCRs...
  14. ncbi request reprint De novo calcium/sulfur SAD phasing of the human formylglycine-generating enzyme using in-house data
    Dirk Roeser
    Department of Molecular Structural Biology, University of Gottingen, D 37077 Gottingen, Germany
    Acta Crystallogr D Biol Crystallogr 61:1057-66. 2005
    ..This work emphasizes the usefulness of de novo phasing using weak anomalous scatterers and in-house data...
  15. ncbi request reprint Crystal structure of Rab9 complexed to GDP reveals a dimer with an active conformation of switch II
    Julia G Wittmann
    Department of Molecular Structural Biology and GZMB, Justus von Liebig Weg 11, Georg August University, 37077 Gottingen, Germany
    FEBS Lett 568:23-9. 2004
    ..GDP displays activated switch region conformations, mimicking those of the GTP state. A hydrophobic tetrad is formed resembling an effector-discriminating epitope found only in GTP-bound Rab proteins...
  16. doi request reprint Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design
    Julia G Wittmann
    Department of Molecular Structural Biology, University of Gottingen, Gottingen, Germany
    Structure 16:82-92. 2008
    ..This mechanism can also explain the observed catalytic promiscuity of OMPD...