Eberhard Ritz

Summary

Country: Germany

Publications

  1. doi request reprint Clinical manifestations and natural history of diabetic kidney disease
    Eberhard Ritz
    University of Heidelberg, Nierenzentrum, Im Neuenheimer Feld 162, Heidelberg 69120, Germany
    Med Clin North Am 97:19-29. 2013
  2. doi request reprint Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic
    Nadezda Koleganova
    Insitute of Pathology, University of Heidelberg, Heidelberg, Germany
    Lab Invest 89:520-30. 2009
  3. doi request reprint Oxidative stress after uninephrectomy alters heart morphology in the apolipoprotein E -/- mouse
    Grzegorz Piecha
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Hypertens 26:2220-9. 2008
  4. doi request reprint A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia
    Nadezda Koleganova
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Kidney Int 75:60-71. 2009
  5. ncbi request reprint Renoprotective effect of a dopamine D3 receptor antagonist in experimental type II diabetes
    Marie Luise P Gross
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Lab Invest 86:262-74. 2006
  6. ncbi request reprint Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat
    Matthias Schaier
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, 69115, Heidelberg, Germany
    J Mol Med (Berl) 82:116-25. 2004
  7. ncbi request reprint Effects of estrogens on cardiovascular structure in uninephrectomized SHRsp rats
    Marie Luise Gross
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 67:849-57. 2005
  8. doi request reprint Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination
    Grzegorz Piecha
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Am J Physiol Renal Physiol 295:F137-44. 2008
  9. ncbi request reprint Comprehensive immunohistological analysis of the endothelin system in human kidney grafts
    Kathrin Frank
    Department of Pathology, University of Heidelberg, Germany
    Nephrol Dial Transplant 21:1365-72. 2006
  10. doi request reprint Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:53-64. 2009

Collaborators

Detail Information

Publications50

  1. doi request reprint Clinical manifestations and natural history of diabetic kidney disease
    Eberhard Ritz
    University of Heidelberg, Nierenzentrum, Im Neuenheimer Feld 162, Heidelberg 69120, Germany
    Med Clin North Am 97:19-29. 2013
    ..The frequency is underestimated because hyperglycemia is often lost in the preterminal phase when diabetic patients lose weight and fasting hyperglycemia...
  2. doi request reprint Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic
    Nadezda Koleganova
    Insitute of Pathology, University of Heidelberg, Heidelberg, Germany
    Lab Invest 89:520-30. 2009
    ..We conclude that lowering parathyroid hormone with a calcimimetic significantly improves cardiac histology and function but not the left ventricular mass in SNX...
  3. doi request reprint Oxidative stress after uninephrectomy alters heart morphology in the apolipoprotein E -/- mouse
    Grzegorz Piecha
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Hypertens 26:2220-9. 2008
    ..The current study on the apolipoprotein E -/- mouse was designed to investigate whether nephron reduction by uninephrectomy causes cardiac remodeling and whether this is prevented by antioxidative treatment...
  4. doi request reprint A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia
    Nadezda Koleganova
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Kidney Int 75:60-71. 2009
    ..Our study shows that in uremic rats, calcitriol increased while R-568 attenuated media calcification and proliferation of vascular smooth muscle and endothelial cells...
  5. ncbi request reprint Renoprotective effect of a dopamine D3 receptor antagonist in experimental type II diabetes
    Marie Luise P Gross
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Lab Invest 86:262-74. 2006
    ..These data suggest that in a model of type II diabetes, the dopamine D3-RA had a beneficial effect on renal morphology and albuminuria, which was comparable in magnitude to that of ACE-i treatment...
  6. ncbi request reprint Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat
    Matthias Schaier
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, 69115, Heidelberg, Germany
    J Mol Med (Berl) 82:116-25. 2004
    ..Receptor-specific retinoids may provide a novel therapeutic approach for the treatment of chronic glomerulonephritis...
  7. ncbi request reprint Effects of estrogens on cardiovascular structure in uninephrectomized SHRsp rats
    Marie Luise Gross
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 67:849-57. 2005
    ..Experimental data on the effect of estrogens on cardiovascular damage are controversial and potential underlying mechanisms especially in renal failure have not been fully clarified...
  8. doi request reprint Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination
    Grzegorz Piecha
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Am J Physiol Renal Physiol 295:F137-44. 2008
    ..Combining the AT1 blocker with mineralocorticoid receptor blockade failed to further increase the regression of glomerulosclerosis...
  9. ncbi request reprint Comprehensive immunohistological analysis of the endothelin system in human kidney grafts
    Kathrin Frank
    Department of Pathology, University of Heidelberg, Germany
    Nephrol Dial Transplant 21:1365-72. 2006
    ..It was the purpose of the present study to analyse by immunohistology the expression of ET-1 as well as of the two ET receptors (ET-RA and ET-RB) in the different cells and compartments of kidney grafts and control kidneys...
  10. doi request reprint Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:53-64. 2009
    ..We conclude that LD isotretinoin attenuates progressive renal damage, whereas HD isotretinoin cumulates and aggravates renal damage independent of blood pressure reduction...
  11. doi request reprint Aldosterone in uremia - beyond blood pressure
    Eberhard Ritz
    Nierenzentrum, Ruperto Carola University Heidelberg, Heidelberg, Germany
    Blood Purif 29:111-3. 2010
    ....
  12. doi request reprint Calcitriol ameliorates capillary deficit and fibrosis of the heart in subtotally nephrectomized rats
    Nadezda Koleganova
    Department of Pathology, Insitute of Pathology, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 24:778-87. 2009
    ..In the present experimental study, we studied the effects of non-hypercalcaemic doses of calcitriol on microvascular disease and interstitial fibrosis of the heart...
  13. doi request reprint Hypertrophy and fibrosis in the cardiomyopathy of uremia--beyond coronary heart disease
    Marie Luise Gross
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Semin Dial 21:308-18. 2008
    ....
  14. pmc High salt intake causes adverse fetal programming--vascular effects beyond blood pressure
    Grzegorz Piecha
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 27:3464-76. 2012
    ..Excess salt intake in pregnancy is known to affect BP in the offspring. The present study was designed to assess whether high salt intake in pregnancy affects BP and vascular morphology in the offspring...
  15. pmc Salt restriction in kidney disease--a missed therapeutic opportunity?
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University of Heidelberg, Nierenzentrum, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    Pediatr Nephrol 24:9-17. 2009
    ....
  16. ncbi request reprint Damage to the peritoneal membrane by glucose degradation products is mediated by the receptor for advanced glycation end-products
    Vedat Schwenger
    Department of Medicine Division of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    J Am Soc Nephrol 17:199-207. 2006
    ..Peritoneal damage by GDP in PDF is dependent at least in part on AGE-RAGE interaction...
  17. ncbi request reprint Do beta-blockers combined with RAS inhibitors make sense after all to protect against renal injury?
    Eberhard Ritz
    Nierenzentrum, Im Neuenheimer Feld 162, D69120 Heidelberg, Germany
    Curr Hypertens Rep 9:409-14. 2007
    ..Several points argue for ancillary treatment with beta-blockers: in CKD often four or more different antihypertensive drugs are required and cardiac indications are frequent...
  18. ncbi request reprint No aggravation of renal injury in apolipoprotein E knockout mice (ApoE(-/-)) after subtotal nephrectomy
    Moriz Buzello
    Department of Pathology, University of Heidelberg, Germany
    Nephrol Dial Transplant 19:566-73. 2004
    ..We investigated whether the course of renal disease after uninephrectomy (UNX) and subtotal nephrectomy (SNX) is altered in ApoE(-/-) mice compared with their genetic controls...
  19. ncbi request reprint Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors
    Hiroaki Ogata
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 14:959-67. 2003
    ..Furthermore, it interferes with the development of cardiovascular risk factors and cardiac remodeling...
  20. ncbi request reprint Effect of endothelin blockade on early cardiovascular remodeling in the one-clip-two-kidney hypertension of the rat
    Tobias Saam
    Department of Nephrology, University of Heidelberg, Germany
    Kidney Blood Press Res 26:325-32. 2003
    ..The effects of ET(A) receptor blockade (ET(A)-RB) on vascular remodeling and their potential relation to BP lowering, have not been clarified...
  21. ncbi request reprint The renal retinoid system: time-dependent activation in experimental glomerulonephritis
    Sabine Liebler
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, D 69115 Heidelberg, Germany
    Am J Physiol Renal Physiol 286:F458-65. 2004
    ..Our data document a stimulation of glomerular retinoid-synthesizing enzymes and expression of retinoid receptors in the early repair phase of THY-GN, suggesting activation of this system in acute renal disease...
  22. doi request reprint Vasculotropic effects of calcimimetics
    Nadezda Koleganova
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Curr Opin Nephrol Hypertens 19:32-6. 2010
    ..The ubiquitous expression of the calcium-sensing receptor, which is targeted by calcimimetics and the pleiotropic effects of calcimimetics, make this class of drugs potential candidates for cardiovascular intervention...
  23. doi request reprint Arterial calcification in patients with chronic kidney disease
    Nadezda Koleganova
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 24:2488-96. 2009
    ..The aim of the present study was to characterize aortic calcification in renal compared with non-renal patients...
  24. ncbi request reprint Renal damage in the SHR/N-cp type 2 diabetes model: comparison of an angiotensin-converting enzyme inhibitor and endothelin receptor blocker
    Marie Luise Gross
    Departments of Pathology, University of Heidelberg, Heidelberg, Germany
    Lab Invest 83:1267-77. 2003
    ..This is particularly the case for podocyte changes pointing to angiotensin II-dependent pathomechanisms...
  25. ncbi request reprint Myocyte loss in early left ventricular hypertrophy of experimental renovascular hypertension
    Moriz Buzello
    Department of Pathology, University of Heidelberg, Germany
    Virchows Arch 442:364-71. 2003
    ..These observations document that experimental renovascular hypertension induces a rapidly developing LVH characterized by marked cardiac remodeling and substantial loss of cadiomyocytes...
  26. ncbi request reprint Beneficial Effects of Estrogens on Indices of Renal Damage in Uninephrectomized SHRsp Rats
    Marie Luise Gross
    Departments of Pathology and Internal Medicine, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 15:348-58. 2004
    ..In parallel, loss of podocytes, evidence of podocyte injury (i.e., desmin expression), and expression of mediator systems of glomerular damage were decreased, pointing to a major renoprotective action of estriol...
  27. ncbi request reprint Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats
    Tobias Odenwald
    Department of Pediatrics, University of Heidelberg, Germany
    J Am Soc Nephrol 17:655-62. 2006
    ..1+/-4 versus 32.5+/-1.4 mmol/kg; P=0.01). The calcimimetic R-568 causes an initial BP increase in sham-operated and uremic rats, which in uremic rats is followed by a marked and sustained antihypertensive effect...
  28. doi request reprint Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats
    Kumiko Nakagawa
    Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany
    Pediatr Nephrol 24:1385-9. 2009
    ..The calcimimetic R-568 exerts acute, CaSR-independent, hypotensive effects via vasodilation and negative chronotropy at concentrations exceeding those required for modulation of PTH secretion...
  29. doi request reprint The challenge of sudden death in dialysis patients
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Germany
    Clin J Am Soc Nephrol 3:920-9. 2008
  30. doi request reprint Cardiovascular problems on hemodialysis: current deficits and potential improvement
    Eberhard Ritz
    Department Internal Medicine, Nierenzentrum, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Clin J Am Soc Nephrol 4:S71-8. 2009
    ..Classical risk factors cannot fully explain the magnitude of the risk. This article addresses some nontraditional approaches to deal with the excessive cardiovascular risk for patients who are on hemodialysis...
  31. doi request reprint Prenatal programming-effects on blood pressure and renal function
    Eberhard Ritz
    Division of Nephrology, Department of Internal Medicine, University of Heidelberg, Heidelberg 69100, Germany
    Nat Rev Nephrol 7:137-44. 2011
    ..This Review outlines the concept of prenatal programming and, in particular, describes its role in kidney disease and hypertension...
  32. doi request reprint Acute phase reaction to gadolinium-DTPA in dialysis patients
    Henning Steen
    Division of Cardiology, Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 24:1274-7. 2009
    ..In an observational series, we found a remarkable frequency of peracute reactions after administration of Gd-DTPA used for cardiovascular evaluation before renal transplantation...
  33. ncbi request reprint Atherosclerosis in dialyzed patients
    Eberhard Ritz
    University of Heidelberg, Department of Nephrology, Heidelberg, Germany
    Blood Purif 22:28-37. 2004
    ....
  34. ncbi request reprint Reversal of glomerulosclerosis after high-dose enalapril treatment in subtotally nephrectomized rats
    Marcin Adamczak
    Department of Internal Medicine, University of Heidelberg, Germany
    J Am Soc Nephrol 14:2833-42. 2003
    ..The study confirms that high-dose ACE inhibitor treatment causes partial reversal of glomerular as well as interstitial lesions in subtotally nephrectomized rats...
  35. ncbi request reprint Beta1-adrenergic blockade augments pulsatile PTH secretion in humans
    Claus P Schmitt
    Departments of Pediatrics and Internal Medicine, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 14:3245-50. 2003
    ..Selective beta-1 adrenergic blockade acutely increases plasma PTH by augmenting the mass of hormone secreted per burst, but it does not alter the rhythmicity of pulsatile PTH release...
  36. ncbi request reprint Managing anaemia and diabetes: a future challenge for nephrologists
    Eberhard Ritz
    University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 20:vi21-5. 2005
    ..The Individualised Risk-profiling In DIabEtes Mellitus (IRIDIEM) study will provide evidence-based guidance in risk factor management, by assessing the efficacy of individualized interventions...
  37. doi request reprint Cardiac problems in the dialysis patient: beyond coronary disease
    Andrew Remppis
    Medical Clinic III, Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Semin Dial 21:319-25. 2008
    ..This short review will therefore go beyond coronary heart disease, focus on the specific cardiac pathology in renal failure, and summarize the contemporary therapeutic strategies in ESRD...
  38. ncbi request reprint Anemia and diabetic nephropathy
    Eberhard Ritz
    Nierenzentrum, Medizinische Universitatsklinik Heidelberg, Im Neuemheimer Feld 162, D 69120 Heidelberg, Germany
    Curr Diab Rep 6:469-72. 2006
    ..A major cause is an inappropriate erythropoietin response to anemia, often accompanied by iron deficiency and therapy with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers...
  39. doi request reprint Lipid abnormalities and cardiovascular risk in renal disease
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 19:1065-70. 2008
    ..Admittedly, in the absence of definite evidence in dialysis patients, we still conclude that the administration of statins is appropriate in patients with manifest coronary disease...
  40. doi request reprint Salt and hypertension
    Eberhard Ritz
    Department of Internal Medicine, Division Nephrology, Nierenzentrum, Heidelberg, Germany
    Nephrology (Carlton) 15:49-52. 2010
    ..Current salt intake is too high. Current evidence documents that salt is crucial to the genesis of hypertension...
  41. ncbi request reprint Cardiovascular complications in the diabetic patient with renal disease: an update in 2003
    Ralf Dikow
    Department of Internal Medicine, University of Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    Nephrol Dial Transplant 18:1993-8. 2003
  42. ncbi request reprint Nephron number in patients with primary hypertension
    Gunhild Keller
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    N Engl J Med 348:101-8. 2003
    ..A diminished number of nephrons has been proposed as one of the factors contributing to the development of primary hypertension...
  43. doi request reprint Drug of choice in the management of hypertension in diabetes and diabetic nephropathy: angiotensin-converting enzyme inhibitors
    Eberhard Ritz
    Division of Nephrology, Department of Internal Medicine, Nierenzentrum, Heidelberg, Germany
    J Clin Hypertens (Greenwich) 13:285-9. 2011
    ..In proteinuric diabetic nephropathy, renin-angiotensin system blockade is clearly indicated, but monotherapy is practically always insufficient to achieve target blood pressure values...
  44. doi request reprint Intestinal-renal syndrome: mirage or reality?
    Eberhard Ritz
    Nierenzentrum, Im Neuenheimer Feld 162, Heidelberg, Germany
    Blood Purif 31:70-6. 2011
    ....
  45. ncbi request reprint An oral load of the early glycation compound lactuloselysine fails to accumulate in the serum of uraemic patients
    Vedat Schwenger
    Department of Nephrology, University of Heidelberg, Bergheimerstr 56a, 69115 Heidelberg, Germany
    Nephrol Dial Transplant 21:383-8. 2006
    ..It has been hypothesized that in renal failure, exogenous glycation compounds from food accumulate and play a major pathogenetic role when renal excretion is impaired...
  46. ncbi request reprint Can we ameliorate quality of life in chronic kidney disease? The nephrologist's point of view
    Eberhard Ritz
    Department of Internal Medicine Nierenzentrum, Ruperto Carola University, Im Neuenheimer Feld 162, Heidelberg, Germany
    J Nephrol 21:S9-11. 2008
    ..Chronic dialysis treatment creates a particular "microcosmos" in which interpersonal relations and psychological problems carry particular weight...
  47. ncbi request reprint PTH pulsatility but not calcium sensitivity is restored after total parathyroidectomy with heterotopic autotransplantation
    Claus P Schmitt
    Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 14:407-14. 2003
    ..In conclusion, pulsatile PTH secretion is partially restored within 2 yr of PTX. However, the capacity of the autotransplanted tissue to adapt to changes in ionized calcium remains profoundly disturbed...
  48. ncbi request reprint Retinoid receptor-specific agonists alleviate experimental glomerulonephritis
    Ingo Lehrke
    Department of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany
    Am J Physiol Renal Physiol 282:F741-51. 2002
    ..Further studies are indicated to define the potential use of retinoid agonists in inflammatory renal disease...
  49. ncbi request reprint Renal dysfunction as a cardiovascular risk factor
    Eberhard Ritz
    Department of Internal Medicine, University of Heidelberg, Bergheimer Strasse 58, Germany
    Curr Hypertens Rep 4:365-8. 2002
    ..Epidemiologic information suggests that renal and cardiovascular outcome run parallel in this segment of the population...
  50. ncbi request reprint Intraperitoneal protein injection in the axolotl: the amphibian kidney as a novel model to study tubulointerstitial activation
    Marie Louise Gross
    Department of Pathology, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Kidney Int 62:51-9. 2002
    ....