A Mankertz

Summary

Affiliation: Robert Koch-Institut
Country: Germany

Publications

  1. doi request reprint Molecular interactions of porcine circoviruses type 1 and type 2 with its host
    Annette Mankertz
    Division of Viral Infections, Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
    Virus Res 164:54-60. 2012
  2. pmc Measles transmission from an anthroposophic community to the general population, Germany 2008
    Maria Wadl
    Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    BMC Public Health 11:474. 2011
  3. doi request reprint Molecular genotyping and epidemiology of measles virus transmission in the World Health Organization European Region, 2007-2009
    Annette Mankertz
    National Reference Centre for Measles, Mumps, and Rubella World Health Organization European Regional Reference Laboratory, Robert Koch Institute, Division of Viral Infection, Berlin, Germany
    J Infect Dis 204:S335-42. 2011
  4. pmc Spread of measles virus D4-Hamburg, Europe, 2008-2011
    Annette Mankertz
    Robert Koch Institute, Berlin, Germany
    Emerg Infect Dis 17:1396-401. 2011
  5. ncbi request reprint Molecular biology of Porcine circovirus: analyses of gene expression and viral replication
    Annette Mankertz
    P24 Xenotransplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Vet Microbiol 98:81-8. 2004
  6. pmc New reporter gene-based replication assay reveals exchangeability of replication factors of porcine circovirus types 1 and 2
    Annette Mankertz
    P11 Xenotransplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Virol 77:9885-93. 2003
  7. ncbi request reprint Analysis of transcription of Porcine circovirus type 1
    Annette Mankertz
    P24 Xenotransplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Gen Virol 83:2743-51. 2002
  8. ncbi request reprint Identification of a protein essential for replication of porcine circovirus
    A Mankertz
    Fachbereich Gentechnik und Genetik, Robert Koch Institut, Berlin, Germany
    J Gen Virol 79:381-4. 1998
  9. ncbi request reprint Replication of porcine circovirus type 1 requires two proteins encoded by the viral rep gene
    A Mankertz
    P24 Xenotransplantation, Robert Koch Institut, Nordufer 20, Berlin, D 13353, Germany
    Virology 279:429-38. 2001
  10. ncbi request reprint Transcription analysis of porcine circovirus (PCV)
    J Mankertz
    Fachbereich Gentechnik und Genetik, Robert Koch Institut, Berlin, Germany
    Virus Genes 16:267-76. 1998

Collaborators

Detail Information

Publications36

  1. doi request reprint Molecular interactions of porcine circoviruses type 1 and type 2 with its host
    Annette Mankertz
    Division of Viral Infections, Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
    Virus Res 164:54-60. 2012
    ..The good news is that some common themes become visible and that certain aspects of the cell life cycle have been identified to be involved in interaction with the pathogen...
  2. pmc Measles transmission from an anthroposophic community to the general population, Germany 2008
    Maria Wadl
    Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    BMC Public Health 11:474. 2011
    ..We investigated this outbreak to guide future public health action...
  3. doi request reprint Molecular genotyping and epidemiology of measles virus transmission in the World Health Organization European Region, 2007-2009
    Annette Mankertz
    National Reference Centre for Measles, Mumps, and Rubella World Health Organization European Regional Reference Laboratory, Robert Koch Institute, Division of Viral Infection, Berlin, Germany
    J Infect Dis 204:S335-42. 2011
    ..The molecular epidemiology of MV transmission in the WHO European Region was studied through the investigation of reported cases and outbreaks to monitor the region's progress toward its measles elimination goal...
  4. pmc Spread of measles virus D4-Hamburg, Europe, 2008-2011
    Annette Mankertz
    Robert Koch Institute, Berlin, Germany
    Emerg Infect Dis 17:1396-401. 2011
    ....
  5. ncbi request reprint Molecular biology of Porcine circovirus: analyses of gene expression and viral replication
    Annette Mankertz
    P24 Xenotransplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Vet Microbiol 98:81-8. 2004
    ..When a replication assay was performed, in which Rep and Rep' protein of PCV1 was used to replicate the origin of PCV1 and PCV2, the rep gene products were found to initiate replication at both origins of replication...
  6. pmc New reporter gene-based replication assay reveals exchangeability of replication factors of porcine circovirus types 1 and 2
    Annette Mankertz
    P11 Xenotransplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Virol 77:9885-93. 2003
    ..Our results indicate that the cis- and trans-acting replication factors of the two viruses are functionally exchangeable...
  7. ncbi request reprint Analysis of transcription of Porcine circovirus type 1
    Annette Mankertz
    P24 Xenotransplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Gen Virol 83:2743-51. 2002
    ....
  8. ncbi request reprint Identification of a protein essential for replication of porcine circovirus
    A Mankertz
    Fachbereich Gentechnik und Genetik, Robert Koch Institut, Berlin, Germany
    J Gen Virol 79:381-4. 1998
    ..Since pOP11 itself is unable to replicate in virus-free porcine kidney cells, the ORF 4 gene product must be essential for replication of porcine circovirus...
  9. ncbi request reprint Replication of porcine circovirus type 1 requires two proteins encoded by the viral rep gene
    A Mankertz
    P24 Xenotransplantation, Robert Koch Institut, Nordufer 20, Berlin, D 13353, Germany
    Virology 279:429-38. 2001
    ..In contrast to other viruses replicating via a rolling circle, Rep protein alone cannot promote replication: Rep and Rep' together comprise the functional replication initiator factor of PCV1...
  10. ncbi request reprint Transcription analysis of porcine circovirus (PCV)
    J Mankertz
    Fachbereich Gentechnik und Genetik, Robert Koch Institut, Berlin, Germany
    Virus Genes 16:267-76. 1998
    ..737. The transcriptional regulatory elements have been identified functionally by CAT assays. They are located within a 258 base points (bp) fragment (pos. 1168 to 1425)...
  11. ncbi request reprint Characterisation of PCV-2 isolates from Spain, Germany and France
    A Mankertz
    Robert Koch Institut, P24 Xenotransplantation, Nordufer 20, 13353, Berlin, Germany
    Virus Res 66:65-77. 2000
    ..PCR screening of randomly collected organ samples from German pigs not affected with PMWS, revealed a rate of infection with PCV-1 of 5% and with PCV-2 of 26.8%, while blood samples showed a lower incidence...
  12. ncbi request reprint Rep and Rep' protein of porcine circovirus type 1 bind to the origin of replication in vitro
    T Steinfeldt
    P24 (Xenotransplantation, Robert Koch-Institut, Nordufer 20, Berlin, 13353, Germany
    Virology 291:152-60. 2001
    ..Two differentially retarded complexes were observed with Rep protein, which presumably result from alternative binding to the MBS or to H3/4...
  13. ncbi request reprint [Molecular surveillance shows progress in measles elimination process]
    S Santibanez
    Fachgebiet Masern, Mumps, Röteln und Viren bei Abwehrschwäche, Nationales Referenzzentrum Masern, Mumps, Röteln, Robert Koch Institut, Nordufer 20, 13353, Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:1238-42. 2013
    ..This article summarizes our experiences with measles virus genotyping and new developments with respect to measles elimination in Germany. ..
  14. ncbi request reprint Cloning and sequencing of columbid circovirus (coCV), a new circovirus from pigeons
    A Mankertz
    P24 Xenotransplantation, Robert Koch Institut, Berlin, Germany
    Arch Virol 145:2469-79. 2000
    ..Phylogenetic analyses suggest classification of CoCV as member of the genus Circovirus of the virus family Circoviridae...
  15. ncbi request reprint [Vaccination coverage against measles and sero-epidemiology of measles-specific IgG antibodies in German children and adolescents]
    C Poethko-Müller
    Abteilung für Epidemiologie und Gesundheitsmonitoring, Robert Koch Institut, General Pape Str 62 66, 12101, Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:1243-52. 2013
    ..Target control is mainly based on verification of 95 % vaccination coverage. In Germany, target verification cannot be based on data from centrally collected registers on vaccination and seroprevalence of measles-specific antibodies...
  16. ncbi request reprint Cloning and sequencing of Duck circovirus (DuCV)
    K Hattermann
    P11 Neue Viren Xenotranplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Arch Virol 148:2471-80. 2003
    ..Phylogenetic analysis shows close relation of DuCV with Goose circovirus and suggests classification of DuCV as a new member of the genus Circovirus of the virus family Circoviridae...
  17. ncbi request reprint [Measles surveillance in Germany. From sentinel to mandatory surveillance]
    A Siedler
    Abteilung für Infektionsepidemiologie, Fachgebiet Impfprävention, Robert Koch Institut, DGZ Ring 1, 13086, Berlin, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:1321-8. 2013
    ..Since mandatory surveillance was established and sentinel surveillance no longer reflected the epidemiologic situation, the latter was abandoned in April 2011. ..
  18. ncbi request reprint Measles outbreak spreading from the community to an anthroposophic school, Berlin, 2011
    S Gillesberg Lassen
    Robert Koch Institute, Department for Infectious Disease Epidemiology, Berlin, Germany
    Epidemiol Infect 142:789-96. 2014
    ....
  19. ncbi request reprint Glycoprotein B of bovine herpesvirus type 4: its phylogenetic relationship to gB equivalents of the herpesviruses
    M Goltz
    Robert Koch Institut, Freien Universitat Berlin, Germany
    Virus Genes 9:53-9. 1994
    ..The alignment of the amino acid sequences revealed that 10 cysteine and 7 proline residues, as well as the motifs SPF and GQLG, were completely conserved among the 20 investigated gBs...
  20. ncbi request reprint Two outbreaks of measles in Germany 2005
    A Siedler
    Respiratory Diseases and Immunization group, Department for Infectious Disease Epidemiology, Robert Koch Institut, Berlin, Germany
    Euro Surveill 11:131-4. 2006
    ..Despite high average vaccination coverage levels, local variations may lead to regionally limited outbreaks...
  21. ncbi request reprint Analysis of the subcellular localization of the proteins Rep, Rep' and Cap of porcine circovirus type 1
    T Finsterbusch
    Robert Koch Institut, viral infections Nordufer 20, 13353 Berlin, Germany
    Virology 343:36-46. 2005
    ....
  22. ncbi request reprint Vaccinated students with negative enzyme immunoassay results show positive measles virus-specific antibody levels by immunofluorescence and plaque neutralisation tests
    Annedore Tischer
    National Reference Centre Measles, Mumps, Rubella, Robert Koch Institute, Berlin, Germany
    J Clin Virol 38:204-9. 2007
    ..In 2003 and 2004, in contrast to previous years, surprisingly many negative results (33% and 54%, respectively) were observed...
  23. ncbi request reprint Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2
    Kim Hattermann
    Neue Viren Xenotransplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Xenotransplantation 11:284-94. 2004
    ..Besides immunological problems like graft rejection, one of the major concerns is the transmission of porcine microorganisms as viruses, bacteria and fungi to a human recipient...
  24. pmc Demonstration of nicking/joining activity at the origin of DNA replication associated with the rep and rep' proteins of porcine circovirus type 1
    Tobias Steinfeldt
    Division of Viral Infections FG12, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Virol 80:6225-34. 2006
    ..The dual "nicking/joining" activities associated with PCV1 Rep and Rep' are pivotal events underlying the RCR-based replication of porcine circoviruses in mammalian cells...
  25. doi request reprint Gene expression of the human Torque Teno Virus isolate P/1C1
    Bettina Mueller
    Robert Koch Institute, FG12 Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Virology 381:36-45. 2008
    ....
  26. doi request reprint Interaction of the replication proteins and the capsid protein of porcine circovirus type 1 and 2 with host proteins
    Tim Finsterbusch
    Division of Viral Infections FG12, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Virology 386:122-31. 2009
    ..The nine cellular proteins are associated with distinct aspects of viral lifecycle and our data is likely to support future research in the field of PCV2 pathogenesis...
  27. ncbi request reprint Measles viruses of genotype H1 evade recognition by vaccine-induced neutralizing antibodies targeting the linear haemagglutinin noose epitope
    Tim Finsterbusch
    National Reference Centre Measles, Mumps, Rubella, Division of Viral Infections FG12, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Gen Virol 90:2739-45. 2009
    ..The loss of several neutralizing epitopes, as shown for H1 viruses currently circulating endemically in Asia, implies that epitope monitoring should be considered to be included in measles surveillance...
  28. doi request reprint Porcine circoviruses--small but powerful
    Tim Finsterbusch
    Division of Viral Infections FG12, Robert Koch Institute, 13353 Berlin, Germany
    Virus Res 143:177-83. 2009
    ..Since we have learned many aspects of the molecular biology of PCV in the last years, it is time for a résumé!..
  29. ncbi request reprint Assessing the risk potential of porcine circoviruses for xenotransplantation: consensus primer-PCR-based search for a human circovirus
    Kim Hattermann
    Robert Koch Institut, 13353 Berlin, Germany
    Xenotransplantation 11:547-50. 2004
    ..In case of circoviruses, two types of porcine circovirus (PCV1 and PCV2) are described, but the existence of an analogous human circovirus has not yet been investigated...
  30. ncbi request reprint A method to diagnose Pigeon circovirus infection in vivo
    Kim Hattermann
    P24 Xenotransplantation, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Virol Methods 104:55-8. 2002
    ..PCR using DNA from dried blood samples is a simple, fast and reliable technique that allows detection of PiCV in vivo and facilitates collection, storage and shipment of samples...
  31. doi request reprint Mumps virus small hydrophobic protein targets ataxin-1 ubiquitin-like interacting protein (ubiquilin 4)
    Maria Woznik
    Department of Biology, Chemistry and Pharmacy, FU Berlin, Berlin, Germany
    J Gen Virol 91:2773-81. 2010
    ..The ectopic expression of A1Up leads to a redistribution of SH to punctate structures that co-localize with the 20S proteasome in transfected or infected mammalian cells...
  32. pmc Further efforts needed to achieve measles elimination in Germany: results of an outbreak investigation
    Ole Wichmann
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    Bull World Health Organ 87:108-15. 2009
    ..To determine morbidity and costs related to a large measles outbreak in Germany and to identify ways to improve the country's national measles elimination strategy...
  33. ncbi request reprint Lack of an effect of a commercial vaccine adjuvant on the development of postweaning multisystemic wasting syndrome (PMWS) in porcine circovirus type 2 (PCV2) experimentally infected conventional pigs
    Ana Resendes
    Centre de Recerca en Sanitat Animals, Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    Vet Res 35:83-90. 2004
    ....
  34. ncbi request reprint A new method to identify cell types that support porcine circovirus type 2 replication in formalin-fixed, paraffin-embedded swine tissues
    Eva Perez-Martín
    Centre de Recerca en Sanitat Animal CReSA, 08193 Bellaterra, Spain
    J Virol Methods 146:86-95. 2007
    ..In summary, the present study permitted the study of cell types that support PCV2 replication by the use of ISH on formalin-fixed, paraffin-embedded tissues of PMWS affected pigs...
  35. pmc Functional analysis of cis- and trans-acting replication factors of porcine circovirus type 1
    Tobias Steinfeldt
    Institute for Genetics, University of Cologne, 50674 Cologne, Germany
    J Virol 81:5696-704. 2007
    ..A covalent link between Rep/Rep' and the DNA after origin cleavage was demonstrated, providing a mechanism for energy conservation for the termination of replication...
  36. pmc High genetic diversity of measles virus, World Health Organization European Region, 2005-2006
    Jacques R Kremer
    World Health Organization WHO Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé Immunology 20A, rue Auguste Lumiere, Luxembourg, Luxembourg
    Emerg Infect Dis 14:107-14. 2008
    ..Thus, despite the reduction of endemic MV circulation, importation of MV from other continents caused prolonged circulation and large outbreaks after their introduction into unvaccinated and highly mobile communities...