Frank Rosenbauer

Summary

Country: Germany

Publications

  1. ncbi Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
    Marina Scheller
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Nat Immunol 7:1037-47. 2006
  2. ncbi Transcription factors in myeloid development: balancing differentiation with transformation
    Frank Rosenbauer
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Nat Rev Immunol 7:105-17. 2007
  3. ncbi Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
    Frank Rosenbauer
    Harvard Institutes of Medicine and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Genet 38:27-37. 2006
  4. pmc PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element
    Alexander K Ebralidze
    Harvard Institutes of Medicine, Harvard Stem Cell Institute, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Genes Dev 22:2085-92. 2008
  5. pmc A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia
    Ulrich Steidl
    Harvard Institutes of Medicine, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    J Clin Invest 117:2611-20. 2007
  6. ncbi Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells
    Ulrich Steidl
    Harvard Institutes of Medicine, Harvard Medical School and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Genet 38:1269-77. 2006
  7. doi PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment
    Jörg Schönheit
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Cell Rep 3:1617-28. 2013
  8. pmc Potential autoregulation of transcription factor PU.1 by an upstream regulatory element
    Yutaka Okuno
    Harvard Institutes of Medicine, Room 954, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 25:2832-45. 2005
  9. ncbi Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
    Frank Rosenbauer
    Harvard Institutes of Medicine, Room 954, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 36:624-30. 2004
  10. pmc Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy
    Katharina Wagner
    Harvard Institutes of Medicine, Room 954, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6338-43. 2006

Collaborators

Detail Information

Publications22

  1. ncbi Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
    Marina Scheller
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Nat Immunol 7:1037-47. 2006
    ..Our data suggest that fine-tuned Wnt stimulation is essential for hematopoiesis and is thus critical for therapeutic hematopoietic stem cell population expansion...
  2. ncbi Transcription factors in myeloid development: balancing differentiation with transformation
    Frank Rosenbauer
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Nat Rev Immunol 7:105-17. 2007
    ..Consequently, therapies designed to restore defective transcription factor functions are an attractive option in the treatment of myeloid and other human cancers...
  3. ncbi Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
    Frank Rosenbauer
    Harvard Institutes of Medicine and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Genet 38:27-37. 2006
    ..These results elucidate how a single transcription factor, PU.1, through the cell context-specific activity of a key cis-regulatory element, affects the development of multiple cell lineages and can induce cancer...
  4. pmc PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element
    Alexander K Ebralidze
    Harvard Institutes of Medicine, Harvard Stem Cell Institute, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Genes Dev 22:2085-92. 2008
    ..We propose that such antisense RNAs will likely be important in the regulation of many genes and may be the reason for the large number of overlapping complementary transcripts with so far unknown function...
  5. pmc A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia
    Ulrich Steidl
    Harvard Institutes of Medicine, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    J Clin Invest 117:2611-20. 2007
    ..Thus we have identified a SNP within a distal enhancer that is associated with a subtype of leukemia and exerts a deleterious effect through remote transcriptional dysregulation in specific progenitor subtypes...
  6. ncbi Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells
    Ulrich Steidl
    Harvard Institutes of Medicine, Harvard Medical School and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Genet 38:1269-77. 2006
    ..Therefore, examination of disturbed gene expression in HSCs can identify genes whose dysregulation is essential for leukemic stem cell function and that are targets for therapeutic interventions...
  7. doi PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment
    Jörg Schönheit
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Cell Rep 3:1617-28. 2013
    ....
  8. pmc Potential autoregulation of transcription factor PU.1 by an upstream regulatory element
    Yutaka Okuno
    Harvard Institutes of Medicine, Room 954, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 25:2832-45. 2005
    ..These data suggest that a potential positive autoregulatory loop mediated through an upstream regulatory element is essential for proper PU.1 gene expression...
  9. ncbi Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
    Frank Rosenbauer
    Harvard Institutes of Medicine, Room 954, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 36:624-30. 2004
    ..1 expression rescued myeloid differentiation of mutant progenitors and AML blasts. These results suggest that tightly graded reduction, rather than complete loss, of a lineage-indispensable transcription factor can induce AML...
  10. pmc Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy
    Katharina Wagner
    Harvard Institutes of Medicine, Room 954, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6338-43. 2006
    ..Taken together, our study provides evidence that myeloid lineage identity of malignant hematopoietic progenitor cells requires the residual expression of C/EBPalpha...
  11. doi DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
    Ann Marie Bröske
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Nat Genet 41:1207-15. 2009
    ....
  12. ncbi Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia
    Steffen Koschmieder
    Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Int J Hematol 81:368-77. 2005
    ..The implications of these findings for the study of hematopoiesis in the future as well as novel approaches to more disease-specific therapies are discussed...
  13. pmc Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance
    Marina Scheller
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    J Exp Med 210:2239-56. 2013
    ..Collectively, our data uncover Irf8 as a roadblock for β-catenin-driven leukemia and imply both factors as targets in combinatorial therapy. ..
  14. pmc The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation
    Mark W Feinberg
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 26:4138-48. 2007
    ..1-/- fetal liver cells along the monocytic lineage and can activate the monocytic-specific CD14 promoter. Thus, KLF4 is a critical regulator in the transcriptional network controlling monocyte differentiation...
  15. doi Macrophage development from HSCs requires PU.1-coordinated microRNA expression
    Saeed Ghani
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Blood 118:2275-84. 2011
    ..In the present study, we describe a PU.1-orchestrated miR program that mediates key functions of PU.1 during myeloid differentiation...
  16. pmc Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells
    Mathias Leddin
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Blood 117:2827-38. 2011
    ..1 regulates its expression in B cells and macrophages by differentially associating with cell type-specific transcription factors at one of its cis-regulatory elements to establish differential activity patterns at other elements...
  17. pmc Effect of transcription-factor concentrations on leukemic stem cells
    Frank Rosenbauer
    Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Blood 106:1519-24. 2005
    ....
  18. pmc Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells
    Philipp B Staber
    Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 49:934-46. 2013
    ..1 binding to an upstream enhancer that formed an active looped chromosome architecture in HSCs. These results establish that PU.1 mediates chromosome looping and functions as a master regulator of HSC proliferation...
  19. ncbi pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1
    Frank Rosenbauer
    Harvard Institutes of Medicine, Harvard Medical School, Rm 954, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 103:4294-301. 2004
    ..1 and the presence of this site. In conclusion, we have identified a novel PU.1-regulated extracellular glycoprotein of the olfactomedin-like family with a possible role in neutrophilic trafficking...
  20. doi The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex
    Max Werth
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Development 137:3835-45. 2010
    ..Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation...
  21. ncbi Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages
    Axel Kallies
    Department of Molecular Genetics, Institute of Molecular Pharmacology, Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Blood 99:3213-9. 2002
    ..Congruently, the expression of a major endosomal/lysosomal protease, cathepsin B, is strongly reduced in ICSBP(-/-) BMMs...
  22. pmc Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion
    Frank Rosenbauer
    Department of Molecular Genetics, Institute of Molecular Pharmacology, and Benjamin Franklin Medical Center, Free University of Berlin, Krahmerstrasse 6, D 12207 Berlin, Germany
    EMBO J 21:211-20. 2002
    ..Our results identify a novel role of Dab2 as an inducer of cell adhesion and spreading, and strongly suggest that the up-regulation of Dab2 contributes to the hematopoietic defect seen in ICSBP(-/-) mice...