B Ehlers

Summary

Affiliation: Robert Koch-Institut
Country: Germany

Publications

  1. pmc Novel polyomaviruses of nonhuman primates: genetic and serological predictors for the existence of multiple unknown polyomaviruses within the human population
    Nelly Scuda
    Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany
    PLoS Pathog 9:e1003429. 2013
  2. pmc Identification of a novel human polyomavirus in organs of the gastrointestinal tract
    Sarah Korup
    Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    PLoS ONE 8:e58021. 2013
  3. ncbi request reprint High prevalence and diversity of species D adenoviruses (HAdV-D) in human populations of four Sub-Saharan countries
    Maude Pauly
    Division 12 Measles, Mumps, Rubella and Viruses affecting immunocompromised patients, Robert Koch Institute, Berlin 13353, Germany
    Virol J 11:25. 2014
  4. doi request reprint The novel human polyomaviruses HPyV6, 7, 9 and beyond
    Bernhard Ehlers
    Division 12 Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Robert Koch Institute, Berlin, Germany
    APMIS 121:783-95. 2013
  5. pmc Discovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach
    Sandra Prepens
    P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Virol J 4:84. 2007
  6. pmc Identification of a novel betaherpesvirus in Mus musculus
    Alla Teterina
    Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    Virol J 6:225. 2009
  7. pmc High genotypic diversity and a novel variant of human cytomegalovirus revealed by combined UL33/UL55 genotyping with broad-range PCR
    Merlin Deckers
    P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Virol J 6:210. 2009
  8. pmc A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla)
    Diana Wevers
    FG12 Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    Virol J 7:303. 2010
  9. doi request reprint Lymphocryptovirus phylogeny and the origins of Epstein-Barr virus
    Bernhard Ehlers
    Research Group Molecular Genetics and Epidemiology of Herpesviruses, Robert Koch Institut, D 13353 Berlin, Germany
    J Gen Virol 91:630-42. 2010
  10. pmc Novel mammalian herpesviruses and lineages within the Gammaherpesvirinae: cospeciation and interspecies transfer
    Bernhard Ehlers
    P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, D 13353 Berlin, Germany
    J Virol 82:3509-16. 2008

Collaborators

Detail Information

Publications37

  1. pmc Novel polyomaviruses of nonhuman primates: genetic and serological predictors for the existence of multiple unknown polyomaviruses within the human population
    Nelly Scuda
    Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany
    PLoS Pathog 9:e1003429. 2013
    ..Together, these results support the existence of additional polyomaviruses circulating within the human population that are genetically and serologically related to existing chimpanzee polyomaviruses. ..
  2. pmc Identification of a novel human polyomavirus in organs of the gastrointestinal tract
    Sarah Korup
    Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    PLoS ONE 8:e58021. 2013
    ..These data indicate that the virus naturally infects humans and that primary infection may already occur in childhood...
  3. ncbi request reprint High prevalence and diversity of species D adenoviruses (HAdV-D) in human populations of four Sub-Saharan countries
    Maude Pauly
    Division 12 Measles, Mumps, Rubella and Viruses affecting immunocompromised patients, Robert Koch Institute, Berlin 13353, Germany
    Virol J 11:25. 2014
    ....
  4. doi request reprint The novel human polyomaviruses HPyV6, 7, 9 and beyond
    Bernhard Ehlers
    Division 12 Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Robert Koch Institute, Berlin, Germany
    APMIS 121:783-95. 2013
    ..In the future, it will be important to unravel the cell types and body compartments of the novel HPyVs' reservoir and to search for possible associations with cancer and non-malignant diseases. ..
  5. pmc Discovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach
    Sandra Prepens
    P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Virol J 4:84. 2007
    ..To illustrate this principle, six novel herpesviruses of the genera Rhadinovirus, Lymphocryptovirus and Cytomegalovirus were discovered in multi-infected samples of non-human primates and phylogenetically characterized...
  6. pmc Identification of a novel betaherpesvirus in Mus musculus
    Alla Teterina
    Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    Virol J 6:225. 2009
    ....
  7. pmc High genotypic diversity and a novel variant of human cytomegalovirus revealed by combined UL33/UL55 genotyping with broad-range PCR
    Merlin Deckers
    P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Virol J 6:210. 2009
    ..Importantly, a novel UL33 genotypic variant could be discovered in several specimens, and one HCMV isolate was plaque-purified containing the novel UL33 genotype and a so far undescribed variant of gB...
  8. pmc A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla)
    Diana Wevers
    FG12 Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    Virol J 7:303. 2010
    ..The mixed phylogenetic clusters of gorilla, chimpanzee, bonobo and human AdVs within the HAdV-B species indicate that host switches may have been a component of the evolution of human and non-human primate HAdV-B viruses...
  9. doi request reprint Lymphocryptovirus phylogeny and the origins of Epstein-Barr virus
    Bernhard Ehlers
    Research Group Molecular Genetics and Epidemiology of Herpesviruses, Robert Koch Institut, D 13353 Berlin, Germany
    J Gen Virol 91:630-42. 2010
    ..2 million years ago...
  10. pmc Novel mammalian herpesviruses and lineages within the Gammaherpesvirinae: cospeciation and interspecies transfer
    Bernhard Ehlers
    P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, D 13353 Berlin, Germany
    J Virol 82:3509-16. 2008
    ..The tree's branching pattern can be interpreted only in part in terms of the cospeciation of virus and host lineages, and a substantial incidence of the interspecies transfer of viruses must also be invoked...
  11. pmc Identification of novel rodent herpesviruses, including the first gammaherpesvirus of Mus musculus
    Bernhard Ehlers
    P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
    J Virol 81:8091-100. 2007
    ....
  12. ncbi request reprint Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene
    Bernhard Ehlers
    Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Gen Virol 87:2781-9. 2006
    ..This peculiarity might contribute to the fulminant pathogenicity of ElHV-1, but also provide a crucial enzymic activity for developing an efficient antiviral therapy with currently available nucleoside analogues...
  13. ncbi request reprint Novel herpesviruses of Suidae: indicators for a second genogroup of artiodactyl gammaherpesviruses
    Bernhard Ehlers
    P11 Neuartige Viren, Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
    J Gen Virol 85:857-62. 2004
    ..This latter genogroup may also contain an as yet undiscovered gammaherpesvirus of domestic pigs, thereby adding a concern to their use in xenotransplantation...
  14. pmc Novel simian homologues of Epstein-Barr virus
    Bernhard Ehlers
    Robert Koch Institut, D 13353, Germany
    J Virol 77:10695-9. 2003
    ..They were tentatively assigned to a novel genogroup of Old World primate LCV. The work described in the paper may also help identify an as yet unknown human LCV...
  15. ncbi request reprint Detection of new DNA polymerase genes of known and potentially novel herpesviruses by PCR with degenerate and deoxyinosine-substituted primers
    B Ehlers
    Robert Koch Institut, Berlin
    Virus Genes 18:211-20. 1999
    ..This is a first indication that novel gamma-herpesviruses are present in wild and zoo equids...
  16. ncbi request reprint Genetic and ultrastructural characterization of a European isolate of the fatal endotheliotropic elephant herpesvirus
    B Ehlers
    Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Gen Virol 82:475-82. 2001
    ..Furthermore, it will aid in the development of antibody-based detection methods and of vaccination strategies against this fatal herpesvirus infection in the endangered Asian elephant...
  17. ncbi request reprint Detection of two novel porcine herpesviruses with high similarity to gammaherpesviruses
    B Ehlers
    Robert Koch Institut, Berlin, Germany
    J Gen Virol 80:971-8. 1999
    ..When using pig organs for xenotransplantation, the presence of these viruses has to be considered...
  18. ncbi request reprint Bovine herpesvirus type 2 is closely related to the primate alphaherpesviruses
    B Ehlers
    Robert Koch Institut, Berlin
    Virus Genes 19:197-203. 1999
    ..Thus one can speculate that BoHV-2 may represent a greater hazard to humans than has been appreciated previously...
  19. pmc Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and identification of an origin of DNA replication
    W Zimmermann
    Department of Genetic Analysis, Genome Sequencing Centre, , 07745 Jena, Robert Koch-Institut, 13353 Berlin, Germany
    J Virol 75:1186-94. 2001
    ..In addition, an origin of replication (ori) in the genome of BoHV-4 was identified by DpnI assays. A minimum of 1.69 kbp located between ORFs 69 and 71 was sufficient to act as a cis signal for replication...
  20. ncbi request reprint Detection and multigenic characterization of a novel gammaherpesvirus in goats
    B Chmielewicz
    Robert Koch Institut, Nordufer 20, 13353, Berlin, Germany
    Virus Res 75:87-94. 2001
    ..Phylogenetic analyses confirmed these relationships. The putative novel goat herpesvirus from which these sequences originate was tentatively designated caprine herpesvirus 2. This virus is the first gammaherpesvirus recognized in goats...
  21. ncbi request reprint The porcine lymphotropic herpesvirus 1 encodes functional regulators of gene expression
    I Lindner
    Robert Koch Institut, P14 Molekulare Genetik und Epidemiologie von Herpesviren, Nordufer 20, 13353 Berlin, Germany
    Virology 357:134-48. 2007
    ..However, the ORF57-encoded protein acted synergistically on ORF50-mediated activation...
  22. ncbi request reprint Characterization of the DNA polymerase loci of porcine cytomegaloviruses from diverse geographic origins
    M Goltz
    Robert Koch Institut, Berlin, Germany
    Virus Genes 21:249-55. 2000
    ..Therefore, these are the first nucleic acid-based test systems which were shown to universally detect PCMV. The application of these assays to organs of domestic pigs from Germany revealed a PCMV prevalence of > 50%...
  23. ncbi request reprint Approaching virus safety in xenotransplantation: a search for unrecognized herpesviruses in pigs
    Barbara Chmielewicz
    Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Xenotransplantation 10:349-56. 2003
    ..Therefore we conclude that pigs bred for the purpose of xenotransplantation pose a negligible risk of transmitting presently unrecognized herpesviruses to organ recipients...
  24. pmc African great apes are naturally infected with polyomaviruses closely related to Merkel cell polyomavirus
    Fabian H Leendertz
    Research Group Emerging Zoonoses, Robert Koch Institute, Berlin, Germany
    J Virol 85:916-24. 2011
    ..This, together with the fact that humans in West and Central Africa frequently hunt and butcher primates, may point toward further MCPyV-like strains spreading to, or already existing in, our species...
  25. ncbi request reprint Sequence analysis of the genome of porcine lymphotropic herpesvirus 1 and gene expression during posttransplant lymphoproliferative disease of pigs
    Michael Goltz
    Robert Koch Institut, Nordufer 20, Berlin, 13353, Germany
    Virology 294:383-93. 2002
    ..These data indicate that PLHV-1 is active during PTLD and may be involved in the etiology of this lymphoproliferative disease...
  26. ncbi request reprint Cloning and sequencing of columbid circovirus (coCV), a new circovirus from pigeons
    A Mankertz
    P24 Xenotransplantation, Robert Koch Institut, Berlin, Germany
    Arch Virol 145:2469-79. 2000
    ..Phylogenetic analyses suggest classification of CoCV as member of the genus Circovirus of the virus family Circoviridae...
  27. doi request reprint Development of a recombinant antigen-based ELISA for the sero-detection of porcine lymphotropic herpesviruses
    Susanne Brema
    Robert Koch Institut, Berlin, Germany
    Xenotransplantation 15:357-64. 2008
    ..The elimination of PLHV from donor pigs is therefore necessary, and requires the availability of nucleic-acid- and antibody-based detection methods...
  28. ncbi request reprint A novel porcine gammaherpesvirus
    Barbara Chmielewicz
    Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
    Virology 308:317-29. 2003
    ..Since PLHV-1 has been implicated in the development of porcine posttransplantation lymphoproliferative disease, all porcine lymphotropic gammaherpesviruses are of concern when pigs are used as donors in xenotransplantation...
  29. ncbi request reprint Discovery of herpesviruses in bats
    Gudrun Wibbelt
    Leibniz Institute for Zoo and Wildlife Research, Wildlife Diseases Pathology, Berlin, Germany
    J Gen Virol 88:2651-5. 2007
    ..In phylogenetic analysis, the three bat GHV formed a separate clade with similar distance to the Percavirus and Rhadinovirus clades. These novel viruses are the first herpesviruses to be described in bats...
  30. doi request reprint Novel cytomegaloviruses in free-ranging and captive great apes: phylogenetic evidence for bidirectional horizontal transmission
    Fabian H Leendertz
    Research Group Emerging Zoonoses, Robert Koch Institut, D 13353 Berlin, Germany
    J Gen Virol 90:2386-94. 2009
    ..Divergence dates were estimated and found to be consistent with overall cospeciational development of major primate CMV lineages. However, CMV transmission between chimpanzees and gorillas in both directions has also occurred...
  31. doi request reprint Metastatic endocervical adenocarcinoma in a western lowland gorilla (Gorilla g. gorilla): no evidence of virus-induced carcinogenesis
    P Olias
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany
    J Med Primatol 41:142-6. 2012
    ..Nevertheless, similar tumours have only been rarely described in Great Apes. This report characterizes the pathological and molecular features of a metastatic endocervical adenocarcinoma in a Western lowland gorilla (Gorilla g. gorilla)...
  32. pmc Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions
    Diana Wevers
    Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    J Virol 85:10774-84. 2011
    ..Most notably, six chimpanzee AdVs of species HAdV-A to HAdV-F revealed a remarkably close relationship to human AdVs, possibly indicating recent interspecies transmission events...
  33. pmc Molecular analysis of varicella vaccines and varicella-zoster virus from vaccine-related skin lesions
    Sonja Thiele
    Division of Viral Infections, Robert Koch Institute, D 13353 Berlin, Germany
    Clin Vaccine Immunol 18:1058-66. 2011
    ....
  34. pmc A novel human polyomavirus closely related to the african green monkey-derived lymphotropic polyomavirus
    Nelly Scuda
    Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Virol 85:4586-90. 2011
    ..The virus was tentatively named human polyomavirus 9 (HPyV9). The previously observed seroreactivity to LPV in human populations might find a partial explanation in the circulation of HPyV9...
  35. pmc Identification and quantification of ovine gammaherpesvirus 2 DNA in fresh and stored tissues of pigs with symptoms of porcine malignant catarrhal fever
    Sarah Albini
    Institute of Virology, Veterinary Medical Faculty, University of Zurich, Zurich, Switzerland
    J Clin Microbiol 41:900-4. 2003
    ..In spite of reduced signal due to fixation and paraffin embedding, ovine gammaherpesvirus 2 DNA in pig brains exceeded the amounts found in sheep brains by orders of magnitude...
  36. ncbi request reprint Identification of novel alpha- and gammaherpesviruses from cutaneous and mucosal lesions of dolphins and whales
    Kara A Smolarek Benson
    Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    J Virol Methods 136:261-6. 2006
    ..The sequencing data strongly suggest that these viruses are most likely cetacean specific and possibly have coevolved with their cetacean hosts...
  37. ncbi request reprint Molecular interactions between porcine and human gammaherpesviruses: implications for xenografts?
    Fabio Santoni
    Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Xenotransplantation 13:308-17. 2006
    ....