Christiane Richter-Landsberg

Summary

Country: Germany

Publications

  1. ncbi request reprint The cytoskeleton in oligodendrocytes. Microtubule dynamics in health and disease
    Christiane Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, PO Box 2503, 26111 Oldenburg, Germany
    J Mol Neurosci 35:55-63. 2008
  2. pmc The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration
    Lisa Schwarz
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, 26111 Oldenburg, Germany
    Int J Cell Biol 2010:717520. 2010
  3. pmc 17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy
    Michael Riedel
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    PLoS ONE 5:e8753. 2010
  4. ncbi request reprint Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration
    Christiane Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, 26111, Oldenburg, Germany
    Acta Neuropathol 126:793-807. 2013
  5. ncbi request reprint The oligodendroglia cytoskeleton in health and disease
    C Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Germany
    J Neurosci Res 59:11-8. 2000
  6. doi request reprint Oligodendrocytes take center stage. Introduction
    Christiane Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, D 26111, Oldenburg, Germany
    J Mol Neurosci 35:1-2. 2008
  7. ncbi request reprint Tau-inclusion body formation in oligodendroglia: the role of stress proteins and proteasome inhibition
    Christiane Richter-Landsberg
    Department of Biology, University of Olderburg, PO Box 2503, D 26111 Oldenburg, Germany
    Int J Dev Neurosci 22:443-51. 2004
  8. ncbi request reprint Organization and functional roles of the cytoskeleton in oligodendrocytes
    C Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, D 26111 Oldenburg, Germany
    Microsc Res Tech 52:628-36. 2001
  9. ncbi request reprint Stress proteins in neural cells: functional roles in health and disease
    C Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, P O Box 2503, 26111 Oldenburg, Germany
    Cell Mol Life Sci 60:337-49. 2003
  10. ncbi request reprint alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes
    C Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    J Neurosci Res 62:9-14. 2000

Collaborators

  • Nina G Bauer
  • Alex E Roher
  • Stefan Probst-Cousin
  • Wolfgang Bruck
  • Bin Zhang
  • J Q Trojanowski
  • Virginia M Y Lee
  • H Ischiropoulos
  • Nancy Bonini
  • Christine Stadelmann
  • M S Forman
  • Olaf Goldbaum
  • Michael Riedel
  • Lisa Schwarz
  • Thomas Stahnke
  • Veronika Seiberlich
  • Monika Noack
  • Victoria Zhukareva
  • Kunihiro Uryu
  • Agata Fernández-Gamba
  • Sandra Bolhuis
  • Sven B Jänen
  • Grit Vollmer
  • Benoit I Giasson
  • Thomas Mronga
  • Deepa V Dabir
  • Takashi Horiguchi
  • Janina Leyk
  • Jonnie Plumb
  • Janika Borchert
  • Chera L Maarouf
  • María Celeste Leal
  • Terence Wu
  • Laura Morelli
  • Markus Bergmann
  • Eduardo M Castano
  • Michael Wille
  • Sebastian Schmitt
  • Hassan Chaachouay
  • Poul Henning Jensen
  • Anne Netzler
  • Eveline Sun
  • Erin H Norris
  • Ikuru Yazawa
  • Kristen Hilburger
  • Chi Tuan Pham
  • Matthew Micsenyi
  • William Welch
  • Christine Bellmann
  • Richard Lightfoot
  • Malte Oppermann
  • Melanie Handschuh
  • Deepa Dabir
  • C H Stewart Cameron
  • Stephen McQuaid
  • W Paul Duprex
  • Pierre Talbot

Detail Information

Publications33

  1. ncbi request reprint The cytoskeleton in oligodendrocytes. Microtubule dynamics in health and disease
    Christiane Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, PO Box 2503, 26111 Oldenburg, Germany
    J Mol Neurosci 35:55-63. 2008
    ..Furthermore, recent data on protein aggregate formation in oligodendroglial cells, which might occur during aging and disease processes, are summarized...
  2. pmc The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration
    Lisa Schwarz
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, 26111 Oldenburg, Germany
    Int J Cell Biol 2010:717520. 2010
    ....
  3. pmc 17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy
    Michael Riedel
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    PLoS ONE 5:e8753. 2010
    ..The causes underlying aggregate formation are not yet understood, impairment of the proteolytic degradation systems might be involved...
  4. ncbi request reprint Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration
    Christiane Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, 26111, Oldenburg, Germany
    Acta Neuropathol 126:793-807. 2013
    ..In this review, we will survey the process of aggresome formation, macroautophagy and the role of autophagosomal proteins and HDAC6 in inclusion body formation...
  5. ncbi request reprint The oligodendroglia cytoskeleton in health and disease
    C Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Germany
    J Neurosci Res 59:11-8. 2000
    ..The role of MTs and their associated proteins in oligodendrocytes during normal development and pathological situations is specifically emphasized in this review...
  6. doi request reprint Oligodendrocytes take center stage. Introduction
    Christiane Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, D 26111, Oldenburg, Germany
    J Mol Neurosci 35:1-2. 2008
  7. ncbi request reprint Tau-inclusion body formation in oligodendroglia: the role of stress proteins and proteasome inhibition
    Christiane Richter-Landsberg
    Department of Biology, University of Olderburg, PO Box 2503, D 26111 Oldenburg, Germany
    Int J Dev Neurosci 22:443-51. 2004
    ....
  8. ncbi request reprint Organization and functional roles of the cytoskeleton in oligodendrocytes
    C Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, D 26111 Oldenburg, Germany
    Microsc Res Tech 52:628-36. 2001
    ..Thus, neurons and glial cells share common cytoskeletal pathologies. During health and disease, MAPs might be important regulators of the structural stability and plasticity of the oligodendroglia cytoskeleton...
  9. ncbi request reprint Stress proteins in neural cells: functional roles in health and disease
    C Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, P O Box 2503, 26111 Oldenburg, Germany
    Cell Mol Life Sci 60:337-49. 2003
    ..This review summarizes the recent literature on the presence and induction of HSPs in neural cells, and their possible functional roles in health and disease are discussed...
  10. ncbi request reprint alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes
    C Richter-Landsberg
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    J Neurosci Res 62:9-14. 2000
    ..Thus, GCIs may be a consequence of altered rather than de novo expression of alpha-synuclein in MSA oligodendrocytes...
  11. doi request reprint alpha-Synuclein promotes the recruitment of tau to protein inclusions in oligodendroglial cells: effects of oxidative and proteolytic stress
    Michael Riedel
    Department of Biology, Molecular Neurobiology, University of Oldenburg, 26111, Oldenburg, Germany
    J Mol Neurosci 39:226-34. 2009
    ..The data indicate that oxidatively modified alpha-synuclein is degraded by the proteasome and that it plays a pro-aggregatory role for tau in this cell culture model system...
  12. ncbi request reprint Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes
    Olaf Goldbaum
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    Glia 53:891-901. 2006
    ..Hence, individual cells respond differently to proteasomal inhibition and the therapeutic use of proteasomal inhibitors, e.g. for the treatment of cancer or inflammatory diseases, needs to be carefully evaluated...
  13. doi request reprint The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition
    Olaf Goldbaum
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    Glia 57:1566-77. 2009
    ..Hence, HSP25 enables astrocytes to prevent irreversible damage and to recover after removal of the proteasomal inhibitor MG-132...
  14. ncbi request reprint Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture
    Olaf Goldbaum
    Department of Biology, Molecular Neurobiology, University of Oldenburg, D 26111 Oldenburg, Germany
    J Neurosci 24:5748-57. 2004
    ..In summary, the data underscore the specific sensitivity of oligodendrocytes to stress situations and point to a causal relationship of proteasomal impairment and inclusion body formation...
  15. doi request reprint The expression of tubulin polymerization promoting protein TPPP/p25alpha is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress
    Olaf Goldbaum
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    Glia 56:1736-46. 2008
    ....
  16. ncbi request reprint The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress
    Nina G Bauer
    University of Oldenburg, Department of Biology, Molecular Neurobiology, D 26111 Oldenburg, Germany
    J Mol Neurosci 29:153-68. 2006
    ..Furthermore, the binding of stress-induced alphaBcrystallin to the MTs points to a possible protective role during disease progression...
  17. ncbi request reprint Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid
    Olaf Goldbaum
    University of Oldenburg, Department of Biology, Molecular Neurobiology, D 26111 Oldenburg, Germany
    J Neurosci 23:8872-80. 2003
    ....
  18. ncbi request reprint Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders
    Thomas Stahnke
    Department of Biology, Molecular Neurobiology, University of Oldenburg, D 26111 Oldenburg, Germany
    J Mol Neurosci 32:25-37. 2007
    ..The data suggest that stress-induced HO-1 initially plays a protective role, while its chronic upregulation, might contribute to oligodendroglial cell death rather than providing protection...
  19. doi request reprint The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases
    Veronika Seiberlich
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    Biochim Biophys Acta 1823:2057-68. 2012
    ..This article is part of a Special Issue entitled: Ubiquitin Drug Discovery and Diagnostics...
  20. ncbi request reprint Mitochondrial pathway is involved in hydrogen-peroxide-induced apoptotic cell death of oligodendrocytes
    Thomas Mronga
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    Glia 46:446-55. 2004
    ..DNA fragmentation could not be attenuated by the ERK1,2 inhibitor PD 98059, indicating that the ERK1,2- pathway in oligodendrocytes may be involved in the initial survival response after exposure to stressful stimuli...
  21. doi request reprint Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress
    Michael Riedel
    Department of Biology, Molecular Neurobiology, University of Oldenburg, P O Box 2503, 26111, Oldenburg, Germany
    J Mol Neurosci 43:290-302. 2011
    ..This effect is not only attributable to the A53T mutation but also is observable in OLN cells expressing wild-type α-syn...
  22. doi request reprint Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes
    Sven B Jänen
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    Glia 58:1766-74. 2010
    ..Hence, the ability of astrocytes to upregulate autophagic degradation might contribute to their resistance against proteasomal stress situations and act as a compensatory mechanism when the proteasome is impaired...
  23. ncbi request reprint Effect of proteasome inhibition by MG-132 on HSP27 oligomerization, phosphorylation, and aggresome formation in the OLN-93 oligodendroglia cell line
    Sandra Bolhuis
    University of Oldenburg, Department of Biology, Molecular Neurobiology, Oldenburg, Germany
    J Neurochem 114:960-71. 2010
    ....
  24. doi request reprint Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells
    Veronika Seiberlich
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, 26111, Oldenburg, Germany
    Cell Biochem Biophys 67:149-60. 2013
    ..Hence, inhibition of DUBs by PR-619 activated the autophagic pathway supporting the hypothesis that the UPS and the autophagy-lysosomal pathway are closely linked together. ..
  25. ncbi request reprint Activation of PP2A-like phosphatase and modulation of tau phosphorylation accompany stress-induced apoptosis in cultured oligodendrocytes
    Olaf Goldbaum
    Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany
    Glia 40:271-82. 2002
    ..Hence, stress-induced activation of PP2A in oligodendrocytes and tau dephosphorylation constitute a major feature of the response to injury in these cells, which eventually undergo apoptotic cell death...
  26. doi request reprint Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes
    Lisa Schwarz
    Department of Biology, Molecular Neurobiology, University of Oldenburg, POB 2503, 26111, Oldenburg, Germany
    J Mol Neurosci 47:256-66. 2012
    ..In conclusion, autophagy and the ubiquitin proteasome system are closely connected, and the presence of LC3-positive vesicles in GCIs indicates that macroautophagy participates in MSA pathogenesis...
  27. pmc Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress
    Agata Fernández-Gamba
    Fundación Instituto Leloir Instituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, Argentina
    J Neurochem 121:985-95. 2012
    ....
  28. ncbi request reprint Triethyltin-induced stress responses and apoptotic cell death in cultured oligodendrocytes
    Thomas Stahnke
    Department of Biology, Molecular Biology, University of Oldenburg, Oldenburg, Germany
    Glia 46:334-44. 2004
    ..Hence, it might be hypothesized that oligodendroglial PCD, rather than axonal degeneration, contributes to myelin damage and deficits observed in rats after treatment with TET in vivo...
  29. doi request reprint HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes
    Monika Noack
    Department of Biology, Molecular Neurobiology, University of Oldenburg, D 26111, Oldenburg, Germany
    Glia 62:535-47. 2014
    ..Hence HDAC6 and dysregulation of the deacetylation and acetylation process in oligodendrocytes may contribute to diseases with oligodendroglial pathology...
  30. pmc Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies
    Kunihiro Uryu
    The Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Pathol 168:947-61. 2006
    ..These data implicate predominantly Hsp90 in the formation of alpha-syn inclusions in PD and related alpha-synucleinopathies...
  31. pmc Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology
    Deepa V Dabir
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Pathol 164:155-66. 2004
    ....
  32. ncbi request reprint Infection of human oligodendroglioma cells by a recombinant measles virus expressing enhanced green fluorescent protein
    Jonnie Plumb
    Neuropathology Laboratory, Royal Group of Hospitals Trust, Belfast, Northern Ireland, United Kingdom
    J Neurovirol 8:24-34. 2002
    ....
  33. pmc Nitration of tau protein is linked to neurodegeneration in tauopathies
    Takashi Horiguchi
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Am J Pathol 163:1021-31. 2003
    ..Taken together, these findings imply that nitrative injury is directly linked to the formation of filamentous tau inclusions...