Christoph Rocken

Summary

Country: Germany

Publications

  1. pmc Her2/neu testing in gastric cancer: evaluating the risk of sampling errors
    V S Warneke
    Department of Pathology, Christian Albrechts University, D 24105 Kiel, Germany
    Ann Oncol 24:725-33. 2013
  2. pmc Vascular CXCR4 expression - a novel antiangiogenic target in gastric cancer?
    Barbara Ingold
    Institute of Pathology Campus Mitte, Charite University Hospital, Berlin, Germany
    PLoS ONE 5:e10087. 2010
  3. doi request reprint [Ways to personalized medicine for gastric cancer]
    C Rocken
    Institut fur Pathologie, Christian Albrechts Universitat Kiel, Arnold Heller Strasse 3 14, Kiel, Germany
    Pathologe 34:403-12. 2013
  4. pmc Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine in advanced esophageal and gastric adenocarcinoma
    Martina Mayr
    Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    BMC Cancer 12:587. 2012
  5. doi request reprint [Molecular pathology of gastric cancer]
    C Rocken
    Institut fur Pathologie, Christian Albrechts Universitat Kiel, Arnold Heller Str 3 14, 24105 Kiel
    Pathologe 33:235-40. 2012
  6. pmc Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma
    Uta Berndt
    Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Mol Cancer 9:177. 2010
  7. doi request reprint [Accreditation in pathology. Systematic presentation and documentation of activities in pathology]
    C Rocken
    Institut fur Pathologie, Christian Albrechts Universitat, Arnold Heller Str 3, 24105, Kiel, Deutschland
    Pathologe 31:268-78. 2010
  8. doi request reprint Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression
    Oleg Tchernitsa
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Pathol 222:310-9. 2010
  9. ncbi request reprint The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer
    Stacy Carl-McGrath
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Int J Oncol 25:1223-32. 2004
  10. ncbi request reprint ATTR amyloid in the carpal tunnel ligament is frequently of wildtype transthyretin origin
    Zarina Gioeva
    Institute of Pathology, Christian Albrechts University Kiel, Kiel, Germany
    Amyloid 20:1-6. 2013

Collaborators

Detail Information

Publications66

  1. pmc Her2/neu testing in gastric cancer: evaluating the risk of sampling errors
    V S Warneke
    Department of Pathology, Christian Albrechts University, D 24105 Kiel, Germany
    Ann Oncol 24:725-33. 2013
    ..We evaluated the risk of sampling errors in specimens of biopsy size, which may be caused by heterogeneous overexpression of Her2/neu in gastric cancer (GC)...
  2. pmc Vascular CXCR4 expression - a novel antiangiogenic target in gastric cancer?
    Barbara Ingold
    Institute of Pathology Campus Mitte, Charite University Hospital, Berlin, Germany
    PLoS ONE 5:e10087. 2010
    ..G-protein-coupled receptors (GPCRs) are prime candidates for novel cancer prevention and treatment strategies. We searched for differentially expressed GPCRs in node positive gastric carcinomas...
  3. doi request reprint [Ways to personalized medicine for gastric cancer]
    C Rocken
    Institut fur Pathologie, Christian Albrechts Universitat Kiel, Arnold Heller Strasse 3 14, Kiel, Germany
    Pathologe 34:403-12. 2013
    ..g. AT1R, AT2R, CXCR4, FZD7, LGR4, LGR5, LGR6). Some of these receptors are also putative stem cell markers and may serve as future targets of an individualized therapy of gastric cancer. ..
  4. pmc Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine in advanced esophageal and gastric adenocarcinoma
    Martina Mayr
    Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    BMC Cancer 12:587. 2012
    ..Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects...
  5. doi request reprint [Molecular pathology of gastric cancer]
    C Rocken
    Institut fur Pathologie, Christian Albrechts Universitat Kiel, Arnold Heller Str 3 14, 24105 Kiel
    Pathologe 33:235-40. 2012
    ..g. ADAM17, CD133, FZD7, LGR5) and correlate with patient prognosis. Thus, molecular phenotyping of gastric cancer is still in its infancy and the search for novel diagnostic, prognostic and predictive biomarkers continues...
  6. pmc Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma
    Uta Berndt
    Department of Medicine, Division of Gastroenterology and Hepatology, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Mol Cancer 9:177. 2010
    ....
  7. doi request reprint [Accreditation in pathology. Systematic presentation and documentation of activities in pathology]
    C Rocken
    Institut fur Pathologie, Christian Albrechts Universitat, Arnold Heller Str 3, 24105, Kiel, Deutschland
    Pathologe 31:268-78. 2010
    ..A department of pathology applying for accreditation is required to document the entire step-wise process leading to a surgical pathological diagnosis...
  8. doi request reprint Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression
    Oleg Tchernitsa
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Pathol 222:310-9. 2010
    ..Gastric cancer shows a complex derangement of the miRNA-ome, including Dicer and Drosha. These changes correlate independently with patient prognosis and probably influence local tumour growth and nodal spread...
  9. ncbi request reprint The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer
    Stacy Carl-McGrath
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Int J Oncol 25:1223-32. 2004
    ....
  10. ncbi request reprint ATTR amyloid in the carpal tunnel ligament is frequently of wildtype transthyretin origin
    Zarina Gioeva
    Institute of Pathology, Christian Albrechts University Kiel, Kiel, Germany
    Amyloid 20:1-6. 2013
    ..No significant difference was found between the two study groups. ATTR amyloid in the carpal tunnel ligament is commonly of wildtype origin and genetic counseling is not mandatory in these patients...
  11. ncbi request reprint Expression of the local angiotensin II system in gastric cancer may facilitate lymphatic invasion and nodal spread
    Stacy Carl-McGrath
    Institutes of Pathology, Charite University Hospital, Berlin, Germany
    Cancer Biol Ther 6:1218-26. 2007
    ....
  12. doi request reprint LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma
    Jan Simon Steffen
    Institute of Pathology, Christian Albrechts University, Kiel, Germany
    Virchows Arch 461:355-65. 2012
    ..025). Our systematic analysis indicates that LGR4 and LGR6 may play a role in GC biology. Future studies will have to demonstrate whether these are also putative diagnostic, prognostic, and/or therapeutic targets for GC...
  13. ncbi request reprint The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer
    Stacy Carl-McGrath
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Int J Oncol 26:17-24. 2005
    ..The resultant modulation of the tumor-host interface may contribute to the pathogenesis, development or progression of gastric cancer...
  14. doi request reprint Prevalence of germline mutations in the TTR gene in a consecutive series of surgical pathology specimens with ATTR amyloid
    Magdalena Eriksson
    Department of Pathology, Medical Clinic of Gastroenterology, Hepatology, and Endocrinology, Charite University Hospital, Berlin, Germany
    Am J Surg Pathol 33:58-65. 2009
    ..To conclude, the hereditary form of ATTR amyloid seems to be more common in elderly patients than previously thought. It is, therefore, important to genetically test every patient when diagnosing ATTR amyloidosis...
  15. pmc The spatial distribution of LGR5+ cells correlates with gastric cancer progression
    Eva Simon
    Institute of Pathology, Christian Albrechts University, Kiel, Germany
    PLoS ONE 7:e35486. 2012
    ..3 months). Our results show that LGR5 is differentially expressed in gastrointestinal cancers and that the spatial histoanatomical distribution of LGR5(+) cells has to be considered when their tumour biological significance is sought...
  16. doi request reprint The role of vascular CXCR4 expression in colorectal carcinoma
    Barbara Ingold
    Institute of Pathology Campus Mitte, Charite University Hospital, Berlin, Germany
    Histopathology 55:576-86. 2009
    ....
  17. doi request reprint Amyloid in endomyocardial biopsies
    Barbara Kieninger
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Virchows Arch 456:523-32. 2010
    ..Glu54Asp) and were classified as suffering from hereditary ATTR amyloidosis. Amyloid in endomyocardial biopsies is most commonly of immunoglobulin light chain origin, followed by non-hereditary and hereditary-type ATTR amyloid...
  18. doi request reprint ELISA-based detection of C4d after liver transplantation--a helpful tool for differential diagnosis between acute rejection and HCV-recurrence?
    Maximilian Schmeding
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, Berlin, Germany
    Transpl Immunol 23:156-60. 2010
    ..Consequently the role and potential value of C4d as a diagnostic marker may not be determined using ELISA-based tissue evaluation...
  19. doi request reprint Comparison of different tissue sampling methods for protein extraction from formalin-fixed and paraffin-embedded tissue specimens
    Ilona Gräntzdörffer
    Department of Pathology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Exp Mol Pathol 88:190-6. 2010
    ..In this study, we explored the possibility to standardize tissue sampling from paraffin blocks and compared the protein extracts with those obtained from fresh frozen material...
  20. pmc KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications
    Katharina Balschun
    Department of Pathology, Christian Albrechts University, Kiel, Germany
    J Mol Diagn 13:436-45. 2011
    ..When metastases occur in these patients, the genotype has diagnostic and therapeutic implications and should be determined from the simultaneous or metachronous distant metastases...
  21. doi request reprint mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours
    Atsuko Kasajima
    Institute of Pathology Department of Internal Medicine, Charite Universitatsmedizin, Berlin, Germany
    Endocr Relat Cancer 18:181-92. 2011
    ..We hypothesise that these differences in mTOR expression and activity might possibly influence response to mTOR inhibitors...
  22. doi request reprint Prognostic and putative predictive biomarkers of gastric cancer for personalized medicine
    Viktoria S Warneke
    Departments of Pathology, Christian Albrechts University, Kiel
    Diagn Mol Pathol 22:127-37. 2013
    ..However, several of them show a correlation with either phenotype and/or prognosis and may be considered to tailor patient treatment in the future, such as KRAS, PIK3CA, MSI, and H. pylori status. ..
  23. doi request reprint Neuroendocrine tumors of midgut and hindgut origin: tumor-node-metastasis classification determines clinical outcome
    Henning Jann
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, University Medicine Berlin, Berlin, Germany
    Cancer 117:3332-41. 2011
    ..The purpose of this study was to test the efficacy of a proposal for TNM staging and grading for midgut and hindgut NETs...
  24. ncbi request reprint Feasibility of histological grading and staging of chronic viral hepatitis using specimens obtained by thin-needle biopsy
    Daniela Petz
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Virchows Arch 442:238-44. 2003
    ..This study showed that grading and staging of chronic viral hepatitis is feasible in TNB specimens and that intra- and interobserver variability poses a greater problem than needle size...
  25. pmc Human papillomavirus infection in head and neck cancer: the role of the secretory leukocyte protease inhibitor
    Markus Hoffmann
    Department of Otorhinolaryngology, Head and Neck Surgery, Christian Albrechts University Kiel, D 24105 Kiel, Germany
    Oncol Rep 29:1962-8. 2013
    ..SLPI may be a potential biomarker identifying head and neck cancer patients not at risk of developing metastases (SLPI-positive), and those at risk to be infected by HPV (SLPI-negative) and likely to develop metastases...
  26. doi request reprint Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Lancet Oncol 9:139-48. 2008
    ..We aimed to clarify these expression patterns and identify potential diagnostic and prognostic uses of selected class I HDAC isoforms in gastric cancer...
  27. pmc The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients
    Christoph Rocken
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Neoplasia 9:716-22. 2007
    ..Our study shows that ACE is differentially expressed in CRCs and that gene polymorphism is associated with gender-specific differences in primary tumor size and patient survival...
  28. doi request reprint Chances and limitations of non-invasive tests in the assessment of liver fibrosis in liver transplant patients
    Carsten Kamphues
    Department of General, Visceral and Transplantation Surgery, Universitatsklinikum Charite, Humboldt Universitat, Berlin, Germany
    Clin Transplant 24:652-9. 2010
    ..Both serum markers AST-to-platelet ratio index and FIB-4 are not feasible to assess liver fibrosis in liver transplant patients...
  29. pmc Hereditary apolipoprotein AI-associated amyloidosis in surgical pathology specimens: identification of three novel mutations in the APOA1 gene
    Magdalena Eriksson
    Department of Pathology, Charite University Hospital, Berlin, Germany
    J Mol Diagn 11:257-62. 2009
    ..Patients with alterations in codons 1 to 75 mostly develop hepatic and renal amyloidosis, while carriers of mutations in residues 173 to 178 mainly suffer from cardiac, laryngeal, and cutaneous amyloidosis...
  30. ncbi request reprint Detection of hepatitis C virus RNA in formalin-fixed, paraffin-embedded thin-needle liver biopsy specimens
    Stefanie Vogt
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Am J Clin Pathol 120:536-43. 2003
    ..TNB yields enough qualitative suitable material to detect HCV RNA by RT-PCR...
  31. doi request reprint Angiotensin II-generating enzymes, angiotensin-converting enzyme (ACE) and mast cell chymase (CMA1), in gastric inflammation may be regulated by H. pylori and associated cytokines
    Stacy Carl-McGrath
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Pathology 41:419-27. 2009
    ..ACE inhibitors have been shown to have a protective or healing effect on gastric ulcers and colitis in animal models, which could be related to the local expression of ACE...
  32. pmc Genotypic and phenotypic characterization of side population of gastric cancer cell lines
    Rosa Schmuck
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Am J Pathol 178:1792-804. 2011
    ..Phenotypic characteristics of this distinct cell population are also present in gastric cancer tissue, and correlate with patient survival...
  33. doi request reprint Cohort study based on the seventh edition of the TNM classification for gastric cancer: proposal of a new staging system
    Viktoria S Warneke
    Department of Pathology, Christian Albrechts University, Arnold Heller Strasse 3, Kiel, Germany
    J Clin Oncol 29:2364-71. 2011
    ..We investigated the effect of the new TNM classification on gastric cancer staging...
  34. doi request reprint Phenotypic and genotypic characterization of carcinomas of the papilla of Vater has prognostic and putative therapeutic implications
    Ilona Kohler
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Am J Clin Pathol 135:202-11. 2011
    ..Besides the poorly differentiated CPV, the most common KRAS wild type makes them a putative target for an anti-epidermal growth factor receptor therapy...
  35. ncbi request reprint The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas
    Elgar Susanne Quabius
    Department of Otorhinolaryngology Head and Neck Surgery, Christian Albrechts University Kiel, D 24105, Kiel, Germany Institute of Immunology, Christian Albrechts University Kiel, D 24105, Kiel, Germany
    Int J Cancer 134:1323-34. 2014
    ..Together with the finding that all patients with HPV infection showed no/low SLPI expression, these data support our intriguing hypothesis that smoking induced upregulated SLPI prevents HPV infections. ..
  36. doi request reprint Integrins and their ligands are expressed in non-small cell lung cancer but not correlated with parameters of disease progression
    Christine Böger
    Department of Pathology, Christian Albrechts University, Arnold Heller Str 3, Haus 14, 24105, Kiel, Germany
    Virchows Arch 464:69-78. 2014
    ..Although integrin expression does not seem to be associated with indicators of progression of NSCLC, the expression of αvβ3 in 89 % and αvβ5 in 100 % of NSCLC is novel and merits to be further investigated...
  37. ncbi request reprint L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progression
    Evelin Grage-Griebenow
    Group Inflammatory Carcinogenesis, Institute for Experimental Medicine, UKSH Campus Kiel, Arnold Heller Str 3, Building 17, 24105 Kiel, Germany
    Mol Oncol 8:982-97. 2014
    ....
  38. ncbi request reprint Safety of mycophenolate mofetil monotherapy in patients after liver transplantation
    Carsten Kamphues
    Department of General, Visceral and Transplantation Surgery, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Ann Transplant 14:40-6. 2009
    ..In several studies an improvement of renal function could be reached by introduction of MMF and withdrawal of CNIs but there is few known about the long-term effects of MMF on liver-, kidney- and bone marrow function...
  39. doi request reprint PTAA and B10: new approaches to amyloid detection in tissue-evaluation of amyloid detection in tissue with a conjugated polyelectrolyte and a fibril-specific antibody fragment
    Barbara Kieninger
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Amyloid 18:47-52. 2011
    ..We analysed the suitability of two little known substances for the detection of amyloid in surgical pathology specimens, that is the conjugated polyelectrolyte polythiophene acetic acid (PTAA) and the camelid antibody domain B10...
  40. ncbi request reprint Nonresponse to pre-operative chemotherapy does not preclude long-term survival after liver resection in patients with colorectal liver metastases
    Ulf P Neumann
    Department of General, Visceral, and Transplantation Surgery, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Surgery 146:52-9. 2009
    ..The aim of the study was to identify risk factors for poor outcome in patients with pre-operative chemotherapy of CRM...
  41. ncbi request reprint Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues
    Stacy Carl-McGrath
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Pathology 40:13-24. 2008
    ..The GSDMDC family has been linked to cancer development and progression, and this is the first study analysing the expression and intracellular localisation of GSDML...
  42. pmc Metabolic signature of electrosurgical liver dissection
    Witigo von Schönfels
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 8:e72022. 2013
    ..Its molecular signature, i.e. the metabolites evolving from electrocauterization which may inhibit hepatic wound healing, have not been systematically studied...
  43. ncbi request reprint Novel bispecific antibodies increase γδ T-cell cytotoxicity against pancreatic cancer cells
    Hans Heinrich Oberg
    Authors Affiliations Institute of Immunology Division of Stem Cell Transplantation and Immunotherapy Institute for Experimental Medicine Institute of Pathology Clinic of General and Thoracic Surgery Institute for Medical Informatics and Statistic, Christian Albrechts University Kiel Municipal Hospital, Department of Surgery and Clinic of Gynaecology and Obstetrics, Kiel, Germany
    Cancer Res 74:1349-60. 2014
    ..Taken together, our results show how bispecific antibodies that selectively recruit γδ T cells to tumor antigens expressed by cancer cells illustrate the tractable use of endogenous γδ T cells for immunotherapy...
  44. doi request reprint Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma
    Ole Ammerpohl
    Institute of Human Genetics, University Hospital Schleswig Holstein, Campus Kiel, Christian Albrechts University, Kiel, Germany
    Int J Cancer 130:1319-28. 2012
    ..0001). Cirrhosis and HCC show distinct patterns of differential methylation with regards to promoter structure, PRC2 targets and CpG islands...
  45. ncbi request reprint The expression of low density lipoprotein receptor-related protein in colorectal carcinoma
    Katrin Obermeyer
    Department of Pathology, Otto von Guericke University, Magdeburg, and Charité University Hospital, Berlin, Germany
    Oncol Rep 17:361-7. 2007
    ..038 and 0.018, respectively). We provide evidence that LRP is expressed in colorectal cancer. As LRP forms complexes with u-PA and its inhibitor, we suspect that LRP can influence the known effects of u-PA on tumor biology...
  46. doi request reprint Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells
    Verena Haselmann
    Division of Molecular Oncology, Institute for Experimental Cancer Research, University of Kiel, Kiel, Germany
    Gastroenterology 146:278-90. 2014
    ..Cancer cells also might have TRAIL-R2 in the cytoplasm or nucleus, although little is known about its activities in these locations. We investigated the functions of nuclear TRAIL-R2 in cancer cell lines...
  47. pmc Differential Expression of SPARC in Intestinal-type Gastric Cancer Correlates with Tumor Progression and Nodal Spread
    Konrad Franke
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Transl Oncol 2:310-20. 2009
    ..In this study, genes that were upregulated in the lymph node metastases of gastric cancer were identified and may serve as putative novel therapeutic target...
  48. ncbi request reprint Immunohistochemical classification of amyloid in surgical pathology revisited
    Anja Kebbel
    Department of Pathology, Otto von Guericke University, Magdeburg, and Department of Pathology, Charite University Hospital, Berlin, Germany
    Am J Surg Pathol 30:673-83. 2006
    ....
  49. pmc KRAS genotyping of paraffin-embedded colorectal cancer tissue in routine diagnostics: comparison of methods and impact of histology
    Wilko Weichert
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    J Mol Diagn 12:35-42. 2010
    ....
  50. ncbi request reprint Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis
    Ole Helm
    Institute for Experimental Medicine, Group Inflammatory Carcinogenesis, UK S H Campus, Kiel, Germany
    Int J Cancer 135:843-61. 2014
    ..Overall, these data demonstrate that TAMs exhibit anti- as well as proinflammatory properties that equally contribute to EMT induction in PDAC initiation and development. ..
  51. pmc Comparative characterization of stroma cells and ductal epithelium in chronic pancreatitis and pancreatic ductal adenocarcinoma
    Ole Helm
    Institute for Experimental Medicine, Group Inflammatory Carcinogenesis, UKSH Campus Kiel, Kiel, Germany
    PLoS ONE 9:e94357. 2014
    ....
  52. doi request reprint Proteomics of pancreatic cancer
    Ilona Gräntzdörffer
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Pancreas 36:329-36. 2008
    ..This will hopefully lead to the discovery of prognostic and predictive biomarkers that help to improve prognosis of pancreatic cancer patients...
  53. ncbi request reprint Localized insulin-derived amyloidosis in patients with diabetes mellitus: a case report
    Saniye Yumlu
    Department of Pathology, Charite University Hospital, D 10117 Berlin, Germany
    Hum Pathol 40:1655-60. 2009
    ....
  54. doi request reprint Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors
    Ulrich Frank Pape
    Department of Hepatology and Gastroenterology, Chariteé Campus Virchow Clinic, Berlin University of Medicine, Berlin, Germany
    Cancer 113:256-65. 2008
    ..In 2006, a new TNM classification system was proposed for the staging and grading of upper GEP NETs...
  55. ncbi request reprint Prevalence and origin of amyloid in kidney biopsies
    Hanna von Hutten
    Department of Pathology, Charite University Hospital, D 10117 Berlin, Germany
    Am J Surg Pathol 33:1198-205. 2009
    ..AFib amyloidosis was found to be the most prevalent type of hereditary renal amyloidosis, illustrating the necessity of a thorough classification of the amyloid proteins...
  56. ncbi request reprint Detection of KRAS and BRAF mutations in advanced colorectal cancer by allele-specific single-base primer extension
    Katharina Balschun
    Institute of Pathology, Christian Albrechts University, Arnold Heller Str 3, D 24105 Kiel, Germany
    Expert Rev Mol Diagn 11:799-802. 2011
    ..In this article, we review a recently published assay for the simultaneous detection of diagnostically relevant KRAS and BRAF mutations and discuss this work in the context of conventional diagnostic methods...
  57. doi request reprint Seminal vesicle amyloidosis does not provide any protection from invasion by prostate cancer
    Andreas Erbersdobler
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    BJU Int 103:324-6. 2009
    ..To determine whether seminal vesicle amyloidosis (SVA, an unusual finding in prostatectomy specimens, with deposits usually localized and asymptomatic) affects the extension of prostate cancer into the SVs...
  58. ncbi request reprint The angiotensin II/angiotensin II receptor system correlates with nodal spread in intestinal type gastric cancer
    Christoph Rocken
    Department of Pathology, Charite University Hospital, Chariteplatz 1, D 10117 Berlin, Germany
    Cancer Epidemiol Biomarkers Prev 16:1206-12. 2007
    ..45-248.24). Our study shows that AT1R and AT2R are expressed locally in gastric cancer and that the combination of AT1R expression and ACE I/D gene polymorphism correlates with nodal spread in intestinal type gastric cancer...
  59. doi request reprint The level of secretory leukocyte protease inhibitor is decreased in metastatic head and neck squamous cell carcinoma
    Christian Cordes
    Department of Otorhinolaryngology, Head and Neck Surgery, Christian Albrechts University Kiel, Arnold Heller Strasse 3, Haus 27, 24105 Kiel, Germany
    Int J Oncol 39:185-91. 2011
    ..Therefore, it can be assumed that SLPI might have a substantial protective effect on the metastasis process of HNSCC...
  60. ncbi request reprint The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism
    Christoph Rocken
    Department of Pathology, Institutes of Experimental Internal Medicine, Clinical Chemistry, and Biometrics, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 11:2526-30. 2005
    ..In the present study, we aimed to substantiate the putative significance of angiotensin I-converting enzyme (ACE) on gastric cancer biology by investigating the influence of its gene polymorphism on gastric cancer progression...
  61. doi request reprint Non-functioning, malignant pancreatic neuroendocrine tumour (PNET): a rare entity during pregnancy
    Carsten H Kamphues
    Department of General, Visceral and Transplantation Surgery, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Langenbecks Arch Surg 394:387-91. 2009
    ..Non-functioning pancreatic neuroendocrine tumours (PNET) are extremely rare tumours. To our knowledge, we are the first to report in the literature on two cases of PNET during pregnancy...
  62. ncbi request reprint Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    J Pathol 207:32-42. 2005
    ..Although no correlation of cathepsin X expression and TNM stage was found, our study demonstrates that cathepsin X plays a role not only in the chronic inflammation of gastric mucosa but also in the tumourigenesis of gastric cancer...
  63. ncbi request reprint 16th Amyloidforum organized by the German Society of Amyloid Diseases, April 2002, Vienna, Austria
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Amyloid 9:207-11. 2002
  64. ncbi request reprint Validation and comparison of anti-αvβ3 and anti-αvβ5 rabbit monoclonal versus murine monoclonal antibodies in four different tumor entities
    Christine Böger
    Departments of Pathology Experimental Cancer Research, Christian Albrechts University, Kiel Department of Biochemistry and Cellular Pharmacology, Oncology Platform, Merck KGaA, Darmstadt, Germany
    Appl Immunohistochem Mol Morphol 21:553-60. 2013
    ..This study suggests that EM22703 and EM09902 staining closely matches the staining of standard MuMAbs and also does so in archival FFPE tissue. ..
  65. doi request reprint Three German fibrinogen Aalpha-chain amyloidosis patients with the p.Glu526Val mutation
    Magdalena Eriksson
    Department of Pathology, Charite University Hospital, Chariteplatz 1, Berlin, Germany
    Virchows Arch 453:25-31. 2008
    ..In the cases described here, the use of antibodies directed against fibrinogen, followed by direct gene sequencing, revealed the underlying cause...
  66. ncbi request reprint Application of proteome analysis to the assessment of prognosis and response prediction in clinical oncology
    Christoph Rocken
    Institute of Pathology, Charite University Hospital, Chariteplatz 1, D 10117 Berlin, Germany
    Curr Cancer Drug Targets 8:141-5. 2008
    ..This review summarizes recent efforts, challenges and limitations of proteome analysis in the assessment of prognosis and response-prediction in human cancers...