Research Topics
| B RiemannSummaryCountry: Germany Publications
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Publications
Early effects of irradiation on [(123)I]-IMT and [(18)F]-FDG uptake in rat C6 glioma cellsBurkhard Riemann
Department of Nuclear Medicine, University of Munster, Germany
Strahlenther Onkol 180:434-41. 2004..However, to date, little is known about the early effects of radiation on [(123)I]-IMT and [(18)F]-FDG uptake in gliomas...- [High non-specific binding of the beta(1) -selective radioligand 2-(125)I-ICI-H]B Riemann
Department of Nuclear Medicine, Munster University, Germany
Nuklearmedizin 42:173-80. 2003..The aim of this study was its evaluation as a putative sub-type selective beta(1)-adrenergic radioligand in cardiac imaging... - Noninvasive grading of untreated gliomas: a comparative study of MR imaging and 3-(iodine 123)-L-alpha-methyltyrosine SPECTBurkhard Riemann
Department of Nuclear Medicine, University of Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
Radiology 225:567-74. 2002..To compare the accuracy of magnetic resonance (MR) imaging scores with that of 3-(iodine 123)-L-alpha-methyltyrosine ((123)I-IMT) single photon emission computed tomography (SPECT) in the noninvasive grading of untreated gliomas... - Kinetic parameters of 3-[(123)I]iodo-L-alpha-methyl tyrosine ([(123)I]IMT) transport in human GOS3 glioma cellsB Riemann
Department of Nuclear MedicineWestfälische Wilhelms Universität, Munster, Germany
Nucl Med Biol 28:293-7. 2001..1 +/- 1.5 microM). The maximum transport velocity (V(max)) amounted to 34.8 +/- 1.9 nmol/mg protein/10 min. Competitive inhibition experiments revealed that [(123)I]IMT transport is mediated principally by the sodium-independent system L... - Evaluation of the extension of cerebral gliomas by scintigraphyM Weckesser
Department of Nuclear Medicine, University of Munster, Germany
Strahlenther Onkol 176:180-5. 2000..123I-IMT transport across the blood brain barrier is mediated by an amino acid carrier, 201Tl accumulation is analogous to cerebral potassium uptake... - Characterization of 3-[(123)I]iodo-L-alpha-methyl tyrosine transport in astrocytes of neonatal ratsK Kopka
Department of Nuclear Medicine, Westfalische Wilhelms Universitat Munster, Germany
J Neurochem 76:97-104. 2001..However, sodium-independent maximum transport velocities (V(max)) differed significantly between neonatal astrocytes and C6 glioma cells (11.1 +/- 0.3 and 39.9 +/- 3.3 nmol/mg protein/10 min, respectively)... - Sequential scintigraphic strategy for the differentiation of brain tumoursP Matheja
Department of Nuclear Medicine, University of Munster, Germany
Eur J Nucl Med 27:550-8. 2000..Based on these preliminary results, a sequential strategy is proposed involving an initial 201Tl SPET study and an additional 123I-IMT SPET study in the event of positive 201Tl uptake... - Characterization of 3-[123I]iodo-L-alpha-methyl tyrosine ([123I]IMT) transport into human Ewing's sarcoma cells in vitroC Franzius
Department of Nuclear Medicine, Westfalische Wilhelms Universitat, Munster, Albert Schweitzer Str 33, 48149, Munster, Germany
Nucl Med Biol 28:123-8. 2001..7+/-3.9 microM) and maximum transport velocitiy amounted to V(max)=20.7+/-0.6 nmol x mg protein(-1) x 10 min(-1). Inhibition experiments revealed the predominance of [(123)I]IMT uptake via sodium-independent system L... - Non-invasive approaches to visualize the endothelin axis in vivo using state-of-the-art molecular imaging modalitiesC Höltke
Department of Nuclear Medicine, University Hospital Munster, Munster, Germany
Mini Rev Med Chem 9:1580-95. 2009..This review summarizes the work that has been published in the past ten years using labeled endothelin receptor ligands for the visualization of endothelin receptor expression in vivo... - I-123-lodo-alpha-methyl tyrosine SPECT in non-parenchymal brain tumoursP Matheja
Department of Nuclear Medicine, , Germany
Nuklearmedizin 41:191-6. 2002..CONCLUSION: Significant accumulation of IMT is seen in the majority of tumours, so that this technique might be helpful for the management of cerebral metastases and lymphomas... 
Radioiodine remnant ablation in differentiated thyroid cancer after combined endogenous and exogenous TSH stimulationA Vrachimis
Department of Nuclear Medicine, Muenster University, Albert Schweitzer Campus 1, Building A1, 48149 Muenster, Germany
Nuklearmedizin 51:67-72. 2012..As yet, the efficacy of RRA after brief THW and single rhTSH administration has not been assessed...- Radioligands for imaging myocardial alpha- and beta-adrenoceptorsB Riemann
Department of Nuclear Medicine, , Germany
Nuklearmedizin 42:4-9. 2003..New radioligands are needed to provide more insight into cardiac pathophysiology which may influence the therapeutic management of patients with cardiovascular disease... - Non-invasive molecular imaging of beta-adrenoceptors in vivo: perspectives for PET-radioligandsK Kopka
Department of Nuclear Medicine, University Hospital of the Westfälische Wilhelms Universität, Munster, Germany
Curr Med Chem 12:2057-74. 2005..Non-invasive quantification of beta-ARs could facilitate the accurate choice and control of therapeutic interventions. Here we summarize the state-of-the-art of the radiochemistry of radioactive beta-AR radioligands... - Metastatic neuroblastoma demonstrated by whole-body PET-CT using 11C-HEDC Franzius
Department of Nuclear Medicine, University Hospital, , Germany
Nuklearmedizin 44:N4-5. 2005 - Therapeutic strategy of papillary microcarcinoma of the thyroid gland: a nuclear medicine perspectiveB Riemann
Department of Nuclear Medicine University Hospital Münster, Munster, Germany
Minerva Endocrinol 34:81-7. 2009..It was the aim of this review to evaluate the current therapeutic concepts in patients with PTMC from a nuclear medicine perspective... - Small animal PET in preclinical studies: opportunities and challengesB Riemann
Department of Nuclear Medicine, University Hospital, Munster, Germany
Q J Nucl Med Mol Imaging 52:215-21. 2008..Due to its significantly improved spatial resolution and its quantitative nature, compared to other techniques small animal PET can be employed to bridge the in vitro, through to preclinical and clinical imaging in humans... - Risk-profile and outcome of small papillary and follicular thyroid carcinomas (<or=1 cm)K Rahbar
Department of Nuclear Medicine, University Hospital Munster, Munster, Germany
Nuklearmedizin 47:188-93. 2008..It was the aim to compare risk-profile and outcome of patients with small papillary (PTC) and follicular thyroid carcinomas (FTC) <or=1 cm... - Bilateral upper limb lymphoedema associated with psoriatic arthritis: a case report and review of the literatureM Bohm
Departments of Dermatology and Nuclear Medicine, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
Br J Dermatol 143:1297-301. 2000..Conservative management and therapy with cyclosporin (for worsening arthritis) resulted in partial resolution of the lymphoedema and improvement of flow parameters on the right side upon repeat lymphoscintigraphy... - Early detection of local tumour recurrence and pulmonary metastasis in cardiac angiosarcoma with PET-CT and MRIKai U Juergens
Department of Clinical Radiology, University of Muenster, Albert-Schweitzer-Strasse 33, Muenster, Germany
Eur Heart J 28:663. 2007 - Radiofluorinated pyrimidine-2,4,6-triones as molecular probes for noninvasive MMP-targeted imagingHans Jörg Breyholz
Department of Nuclear Medicine, University of Munster, Germany
ChemMedChem 5:777-89. 2010..The radiosynthesis and the in vivo biodistribution of the first (18)F-labeled prototype, MMP-targeted tracer [(18)F]26, suitable for molecular imaging by means of positron emission tomography (PET) were realized... - Risk stratification of patients with locally aggressive differentiated thyroid cancer. Results of the MSDS trialBurkhard Riemann
Department of Nuclear Medicine, University Hospital, 48149 Muenster, Germany
Nuklearmedizin 49:79-84. 2010..The aim of the present study was to compare the survival of patients with minimum and extensive extrathyroidal growth according to the new AJCC/UICC TNM staging system 2009... - Prognostic significance of amino acid transport imaging in patients with brain tumorsMatthias Weckesser
Department of Nuclear Medicine, Munster University, Munster, Germany
Neurosurgery 50:958-64; discussion 964-5. 2002..To evaluate the prognostic significance of presence, intensity, and extent of amino acid uptake in patients with suspected primary or recurrent brain tumors... 
Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3Larissa Fabritz
Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Street 33, D 48129 Munster, Germany
Cardiovasc Res 87:60-72. 2010..Beta-adrenoceptor blockers appear less effective in LQT3 than in other forms of the disease...- PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studiesCarsten Höltke
Department of Nuclear Medicine, Albert Schweitzer Str 33, University Hospital Munster, D 48149 Munster, Germany
Bioorg Med Chem 17:7197-208. 2009..The biodistribution studies showed a high accumulation of the tracer in bile and intestine. In vivo we were able to show that the visualization of the heart as a major target organ with high ET(A)R expression is possible... - 3-[123I]Iodo-L-alpha-methyl tyrosine transport into human fibroblasts and comparison with Ewing's sarcoma cellsChristiane Franzius
Department of Nuclear Medicine, University Hospital, Muenster, Germany
Nucl Med Biol 29:483-90. 2002..These results were compared with those determined in two malignantly transformed extracranial cell lines, the human Ewing's sarcoma cell lines VH-64 and CADO-ES-1... - Design of new beta1-selective adrenoceptor ligands as potential radioligands for in vivo imagingKlaus Kopka
Department of Nuclear Medicine, Albert Schweitzer Str 33, University Hospital Munster, 48149, Munster, Germany
Bioorg Med Chem 11:3513-27. 2003.... - Impaired relaxation in transgenic mice overexpressing junctinUwe Kirchhefer
Institut fur Pharmakologie und Toxikologie, Westfalische Wilhelms Universitat, Domagkstrasse 12, 48149 Munster, Germany
Cardiovasc Res 59:369-79. 2003..Junctin is a major transmembrane protein in cardiac junctional sarcoplasmic reticulum, which forms a quaternary complex with the ryanodine receptor (Ca(2+) release channel), triadin, and calsequestrin... - Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivoKlaus Kopka
Department of Nuclear Medicine, University Hospital of the Westfälische Wilhelms Universität, Muenster, Germany
Nucl Med Biol 31:257-67. 2004..The preliminary biological evaluation warrant further studies of these radioiodinated MMP inhibitors as potential new radiotracers for imaging MMP activity in vivo... - Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonistsUwe Kirchhefer
Institut fur Pharmakologie und Toxikologie, Westfalische Wilhelms Universitat, Domagkstr 12, 48149 Munster, Germany
Cardiovasc Res 62:122-34. 2004..Moreover, triadin 1 appears to anchor calsequestrin to the ryanodine receptor... - Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivoMichael Schäfers
Department of Nuclear Medicine, Hospital of the Westfälische Wilhelms University, Munster, Germany
Circulation 109:2554-9. 2004..Matrix metalloproteinases (MMPs) are enzymes involved in the proteolytic degradation of extracellular matrix. They play an important role in several disease processes, such as inflammation, cancer, and atherosclerosis... - Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM geneFrank U Müller
Institute of Pharmacology and Toxicology, University of Munster, Germany
FASEB J 17:103-5. 2003.... - Synthesis and first in vivo evaluation of new selective high affinity beta1-adrenoceptor radioligands for SPECT based on ICI 89,406Stefan Wagner
Department of Nuclear Medicine, University Hospital Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
Bioorg Med Chem 12:4117-32. 2004..Therefore further studies in a different animal model will be carried out... - Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic miceFrank U Müller
Institute of Pharmacology and Toxicology, University of Munster, Domagkstrasse 12, D 48149 Munster, Germany
J Biol Chem 280:6906-14. 2005..Our results indicate that heart-directed expression of CREM-IbDeltaC-X leads to complex cardiac alterations, suggesting CREM as a central regulator of cardiac morphology, function, and gene expression... - Multimodality molecular imaging--from target description to clinical studiesO Schober
Department of Nuclear Medicine, University Hospital Munster, Albert Schweitzer Str 33, 48149, Munster, Germany
Eur J Nucl Med Mol Imaging 36:302-14. 2009..e. from target description to clinical studies. The following topics are addressed: targets, radiochemistry and radiopharmacy, devices and computer science, animals and preclinical evaluations, and patients and clinical evaluations... - Primary tumour size is a prognostic parameter in patients suffering from differentiated thyroid carcinoma with extrathyroidal growth: results of the MSDS trialJan Alexander Krämer
Department of Nuclear Medicine, University Hospital Munster, Albert Schweitzer Strasse 33, Munster, Germany
Eur J Endocrinol 163:637-44. 2010.... - Proliferation-dependent changes in amino acid transport and glucose metabolism in glioma cell linesBurkhard Riemann
Eur J Nucl Med Mol Imaging 32:369-70; author reply 371. 2005 - Characterization of the RET protooncogene transmembrane domain mutation S649L associated with nonaggressive medullary thyroid carcinomaMario Colombo-Benkmann
Department of General Surgery, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
Eur J Endocrinol 158:811-6. 2008..For rare and novel RET mutations associated with hereditary medullary thyroid carcinoma (MTC), clinical and functional studies are needed to classify the RET mutation into one of the three clinical risk groups...