Felix Ruckert

Summary

Country: Germany

Publications

  1. doi Five primary human pancreatic adenocarcinoma cell lines established by the outgrowth method
    Felix Ruckert
    Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    J Surg Res 172:29-39. 2012
  2. doi RET-protooncogene variants in patients with sporadic neoplasms of the digestive tract and the central nervous system
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr, Dresden, Germany
    Int J Colorectal Dis 26:835-40. 2011
  3. doi Chronic pancreatitis: early results of pancreatoduodenectomy and analysis of risk factors
    Felix Ruckert
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Pancreas 40:925-30. 2011
  4. doi Quality of life in patients after pancreaticoduodenectomy for chronic pancreatitis
    Felix Ruckert
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Gastrointest Surg 15:1143-50. 2011
  5. pmc Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 47, 01307 Dresden, Germany
    BMC Cancer 10:379. 2010
  6. doi Functional analysis of LOXL2 in pancreatic carcinoma
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Int J Colorectal Dis 25:303-11. 2010
  7. pmc Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma
    F Ruckert
    Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, Dresden 01307, Germany
    Br J Cancer 99:1484-92. 2008
  8. doi Pathohistological subtype predicts survival in patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas
    Marius Distler
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Ann Surg 258:324-30. 2013
  9. doi Inhibition of MIF leads to cell cycle arrest and apoptosis in pancreatic cancer cells
    Axel Denz
    Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
    J Surg Res 160:29-34. 2010
  10. pmc Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma
    Marius Distler
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, Dresden 01307, Germany
    BMC Surg 13:12. 2013

Detail Information

Publications22

  1. doi Five primary human pancreatic adenocarcinoma cell lines established by the outgrowth method
    Felix Ruckert
    Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    J Surg Res 172:29-39. 2012
    ..New pancreatic cancer cell lines are therefore important for the study of its biology. In the present study, we report the establishment and characterization of five new pancreatic cancer cell lines (PaCaDD-43, -60, -119, -135, -137)...
  2. doi RET-protooncogene variants in patients with sporadic neoplasms of the digestive tract and the central nervous system
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr, Dresden, Germany
    Int J Colorectal Dis 26:835-40. 2011
    ..The aim of this study was to evaluate if germline variants of the RET protooncogene are associated with GBM, pancreatic cancer and gastric cancer (GC)...
  3. doi Chronic pancreatitis: early results of pancreatoduodenectomy and analysis of risk factors
    Felix Ruckert
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Pancreas 40:925-30. 2011
    ....
  4. doi Quality of life in patients after pancreaticoduodenectomy for chronic pancreatitis
    Felix Ruckert
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Gastrointest Surg 15:1143-50. 2011
    ..This retrospective study examined long-term quality of life and relief of symptoms in a homogenous consecutive cohort of 67 patients undergoing PD for chronic pancreatitis...
  5. pmc Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 47, 01307 Dresden, Germany
    BMC Cancer 10:379. 2010
    ..We aimed to compare the benefit of simultaneous gene silencing (SGS) of several candidate genes with conventional gene silencing of single genes...
  6. doi Functional analysis of LOXL2 in pancreatic carcinoma
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Int J Colorectal Dis 25:303-11. 2010
    ..To get more insight into the aggressive growth and infiltrating nature of pancreatic cancer, we evaluated the functional role of LOXL2 in pancreatic cancer cells...
  7. pmc Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma
    F Ruckert
    Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, Dresden 01307, Germany
    Br J Cancer 99:1484-92. 2008
    ..Co-expression of KLK10 and KLK6 plays an unfavourable role in PDAC. Our results suggest that this effect is likely mediated by an interaction with the factors of the extracellular matrix and enhancement of cancer cell motility...
  8. doi Pathohistological subtype predicts survival in patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas
    Marius Distler
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Ann Surg 258:324-30. 2013
    ..To investigate different subtypes of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and their prognostic value...
  9. doi Inhibition of MIF leads to cell cycle arrest and apoptosis in pancreatic cancer cells
    Axel Denz
    Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
    J Surg Res 160:29-34. 2010
    ....
  10. pmc Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma
    Marius Distler
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, Dresden 01307, Germany
    BMC Surg 13:12. 2013
    ..The goal of this study was to investigate the clinical outcome and prognostic factors in patients after resection for ductal adenocarcinoma of the pancreatic head...
  11. pmc Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden
    PLoS ONE 5:e12243. 2010
    ..Therefore, gene expression analysis of microdissected pancreatic tumor tissue was implemented in a model of the apoptosis pathway obtained by computational protein interaction prediction...
  12. pmc Google goes cancer: improving outcome prediction for cancer patients by network-based ranking of marker genes
    Christof Winter
    Department of Bioinformatics, Biotechnology Center, Technische Universitat Dresden, Dresden, Germany
    PLoS Comput Biol 8:e1002511. 2012
    ..As the amount of genomic data of individual tumors grows rapidly, our algorithm meets the need for powerful computational approaches that are key to exploit these data for personalized cancer therapies in clinical practice...
  13. pmc Curative resection of a primarily unresectable acinar cell carcinoma of the pancreas after chemotherapy
    Marius Distler
    Department of General, Thoracic and Vascular Surgery, University of Dresden, Dresden, Germany
    World J Surg Oncol 7:22. 2009
    ..At the time of diagnosis only 50% of the tumors appear to be resectable. Reliable data for an effective adjuvant or neoadjuvant treatment are not available...
  14. doi Hepatocyte nuclear factor (HNF) 4α expression distinguishes ampullary cancer subtypes and prognosis after resection
    Florian Ehehalt
    Department of General, Thoracic and Vascular Surgery, University Hospital Dresden, Germany
    Ann Surg 254:302-10. 2011
    ..To investigate biological differences and prognostic indicators of different ampullary cancer (AC) subtypes...
  15. ncbi Recent patents concerning targeted therapy of apoptosis resistance in pancreatic cancer
    Kristin Werner
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Recent Pat DNA Gene Seq 5:28-34. 2011
    ..The present review aims at giving an overview on these new treatment modalities...
  16. ncbi Palliative treatment of obstructive jaundice in patients with carcinoma of the pancreatic head or distal biliary tree. Endoscopic stent placement vs. hepaticojejunostomy
    Marius Distler
    Department of General, Thoracic, and Vascular Surgery, Technical University Hospital, Dresden, Germany
    JOP 11:568-74. 2010
    ..Palliative procedures play an important role in the treatment of malignancies of the pancreatic head/distal biliary tree, as only 20-30% can be cured by surgical resection...
  17. doi Pancreatic heterotopia of the duodenum: anatomic anomaly or clinical challenge?
    Marius Distler
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
    J Gastrointest Surg 15:631-6. 2011
    ..In most cases, these heterotopias are asymptomatic and are only incidentally detected upon pathohistological examination or autopsy. We analyzed our cases of duodenal PH with respect to their clinical relevance and impact...
  18. ncbi An update on molecular research of pancreatic adenocarcinoma
    Christian Krautz
    Department of General, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, Germany
    Anticancer Agents Med Chem 11:411-7. 2011
    ..This review provides an overview of the molecular mechanisms and pathways known to enhance development and progression of pancreatic ductal adenocarcinoma (PDAC)...
  19. doi Evaluation of the International Study Group of Pancreatic Surgery definition of post-pancreatectomy hemorrhage in a high-volume center
    Robert Grutzmann
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Surgery 151:612-20. 2012
    ..Recently, the International Study Group of Pancreatic Surgery (ISGPS) issued a new definition for PPH. To evaluate and validate this new definition, we analyzed data retrospectively from our center...
  20. doi Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling
    Christian Pilarsky
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    J Cell Mol Med 12:2823-35. 2008
    ..The overexpression of WNT5a, a gene involved in the non canonical Wnt signalling and chondrocyte development might contribute to the strong desmoplastic reaction seen in pancreatic cancer...
  21. pmc Feedback within the inter-cellular communication and tumorigenesis in carcinomas
    Felix Ruckert
    Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
    PLoS ONE 7:e36719. 2012
    ..This constant communication between the stromal cells and the tumor cells causes a perpetually activated state of tumor cells analogous to resonance disaster...
  22. ncbi Who profits from neoadjuvant radiochemotherapy for locally advanced esophageal carcinoma?
    Stephan Kersting
    Department of General, Thoracic and Vascular Surgery, School of Medicine, Dresden University of Technology, Dresden, Germany
    J Gastroenterol Hepatol 24:886-95. 2009
    ..This prospective, non-randomized trial was performed to evaluate the survival benefit of neoadjuvant radiochemotherapy prior to surgery in comparison with surgery only...