Matthias Rothermundt

Summary

Country: Germany

Publications

  1. ncbi request reprint Association between genetic variants of IL-1beta, IL-6 and TNF-alpha cytokines and cognitive performance in the elderly general population of the MEMO-study
    Bernhard T Baune
    Department of Psychiatry, School of Medicine, James Cook University, QLD 4814, Australia
    Psychoneuroendocrinology 33:68-76. 2008
  2. doi request reprint Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice
    Olaf Schulte-Herbrüggen
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, CBF, Berlin, Germany
    Neurosci Lett 442:100-3. 2008
  3. ncbi request reprint Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, Albert Schweitzer Str 11, D 48301 Muenster, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:361-4. 2007
  4. ncbi request reprint Inflammatory markers in major depression and melancholia
    M Rothermundt
    Department of Psychiatry and Psychotherapy, Westfaelische Wilhelms University, Albert Schweitzer Strasse 11, D 48129 Muenster, Germany
    J Affect Disord 63:93-102. 2001
  5. ncbi request reprint Increased S100B blood levels in unmedicated and treated schizophrenic patients are correlated with negative symptomatology
    M Rothermundt
    Department of Psychiatry, University of Muenster School of Medicine, Albert Schweitzer Str 11, D 48129 Muenster, Germany
    Mol Psychiatry 6:445-9. 2001
  6. ncbi request reprint S-100B is increased in melancholic but not in non-melancholic major depression
    M Rothermundt
    Department of Psychiatry, University of Muenster, Albert Schweitzer Str 11, D 48129 Muenster, Germany
    J Affect Disord 66:89-93. 2001
  7. ncbi request reprint S100B in schizophrenia: an update
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Gen Physiol Biophys 28:F76-81. 2009
  8. ncbi request reprint S100B serum levels and long-term improvement of negative symptoms in patients with schizophrenia
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 29:1004-11. 2004
  9. ncbi request reprint S100B in brain damage and neurodegeneration
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Microsc Res Tech 60:614-32. 2003
  10. ncbi request reprint Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study
    Patricia Ohrmann
    Department of Psychiatry, University of Muenster, Albert Schweitzer Strasse 11, D 48149 Muenster, NRW, Germany
    J Psychiatr Res 41:625-34. 2007

Detail Information

Publications40

  1. ncbi request reprint Association between genetic variants of IL-1beta, IL-6 and TNF-alpha cytokines and cognitive performance in the elderly general population of the MEMO-study
    Bernhard T Baune
    Department of Psychiatry, School of Medicine, James Cook University, QLD 4814, Australia
    Psychoneuroendocrinology 33:68-76. 2008
    ..Further research is needed to prospectively examine changes in cognitive performance in relation to cytokine genotypes...
  2. doi request reprint Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice
    Olaf Schulte-Herbrüggen
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, CBF, Berlin, Germany
    Neurosci Lett 442:100-3. 2008
    ..As referred to changes in NA levels functional studies are warranted to elucidate the link between S100B protein and the noradrenergic metabolism...
  3. ncbi request reprint Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, Albert Schweitzer Str 11, D 48301 Muenster, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:361-4. 2007
    ..Patients with increased S100B levels showed elevated myo-inositol concentrations. This pilot study demonstrates a concomitant elevation of two markers indicating astrocyte activation in a subgroup of schizophrenic patients...
  4. ncbi request reprint Inflammatory markers in major depression and melancholia
    M Rothermundt
    Department of Psychiatry and Psychotherapy, Westfaelische Wilhelms University, Albert Schweitzer Strasse 11, D 48129 Muenster, Germany
    J Affect Disord 63:93-102. 2001
    ..Since melancholic depression is psychopathologically and possibly etiologically different from non-melancholic MD, we focused on investigating immune parameters in these two subgroups...
  5. ncbi request reprint Increased S100B blood levels in unmedicated and treated schizophrenic patients are correlated with negative symptomatology
    M Rothermundt
    Department of Psychiatry, University of Muenster School of Medicine, Albert Schweitzer Str 11, D 48129 Muenster, Germany
    Mol Psychiatry 6:445-9. 2001
    ..Schizophrenic patients display a loss of astroglial integrity which is not caused by neuroleptic medication. Continuously increased S100B levels are associated with negative symptomatology...
  6. ncbi request reprint S-100B is increased in melancholic but not in non-melancholic major depression
    M Rothermundt
    Department of Psychiatry, University of Muenster, Albert Schweitzer Str 11, D 48129 Muenster, Germany
    J Affect Disord 66:89-93. 2001
    ..Recent evidence suggests that neurodegeneration may be involved in the pathophysiology of major depression. The astroglial peptide S-100B was shown to be increased in many diseases causing neuronal cell damage or degeneration...
  7. ncbi request reprint S100B in schizophrenia: an update
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Gen Physiol Biophys 28:F76-81. 2009
    ..These findings suggest that the activation of astrocytes might be an important pathogenic factor for the development of schizophrenia...
  8. ncbi request reprint S100B serum levels and long-term improvement of negative symptoms in patients with schizophrenia
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 29:1004-11. 2004
    ..This might indicate that S100B in schizophrenic patients either promotes apoptotic mechanisms by itself or is released from astrocytes as part of an attempt to repair a degenerative or destructive process...
  9. ncbi request reprint S100B in brain damage and neurodegeneration
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Microsc Res Tech 60:614-32. 2003
    ..Methodological problems are discussed and perspectives for future research are outlined...
  10. ncbi request reprint Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study
    Patricia Ohrmann
    Department of Psychiatry, University of Muenster, Albert Schweitzer Strasse 11, D 48149 Muenster, NRW, Germany
    J Psychiatr Res 41:625-34. 2007
    ....
  11. doi request reprint Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia
    Anya Pedersen
    University Medical Faculty, Department of Psychiatry, 48149 Munster, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:1789-92. 2008
    ..The findings support the hypothesis that astrocyte activation might contribute to the development of cognitive dysfunction in schizophrenia...
  12. doi request reprint Learning potential on the WCST in schizophrenia is related to the neuronal integrity of the anterior cingulate cortex as measured by proton magnetic resonance spectroscopy
    Patricia Ohrmann
    Department of Psychiatry, University of Muenster, Germany
    Schizophr Res 106:156-63. 2008
    ..The neurobiological basis of cognitive remediation has not been elucidated so far, although structural, functional and metabolic abnormalities of the prefrontal cortex have been associated with cognitive impairment...
  13. pmc Neural correlates of set-shifting: decomposing executive functions in schizophrenia
    Andreas Wilmsmeier
    Department of Psychiatry, University of Muenster, Muenster, Germany
    J Psychiatry Neurosci 35:321-9. 2010
    ..We investigated the neural correlates of this mechanism by means of functional magnetic resonance imaging (fMRI) in patients with schizophrenia and healthy controls...
  14. ncbi request reprint The astroglial protein S100B and visually evoked event-related potentials before and after antidepressant treatment
    Guenter Hetzel
    Department of Psychiatry, University of Muenster, Albert Schweitzer Str 11, 48129 Muenster, Germany
    Psychopharmacology (Berl) 178:161-6. 2005
    ..Increased levels have been shown to be positively correlated with therapeutic response in major depression. Event-related potentials (ERP) have been reported to be impaired in depressed patients...
  15. ncbi request reprint Basal prolactin values correlate with response to reboxetine treatment in major depression, but not with response to citalopram
    Olaf Moeller
    Affective Disorders Research Unit, Department of Psychiatry, University of Munster, Munster, Germany
    Neuropsychobiology 51:67-71. 2005
    ..As measurement of BPV is simple, further studies are suggested to examine the possible clinical value of the link between prolactin, noradrenergic function in major depression and treatment response...
  16. ncbi request reprint S100B and response to treatment in major depression: a pilot study
    Volker Arolt
    Department of Psychiatry, University of Muenster, Albert Schweitzer Strasse 11, D 48129 Muenster, Germany
    Eur Neuropsychopharmacol 13:235-9. 2003
    ..These results suggest that neuroprotective functions of S100B counterbalance neurodegenerative mechanisms that are involved in the pathophysiology of major depression and in the response to antidepressant treatment...
  17. doi request reprint Association analysis of Rgs7 variants with panic disorder
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    J Neural Transm 116:1523-8. 2009
    ..Our results argue against a major role of Rgs7 gene variants in the pathogenesis of PD, but are consistent with a minor gender-specific effect on PD, particularly PDAgP...
  18. ncbi request reprint Autocrine S100B effects on astrocytes are mediated via RAGE
    Gerald Ponath
    Department of Psychiatry, Molecular Psychiatry Division, University of Muenster, Germany
    J Neuroimmunol 184:214-22. 2007
    ..S100B induced IL-6 and TNF-alpha secretion was blocked by the use of RAGE siRNA specific for knocking down RAGE expression...
  19. doi request reprint Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personality
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Albert Schweitzer Strasse 11, 48149 Muenster, Germany
    J Psychiatr Res 44:930-7. 2010
    ..Our data provide further support for an important role of ADORA2A variants in the pathogenesis of anxiety disorders and anxious personality reflecting their potential as basic susceptibility factors...
  20. doi request reprint Risk variants in the S100B gene predict elevated S100B serum concentrations in healthy individuals
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:291-7. 2010
    ....
  21. doi request reprint Adjunctive antidepressant treatment with quetiapine in agitated depression: positive effects on symptom reduction, psychopathology and remission rates
    Udo Dannlowski
    Department of Psychiatry, University of Munster, Germany
    Hum Psychopharmacol 23:587-93. 2008
    ..To investigate the adjunctive effects of quetiapine on overall treatment response and on specific symptoms in agitated depression...
  22. ncbi request reprint Reduced implicit and explicit sequence learning in first-episode schizophrenia
    Anya Pedersen
    Department of Psychiatry, School of Medicine, University of Muenster, Germany
    Neuropsychologia 46:186-95. 2008
    ..This deficit would be consistent with a fronto-striatal dysfunction and might constitute a crucial factor for the acquisition of new information...
  23. ncbi request reprint Different activation patterns of proinflammatory cytokines in melancholic and non-melancholic major depression are associated with HPA axis activity
    Florian Kaestner
    Department of Psychiatry, University of Muenster, Albert Schweitzer Strasse 11, D 48149 Muenster, Germany
    J Affect Disord 87:305-11. 2005
    ....
  24. doi request reprint A new pathophysiological aspect of S100B in schizophrenia: potential regulation of S100B by its scavenger soluble RAGE
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Biol Psychiatry 65:1107-10. 2009
    ..Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia...
  25. ncbi request reprint S100B in schizophrenic psychosis
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Int Rev Neurobiol 59:445-70. 2004
    ..Evidence and limitations of the available studies are pointed out and promising future research strategies are outlined...
  26. ncbi request reprint Search for atypical lymphocytes in schizophrenia
    Sebastian Rudolf
    Department of Psychiatry and Psychotherapy, University of Lübeck School of Medicine, Ratzeburger Allee 160, 23538 Luebeck, Germany
    World J Biol Psychiatry 5:33-7. 2004
    ..Further studies should concentrate on intracellular and functional aspects of the different lymphocyte subgroups...
  27. ncbi request reprint [The immunology of psychiatric disorders]
    Volker Arolt
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Munster
    Psychother Psychosom Med Psychol 55:36-48. 2005
    ..Possible future research directions are delineated...
  28. ncbi request reprint Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment
    V Arolt
    Department of Psychiatry, University of Muenster, Germany
    Mol Psychiatry 5:150-8. 2000
    ..It is suggested that these immunological abnormalities are associated with acute exacerbation, rather than with a clinical subtype of schizophrenia...
  29. ncbi request reprint Immunological research in clinical psychiatry: report on the consensus debate during the 7th Expert Meeting on Psychiatry and Immunology
    V Arolt
    Department of Psychiatry, University of Muenster, Albert Schweitzer Strasse 11, D 48129 Muenster, Germany
    Mol Psychiatry 7:822-6. 2002
    ....
  30. ncbi request reprint [Depressive disorders with somatic illnesses]
    V Arolt
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitätsklinikum Muenster
    Nervenarzt 74:1033-52; quiz 1053-4. 2003
    ..High depressive co-morbidity and burden of illness for both the individual and the society form a stark contrast to the obviously still insufficient diagnostic and therapeutic strategies in daily medical routine...
  31. ncbi request reprint The impact of the selective monoamine reuptake inhibitors reboxetine and citalopram on visually-evoked event-related potentials in depressed patients
    G Hetzel
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Pharmacopsychiatry 37:200-5. 2004
    ..Therefore, we were interested in the impact of different monoamine reuptake inhibitors on ERP...
  32. ncbi request reprint Depression in medical patients
    Volker Arolt
    Department of Psychiatry, University of Munster, Munster, Germany
    Adv Psychosom Med 26:98-117. 2004
  33. ncbi request reprint Chromosome 4q31-34 panic disorder risk locus: association of neuropeptide Y Y5 receptor variants
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:510-6. 2008
    ..However, in order to allow for conclusive evaluation of the present finding and to exclude a false positive result, further studies in larger, independent, preferably family based samples are warranted...
  34. ncbi request reprint Immunological dysfunction in schizophrenia: a systematic approach
    M Rothermundt
    Department of Psychiatry, University of Lübeck School of Medicine, Germany
    Neuropsychobiology 37:186-93. 1998
    ..Specifically cellular changes, deviating cytokine production and interfering variables were studied in order to improve our understanding of how these factors interact...
  35. ncbi request reprint The influence of typical and atypical neuroleptic drugs in the production of interleukin-2 and interferon-gamma in vitro
    Sebastian Rudolf
    Department of Psychiatry and Psychotherapy, University of Lubeck, Germany
    Neuropsychobiology 46:180-5. 2002
    ..Furthermore, our findings allow us to conclude that, in contrast to the antidepressant drug, the typical and atypical neuroleptic drugs seem to influence the examined cytokine levels...
  36. ncbi request reprint Review of immunological and immunopathological findings in schizophrenia
    M Rothermundt
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Brain Behav Immun 15:319-39. 2001
    ..On the basis of the findings, perspectives for future research are outlined aiming at a precise and consequent strategy to elucidate a potential involvement of immune mechanisms in the etiopathogenesis of schizophrenia...
  37. ncbi request reprint Oral citalopram and reboxetine challenge tests before and after selective antidepressant treatment
    Olaf Moeller
    J Psychiatr Res 37:261-2. 2003
  38. ncbi request reprint Target evaluation processing and serum levels of nerve tissue protein S100B in patients with remitted major depression
    Detlef E Dietrich
    Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany
    Neurosci Lett 354:69-73. 2004
    ..These findings provide evidence of a correlation between S100B levels and attentional processes in patients with recurrent depression and further substantiate S100B's role as a marker in the course of affective disorders...
  39. doi request reprint Serum levels of S100B are decreased in chronic starvation and normalize with weight gain
    Kristian Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Neural Transm 115:937-40. 2008
    ..We found that nutritional status was an important factor influencing serum levels of S100B...
  40. ncbi request reprint Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism
    Birte Svensson
    Interdisciplinary Center of Clinical Research, Research Group Apoptosis and Cell Death, Faculty of Medicine, Munster, Germany
    J Cereb Blood Flow Metab 22:1170-5. 2002
    ..These data suggest that VEGF-induced protection against hypoxic injury primarily involves the inhibition of excitotoxic processes...