D W Richter

Summary

Country: Germany

Publications

  1. ncbi Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis
    Evgeni Ponimaskin
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Germany
    Mol Pharmacol 67:1434-43. 2005
  2. ncbi Serotonin receptors: guardians of stable breathing
    Diethelm W Richter
    II Physiological Institute, Neuro and Sensory Neurophysiology, University of Gottingen, Humboldtallee 23, D37073 Göttingen, Germany
    Trends Mol Med 9:542-8. 2003
  3. ncbi Commentary on eupneic breathing patterns and gasping
    Diethelm W Richter
    Zentrum Physiologie und Pathophysiologie, Abteilung Neuro und Sinnesphysiologie, Georg August Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Respir Physiol Neurobiol 139:121-30. 2003
  4. ncbi Studying rhythmogenesis of breathing: comparison of in vivo and in vitro models
    D W Richter
    Dept of Physiology II, Georg August Universitat Gottingen, 37073, Gottingen, Germany
    Trends Neurosci 24:464-72. 2001
  5. ncbi Intracellular signal pathways controlling respiratory neurons
    D W Richter
    Department of Neurophysiology, University of Gottingen, Germany
    Respir Physiol 110:113-23. 1997
  6. ncbi Reorganisation of respiratory network activity after loss of glycinergic inhibition
    D Büsselberg
    Georg August Universitat Gottingen, II Department of Physiology, Germany
    Pflugers Arch 441:444-9. 2001
  7. ncbi Nucleus raphe obscurus evokes 5-HT-1A receptor-mediated modulation of respiratory neurons
    P M Lalley
    II Physiology Institute, University of Gottingen, Germany
    Brain Res 747:156-9. 1997
  8. ncbi Metabotropic glutamate receptors and blockade of glial Krebs cycle depress glycinergic synaptic currents of mouse hypoglossal motoneurons
    S Hülsmann
    Abt Neuro und Sinnesphysiologie, Zentrum Physiologie und Pathophysiologie, Georg August Universitat Gottingen, Germany
    Eur J Neurosci 12:239-46. 2000
  9. ncbi Cytoskeleton mediates inhibition of the fast Na+ current in respiratory brainstem neurons during hypoxia
    S L Mironov
    II Department of Physiology, University of Gottingen, Germany
    Eur J Neurosci 11:1831-4. 1999
  10. ncbi Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats
    D W Richter
    II Department of Physiology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Physiol 514:567-78. 1999

Collaborators

Detail Information

Publications47

  1. ncbi Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis
    Evgeni Ponimaskin
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Germany
    Mol Pharmacol 67:1434-43. 2005
    ....
  2. ncbi Serotonin receptors: guardians of stable breathing
    Diethelm W Richter
    II Physiological Institute, Neuro and Sensory Neurophysiology, University of Gottingen, Humboldtallee 23, D37073 Göttingen, Germany
    Trends Mol Med 9:542-8. 2003
    ..Specific activation of these pathways effectively prevails respiratory disturbances and can be extended to treatment of life-threatening respiratory disorders in patients...
  3. ncbi Commentary on eupneic breathing patterns and gasping
    Diethelm W Richter
    Zentrum Physiologie und Pathophysiologie, Abteilung Neuro und Sinnesphysiologie, Georg August Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Respir Physiol Neurobiol 139:121-30. 2003
    ....
  4. ncbi Studying rhythmogenesis of breathing: comparison of in vivo and in vitro models
    D W Richter
    Dept of Physiology II, Georg August Universitat Gottingen, 37073, Gottingen, Germany
    Trends Neurosci 24:464-72. 2001
    ..We have taken note of these in formulating a 'maturational network-burster model' for rhythm generation that includes most features of the existing models of respiratory rhythm generation...
  5. ncbi Intracellular signal pathways controlling respiratory neurons
    D W Richter
    Department of Neurophysiology, University of Gottingen, Germany
    Respir Physiol 110:113-23. 1997
    ..The clinical significance of these intracellular signal pathways is demonstrated in a case of a child suffering from apneustic breathing, who was successfully treated with a 5HT-1A receptor agonist...
  6. ncbi Reorganisation of respiratory network activity after loss of glycinergic inhibition
    D Büsselberg
    Georg August Universitat Gottingen, II Department of Physiology, Germany
    Pflugers Arch 441:444-9. 2001
    ....
  7. ncbi Nucleus raphe obscurus evokes 5-HT-1A receptor-mediated modulation of respiratory neurons
    P M Lalley
    II Physiology Institute, University of Gottingen, Germany
    Brain Res 747:156-9. 1997
    ..These effects originate from pre- and post-synaptic inhibitory processes that involve 5-HT-1A receptor activation...
  8. ncbi Metabotropic glutamate receptors and blockade of glial Krebs cycle depress glycinergic synaptic currents of mouse hypoglossal motoneurons
    S Hülsmann
    Abt Neuro und Sinnesphysiologie, Zentrum Physiologie und Pathophysiologie, Georg August Universitat Gottingen, Germany
    Eur J Neurosci 12:239-46. 2000
    ..Our results suggest that glial regulation of extracellular glutamate uptake can prevent spill-over of glutamate, and glutamatergic depression of glycinergic inhibition in hypoglossal motoneurons...
  9. ncbi Cytoskeleton mediates inhibition of the fast Na+ current in respiratory brainstem neurons during hypoxia
    S L Mironov
    II Department of Physiology, University of Gottingen, Germany
    Eur J Neurosci 11:1831-4. 1999
    ....
  10. ncbi Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats
    D W Richter
    II Department of Physiology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Physiol 514:567-78. 1999
    ..5. The results reveal a temporal sequence in the release of neurotransmitters and neuromodulators and suggest a specific role for each of them in the sequential development of hypoxic respiratory disturbances...
  11. ncbi [Serotonin receptor 1A-modulated dephosphorylation of glycine receptor α3: a new molecular mechanism of breathing control for compensation of opioid-induced respiratory depression without loss of analgesia]
    T Manzke
    Abteilung Neuro und Sinnesphysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Deutschland
    Schmerz 25:272-81. 2011
    ..The molecular mechanism presented here opens new pharmacological possibilities to treat opioid-induced respiratory depression and respiratory disorders due to disturbed inhibitory synaptic transmission, such as hyperekplexia...
  12. ncbi Selective lesioning of the cat pre-Bötzinger complex in vivo eliminates breathing but not gasping
    J M Ramirez
    Department of Physiology, University of Gottingen, D 37073 Gottingen, Germany
    J Physiol 507:895-907. 1998
    ..We call this the 'omega-conotoxin GVIA tracing' method...
  13. ncbi L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia
    S L Mironov
    II Department of Physiology, University of Gottingen, Humboldtallee 23, 37075 Gottingen, Germany
    J Physiol 512:75-87. 1998
    ..7. We suggest that L-type Ca2+ channels contribute to the early hypoxic response of the respiratory centre. Glutamate release during hypoxia stimulates postsynaptic metabotropic glutamate receptors, which activate the Ca2+ channels...
  14. ncbi Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress
    M Haller
    Physiologisches Institut, Georg August Universitat Gottingen, D 37073 Gottingen, Germany
    J Neurophysiol 86:412-21. 2001
    ..Cell swelling can be attributed to hypoxic release of neurotransmitters and neuromodulators and to inhibition of Na(+)/K(+)-pump activity...
  15. ncbi Hyperpolarization-activated current, Ih, in inspiratory brainstem neurons and its inhibition by hypoxia
    S L Mironov
    II Department of Physiology, University of Gottingen, Humboldtallee 23, Gottingen 37073, Germany
    Eur J Neurosci 12:520-6. 2000
    ..We conclude that although Ih channels are functional in a minority of inspiratory neurons, Ih does not contribute to respiratory rhythm generation or its modulation by hypoxia...
  16. ncbi A combined blockade of glycine and calcium-dependent potassium channels abolishes the respiratory rhythm
    D Büsselberg
    Georg August Universitat Gottingen, Abteilung für Neuro und Sinnesphysiologie, Humboldtallee 23, D 37073 Gottingen, Germany
    Neuroscience 122:831-41. 2003
    ..The data imply that failure of glycine receptors provokes enhanced bursting behaviour of respiratory neurones, whilst the additional blockade of BKCa channels by charybdotoxin or with pentobarbital abolishes the respiratory rhythm...
  17. ncbi Hypoxic modulation of L-type Ca(2+) channels in inspiratory brainstem neurones: intracellular signalling pathways and metabotropic glutamate receptors
    S L Mironov
    II Department of Physiology, University of Gottingen, Humboldtallee 23, D 37073, Gottingen, Germany
    Brain Res 869:166-77. 2000
    ..Glutamate release and concomitant activation of Ca(L) channels are responsible for accelerating of respiratory rhythm during early hypoxia...
  18. ncbi Histaminergic modulation of the intact respiratory network of adult mice
    M Dutschmann
    Georg August Universitat Gottingen, Institut für Neuro und Sinnesphysiologie, Humboldtallee 23, 37073 Gottingen, Germany
    Pflugers Arch 445:570-6. 2003
    ..The data indicate that histaminergic neuromodulation acts predominantly via H-1 receptors...
  19. ncbi 5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia
    Till Manzke
    Department of Neuro and Sensory Physiology, University of Goettingen, Humboldtallee 23, 37073 Goettingen, Germany
    Science 301:226-9. 2003
    ..These findings imply the prospect of a fine-tuned recovery from opioid-induced respiratory depression, through adjustment of intracellular adenosine 3',5'-monophosphate levels through the convergent signaling pathways in neurons...
  20. ncbi Dynamic activation of K(ATP) channels in rhythmically active neurons
    M Haller
    Physiologisches Institut, Georg August Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    J Physiol 537:69-81. 2001
    ..Such dynamic adjustment of channel activity operates over a high range of metabolic demands, starting below physiological conditions and extending into pathological situations of energy depletion...
  21. ncbi Oscillations and hypoxic changes of mitochondrial variables in neurons of the brainstem respiratory centre of mice
    S L Mironov
    II Department of Physiology, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    J Physiol 533:227-36. 2001
    ..Therefore mitochondrial depolarization and Ca2+ uptake can contribute to the biphasic reaction of the respiratory network during hypoxia...
  22. ncbi Metabolic coupling between glia and neurons is necessary for maintaining respiratory activity in transverse medullary slices of neonatal mouse
    S Hülsmann
    Zentrum Physiologie und Pathophysiologie, Abt Neuro und Sinnesphysiologie, Georg August Universitat, Humboldtallee 23, 37073 Gottingen, Germany
    Eur J Neurosci 12:856-62. 2000
    ..This data demonstrates that the glutamate-glutamine cycle in astrocytes and their supply of glutamine to neuronal glutamatergic terminals is essential for the rhythm generation in the respiratory centre...
  23. ncbi Voltage-clamp analysis of neurons within deep layers of the brain
    D W Richter
    II Physiologisches Institut, Universitat Gottingen, Germany
    J Neurosci Methods 67:121-3. 1996
    ....
  24. ncbi Serotonin targets inhibitory synapses to induce modulation of network functions
    Till Manzke
    Department of Neuro and Sensory Physiology, University of Gottingen, 37073 Gottingen, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2589-602. 2009
    ..The changes in network operation are robust and help to overcome opiate-induced respiratory depression. Hence, 5-HT(1A)R activation stabilizes the rhythmicity of breathing during opiate medication of pain...
  25. ncbi Morphogenic signaling in neurons via neurotransmitter receptors and small GTPases
    Evgeni Ponimaskin
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Humboldtallee 23, Gottingen, 37073, Germany
    Mol Neurobiol 35:278-87. 2007
    ....
  26. ncbi Developmental changes of serotonin 4(a) receptor expression in the rat pre-Bötzinger complex
    Till Manzke
    Department of Neuro and Sensory Physiology, Georg August University of Gottingen, 37073 Gottingen, Germany
    J Comp Neurol 506:775-90. 2008
    ..We conclude that 5-HT(4(a))Rs are important not only for neuromodulation of cellular excitability but also for respiratory network formation...
  27. ncbi Quantitative measurement of cAMP concentration using an exchange protein directly activated by a cAMP-based FRET-sensor
    Petrus S Salonikidis
    Department of Neuro and Sensory Physiology, Center for Physiology and Pathophysiology, Goettingen, Germany
    Biophys J 95:5412-23. 2008
    ..As a proof of principle, we measured the specially resolved cAMP concentration within living cells and determined the dynamic changes of cAMP levels after stimulation of the Gs-coupled serotonin receptor subtype 7 (5-HT7)...
  28. ncbi The respiratory rhythm in mutant oscillator mice
    D Büsselberg
    Georg August Universitat Gottingen, II Physiologisches Institut, Humboldtallee 23, D 37073 Gottingen, Germany
    Neurosci Lett 316:99-102. 2001
    ..Postsynaptic activity and membrane potential trajectories of respiratory neurones revealed a persistence of GABAergic inhibition and changes in respiratory rhythm and pattern generation...
  29. ncbi Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice
    Till Manzke
    Department of Neuro and Sensory Physiology, University of Gottingen, Gottingen, Germany
    J Clin Invest 120:4118-28. 2010
    ....
  30. ncbi The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity
    Evgeni G Ponimaskin
    Abteilung Neuro- und Sinnesphysiologie, Physiologisches Institut, , Humboldtallee 23, , Germany
    J Biol Chem 277:2534-46. 2002
    ..In contrast, the rate of isomerization from R to R* for the Cys(386) --> Ser as well as for the triple, non-palmitoylated mutant (Cys(328) --> Ser/Cys(329) --> Ser/Cys(386) -->Ser) was similar to that obtained for the wild type...
  31. ncbi Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling
    Ute Renner
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Gottingen, Germany
    Mol Pharmacol 72:502-13. 2007
    ..More importantly, the raft localization of the 5-HT1A receptor seems to be involved in receptor-mediated signaling...
  32. ncbi Mitochondrial organization and motility probed by two-photon microscopy in cultured mouse brainstem neurons
    Michael Muller
    Zentrum Physiologie und Pathophysiologie, Abteilung Neuro und Sinnesphysiologie, Georg August Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Exp Cell Res 303:114-27. 2005
    ....
  33. ncbi 5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology
    Elena Kvachnina
    Abteilung Neurologie und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Neurosci 25:7821-30. 2005
    ....
  34. ncbi Stimulation- and palmitoylation-dependent changes in oligomeric conformation of serotonin 5-HT1A receptors
    Fritz Kobe
    DFG Research Center for the Molecular Physiology of the Brain CMPB, University of Gottingen, Germany
    Biochim Biophys Acta 1783:1503-16. 2008
    ..In contrast, the agonist-mediated decrease of FRET signal was completely abolished in oligomers composed by non-palmitoylated receptor mutants, demonstrating the importance of palmitoylation in modulation of the structure of oligomers...
  35. ncbi Constitutive Gs-mediated, but not G12-mediated, activity of the 5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of its C-terminal domain
    Elena Kvachnina
    Department Neuro and Sensory Physiology, University of Gottingen, Gottingen, Germany
    Biochim Biophys Acta 1793:1646-55. 2009
    ..This demonstrates a functional importance of 5-HT(7(a)) dynamic palmitoylation for the fine tuning of receptor-mediated signaling...
  36. ncbi The 5-hydroxytryptamine(1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi protein
    Ekaterina Papoucheva
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Humboldtallee 23, D 37073 Goettingen, Germany
    J Biol Chem 279:3280-91. 2004
    ....
  37. ncbi 5-Hydroxytryptamine 4(a) receptor is coupled to the Galpha subunit of heterotrimeric G13 protein
    Evgeni G Ponimaskin
    Abteilung Neuro- und Sinnesphysiologie, , Humboldtallee 23, , Germany
    J Biol Chem 277:20812-9. 2002
    ..These data suggest that by activating 5-HT(4(a)) receptor-G(13) pathway, serotonin plays a prominent role in regulating neuronal architecture in addition to its classical role in neurotransmission...
  38. ncbi Differential modulation of I(h) by 5-HT receptors in mouse CA1 hippocampal neurons
    Ulf Bickmeyer
    Abteilung Neuro- und Sinnesphysiologie, , Humboldtallee 23, , Germany
    Eur J Neurosci 16:209-18. 2002
    ..A similar expression pattern was found with a new antibody against 5-HT(7) receptors which reveals immunofluorescence staining on the cell bodies of pyramidal neurons...
  39. ncbi Blockade of astrocyte metabolism causes delayed excitation as revealed by voltage-sensitive dyes in mouse brainstem slices
    Swen Hülsmann
    Abteilung Neuro und Sinnesphysiologie, Zentrum Physiologie und Pathophysiologie, Georg August Universitat Gottingen, Humboldtallee 23, 37073, Gottingen, Germany
    Exp Brain Res 150:117-21. 2003
    ....
  40. ncbi Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation
    Clemens Neusch
    Dept of Neurology, Georg August Univ Göttingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Neurophysiol 95:1843-52. 2006
    ..1 channels 1) are expressed in perineuronal processes of astrocytes, 2) constitute the major part of the astrocytic Kir conductance, and 3) contribute to regulation of extracellular K+ in the respiratory network...
  41. ncbi Effects of functional knock-out of alpha 1 glycine-receptors on breathing movements in oscillator mice
    Uwe Markstahler
    Georg August Universitat Gottingen, II Department of Neurophysiology, Humboldtallee 23, 37073 Gottingen, Germany
    Respir Physiol Neurobiol 130:33-42. 2002
    ..1 microliters in control animals. In comparison, oscillator mice showed significant lower values after p14. After p15, minute ventilation of oscillator mice declined as compared with control animals leading to respiratory acidosis at p20...
  42. ncbi Calcium-regulated potassium currents secure respiratory rhythm generation after loss of glycinergic inhibition
    Ming Gao Zhao
    Department of Neuro and Sensory Physiology, Georg August University Gottingen, Humboldtallee 23, 37073 Gottingen
    Eur J Neurosci 24:145-54. 2006
    ....
  43. ncbi Disturbances of breathing in Rett syndrome: results from patients and animal models
    Georg M Stettner
    Department of Pediatrics and Pediatric Neurology, Georg August University, Robert-Koch-Str. 40, , Germany
    Adv Exp Med Biol 605:503-7. 2008
  44. ncbi Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality
    Jesus Gomeza
    Department of Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany
    Neuron 40:797-806. 2003
    ..Thus, postnatal GlyT2 function is crucial for efficient transmitter loading of synaptic vesicles in glycinergic nerve terminals, and the GlyT2 gene constitutes a candidate disease gene in human hyperekplexia patients...
  45. ncbi 5-HT-receptor-induced changes of the intracellular cAMP level monitored by a hyperpolarization-activated cation channel
    Martin Heine
    Institute of Physiology and Pathophysiology, Department of Neuro- and Sensory Physiology Humboldtallee 23, , Germany
    Pflugers Arch 443:418-26. 2002
    ..1 microM 5-HT induced an increase of cAMP of about 4.6+/-1.5 microM, whereas cAMP levels decreased from a control value of 1+/-0.2 microM to 0.41+/-0.1 microM after stimulation of the m5-HT1A-receptors...
  46. ncbi Diversity of functional astroglial properties in the respiratory network
    Dennis Grass
    Department of Neuro- and Sensory Physiology, Center for Physiology and Pathophysiology, Georg-August-University, , Germany
    J Neurosci 24:1358-65. 2004
    ....
  47. ncbi Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice
    Georg M Stettner
    Department of Pediatrics and Pediatric Neurology, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
    J Physiol 579:863-76. 2007
    ....