Research Topics
Species | C H RickertSummaryCountry: Germany Publications
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Publications
Prognosis-related histomorphological and immunohistochemical markers in central nervous system tumors of childhood and adolescenceChristian H Rickert
Institute of Neuropathology, Munster University Hospital, Germany
Acta Neuropathol 109:69-92. 2005....
Chromosomal imbalances in choroid plexus tumorsChristian H Rickert
Institute of Neuropathology, University Hospital Munster, Munster, Germany
Am J Pathol 160:1105-13. 2002..Furthermore, gain of 9p and loss of 10q seem to be correlated with a more favorable prognosis in choroid plexus carcinomas...
Genetic characterisation of granular cell tumoursChristian H Rickert
Institute of Neuropathology, University Hospital Munster, Domagkstr 19, 48129 Munster, Germany
Acta Neuropathol 103:309-12. 2002....
Neuropathology of Raine syndromeChristian H Rickert
Institute of Neuropathology, University Hospital, Domagkstrasse 19, 48129 Munster, Germany
Acta Neuropathol 103:281-7. 2002..This inverse relationship between mineralisation and regional blood flow was reflected in the varying distribution of calcospherites in grey and white matter as well as in the white matter of different lobes...
No chromosomal imbalances detected by comparative genomic hybridisation in subependymal giant cell astrocytomasChristian H Rickert
Institute of Neuropathology, University Hospital Munster, Domagkstr 19, 48149 Munster, Germany
Acta Neuropathol 104:206-8. 2002....
No chromosomal imbalances detected by comparative genomic hybridisation in a case of fetal immature teratomaChristian H Rickert
Gerhard Domagk Institute of Neuropathology, University Hospital Munster, Westfalische Wilhelms Universitat, Domagkstrasse 17, 48129 Munster, Germany
Childs Nerv Syst 18:639-43. 2002....
Mycotic cerebral vasculitis in a paediatric cardiac transplant patient excludes misadventureC H Rickert
Institute of Neuropathology, University Hospital Munster, Germany
Int J Legal Med 116:233-7. 2002..This case illustrates that it is of paramount importance to copiously sample and investigate the basal cerebral arteries in cases of subarachnoid haemorrhage of unknown origin, in particular in a medico-legal context...
Lack of chromosomal imbalances in adamantinomatous and papillary craniopharyngiomasC H Rickert
Institute of Neuropathology, University Hospital Munster, Gerhard Domagk Institute of Pathology, Domagkstrasse 17, D 48149 Munster, Germany
J Neurol Neurosurg Psychiatry 74:260-1. 2003..These data suggest that chromosomal imbalances are a rare event in both adamantinomatous and papillary craniopharyngiomas...
Immunoglobulin deposition in sural nerves of AIDS patients with distal-symmetric HIV-associated polyneuropathyC H Rickert
Gerhard Domagk Institute of Pathology, University Hospital Munster, Germany
Eur J Med Res 7:472-6. 2002..In peripheral nerves they may be responsible for some of the common alterations in the development of AIDS-associated distal symmetric polyneuropathy...
Extraneural metastases of paediatric brain tumoursChristian H Rickert
Gerhard Domagk Institute of Pathology and Institute of Neuropathology, University Hospital Munster, Domagkstr 17, 48149 Munster, Germany
Acta Neuropathol 105:309-27. 2003..5-100% deceased children), whereas 60% of children suffering from germinomas were still alive at the time of reporting...
Comparative genomic hybridization in central and peripheral nervous system tumors of childhood and adolescenceChristian H Rickert
Institute of Neuropathology, University Hospital Munster, Munster, Germany
J Neuropathol Exp Neurol 63:399-417. 2004..0%), and pilocytic astrocytomas (50/5.6%). This article provides a short review of the CGH technique and its pitfalls, summarizes the current CGH-related data on pediatric brain tumors and muses on the future of CGH...
Cerebral c-jun expression mapping in sudden infant death syndromeChristian H Rickert
Institute of Neuropathology, University Hospital Munster, Domagkstrasse 19, 48149 Munster, Germany
Acta Neuropathol 107:119-26. 2004....
Chromosomal imbalances detected by comparative genomic hybridisation in atypical teratoid/rhabdoid tumoursChristian H Rickert
Institute of Pathology, University Hospital Munster, Domagkstrasse 17, 48149 Munster, Germany
Childs Nerv Syst 20:221-4. 2004..2 are regarded as a crucial step in their molecular pathogenesis. Apart from monosomy or deletions of chromosome 22 not much data exists on additional chromosomal aberrations...
Prognosis-related molecular markers in pediatric central nervous system tumorsChristian H Rickert
Institute of Neuropathology, Department of Pediatric Hematology and Oncology, Munster University Hospital, Germany
J Neuropathol Exp Neurol 63:1211-24. 2004..This review discusses the predictive potential of molecular markers for clinical outcome and their influence on therapeutic decision-making among children with brain tumors...
Fetal ependymoma associated with Down's syndromeChristian H Rickert
Institute of Neuropathology, University Hospital Munster, Germany
Acta Neuropathol 103:78-81. 2002..Immunohistochemistry showed strong reactivity for GFAP, in particular of the fibrillary elements of the pseudorosettes, while the neuronal marker synaptophysin was not expressed. The Ki67/MIB-1 proliferation index was 0.5%...
Increased chromosomal imbalances in recurrent pituitary adenomasC H Rickert
Institute of Neuropathology, University Clinics Münster, Domagkstr 19, 48129 Munster, Germany
Acta Neuropathol 102:615-20. 2001..The average MIB-1 proliferation indices were 1.2% for primary and 1.9% for recurrent adenomas (P < 0.005). Our findings suggest that acquisition of certain chromosomal imbalances is related to and may underlie adenoma recurrence...
Tumors of the choroid plexusC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat, Domagkstrasse 19, Munster, Germany
Microsc Res Tech 52:104-11. 2001....
Cerebral malakoplakia associated with Escherichia coli infectionC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat, Munster, Germany
Acta Neuropathol 99:595-8. 2000..coli-associated abscess. This case indicates that malakoplakia of the brain might also be a histiocytic reaction against bacterial antigens of the E. coli family...
Melanotic progonoma of the brain: a case report and reviewC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat, Munster, Germany
Childs Nerv Syst 14:389-93. 1998..We present the case of a 1-year-old boy suffering from a melanotic progonoma of the pineal gland, who died at the age of 22 months with extensive spinal and abdominal metastases 10 months after partial removal of the tumor...
Comparative genomic hybridization in pineal parenchymal tumorsC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat, Munster, Germany
Genes Chromosomes Cancer 30:99-104. 2001..Furthermore, imbalances in higher-grade pineal parenchymal tumors mainly affect gains of 12q and losses of chromosome 22...
Chromosomal imbalances in primary lymphomas of the central nervous systemC H Rickert
Institute of Neuropathology, Gerhard Domagk Institute of Pathology, University of Munster, Munster, Germany
Am J Pathol 155:1445-51. 1999....
Neglect-associated fatal Marchiafava-Bignami disease in a non-alcoholic womanC H Rickert
Institute of Neuropathology, University Clinics Münster, Germany
Int J Legal Med 115:90-3. 2001..This is the first known case of Marchiafava-Bignami disease in a non-alcoholic woman and the first case in the forensic setting of neglect...
Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult casesC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat Munster, Domagkstr 19, D 48129, Munster, Germany
Am J Pathol 158:1525-32. 2001..Furthermore, gains of chromosomal material on 1q might be correlated with a worse prognosis in pediatric anaplastic astrocytomas...
Epidemiological features of brain tumors in the first 3 years of lifeC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat, Munster, Germany
Childs Nerv Syst 14:547-50. 1998..3%, 36.0%, and 32.1%). In the 1st year of life the most common neoplasms were PNETs (22.7%) and in the 2nd year both astrocytomas and ependymomas (24.0 % each); astrocytomas (35.7%) prevailed in the 3rd year of life...
Sudden unexpected death in young adults with chronic hydrocephalusC H Rickert
Institute of Neuropathology, University of Munster, Germany
Int J Legal Med 114:331-7. 2001....
Chromosomal aberrations in pituitary carcinoma metastasesC H Rickert
Institute of Neuropathology, University Clinics Münster, Germany
Acta Neuropathol 102:117-20. 2001..To date, gains of chromosome 14q have not been reported among pituitary tumors. It remains to be shown whether gain of 14q is associated with malignant progression and metastatic dissemination of pituitary carcinomas...
Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classificationC H Rickert
Institute of Neuropathology, University Clinics Münster, Germany
Childs Nerv Syst 17:503-11. 2001..The topography, sex distribution and histology of 340 primary CNS tumors in children up to 17 years of age were investigated and (re-)classified according to the latest WHO classification of nervous system tumors...
Neuropathology and prognosis of foetal brain tumoursC H Rickert
Institute of Neuropathology and Gerhard Domagk Institute of Pathology, Westfalische Wilhelms Universitat, Domagkstr 19, D 48129 Munster, Germany
Acta Neuropathol 98:567-76. 1999..Foetal brain tumours have a mainly unfavourable clinical outcome. However, their prognosis has improved in the last decade...
High uptake of L-3-[123I]iodo-alpha-methyl tyrosine in pilocytic astrocytomasM Weckesser
Department of Nuclear Medicine, Munster University, Albert Schweitzer Strasse 33, 48149 Munster, Germany
Eur J Nucl Med 28:273-81. 2001..7, n = 6) did not attain statistical significance. IMT SPET results indicative of malignancy are regularly found in pilocytic astrocytomas, despite their good prognosis. No uptake may be detected in largely cystic or in small tumours...
Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal regionM Hasselblatt
Institute of Neuropathology, University Hospital Munster, Munster, Germany
Neuropathol Appl Neurobiol 32:278-83. 2006..Antibodies directed against these antigens are thus expected to be valuable markers in the diagnosis of papillary tumours located in the vicinity of the third ventricle...
[Clinical value of amino acid imaging in paediatric brain tumours. Comparison with MRI]K Lang
Leitender Oberarzt, Klinik und Poliklinik fur Nuklearmedizin, Westfalische Wilhelms Universitat, Albert Schweitzer Str 33, 48149 Munster
Nuklearmedizin 44:131-6. 2005....
[Primary central nervous system lymphoma as a neurological manifestation of AIDS stage]S Happe
Klinik und Poliklinik fur Neurologie, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Strasse 33, 48129 Munster
Nervenarzt 72:136-42. 2001..The main criteria for differential diagnosis from other secondary neuromanifestations such as cerebral toxoplasmosis, progressive multifocal leukoencephalopathy, abscesses, and infarctions are described...
Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analysesJ Mühlisch
Department of Pediatric Hematology and Oncology, University Children s Hospital Muenster, 48129 Muenster, Germany
J Neurooncol 83:17-29. 2007..Therapeutic and diagnostic implications urge into depth analyses of methylation as a mechanism, which might fill some of the gaps of our understanding of brain tumor origin...
Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhoodJ Mühlisch
Department of Pediatric Hematology and Oncology, University Children s Hospital Muenster, Germany
Oncogene 25:1111-7. 2006..Further studies of epigenetic changes in these rare tumors are warranted as their biology remains obscure and treatment efforts have been rather unsuccessfull...
[Correlation between clinical apparatus-based differential diagnosis and neuropathological diagnosis in patients with AIDS]E Akova-Oztürk
Klinik und Poliklinik fur Neurologie, Universitatsklinikum Munster
Nervenarzt 75:763-9. 2004..During the course of HIV infection, the majority of patients develop opportunistic cerebral neuro-manifestations. If conventional diagnostic tools are not sufficient, a stereotactic biopsy is often necessary...
Plasma cell granuloma involving the brain and the lungC Greiner
Department of Neurosurgery, University of Muenster, Muenster, Germany
Acta Neurochir (Wien) 145:1127-31. 2003..Symptomatic plasma cell granulomas (PCG) of the central nervous system (CNS) are a rare entity, especially in association with an extracranial manifestation...
Somatostatin receptor subtype 2 is expressed by supratentorial primitive neuroectodermal tumors of childhood and can be targeted for somatostatin receptor imagingMichael C Frühwald
Department of Pediatric Hematology and Oncology, University Children s Hospital Muenster, Muenster, Germany
Clin Cancer Res 10:2997-3006. 2004..Novel and refined imaging methodologies are urgently needed...
Cytogenetic features of ependymoblastomasChristian H Rickert
Department of Anatomical Pathology, Royal Children s Hospital Melbourne, Flemington Road, Parkville, Vic, 3052, Australia, and Institute of Neuropathology, University Hospital Munster, Germany
Acta Neuropathol 111:559-62. 2006..All three had died of their disease after a post-operative survival of 9 months (range 6-14 months). Our CGH data suggest that ependymoblastomas show distinct and fairly consistent chromosomal aberrations...
Prognostic significance of amino acid transport imaging in patients with brain tumorsMatthias Weckesser
Department of Nuclear Medicine, Munster University, Munster, Germany
Neurosurgery 50:958-64; discussion 964-5. 2002..To evaluate the prognostic significance of presence, intensity, and extent of amino acid uptake in patients with suspected primary or recurrent brain tumors...
Cerebral vascular and metabolic response to sustained systemic inflammation in ovine traumatic brain injuryHenning D Stubbe
Department of Anesthesiology and Intensive Care, University Hospital, Munster, Germany
J Cereb Blood Flow Metab 24:1400-8. 2004..Different mechanisms appear to induce cerebral vasodilation in response to inflammation and hypercapnia...
Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approachMartin Hasselblatt
Institute of Neuropathology, University Hospital Munster, Domagkstrasse 19, 48129 Munster, Germany
Am J Surg Pathol 30:66-74. 2006..Our data suggest that antibodies directed against Kir7.1 and stanniocalcin-1 might serve as sensitive and specific diagnostic markers for choroid plexus tumors...
Rosetted glioneuronal tumor: a case with proliferating neuronal nodulesK Keyvani
Institute of Neuropathology, Westfalische Wilhelms Universitat Munster, Germany
Acta Neuropathol 101:525-8. 2001..Remarkably, highest proliferative activity was observed within the neuronal nodules. Comparative genomic hybridization revealed a gain of chromosome 7q and a loss on chromosome 9p...
Chromosomal imbalances and NF2 mutational analysis in a series of 10 spinal nerve sheath myxomasC H Rickert
Institute of Neuropathology, University Hospital Munster, Munster, Germany
Histopathology 50:252-7. 2007..Nerve sheath myxomas are diagnostically challenging, mainly cutaneous spindle cell neoplasms exhibiting Schwann cell differentiation. They are frequently mistaken for neurothekeomas and their genetic features are essentially unknown...
O-(2-[18F]fluorethyl)-L-tyrosine PET in the clinical evaluation of primary brain tumoursM Weckesser
Department of Nuclear Medicine, Munster University, Albert Schweitzer Strasse 33, 48149, Munster, Germany
Eur J Nucl Med Mol Imaging 32:422-9. 2005..The aim of this study was to evaluate the differential uptake of O-(2-[18F]fluorethyl)-L-tyrosine (FET) in suspected primary brain tumours...
Chromosomal imbalances in clear cell ependymomasChristian H Rickert
Department of Anatomical Pathology, Royal Children s Hospital Melbourne, Melbourne, Australia, and Institute of Neuropathology, University Hospital Munster, Munster, Germany
Mod Pathol 19:958-62. 2006....
Familial occurrence of dysembryoplastic neuroepithelial tumorM Hasselblatt
Institute of Neuropathology, Gerhard-Domagk-Institute of Pathology, University Hospital, , Germany
Neurology 62:1020-1. 2004
Prognostic implications of atypical histologic features in choroid plexus papillomaAstrid Jeibmann
Institute of Neuropathology, , , Germany
J Neuropathol Exp Neurol 65:1069-73. 2006..Close follow up of patients harboring atypical choroid plexus papillomas may be warranted...
Raine syndrome: report of a family with three affected sibs and further delineation of the syndromeGeorg Hulskamp
Klinik und Poliklinik für Kinderheilkunde Allgemeine Kinderheilkunde, Westfalische Wilhelms Universitat, Munster, Germany
Clin Dysmorphol 12:153-60. 2003..Further research is required to detect the underlying metabolic and molecular defects of this autosomal recessive syndrome...
Leptomeningeal neurons are a common finding in infants and are increased in sudden infant death syndromeChristian H Rickert
Institute of Neuropathology, University Hospital Munster, Germany
Acta Neuropathol 117:275-82. 2009....
Cerebral response to norepinephrine compared with fluid resuscitation in ovine traumatic brain injury and systemic inflammationHenning D Stubbe
, , Germany
Crit Care Med 34:2651-7. 2006..CONCLUSION: We conclude that despite identical carotid blood flows, only CPP management with norepinephrine reduced the cerebral oxygen deficit in this model...
Cellular and reticular variants of hemangioblastoma differ in their cytogenetic profilesChristian H Rickert
Department of Anatomical Pathology, Royal Children s Hospital Melbourne, Parkville, Vic, Australia
Hum Pathol 37:1452-7. 2006..16). In conclusion, our data may point toward different genetic pathways in the pathogenesis of the 2 histologic subtypes of capillary hemangioblastoma...
Rosetted glioneuronal tumour of the spine: clinical, histological and cytogenetic dataChristian H Rickert
Acta Neuropathol 112:231-3. 2006
Amniotic air insufflation during minimally invasive fetoscopic fetal cardiac interventions is safe for the fetal brain in sheepThomas Kohl
Division of Obstetrics and Prenatal Medicine, University Hospital of Bonn, Bonn, Germany
J Thorac Cardiovasc Surg 128:467-71. 2004..The purpose of this study was to assess any histologically discernible effects from this approach on the fetal brain after short-term studies and long-term survival in sheep...
Localisation of congenital glioblastomas in the JapaneseChristian H Rickert
Childs Nerv Syst 19:1-2. 2003
Cortical dysplasia: neuropathological aspectsChristian H Rickert
Department of Anatomical Pathology, Royal Children s Hospital, Flemington Road, 3052, Parkville VIC, Australia
Childs Nerv Syst 22:821-6. 2006..quot; IMMUNOHISTOCHEMISTRY AND STRUCTURAL FINDINGS: Immunohistochemistry is not essential in making the diagnosis of FCD or microdysgenesis but allows further characterization of cell types...
