E Ritz

Summary

Country: Germany

Publications

  1. ncbi request reprint Lipid changes and statins in chronic renal insufficiency
    Eberhard Ritz
    Ruperto Carola University Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 17:S226-30. 2006
  2. pmc Phosphate additives in food--a health risk
    Eberhard Ritz
    Nierenzentrum Heidelberg, 69120 Heidelberg, Germany
    Dtsch Arztebl Int 109:49-55. 2012
  3. pmc Effect of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial
    Andreas Tomaschitz
    Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz, 8036, Austria
    BMC Endocr Disord 12:19. 2012
  4. ncbi request reprint Salt intake in kidney disease--a missed therapeutic opportunity?
    Hiddo J Lambers Heerspink
    Correspondence and offprint requests to Eberhard Ritz E mail
    Nephrol Dial Transplant 27:3435-42. 2012
  5. doi request reprint Sodium chloride intake: is lower always better?
    Hiddo Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Am Soc Nephrol 23:1136-9. 2012
  6. pmc Renal protection in diabetes: lessons from ONTARGET
    Eberhard Ritz
    Universitat Erlangen, Medizinische Klinik IV, Erlangen, Germany
    Cardiovasc Diabetol 9:60. 2010
  7. ncbi request reprint Angiotensin receptor antagonists in patients with nephropathy due to type 2 diabetes
    Ritz Eberhard
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Ann Med 34:507-13. 2002
  8. doi request reprint Lipid abnormalities and cardiovascular risk in renal disease
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 19:1065-70. 2008
  9. doi request reprint A new dawn in cardiovascular protection: total cardiovascular risk: rigorous treatment of risk factors. Introduction
    Eberhard Ritz
    Division of Nephrology, Department of Internal Medicine, Ruperto Carola University of Heidelberg, Germany
    Nat Clin Pract Cardiovasc Med 5:S1-2. 2008
  10. ncbi request reprint Salt--a potential 'uremic toxin'?
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University Heidelberg, Heidelberg, Germany
    Blood Purif 24:63-6. 2006

Collaborators

Detail Information

Publications145 found, 100 shown here

  1. ncbi request reprint Lipid changes and statins in chronic renal insufficiency
    Eberhard Ritz
    Ruperto Carola University Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 17:S226-30. 2006
    ..e. interference with proximal tubular reabsorption of protein) meanwhile has been well documented...
  2. pmc Phosphate additives in food--a health risk
    Eberhard Ritz
    Nierenzentrum Heidelberg, 69120 Heidelberg, Germany
    Dtsch Arztebl Int 109:49-55. 2012
    ..Therefore, phosphate additives in food are a matter of concern, and their potential impact on health may well have been underappreciated...
  3. pmc Effect of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial
    Andreas Tomaschitz
    Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz, 8036, Austria
    BMC Endocr Disord 12:19. 2012
    ..abstract:..
  4. ncbi request reprint Salt intake in kidney disease--a missed therapeutic opportunity?
    Hiddo J Lambers Heerspink
    Correspondence and offprint requests to Eberhard Ritz E mail
    Nephrol Dial Transplant 27:3435-42. 2012
    ..e. the first choice antihypertensive agents for the treatment of CKD...
  5. doi request reprint Sodium chloride intake: is lower always better?
    Hiddo Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Am Soc Nephrol 23:1136-9. 2012
    ..This approach will have implications for health care policies and labeling of the salt content of purchased foods...
  6. pmc Renal protection in diabetes: lessons from ONTARGET
    Eberhard Ritz
    Universitat Erlangen, Medizinische Klinik IV, Erlangen, Germany
    Cardiovasc Diabetol 9:60. 2010
    ....
  7. ncbi request reprint Angiotensin receptor antagonists in patients with nephropathy due to type 2 diabetes
    Ritz Eberhard
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Ann Med 34:507-13. 2002
    ..This review provides an in-depth discussion of the results of these studies and provides recommendations for patient management...
  8. doi request reprint Lipid abnormalities and cardiovascular risk in renal disease
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 19:1065-70. 2008
    ..Admittedly, in the absence of definite evidence in dialysis patients, we still conclude that the administration of statins is appropriate in patients with manifest coronary disease...
  9. doi request reprint A new dawn in cardiovascular protection: total cardiovascular risk: rigorous treatment of risk factors. Introduction
    Eberhard Ritz
    Division of Nephrology, Department of Internal Medicine, Ruperto Carola University of Heidelberg, Germany
    Nat Clin Pract Cardiovasc Med 5:S1-2. 2008
  10. ncbi request reprint Salt--a potential 'uremic toxin'?
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University Heidelberg, Heidelberg, Germany
    Blood Purif 24:63-6. 2006
    ..However, it is possible, and indeed likely, that sodium plays an adverse role in the genesis of target organ damage in terminal renal failure...
  11. doi request reprint The challenge of sudden death in dialysis patients
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Germany
    Clin J Am Soc Nephrol 3:920-9. 2008
  12. doi request reprint Obesity and chronic kidney disease
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Semin Nephrol 29:504-11. 2009
    ..This article summarizes the current hypotheses that link visceral obesity and kidney malfunction and provides information on the epidemiology and renal pathology resulting from visceral obesity...
  13. doi request reprint Cardiovascular problems on hemodialysis: current deficits and potential improvement
    Eberhard Ritz
    Department Internal Medicine, Nierenzentrum, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Clin J Am Soc Nephrol 4:S71-8. 2009
    ..Classical risk factors cannot fully explain the magnitude of the risk. This article addresses some nontraditional approaches to deal with the excessive cardiovascular risk for patients who are on hemodialysis...
  14. ncbi request reprint Compelling drug indications in diabetic and nondiabetic nephropathy
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University, Bergheimerstrasse 58, D69115 Heidelberg, Germany
    Curr Hypertens Rep 6:293-9. 2004
    ....
  15. doi request reprint Aldosterone in uremia - beyond blood pressure
    Eberhard Ritz
    Nierenzentrum, Ruperto Carola University Heidelberg, Heidelberg, Germany
    Blood Purif 29:111-3. 2010
    ....
  16. doi request reprint Renal research in 19th century Germany
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University Heidelberg, Germany
    Am J Kidney Dis 55:1121-9. 2010
    ....
  17. ncbi request reprint Heart and kidney: fatal twins?
    Eberhard Ritz
    Department of Nephrology, Ruprecht Karl University, Heidelberg, Germany
    Am J Med 119:S31-9. 2006
    ..Still to be resolved, however, is the optimal dosage; several recent studies indicate that the dosage required for maximal blood pressure reduction is insufficient to provide maximal renoprotection...
  18. doi request reprint Salt and hypertension
    Eberhard Ritz
    Department of Internal Medicine, Division Nephrology, Nierenzentrum, Heidelberg, Germany
    Nephrology (Carlton) 15:49-52. 2010
    ..Current salt intake is too high. Current evidence documents that salt is crucial to the genesis of hypertension...
  19. ncbi request reprint [Smoking -- the futile fight against the vice. A historical perspective]
    E Ritz
    Medizinische Universitatsklinik, Heidelberg
    Dtsch Med Wochenschr 130:2947-51. 2005
  20. ncbi request reprint Diabetic nephropathy and anaemia
    E Ritz
    Department Internal Medicine, Ruperto Carola University Heidelberg, Germany
    Eur J Clin Invest 35:66-74. 2005
    ....
  21. ncbi request reprint [Historical roles of salt]
    E Ritz
    Medizinische Universitatsklinik Heidelberg
    Dtsch Med Wochenschr 129:2780-3. 2004
    ..In the past salt was essential to preserve food. The past importance of salt as a commodity can well be compared with that of oil today. These and further historical aspects of the role of salt are briefly dealt with in this article...
  22. pmc Salt restriction in kidney disease--a missed therapeutic opportunity?
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University of Heidelberg, Nierenzentrum, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    Pediatr Nephrol 24:9-17. 2009
    ....
  23. ncbi request reprint Hemodialysis--from early days to tomorrow
    Eberhard Ritz
    Department Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Contrib Nephrol 149:1-9. 2005
    ..Elucidating and correcting the cardiovascular risk is the most important challenge to clinical nephrology today...
  24. ncbi request reprint Managing mineral balance in end-stage renal disease
    Eberhard Ritz
    Klinikum der Universitat Heidelberg, Sektion Nephrologie, Bergheimer Strasse 56a, D 69115 Heidelberg, Germany
    Nephrol Dial Transplant 19:i1-3. 2004
  25. ncbi request reprint Atherosclerosis in dialyzed patients
    Eberhard Ritz
    University of Heidelberg, Department of Nephrology, Heidelberg, Germany
    Blood Purif 22:28-37. 2004
    ....
  26. ncbi request reprint Managing anaemia and diabetes: a future challenge for nephrologists
    Eberhard Ritz
    University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 20:vi21-5. 2005
    ..The Individualised Risk-profiling In DIabEtes Mellitus (IRIDIEM) study will provide evidence-based guidance in risk factor management, by assessing the efficacy of individualized interventions...
  27. ncbi request reprint Kidney and hypertension-causes. Update 2003
    Eberhard Ritz
    Department of Internal Medicine, Heidelberg, Germany
    Herz 28:663-7. 2003
    ..Fifth, the pulse pressure profile is altered as a consequence of premature and accelerated aging causing stiffening of the aorta. Knowledge of these pathomechanisms is important for selection of appropriate antihypertensive treatment...
  28. ncbi request reprint Disorders of phosphate metabolism--pathomechanisms and management of hypophosphataemic disorders
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University, Bergheimer Str 58, Heidelberg D 69115, Germany
    Best Pract Res Clin Endocrinol Metab 17:547-58. 2003
    ..In patients with gastrointestinal intolerance to phosphate or with severely symptomatic bone disease, prolonged intravenous administration of Pi is necessary...
  29. ncbi request reprint Lifestyle modification and progressive renal failure
    Eberhard Ritz
    Nierenzentrum Department Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Nephrology (Carlton) 10:387-92. 2005
    ..Alcohol consumption, according to some preliminary information, has a bimodal relationship to cardiovascular risk and progression, with moderate consumption being protective...
  30. ncbi request reprint Renal dysfunction: a novel indicator and potential promoter of cardiovascular risk
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Clin Med 3:357-60. 2003
    ..Great progress has been made in providing algorithms to detect patients at risk and to identify interventions to reduce the risk...
  31. doi request reprint Role of sodium intake in the progression of chronic kidney disease
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    J Ren Nutr 19:61-2. 2009
    ..The effect of salt restriction cannot be reproduced by treatment with diuretics. Inappropriate increase of intrarenal angiotensin II and increased reactive oxygen species are the major culprits responsible for salt-related renal damage...
  32. ncbi request reprint Can we ameliorate quality of life in chronic kidney disease? The nephrologist's point of view
    Eberhard Ritz
    Department of Internal Medicine Nierenzentrum, Ruperto Carola University, Im Neuenheimer Feld 162, Heidelberg, Germany
    J Nephrol 21:S9-11. 2008
    ..Chronic dialysis treatment creates a particular "microcosmos" in which interpersonal relations and psychological problems carry particular weight...
  33. ncbi request reprint [Diuretics for the treatment of edema]
    Eberhard Ritz
    Klinikum der Universitat Heidelberg, Sektion Nephrologie
    Pharm Unserer Zeit 35:342-5. 2006
  34. ncbi request reprint Hypertension and kidney disease
    E Ritz
    Nierenzentrum, Heidelberg, Germany
    Clin Nephrol 74:S39-43. 2010
    ..The possible role of non muscular heavy chain type II isoform A protein which is associated with non diabetic chronic kidney disease in subjects of African ancestry remains to be determined...
  35. ncbi request reprint [Sodium at the crossroads of history and culture]
    E Ritz
    Ruperto Carola Universität Heidelberg, Germany
    Nephrol Ther 3:S84-90. 2007
    ..It broaches the important question of "salt hunger" of the vital role of salt in past times, a costly substance because it was indispensable, and the basis of a tax (the salt tax) which underlay the French Revolution...
  36. ncbi request reprint [The kidney in the Bible]
    E Ritz
    Medizinische Universitätsklinik Nierenzentrum, Ruperto Carola Universität Heidelberg
    Dtsch Med Wochenschr 131:2916-9. 2006
  37. ncbi request reprint Blood pressure in diabetic nephropathy--current controversies
    E Ritz
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    J Intern Med 249:215-23. 2001
    ..Apart from blood pressure, proteinuria should be monitored and dosing of ACE inhibitors should be guided, also by reduction of protein excretion...
  38. ncbi request reprint Do beta-blockers combined with RAS inhibitors make sense after all to protect against renal injury?
    Eberhard Ritz
    Nierenzentrum, Im Neuenheimer Feld 162, D69120 Heidelberg, Germany
    Curr Hypertens Rep 9:409-14. 2007
    ..Several points argue for ancillary treatment with beta-blockers: in CKD often four or more different antihypertensive drugs are required and cardiac indications are frequent...
  39. ncbi request reprint Hyperphosphatemia in renal failure
    Eberhard Ritz
    Department Internal Medicine and Pathology, Ruperto Carola University, Heidelberg, Germany
    Blood Purif 23:6-9. 2005
    ..Currently sevelamer and lanthanum carbonate have been introduced and trivalent iron preparations are under development...
  40. ncbi request reprint End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions
    E Ritz
    Department of Internal Medicine, Ruperto Carola University Heidelberg, Germany
    Am J Kidney Dis 34:795-808. 1999
    ..It is argued that the challenge for the future will be better patient management in earlier phases of diabetic nephropathy to attenuate or prevent progression, as well as cardiovascular complications...
  41. doi request reprint Drug of choice in the management of hypertension in diabetes and diabetic nephropathy: angiotensin-converting enzyme inhibitors
    Eberhard Ritz
    Division of Nephrology, Department of Internal Medicine, Nierenzentrum, Heidelberg, Germany
    J Clin Hypertens (Greenwich) 13:285-9. 2011
    ..In proteinuric diabetic nephropathy, renin-angiotensin system blockade is clearly indicated, but monotherapy is practically always insufficient to achieve target blood pressure values...
  42. ncbi request reprint Target level for hemoglobin correction in patients with diabetes and CKD: primary results of the Anemia Correction in Diabetes (ACORD) Study
    Eberhard Ritz
    Department of Internal Medicine, University of Heidelberg Medical Clinic I, University Hospital Mannheim, Germany
    Am J Kidney Dis 49:194-207. 2007
    ..The Anemia CORrection in Diabetes (ACORD) Study aimed to investigate the effect of anemia correction on cardiac structure, function, and outcomes in patients with diabetes with anemia and early diabetic nephropathy...
  43. ncbi request reprint Total cardiovascular risk management
    Eberhard Ritz
    Division of Nephrology, Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Am J Cardiol 100:53J-60J. 2007
    ..Clearly, isolated treatment of hypertension is no longer sufficient; risk factors and target organ damage need to be actively searched for and treated if long-term cardiovascular health is to be improved...
  44. ncbi request reprint Is the renal risk of adults determined in utero?
    E Ritz
    Department of Internal Medicine, Division of Nephrology, Ruprecht Karl University of Heidelberg, Heidelberg, Germany
    Kidney Int 72:667-8. 2007
    ..The results of the prospective study of Verburg et al., sequentially measuring the growth of fetuses and the volume of their kidneys in a large population-based sample, identify some determinants of impaired growth of fetal kidneys...
  45. doi request reprint Prenatal programming-effects on blood pressure and renal function
    Eberhard Ritz
    Division of Nephrology, Department of Internal Medicine, University of Heidelberg, Heidelberg 69100, Germany
    Nat Rev Nephrol 7:137-44. 2011
    ..This Review outlines the concept of prenatal programming and, in particular, describes its role in kidney disease and hypertension...
  46. ncbi request reprint Renal dysfunction as a cardiovascular risk factor
    Eberhard Ritz
    Department of Internal Medicine, University of Heidelberg, Bergheimer Strasse 58, Germany
    Curr Hypertens Rep 4:365-8. 2002
    ..Epidemiologic information suggests that renal and cardiovascular outcome run parallel in this segment of the population...
  47. doi request reprint Is there an obesity-metabolic syndrome related glomerulopathy?
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Curr Opin Nephrol Hypertens 20:44-9. 2011
    ..This form of FSGS represents the tip of an iceberg: a much broader spectrum of renal malfunction is linked to visceral obesity, which is closely connected to, but not completely identical with, the concept of 'metabolic syndrome'...
  48. doi request reprint Intestinal-renal syndrome: mirage or reality?
    Eberhard Ritz
    Nierenzentrum, Im Neuenheimer Feld 162, Heidelberg, Germany
    Blood Purif 31:70-6. 2011
    ....
  49. ncbi request reprint Anemia and diabetic nephropathy
    Eberhard Ritz
    Nierenzentrum, Medizinische Universitatsklinik Heidelberg, Im Neuemheimer Feld 162, D 69120 Heidelberg, Germany
    Curr Diab Rep 6:469-72. 2006
    ..A major cause is an inappropriate erythropoietin response to anemia, often accompanied by iron deficiency and therapy with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers...
  50. ncbi request reprint Hypertension and antihypertensive treatment of diabetic nephropathy
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Nat Clin Pract Nephrol 2:562-7. 2006
    ..In addition to blood pressure, proteinuria is a treatment target and should be reduced to below 1 g/24 h...
  51. ncbi request reprint Compounds in development to combat hyperphosphataemia
    E Ritz
    Medizinische Klinik I der Universitat Heidelberg, Sektion Nephrologie, Bergheimerstr 56a, 69115 Heidelberg, Germany
    Expert Opin Investig Drugs 10:2185-90. 2001
    ....
  52. ncbi request reprint Effects of all-trans retinoic acid on renin-angiotensin system in rats with experimental nephritis
    C Dechow
    Division of Nephrology, University of Heidelberg, D-69115, Germany
    Am J Physiol Renal Physiol 281:F909-19. 2001
    ..In conclusion, all-trans-RA influences the renal RAS in anti-Thy1.1 nephritis by decreasing ANG II synthesis and receptor expression. The beneficial effect of retinoids may be explained, at least in part, by reduction of RAS activity...
  53. ncbi request reprint Effects of ACE inhibition and bradykinin antagonism on cardiovascular changes in uremic rats
    K Amann
    Departments of Pathology, Heidelberg, Erlangen, Germany
    Kidney Int 58:153-61. 2000
    ....
  54. ncbi request reprint Endothelin A receptor blockade prevents capillary/myocyte mismatch in the heart of uremic animals
    K Amann
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 11:1702-11. 2000
    ..The results support a role of ET-1 in the genesis of left ventricular capillary/myocyte mismatch in uremia...
  55. ncbi request reprint Retinoic acid reduces glomerular injury in a rat model of glomerular damage
    J Wagner
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 11:1479-87. 2000
    ..001). It is concluded that all-trans-RA limits glomerular proliferation, glomerular lesions, and albuminuria in an established model of renal damage. The findings point to retinoids as potential novel modulators of glomerular injury...
  56. ncbi request reprint Isotretinoin alleviates renal damage in rat chronic glomerulonephritis
    M Schaier
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 60:2222-34. 2001
    ..Retinoids may provide a novel therapeutic option for the treatment of glomerulonephritis...
  57. ncbi request reprint Antihypertensive therapy in renal patients - benefits and difficulties
    V Schwenger
    Klinikum der Universitat Heidelberg, Sektion Nephrologie, Heidelberg, Deutschland
    Nephron 83:202-13. 1999
    ..Thus it is very important to lower the nighttime blood pressure and to detect nighttime blood pressure increases using ambulatory blood pressure measurements...
  58. ncbi request reprint Effects of low dose sympathetic inhibition on glomerulosclerosis and albuminuria in subtotally nephrectomized rats
    K Amann
    Department of Pathology, University of Heidelberg, Germany
    J Am Soc Nephrol 11:1469-78. 2000
    ..In kidneys of SNX rats, indirect evidence was found for increased activity of a reduced number of nerve fibers...
  59. ncbi request reprint ACE-inhibition is superior to endothelin A receptor blockade in preventing abnormal capillary supply and fibrosis of the heart in experimental diabetes
    M L Gross
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Diabetologia 47:316-24. 2004
    ..To this end we compared the effects of an ET receptor A blocker (ETA-RB) with that of an ACE-inhibitor (ACE-i) or their combination in rats with Streptozotocin (STZ) diabetes...
  60. ncbi request reprint Retinoids inhibit the actions of angiotensin II on vascular smooth muscle cells
    V Haxsen
    Department of Nephrology, University Hospital, University of Heidelberg, Heidelberg, Germany
    Circ Res 88:637-44. 2001
    ..Our findings demonstrate that retinoids are potent inhibitors of the actions of Ang II on VSMCs. The findings support the notion that retinoids may interfere with proliferative vascular disease...
  61. ncbi request reprint Optimal blood pressure control versus additional immunosuppressive therapy in idiopathic membranous nephropathy - a retrospective analysis
    R Dikow
    Department of Nephrology, University Hospital of Heidelberg, Heidelberg, Germany
    Clin Nephrol 72:366-72. 2009
    ....
  62. ncbi request reprint Comparison of renal morphology in the Streptozotocin and the SHR/N-cp models of diabetes
    M L Gross
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Lab Invest 84:452-64. 2004
    ..In contrast, the diabetic SHR/N-cp exhibits marked structural lesions, particularly podocyte damage and mesangial expansion that promise to make it a more suitable model for investigation of diabetic glomerulosclerosis...
  63. pmc Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study
    E Ritz
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Diabetologia 53:49-57. 2010
    ..This may be important because even within the normoalbuminuric range, higher rates of albuminuria are known to be associated with higher renal and cardiovascular risk...
  64. ncbi request reprint Capillary/myocyte mismatch in the heart in renal failure--a role for erythropoietin?
    K Amann
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 15:964-9. 2000
    ..e. capillary/myocyte mismatch in experimental renal failure...
  65. ncbi request reprint Renal failure and ACE inhibition: how much is too much?
    M L Gross
    Department Pathology, University of Heidelberg, Im Neuenheimer Feld, 69120 Heidelberg, Germany
    Z Kardiol 94:81-6. 2005
    ..Ongoing studies try to define the relative merits of high dose monotherapy (ACE inhibitors or angiotensin receptor blockers) versus a combination therapy of the two...
  66. ncbi request reprint Differential effects of ACE inhibitors and vasodilators on renal function curve in patients with primary hypertension
    D Fliser
    Department of Internal Medicine, University of Heidelberg, Germany
    Blood Press 2:296-300. 1993
    ....
  67. ncbi request reprint Renal endothelin-1 and endothelin receptor type B expression in glomerular diseases with proteinuria
    I Lehrke
    Department of Nephrology, University of Heidelberg, Germany
    J Am Soc Nephrol 12:2321-9. 2001
    ..It is concluded that the increased ET-R(B) and ET-1 mRNA and protein expression observed in animal models of renal disease is also demonstrable among patients with renal disease and high-grade proteinuria...
  68. ncbi request reprint Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 16:2456-61. 2005
    ..The endogenous NO synthase inhibitor ADMA is significantly associated with progression of nondiabetic kidney diseases. Lowering plasma ADMA concentrations may be a novel therapeutic target to prevent progressive renal impairment...
  69. ncbi request reprint Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Osteology, and Rheumatology, University of Hamburg, Hamburg, Germany
    Kidney Int 67:799-812. 2005
    ..In our opinion patients with proteinuria >1 g/day despite optimal blood pressure control under RAS-blocking monotherapy are a high-risk group which will presumably benefit from combination therapy...
  70. ncbi request reprint Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study
    Danilo Fliser
    Department of Internal Medicine, Hannover Medical School, Germany
    J Am Soc Nephrol 18:2600-8. 2007
    ..In conclusion, FGF23 is a novel independent predictor of progression of renal disease in patients with nondiabetic CKD. Its pathophysiological significance remains to be elucidated...
  71. ncbi request reprint How should we manage anaemia in patients with diabetes?
    Ralf Dikow
    Department of Nephrology, University of Heidelberg, Germany
    Nephrol Dial Transplant 17:67-72. 2002
    ..Further studies are required to determine whether reversal of anaemia has beneficial effects on microvascular and macrovascular diabetic complications, particularly cardiac disease, retinopathy and peripheral arterial disease...
  72. doi request reprint Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination
    Grzegorz Piecha
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Am J Physiol Renal Physiol 295:F137-44. 2008
    ..Combining the AT1 blocker with mineralocorticoid receptor blockade failed to further increase the regression of glomerulosclerosis...
  73. ncbi request reprint Renoprotective effect of a dopamine D3 receptor antagonist in experimental type II diabetes
    Marie Luise P Gross
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Lab Invest 86:262-74. 2006
    ..These data suggest that in a model of type II diabetes, the dopamine D3-RA had a beneficial effect on renal morphology and albuminuria, which was comparable in magnitude to that of ACE-i treatment...
  74. doi request reprint Sympathetic overactivity--the Cinderella of cardiovascular risk factors in dialysis patients
    Oliver Vonend
    Department of Nephrology, Heinich Heine University of Duesseldorf, Germany
    Semin Dial 21:326-30. 2008
    ..The available experimental and clinical evidence to suggest such a pathophysiological role of sympathetic overactivity is summarized in this current review...
  75. ncbi request reprint Combination treatment with an ET(A)-receptor blocker and an ACE inhibitor is not superior to the respective monotherapies in attenuating chronic transplant nephropathy in a 'Fisher-to-Lewis' rat model
    Judith Adams
    Department of Urology, Ruperto Carola University, Heidelberg, Germany
    Nephrol Dial Transplant 17:780-7. 2002
    ..It is unknown (i) which of both pharmacological interventions attenuates CTN more effectively and (ii) whether combination therapy exerts additive nephroprotection...
  76. doi request reprint Metabolic syndrome and kidney disease
    Eberhard Ritz
    Ruperto Carola University Heidelberg, Heidelberg, Germany
    Blood Purif 26:59-62. 2008
    ..Recent evidence points to adverse effects of aldosterone on podocytes, mediated by reactive oxygen species and resulting from hypothetical stimulants of aldosterone synthesis by visceral adipocytes...
  77. ncbi request reprint Renal damage in the SHR/N-cp type 2 diabetes model: comparison of an angiotensin-converting enzyme inhibitor and endothelin receptor blocker
    Marie Luise Gross
    Departments of Pathology, University of Heidelberg, Heidelberg, Germany
    Lab Invest 83:1267-77. 2003
    ..This is particularly the case for podocyte changes pointing to angiotensin II-dependent pathomechanisms...
  78. ncbi request reprint Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat
    Matthias Schaier
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, 69115, Heidelberg, Germany
    J Mol Med (Berl) 82:116-25. 2004
    ..Receptor-specific retinoids may provide a novel therapeutic approach for the treatment of chronic glomerulonephritis...
  79. doi request reprint Oxidative stress after uninephrectomy alters heart morphology in the apolipoprotein E -/- mouse
    Grzegorz Piecha
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Hypertens 26:2220-9. 2008
    ..The current study on the apolipoprotein E -/- mouse was designed to investigate whether nephron reduction by uninephrectomy causes cardiac remodeling and whether this is prevented by antioxidative treatment...
  80. doi request reprint Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic
    Nadezda Koleganova
    Insitute of Pathology, University of Heidelberg, Heidelberg, Germany
    Lab Invest 89:520-30. 2009
    ..We conclude that lowering parathyroid hormone with a calcimimetic significantly improves cardiac histology and function but not the left ventricular mass in SNX...
  81. ncbi request reprint Nephron number and renal risk in hypertension and diabetes
    Marie Luise Gross
    Department of Pathology, Ruprecht Karl University, Heidelberg, Germany
    J Am Soc Nephrol 16:S27-9. 2005
    ..Furthermore, intrauterine programming during organogenesis, e.g., by hyperglycemia, seems to be important: In animal experiments, offspring of either hyperglycemic or diabetic mothers have fewer nephrons...
  82. ncbi request reprint Randomized controlled trial on the efficacy and safety of atorvastatin in patients with type 2 diabetes on hemodialysis (4D study): demographic and baseline characteristics
    Christoph Wanner
    Division of Nephrology, University Clinic, Wurzburg, Germany
    Kidney Blood Press Res 27:259-66. 2004
    ..The results of the study will provide important information on the efficacy and safety of atorvastatin to support its use in patients with an impaired renal function who are at a high risk of vascular morbidity and mortality...
  83. ncbi request reprint Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors
    Hiroaki Ogata
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 14:959-67. 2003
    ..Furthermore, it interferes with the development of cardiovascular risk factors and cardiac remodeling...
  84. ncbi request reprint Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects
    Jan T Kielstein
    Department of Internal Medicine, Medical School Hannover, Germany
    Circulation 107:1891-5. 2003
    ....
  85. ncbi request reprint Myocyte loss in early left ventricular hypertrophy of experimental renovascular hypertension
    Moriz Buzello
    Department of Pathology, University of Heidelberg, Germany
    Virchows Arch 442:364-71. 2003
    ..These observations document that experimental renovascular hypertension induces a rapidly developing LVH characterized by marked cardiac remodeling and substantial loss of cadiomyocytes...
  86. doi request reprint Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:53-64. 2009
    ..We conclude that LD isotretinoin attenuates progressive renal damage, whereas HD isotretinoin cumulates and aggravates renal damage independent of blood pressure reduction...
  87. ncbi request reprint The clinical management of hyperphosphatemia
    Eberhard Ritz
    Klinikum der Universitat Heidelberg, Heidelberg, Germany
    J Nephrol 18:221-8. 2005
    ..In this article, the consequences of hyperphosphatemia are reviewed, and recent developments in the treatment of the condition are discussed...
  88. ncbi request reprint Pathophysiology of hypertensive renal damage
    E Ritz
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Am J Hypertens 6:241S-244S. 1993
    ..Several studies have provided encouraging evidence that antihypertensive therapy, particularly with angiotensin-converting enzyme inhibitors or calcium antagonists, can slow the progression of renal damage...
  89. ncbi request reprint Renal disease and hypertension in non-insulin-dependent diabetes mellitus
    N Ismail
    Department of Internal Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Kidney Int 55:1-28. 1999
    ....
  90. ncbi request reprint Sympathetic overactivity and arterial hypertension in renal failure
    S R Orth
    Department of Nephrology, Ruperto Carola University Heidelberg, Germany
    Nephrol Dial Transplant 16:67-9. 2001
    ..The sequelae of sympathetic overactivity extend beyond their effects on blood pressure and include accelerated progression of renal failure and presumably increased cardiac arrhythmia...
  91. ncbi request reprint Consequences of late referral in diabetic renal disease
    E Ritz
    University of Heidelberg, Department of Internal Medicine, Heidelberg, Germany
    Acta Diabetol 39:S3-8. 2002
    ....
  92. ncbi request reprint Calcification of coronary intima and media: immunohistochemistry, backscatter imaging, and x-ray analysis in renal and nonrenal patients
    Marie Luise Gross
    Institute of Pathology, Heidelberg, Germany
    Clin J Am Soc Nephrol 2:121-34. 2007
    ..A more marked inflammatory response in renal patients is suggested by more frequent presence and greater intensity of markers of inflammation...
  93. ncbi request reprint Retinoid receptor-specific agonists alleviate experimental glomerulonephritis
    Ingo Lehrke
    Department of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany
    Am J Physiol Renal Physiol 282:F741-51. 2002
    ..Further studies are indicated to define the potential use of retinoid agonists in inflammatory renal disease...
  94. ncbi request reprint Cardiovascular abnormalities and hypertension in the elderly dialysis patient
    Ralf Dikow
    Department Internal Medicine, Ruperto Carola University of Heidelberg, Heidelberg, Germany
    Semin Dial 15:121-6. 2002
    ..The latter observation has led to an "old for old" program in Europe...
  95. doi request reprint Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats
    Grzegorz Piecha
    Institute of Pathology, Univ of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Am J Physiol Renal Physiol 294:F748-57. 2008
    ..Calcitriol and R-568 were similarly effective in ameliorating kidney damage...
  96. ncbi request reprint Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats
    Tobias Odenwald
    Department of Pediatrics, University of Heidelberg, Germany
    J Am Soc Nephrol 17:655-62. 2006
    ..1+/-4 versus 32.5+/-1.4 mmol/kg; P=0.01). The calcimimetic R-568 causes an initial BP increase in sham-operated and uremic rats, which in uremic rats is followed by a marked and sustained antihypertensive effect...
  97. ncbi request reprint Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study
    Bjoern Becker
    Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Am Soc Nephrol 16:1091-8. 2005
    ..Moreover, hypoadiponectinemia is a novel putative CV risk factor in patients with mild and moderate renal failure...
  98. ncbi request reprint Cardiovascular complications in the diabetic patient with renal disease: an update in 2003
    Ralf Dikow
    Department of Internal Medicine, University of Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    Nephrol Dial Transplant 18:1993-8. 2003
  99. ncbi request reprint Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  100. doi request reprint Arterial calcification in patients with chronic kidney disease
    Nadezda Koleganova
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 24:2488-96. 2009
    ..The aim of the present study was to characterize aortic calcification in renal compared with non-renal patients...
  101. ncbi request reprint Late referral--a major cause of poor outcome in the very elderly dialysis patient
    Vedat Schwenger
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Nephrol Dial Transplant 21:962-7. 2006
    ..There is little documentation whether late referral is more frequent in the very elderly (> or =75 years) as compared with non-elderly patients and whether it contributes, at least in part, to their particularly poor outcome...