Research Topics
| Thomas RudigerSummaryCountry: Germany Publications
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Detail Information
Publications
Differential diagnosis between classic Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and paragranuloma by paraffin immunohistochemistryT Rudiger
Department of Pathology, University of Wurzburg, Germany
Am J Surg Pathol 22:1184-91. 1998....
Workshop report on Hodgkin's disease and related diseases ('grey zone' lymphoma)T Rudiger
University of Wurzburg, Germany
Ann Oncol 9:S31-8. 1998..A distinctive subset of cases representing mediastinal large B-cell lymphomas with features of Hodgkin's lymphoma was identified...
[Peripheral NK/T-cell lymphoma]T Rudiger
Institut fur Pathologie, Universitat Wurzburg
Pathologe 28:55-8. 2007..In addition, there is a clonal infection by Epstein-Barr virus in the T-lymphocytes. In the differential diagnosis, B-cell lymphomas are more frequent at all localizations than T- or NK-cell lymphomas...
Workshop on the relationship between nodular lymphocyte predominant Hodgkin's lymphoma and T cell/histiocyte-rich B cell lymphomaT Rudiger
Department of Pathology, University of Wurzburg, Germany
Ann Oncol 13:44-51. 2002
Quality assurance in immunohistochemistry: results of an interlaboratory trial involving 172 pathologistsThomas Rudiger
Institute of Pathology, Technical University Munchen, Germany
Am J Surg Pathol 26:873-82. 2002..Multisample tissue blocks provide a promising tool to standardize quantitative immunohistochemical parameters, such as receptor or proliferation scores...
[WHO-classification of malignant lymphomas]T Rudiger
Institut fur Pathologie, Universitat Wurzburg
Radiologe 42:936-42. 2002..Therefore,patients should be treated within such a study...
[Interlaboratory trial 2000 " Immunohistochemistry" of the German Society for Pathology and the Professional Association of German Pathologists]T Rudiger
Institut fur Pathologie, Universitat Wurzburg
Pathologe 24:70-8. 2003....
Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphomaLudmila Boudova
Department of Pathology, Josef Schneider Str 2, D 97080 Wurzburg, Germany
Blood 102:3753-8. 2003..This morphologic pattern suggests a biologic continuum between NLPHL and T/HRBCL...
Peripheral T-cell lymphoma with progression to a clonally related, Epstein Barr virus+, cytotoxic aggressive T-cell lymphoma: evidence for secondary EBV infection of an established malignant T-cell cloneRupert Langer
Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
Am J Surg Pathol 34:1382-7. 2010..This case shows that secondary EBV infection of an established malignant T-cell clone can occur and may contribute to aggressive transformation of PTCL...
CD52 expression in peripheral T-cell lymphomas determined by combined immunophenotyping using tumor cell specific T-cell receptor antibodiesEva Geissinger
Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany
Leuk Lymphoma 50:1010-6. 2009..Our approach helps to precisely define CD52 expression in the tumor cell population of PTCL and might therefore be valuable when evaluating the response to alemtuzumab therapy in prospective clinical trials...
Evaluation of FoxP3 expression in peripheral T-cell lymphomaIrina Bonzheim
Institute of Pathology, University of Wurzburg, Wurzburg, Germany
Am J Clin Pathol 130:613-9. 2008..Among ALCL cases, 4 of 6 ALK+ cases displayed weak and inhomogeneous FoxP3 expression in the tumor cells. FoxP3+ PTCL-NOS presumably derived from bona fide Treg cells occurs but seems rare in the Western population...
Genomic profiling of peripheral T-cell lymphoma, unspecified, and anaplastic large T-cell lymphoma delineates novel recurrent chromosomal alterationsAndreas Zettl
Department of Pathology, University of Wurzburg, Wurzburg, Germany
Am J Pathol 164:1837-48. 2004..The genetics of PTCL NOS and ALK-negative ALCL differ from other T-NHLs characterized genetically so far, among them enteropathy-type T-cell lymphoma, T-cell prolymphocytic leukemia, and adult T-cell lymphoma/leukemia...
Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomasIrina Bonzheim
Institute of Pathology, University of Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
J Hematop 1:11-21. 2008..Therefore, SNPs in these genes are not associated with the apoptotic defect and autoimmune phenomena in AILT...
'Normal counterparts' of nodal peripheral T-cell lymphomaThomas Rudiger
Institute of Pathology, University of Wurzburg, Wurzburg, Germany
Hematol Oncol 24:175-80. 2006..A comparison between the lymphomas and their normal counterparts may contribute to the understanding of the underlying transformation mechanisms...
Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferationsEva Geissinger
Institute of Pathology, University of Wuerzburg, Josef Schneider Strasse 2, Wuerzburg, Germany
Haematologica 95:1697-704. 2010..While all these entities are characterized by proliferation of highly atypical, anaplastic CD30(+) T cells, the expression of T-cell specific antigens in the tumor cells is not consistently detectable...
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolutionZhengrong Mao
Institute of Pathology, University of Wurzburg, Germany
Am J Surg Pathol 31:1605-14. 2007..HRS or HRS-like cells in all 3 unrelated cases showed evidence of Epstein-Barr virus infection. Of interest, 5/6 cases of B-CLL with HL, and 5/6 cases of B-CLL with HRS cells showed mutated IgVH genes...
Identification of the tumor cells in peripheral T-cell lymphomas by combined polymerase chain reaction-based T-cell receptor beta spectrotyping and immunohistological detection with T-cell receptor beta chain variable region segment-specific antibodiesEva Geissinger
Institute of Pathology, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
J Mol Diagn 7:455-64. 2005..The combination of TCRVbeta polymerase chain reaction and immunohistochemistry may facilitate more reliable detection and characterization of tumor cells in PTCL...
The role of high-dose therapy in peripheral T-cell lymphomasPeter Reimer
Medizinische Poliklinik, University of Wuerzburg, Germany
Clin Lymphoma Myeloma 6:373-9. 2006..Overall, because data on high-dose therapy for PTCL are limited, larger and randomized studies are necessary to definitely confirm the preliminary results...
Autologous stem-cell transplantation as first-line therapy in peripheral T-cell lymphomas: results of a prospective multicenter studyPeter Reimer
Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Wurzburg, Germany
J Clin Oncol 27:106-13. 2009..Therefore, we initiated the first prospective multicenter study on upfront autoSCT in PTCL and recently reported good feasibility and efficacy of this approach. Here, we present the final analysis of the study...
Noninvasive imaging of angiogenesis inhibition following nitric oxide synthase blockade in the ischemic rat heart in vivoChristiane Waller
Medizinische Universitatsklinik, Wurzburg, Germany
Microcirculation 12:339-47. 2005..Nitric oxide synthase inhibition has anti-angiogenic properties. Magnetic resonance (MR) imaging was used to image the functional significance of these microvascular changes in a rat model of chronic ischemic myocardium in vivo...
Myeloablative radiochemotherapy followed by autologous peripheral blood stem cell transplantation as first-line therapy in peripheral T-cell lymphomas: first results of a prospective multicenter studyPeter Reimer
Medizinische Poliklinik, University of Wuerzburg, Klinikstr 6 8, Wuerzburg, Germany
Hematol J 5:304-11. 2004..Our data suggest a substantial impact on outcome, however, longer follow-up is necessary to confirm survival benefit...
Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrenceMartin Spahn
Department of Urology and Paediatric Urology, University of Wurzburg, Wurzburg, Germany
Int J Cancer 127:394-403. 2010..Our results showed that progressive miR-221 downregulation hallmarks metastasis and presents a novel prognostic marker in high risk PCa. This suggests that miR-221 has potential as a diagnostic marker and therapeutic target in PCa...
Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomasPhilipp Strobel
Institute of Pathology, University of Wuerzburg, Germany
Blood 100:159-66. 2002..The acquisition of the CD45RA(+) phenotype on CD4(+) T cells during terminal intratumorous thymopoiesis is associated with the presence of MG in most thymoma patients...
Cytomorphologic, immunohistochemical, and cytogenetic profiles of follicular lymphoma: 2 types of follicular lymphoma grade 3German Ott
Pathologisches Institut and Poliklinik für Innere Medizin, University of Wurzburg, Germany
Blood 99:3806-12. 2002....
