Brunhilde Schweiger

Summary

Affiliation: Robert Koch-Institut
Country: Germany

Publications

  1. doi request reprint [Detection of local influenza outbreaks and role of virological diagnostics]
    B Schweiger
    Fachgebiet Influenza und respiratorische Infektionen, Robert Koch Institut, Nordufer 20, 13353, Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:28-37. 2013
  2. pmc Comparison of the novel ResPlex III assay and existing techniques for the detection and subtyping of influenza virus during the influenza season 2006-2007
    M Eggers
    Laboratory Prof G Enders and Partner and Institute of Virology, Infectious Diseases and Epidemiology e V, Rosenbergstrasse 85, 70193, Stuttgart, Germany
    Eur J Clin Microbiol Infect Dis 31:1257-65. 2012
  3. ncbi request reprint Antigenic drift and variability of influenza viruses
    B Schweiger
    National Reference Center for Influenza, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Med Microbiol Immunol 191:133-8. 2002
  4. ncbi request reprint Reassortment between human A(H3N2) viruses is an important evolutionary mechanism
    B Schweiger
    National Reference Centre for Influenza, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Vaccine 24:6683-90. 2006
  5. ncbi request reprint [Molecular characterization of human influenza viruses--a look back on the last 10 years]
    Brunhilde Schweiger
    Nationales Referenzzentrum für Influenza, FG Virale Infektionen, Robert Koch Institut, Berlin
    Berl Munch Tierarztl Wochenschr 119:167-78. 2006
  6. pmc Comparison of shedding characteristics of seasonal influenza virus (sub)types and influenza A(H1N1)pdm09; Germany, 2007-2011
    Thorsten Suess
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    PLoS ONE 7:e51653. 2012
  7. doi request reprint Early detection of influenza A and B infection in infants and children using conventional and fluorescence-based rapid testing
    Barbara Rath
    Department of Paediatrics, Division of Pneumonology Immunology, Charité University Medical Centre, Augustenburger Platz 1, Berlin, Germany
    J Clin Virol 55:329-33. 2012
  8. pmc Prospective hospital-based case-control study to assess the effectiveness of pandemic influenza A(H1N1)pdm09 vaccination and risk factors for hospitalization in 2009-2010 using matched hospital and test-negative controls
    Wiebke Hellenbrand
    Immunization Unit, Department of Infectious Disease Epidemiology, Robert Koch Institute, DGZ Ring 1, 13086 Berlin, Germany
    BMC Infect Dis 12:127. 2012
  9. doi request reprint Preventable and non-preventable risk factors for influenza transmission and hygiene behavior in German influenza households, pandemic season (H1N1) 2009/2010
    Cornelius Remschmidt
    Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    Influenza Other Respir Viruses 7:418-25. 2013
  10. ncbi request reprint Shedding and transmission of novel influenza virus A/H1N1 infection in households--Germany, 2009
    Thorsten Suess
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    Am J Epidemiol 171:1157-64. 2010

Detail Information

Publications38

  1. doi request reprint [Detection of local influenza outbreaks and role of virological diagnostics]
    B Schweiger
    Fachgebiet Influenza und respiratorische Infektionen, Robert Koch Institut, Nordufer 20, 13353, Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:28-37. 2013
    ....
  2. pmc Comparison of the novel ResPlex III assay and existing techniques for the detection and subtyping of influenza virus during the influenza season 2006-2007
    M Eggers
    Laboratory Prof G Enders and Partner and Institute of Virology, Infectious Diseases and Epidemiology e V, Rosenbergstrasse 85, 70193, Stuttgart, Germany
    Eur J Clin Microbiol Infect Dis 31:1257-65. 2012
    ....
  3. ncbi request reprint Antigenic drift and variability of influenza viruses
    B Schweiger
    National Reference Center for Influenza, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Med Microbiol Immunol 191:133-8. 2002
    ..Our results suggest that molecular analysis of the HA gene is important to complement the antigenic characterization for a better selection of appropriate vaccine strains...
  4. ncbi request reprint Reassortment between human A(H3N2) viruses is an important evolutionary mechanism
    B Schweiger
    National Reference Centre for Influenza, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Vaccine 24:6683-90. 2006
    ....
  5. ncbi request reprint [Molecular characterization of human influenza viruses--a look back on the last 10 years]
    Brunhilde Schweiger
    Nationales Referenzzentrum für Influenza, FG Virale Infektionen, Robert Koch Institut, Berlin
    Berl Munch Tierarztl Wochenschr 119:167-78. 2006
    ..Reassortant B viruses possessing a Victoria/87-lineage HA and a Yamagata/88-like NA were predominant in Germany during 2002/03 and 2004/05...
  6. pmc Comparison of shedding characteristics of seasonal influenza virus (sub)types and influenza A(H1N1)pdm09; Germany, 2007-2011
    Thorsten Suess
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    PLoS ONE 7:e51653. 2012
    ..We conducted a prospective household study to investigate viral shedding in seasonal and pandemic influenza between 2007 and 2011 in Berlin and Munich, Germany...
  7. doi request reprint Early detection of influenza A and B infection in infants and children using conventional and fluorescence-based rapid testing
    Barbara Rath
    Department of Paediatrics, Division of Pneumonology Immunology, Charité University Medical Centre, Augustenburger Platz 1, Berlin, Germany
    J Clin Virol 55:329-33. 2012
    ..The appropriate management of infants and children with influenza depends on the accurate and timely diagnosis, ideally at the point of care (POC)...
  8. pmc Prospective hospital-based case-control study to assess the effectiveness of pandemic influenza A(H1N1)pdm09 vaccination and risk factors for hospitalization in 2009-2010 using matched hospital and test-negative controls
    Wiebke Hellenbrand
    Immunization Unit, Department of Infectious Disease Epidemiology, Robert Koch Institute, DGZ Ring 1, 13086 Berlin, Germany
    BMC Infect Dis 12:127. 2012
    ....
  9. doi request reprint Preventable and non-preventable risk factors for influenza transmission and hygiene behavior in German influenza households, pandemic season (H1N1) 2009/2010
    Cornelius Remschmidt
    Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    Influenza Other Respir Viruses 7:418-25. 2013
    ..We conducted another household-based study during the pandemic season 2009/2010...
  10. ncbi request reprint Shedding and transmission of novel influenza virus A/H1N1 infection in households--Germany, 2009
    Thorsten Suess
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    Am J Epidemiol 171:1157-64. 2010
    ..Compared with other nasopharyngeal specimen types, nasal wash was the most sensitive. These results support the notion that epidemiologic and virologic characteristics of NIV are in many aspects similar to those of seasonal influenza...
  11. doi request reprint Human adenoviruses in respiratory infections: sequencing of the hexon hypervariable region reveals high sequence variability
    Barbara Biere
    Robert Koch Institut, Nationales Referenzzentrum für Influenza, Nordufer 20, 13353 Berlin, Germany
    J Clin Virol 47:366-71. 2010
    ..The molecular typing of hAdV hexon sequences can help to speed up the discrimination of serotypes, thus improving on-time epidemiological examinations and patient care...
  12. pmc Lessons from a one-year hospital-based surveillance of acute respiratory infections in Berlin- comparing case definitions to monitor influenza
    Matthias Nachtnebel
    Department of Infectious Disease Epidemiology, Robert Koch Institute, DGZ Ring 1, Berlin 13086, Germany
    BMC Public Health 12:245. 2012
    ..12.2009 to 12.12.2010 according to different case definitions (CD) and determined the proportion of cases with influenza A(H1N1)pdm09 (pH1N1). We compared the sensitivity and specificity of CD for capturing pandemic pH1N1 cases...
  13. pmc Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany
    Janine Reiche
    Division of Influenza Viruses and Other Respiratory Viruses, National Reference Centre for Influenza, Robert Koch Institute, Berlin, Germany
    PLoS ONE 9:e88342. 2014
    ..It is one of only few long-term surveillance studies in Europe, and allows comparative molecular analyses of HMPV circulating worldwide. ..
  14. pmc The role of facemasks and hand hygiene in the prevention of influenza transmission in households: results from a cluster randomised trial; Berlin, Germany, 2009-2011
    Thorsten Suess
    Department of Infectious Disease Epidemiology, Robert Koch Institute, DGZ Ring 1, 13086 Berlin, Germany
    BMC Infect Dis 12:26. 2012
    ..We aimed to investigate efficacy, acceptability, and tolerability of NPI in households with influenza index patients...
  15. pmc The first wave of pandemic influenza (H1N1) 2009 in Germany: from initiation to acceleration
    Gabriele Poggensee
    Department for Infectious Disease Epidemiology, Robert Koch Institute, DGZ Ring 1, 13086 Berlin, Germany
    BMC Infect Dis 10:155. 2010
    ..However, the first wave with measurable burden of disease started only in October 2009. The basic epidemiological and clinical characteristics of the pandemic were analysed in order to understand the course of the pandemic in Germany...
  16. pmc Quantitative influenza follow-up testing (QIFT)--a novel biomarker for the monitoring of disease activity at the point-of-care
    Xi Chen
    Department of Paediatrics, Division of Pneumonology Immunology, Charité University Medical Centre, Berlin, Germany
    PLoS ONE 9:e92500. 2014
    ..Signal/control fluorescent readouts (Quantitative Influenza Follow-up Testing = QIFT) are evaluated as a potential biomarker for the monitoring of disease activity at the POC...
  17. pmc Seasonal influenza risk in hospital healthcare workers is more strongly associated with household than occupational exposures: results from a prospective cohort study in Berlin, Germany, 2006/07
    Chris J Williams
    Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    BMC Infect Dis 10:8. 2010
    ..We aimed to compare the risk of influenza infection in healthcare workers in acute hospital care with that in non-healthcare workers over the same season...
  18. ncbi request reprint Virus load kinetics and resistance development during oseltamivir treatment in infants and children infected with Influenza A(H1N1) 2009 and Influenza B viruses
    Barbara Rath
    Department of Pediatrics, Division of Pneumonology Immunology, Charite University Medical Center, Augustenburger Platz 1, 13353 Berlin, Germany
    Pediatr Infect Dis J 31:899-905. 2012
    ..This study aims to investigate virus load kinetics and resistance development during oseltamivir therapy in infants and children infected with influenza A(H1N1) 2009 and influenza B viruses...
  19. doi request reprint Pandemic influenza A (H1N1) outbreak among 15 school-aged HIV-1-infected children
    Cornelia Feiterna-Sperling
    Department of Pediatric Pneumology and Immunology, Helmut Ruska Haus, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Infect Dis 51:e90-4. 2010
    ..Oseltamivir shortened the duration of viral shedding...
  20. ncbi request reprint A new and rapid genotypic assay for the detection of neuraminidase inhibitor resistant influenza A viruses of subtype H1N1, H3N2, and H5N1
    Susanne Duwe
    National Reference Centre for Influenza, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Virol Methods 153:134-41. 2008
    ..The results obtained with these controls showed that the assay can discriminate clearly the wild-type virus from a mutant virus. The detection limit of minor virus variants within the viral quasispecies amounts to 10%...
  21. pmc Differentiation of influenza B virus lineages Yamagata and Victoria by real-time PCR
    Barbara Biere
    Robert Koch Institut, FG17 Influenza Respiratorische Viren, Nordufer 20, 13353 Berlin, Germany
    J Clin Microbiol 48:1425-7. 2010
    ..We present the first real-time PCR assay for virus lineage differentiation to supplement classical antigenic analyses. The assay was successfully applied to 310 primary samples collected in Germany from 2007 to 2009...
  22. ncbi request reprint Development of a PCR-based assay for detection, quantification, and genotyping of human adenoviruses
    Barbara Chmielewicz
    Robert Koch Institut, Zentrum für Biologische Sicherheit 1, FG12 Virale Infektionen, Berlin, Germany
    Clin Chem 51:1365-73. 2005
    ..A method for virus quantification in clinical specimens is essential for monitoring patient adenoviral loads and evaluating new therapeutic approaches...
  23. pmc SARS coronavirus detection
    Andreas Nitsche
    Robert Koch Institut, Berlin, Germany
    Emerg Infect Dis 10:1300-3. 2004
    ..The assays consider all currently available SARS-CoV sequences and are optimized for two prominent real-time PCR platforms...
  24. doi request reprint Genotypic and phenotypic resistance of pandemic A/H1N1 influenza viruses circulating in Germany
    Susanne C Duwe
    Robert Koch Institut, National Reference Centre for Influenza, Nordufer 20, 13353 Berlin, Germany
    Antiviral Res 89:115-8. 2011
    ..Our data demonstrate a low incidence of oseltamivir-resistant pandemic A/H1N1 influenza variants isolated under drug selection pressure as well as community-acquired or naturally evolving viruses...
  25. pmc Diagnostic approach for the differentiation of the pandemic influenza A(H1N1)v virus from recent human influenza viruses by real-time PCR
    Martin Schulze
    Robert Koch Institut, Fachgebiet 17 Influenza Respiratorische Viren, Berlin, Germany
    PLoS ONE 5:e9966. 2010
    ....
  26. pmc Protective measures and H5N1-seroprevalence among personnel tasked with bird collection during an outbreak of avian influenza A/H5N1 in wild birds, Ruegen, Germany, 2006
    Wei Cai
    Department for Infectious Disease Epidemiology, Robert Koch Institute, DGZ Ring 1, Berlin, Germany
    BMC Infect Dis 9:170. 2009
    ..The aim of this study was to investigate the use of recommended protective measures and to measure H5N1-seroprevalence among personnel tasked with bird collection...
  27. doi request reprint Generation and characterisation of monoclonal antibodies against influenza virus A, subtype H5N1
    Sonja Linke
    National Reference Center for Influenza, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Virol Methods 175:85-94. 2011
    ..With this ELISA, as little as 0.005 HA units or 0.1 ng/ml H5N1 was detected, surpassing other ELISA tests. The novel reagents have the potential to improve significantly available rapid antigen detection systems...
  28. pmc Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007
    Janine Reiche
    FG12 Virale Infektionen, NRZ Influenza, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Clin Microbiol 47:1800-10. 2009
    ..This study provides for the first time data on the circulation pattern of RSV group A genotypes and their molecular characterization in Germany during nine consecutive epidemic seasons...
  29. pmc The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue
    Jessica Knepper
    Division of Influenza and Other Respiratory Viruses, Robert Koch Institut, Berlin, Germany
    MBio 4:e00601-13. 2013
    ....
  30. pmc Avian influenza virus risk assessment in falconry
    Andrea Kohls
    Free University of Berlin, Faculty of Veterinary Medicine, Institute of Poultry Diseases, Berlin, Germany
    Virol J 8:187. 2011
    ..Both (hunting birds and prey birds) seem to be highly susceptible to some AIV strains, especially H5N1. We therefore conducted a field study to investigate AIV infections in falconers, their falconry birds as well as prey birds...
  31. ncbi request reprint Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey
    Barbara Chmielewicz
    Robert Koch Institut, Projektgruppe 11, HIV Variabilität und Molekulare Epidemiologie, Nordufer 20, Berlin, Germany
    J Med Virol 77:232-7. 2005
    ..The adenovirus detected was characterized further by genotyping and was identified as a species B2 virus with the highest similarity to adenovirus type 11a...
  32. ncbi request reprint Pandemic human viruses cause decline of endangered great apes
    Sophie Köndgen
    Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
    Curr Biol 18:260-4. 2008
    ..These observations illustrate the challenge of maximizing the benefit of research and tourism to great apes while minimizing the negative side effects...
  33. pmc Predominance of HA-222D/G polymorphism in influenza A(H1N1)pdm09 viruses associated with fatal and severe outcomes recently circulating in Germany
    Marianne Wedde
    Robert Koch Institut, National Reference Centre for Influenza, Berlin, Germany
    PLoS ONE 8:e57059. 2013
    ..Thus, amino acid changes at HA position 222 may be the result of viral intra-host evolution leading to the generation of variants with an altered viral tropism...
  34. pmc Global distribution of novel rhinovirus genotype
    Thomas Briese
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Emerg Infect Dis 14:944-7. 2008
    ..Molecular dating indicates that these viruses have been circulating for at least 250 years...
  35. ncbi request reprint A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany
    Neil Renwick
    Center for Infection and Immunity, Mailman School of Public Health, and College of Physicians and Surgeons, Columbia University, 722 W 168th Street, New York, NY 10032, USA
    J Infect Dis 196:1754-60. 2007
    ..Infections with the novel genotype were associated with upper-respiratory-tract symptoms but, more frequently, with bronchitis, bronchiolitis, and pneumonia...
  36. ncbi request reprint Fatal influenza A virus infection in a child vaccinated against influenza
    Peter Thomas
    Kinderklinik, Klinikum Krefeld, Robert Koch Institut, Germany
    Pediatr Infect Dis J 22:201-2. 2003
    ..This case indicates that a primary viral pneumonia with influenza A virus complicated by a bacterial superinfection with S. aureus can run a fatal course even in a vaccinated child...
  37. ncbi request reprint [Influenza in Germany. "Caution! Influenza--danger"]
    Brunhilde Schweiger
    Influenza Referenzzentrums, Robert Koch Institut RKI, Berlin
    Krankenpfl J 41:162-3. 2003
  38. ncbi request reprint Programme of the Community Network of Reference Laboratories for Human Influenza to improve Influenza Surveillance in Europe
    Adam Meijer
    Netherlands Institute for Health Services Research NIVEL, European Influenza Surveillance Scheme Co ordination Centre, Otterstraat 118 124, 3513 Utrecht, CR, The Netherlands
    Vaccine 24:6717-23. 2006
    ....